Trait: age at menarche

Experimental Factor Ontology (EFO) Information
Identifier EFO_0004703
Description The age of onset of (human) menarche, the beginning of the first menstrual cycle in an individual
Trait category
Other measurement
Mapped terms 2 mapped terms
  • NCIt:C19666
  • SNOMEDCT:398700009

Associated Polygenic Score(s)

Filter PGS by Participant Ancestry
Individuals included in:
G - Source of Variant Associations (GWAS)
D - Score Development/Training
E - PGS Evaluation
List of ancestries includes:
Display options:
Ancestry legend
Multi-ancestry (including European)
Multi-ancestry (excluding European)
African
East Asian
South Asian
Additional Asian Ancestries
European
Greater Middle Eastern
Hispanic or Latin American
Additional Diverse Ancestries
Not Reported
Polygenic Score ID & Name PGS Publication ID (PGP) Reported Trait Mapped Trait(s) (Ontology) Number of Variants Ancestry distribution
GWAS
Dev
Eval
 Scoring File (FTP Link)
PGS001915
(portability-PLR_F_menarche)
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Age when periods started (menarche) age at menarche 38,940
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS001915/ScoringFiles/PGS001915.txt.gz
PGS002131
(portability-ldpred2_F_menarche)
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Age when periods started (menarche) age at menarche 854,735
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS002131/ScoringFiles/PGS002131.txt.gz
PGS002310
(repro_MENARCHE_AGE.BOLT-LMM)
 PGP000332 |
Weissbrod O et al. Nat Genet (2022)
 Age at menarche age at menarche 1,109,311
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS002310/ScoringFiles/PGS002310.txt.gz
PGS002382
(repro_MENARCHE_AGE.P+T.0.0001)
 PGP000332 |
Weissbrod O et al. Nat Genet (2022)
 Age at menarche age at menarche 6,332
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS002382/ScoringFiles/PGS002382.txt.gz
PGS002431
(repro_MENARCHE_AGE.P+T.0.001)
 PGP000332 |
Weissbrod O et al. Nat Genet (2022)
 Age at menarche age at menarche 21,880
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS002431/ScoringFiles/PGS002431.txt.gz
PGS002480
(repro_MENARCHE_AGE.P+T.0.01)
 PGP000332 |
Weissbrod O et al. Nat Genet (2022)
 Age at menarche age at menarche 115,583
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS002480/ScoringFiles/PGS002480.txt.gz
PGS002529
(repro_MENARCHE_AGE.P+T.1e-06)
 PGP000332 |
Weissbrod O et al. Nat Genet (2022)
 Age at menarche age at menarche 1,546
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS002529/ScoringFiles/PGS002529.txt.gz
PGS002578
(repro_MENARCHE_AGE.P+T.5e-08)
 PGP000332 |
Weissbrod O et al. Nat Genet (2022)
 Age at menarche age at menarche 891
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS002578/ScoringFiles/PGS002578.txt.gz
PGS002627
(repro_MENARCHE_AGE.PolyFun-pred)
 PGP000332 |
Weissbrod O et al. Nat Genet (2022)
 Age at menarche age at menarche 831,098
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS002627/ScoringFiles/PGS002627.txt.gz
PGS002676
(repro_MENARCHE_AGE.SBayesR)
 PGP000332 |
Weissbrod O et al. Nat Genet (2022)
 Age at menarche age at menarche 988,120
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS002676/ScoringFiles/PGS002676.txt.gz
PGS002815
(ExPRSweb_AgeAtMenarche_ieu-a-1095_LASSOSUM_UKB_20211120)
 PGP000393 |
Ma Y et al. Am J Hum Genet (2022)
 Age at menarche age at menarche 137,734
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS002815/ScoringFiles/PGS002815.txt.gz
PGS002816
(ExPRSweb_AgeAtMenarche_ieu-a-1095_PT_UKB_20211120)
 PGP000393 |
Ma Y et al. Am J Hum Genet (2022)
 Age at menarche age at menarche 13,852
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS002816/ScoringFiles/PGS002816.txt.gz
PGS002817
(ExPRSweb_AgeAtMenarche_ieu-a-1095_PLINK_UKB_20211120)
 PGP000393 |
Ma Y et al. Am J Hum Genet (2022)
 Age at menarche age at menarche 13,852
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS002817/ScoringFiles/PGS002817.txt.gz
PGS002818
(ExPRSweb_AgeAtMenarche_ieu-a-1095_DBSLMM_UKB_20211120)
 PGP000393 |
Ma Y et al. Am J Hum Genet (2022)
 Age at menarche age at menarche 991,712
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS002818/ScoringFiles/PGS002818.txt.gz
PGS002819
(ExPRSweb_AgeAtMenarche_ieu-a-1095_PRSCS_UKB_20211120)
 PGP000393 |
Ma Y et al. Am J Hum Genet (2022)
 Age at menarche age at menarche 895,562
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS002819/ScoringFiles/PGS002819.txt.gz
PGS003508
(cont-decay-F_menarche)
 PGP000457 |
Ding Y et al. bioRxiv (2022)
|Pre		 Age when periods started (menarche) age at menarche 979,739
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS003508/ScoringFiles/PGS003508.txt.gz

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		Evaluated Score PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM010203 PGS001915
(portability-PLR_F_menarche)
 PSS009375|
European Ancestry|
5,746 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Age when periods started (menarche) — — Partial Correlation (partial-r): 0.2798 [0.2557, 0.3035] sex, age, birth date, deprivation index, 16 PCs —
PPM010204 PGS001915
(portability-PLR_F_menarche)
 PSS009149|
European Ancestry|
1,292 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Age when periods started (menarche) — — Partial Correlation (partial-r): 0.2408 [0.1884, 0.2919] sex, age, birth date, deprivation index, 16 PCs —
PPM010205 PGS001915
(portability-PLR_F_menarche)
 PSS008703|
European Ancestry|
1,920 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Age when periods started (menarche) — — Partial Correlation (partial-r): 0.2576 [0.2152, 0.2992] sex, age, birth date, deprivation index, 16 PCs —
PPM010206 PGS001915
(portability-PLR_F_menarche)
 PSS008477|
Greater Middle Eastern Ancestry|
221 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Age when periods started (menarche) — — Partial Correlation (partial-r): 0.1617 [0.0242, 0.2932] sex, age, birth date, deprivation index, 16 PCs —
PPM010207 PGS001915
(portability-PLR_F_menarche)
 PSS008255|
South Asian Ancestry|
1,460 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Age when periods started (menarche) — — Partial Correlation (partial-r): 0.0834 [0.0319, 0.1345] sex, age, birth date, deprivation index, 16 PCs —
PPM010209 PGS001915
(portability-PLR_F_menarche)
 PSS007819|
African Ancestry|
771 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Age when periods started (menarche) — — Partial Correlation (partial-r): 0.0913 [0.02, 0.1618] sex, age, birth date, deprivation index, 16 PCs —
PPM010210 PGS001915
(portability-PLR_F_menarche)
 PSS008923|
African Ancestry|
994 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Age when periods started (menarche) — — Partial Correlation (partial-r): 0.0772 [0.0145, 0.1393] sex, age, birth date, deprivation index, 16 PCs —
PPM010208 PGS001915
(portability-PLR_F_menarche)
 PSS008033|
East Asian Ancestry|
611 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Age when periods started (menarche) — — Partial Correlation (partial-r): 0.1105 [0.0302, 0.1894] sex, age, birth date, deprivation index, 16 PCs —
PPM011908 PGS002131
(portability-ldpred2_F_menarche)
 PSS008033|
East Asian Ancestry|
611 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Age when periods started (menarche) — — Partial Correlation (partial-r): 0.0879 [0.0074, 0.1673] sex, age, birth date, deprivation index, 16 PCs —
PPM011903 PGS002131
(portability-ldpred2_F_menarche)
 PSS009375|
European Ancestry|
5,746 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Age when periods started (menarche) — — Partial Correlation (partial-r): 0.2831 [0.2591, 0.3067] sex, age, birth date, deprivation index, 16 PCs —
PPM011904 PGS002131
(portability-ldpred2_F_menarche)
 PSS009149|
European Ancestry|
1,292 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Age when periods started (menarche) — — Partial Correlation (partial-r): 0.245 [0.1926, 0.296] sex, age, birth date, deprivation index, 16 PCs —
PPM011905 PGS002131
(portability-ldpred2_F_menarche)
 PSS008703|
European Ancestry|
1,920 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Age when periods started (menarche) — — Partial Correlation (partial-r): 0.2575 [0.215, 0.299] sex, age, birth date, deprivation index, 16 PCs —
PPM011906 PGS002131
(portability-ldpred2_F_menarche)
 PSS008477|
Greater Middle Eastern Ancestry|
221 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Age when periods started (menarche) — — Partial Correlation (partial-r): 0.1354 [-0.0027, 0.2685] sex, age, birth date, deprivation index, 16 PCs —
PPM011907 PGS002131
(portability-ldpred2_F_menarche)
 PSS008255|
South Asian Ancestry|
1,460 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Age when periods started (menarche) — — Partial Correlation (partial-r): 0.0945 [0.0431, 0.1454] sex, age, birth date, deprivation index, 16 PCs —
PPM011909 PGS002131
(portability-ldpred2_F_menarche)
 PSS007819|
African Ancestry|
771 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Age when periods started (menarche) — — Partial Correlation (partial-r): 0.1018 [0.0306, 0.1721] sex, age, birth date, deprivation index, 16 PCs —
PPM011910 PGS002131
(portability-ldpred2_F_menarche)
 PSS008923|
African Ancestry|
994 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Age when periods started (menarche) — — Partial Correlation (partial-r): 0.1087 [0.0462, 0.1703] sex, age, birth date, deprivation index, 16 PCs —
PPM013124 PGS002310
(repro_MENARCHE_AGE.BOLT-LMM)
 PSS009684|
East Asian Ancestry|
554 individuals
 PGP000332 |
Weissbrod O et al. Nat Genet (2022)
 Reported Trait: Age of Menarche — — Incremental R2 (full model vs. covariates alone): 0.007 age, sex, age*sex, assessment center, genotyping array, 10 PCs —
PPM013173 PGS002310
(repro_MENARCHE_AGE.BOLT-LMM)
 PSS009685|
European Ancestry|
23,774 individuals
 PGP000332 |
Weissbrod O et al. Nat Genet (2022)
 Reported Trait: Age of Menarche — — Incremental R2 (full model vs. covariates alone): 0.0995 age, sex, age*sex, assessment center, genotyping array, 10 PCs —
PPM013222 PGS002310
(repro_MENARCHE_AGE.BOLT-LMM)
 PSS009686|
South Asian Ancestry|
3,465 individuals
 PGP000332 |
Weissbrod O et al. Nat Genet (2022)
 Reported Trait: Age of Menarche — — Incremental R2 (full model vs. covariates alone): 0.0299 age, sex, age*sex, assessment center, genotyping array, 10 PCs —
PPM013075 PGS002310
(repro_MENARCHE_AGE.BOLT-LMM)
 PSS009683|
African Ancestry|
3,392 individuals
 PGP000332 |
Weissbrod O et al. Nat Genet (2022)
 Reported Trait: Age of Menarche — — Incremental R2 (full model vs. covariates alone): 0.0078 age, sex, age*sex, assessment center, genotyping array, 10 PCs —
PPM013510 PGS002382
(repro_MENARCHE_AGE.P+T.0.0001)
 PSS009686|
South Asian Ancestry|
3,465 individuals
 PGP000332 |
Weissbrod O et al. Nat Genet (2022)
 Reported Trait: Age of Menarche — — Incremental R2 (full model vs. covariates alone): 0.0134 age, sex, age*sex, assessment center, genotyping array, 10 PCs —
PPM013363 PGS002382
(repro_MENARCHE_AGE.P+T.0.0001)
 PSS009683|
African Ancestry|
3,392 individuals
 PGP000332 |
Weissbrod O et al. Nat Genet (2022)
 Reported Trait: Age of Menarche — — Incremental R2 (full model vs. covariates alone): 0.0008 age, sex, age*sex, assessment center, genotyping array, 10 PCs —
PPM013412 PGS002382
(repro_MENARCHE_AGE.P+T.0.0001)
 PSS009684|
East Asian Ancestry|
554 individuals
 PGP000332 |
Weissbrod O et al. Nat Genet (2022)
 Reported Trait: Age of Menarche — — Incremental R2 (full model vs. covariates alone): 0.0196 age, sex, age*sex, assessment center, genotyping array, 10 PCs —
PPM013461 PGS002382
(repro_MENARCHE_AGE.P+T.0.0001)
 PSS009685|
European Ancestry|
23,774 individuals
 PGP000332 |
Weissbrod O et al. Nat Genet (2022)
 Reported Trait: Age of Menarche — — Incremental R2 (full model vs. covariates alone): 0.051 age, sex, age*sex, assessment center, genotyping array, 10 PCs —
PPM013559 PGS002431
(repro_MENARCHE_AGE.P+T.0.001)
 PSS009683|
African Ancestry|
3,392 individuals
 PGP000332 |
Weissbrod O et al. Nat Genet (2022)
 Reported Trait: Age of Menarche — — Incremental R2 (full model vs. covariates alone): 0.0002 age, sex, age*sex, assessment center, genotyping array, 10 PCs —
PPM013657 PGS002431
(repro_MENARCHE_AGE.P+T.0.001)
 PSS009685|
European Ancestry|
23,774 individuals
 PGP000332 |
Weissbrod O et al. Nat Genet (2022)
 Reported Trait: Age of Menarche — — Incremental R2 (full model vs. covariates alone): 0.0432 age, sex, age*sex, assessment center, genotyping array, 10 PCs —
PPM013706 PGS002431
(repro_MENARCHE_AGE.P+T.0.001)
 PSS009686|
South Asian Ancestry|
3,465 individuals
 PGP000332 |
Weissbrod O et al. Nat Genet (2022)
 Reported Trait: Age of Menarche — — Incremental R2 (full model vs. covariates alone): 0.0032 age, sex, age*sex, assessment center, genotyping array, 10 PCs —
PPM013608 PGS002431
(repro_MENARCHE_AGE.P+T.0.001)
 PSS009684|
East Asian Ancestry|
554 individuals
 PGP000332 |
Weissbrod O et al. Nat Genet (2022)
 Reported Trait: Age of Menarche — — Incremental R2 (full model vs. covariates alone): 0.0047 age, sex, age*sex, assessment center, genotyping array, 10 PCs —
PPM013755 PGS002480
(repro_MENARCHE_AGE.P+T.0.01)
 PSS009683|
African Ancestry|
3,392 individuals
 PGP000332 |
Weissbrod O et al. Nat Genet (2022)
 Reported Trait: Age of Menarche — — Incremental R2 (full model vs. covariates alone): 0.0003 age, sex, age*sex, assessment center, genotyping array, 10 PCs —
PPM013804 PGS002480
(repro_MENARCHE_AGE.P+T.0.01)
 PSS009684|
East Asian Ancestry|
554 individuals
 PGP000332 |
Weissbrod O et al. Nat Genet (2022)
 Reported Trait: Age of Menarche — — Incremental R2 (full model vs. covariates alone): 0.0008 age, sex, age*sex, assessment center, genotyping array, 10 PCs —
PPM013853 PGS002480
(repro_MENARCHE_AGE.P+T.0.01)
 PSS009685|
European Ancestry|
23,774 individuals
 PGP000332 |
Weissbrod O et al. Nat Genet (2022)
 Reported Trait: Age of Menarche — — Incremental R2 (full model vs. covariates alone): 0.0203 age, sex, age*sex, assessment center, genotyping array, 10 PCs —
PPM013902 PGS002480
(repro_MENARCHE_AGE.P+T.0.01)
 PSS009686|
South Asian Ancestry|
3,465 individuals
 PGP000332 |
Weissbrod O et al. Nat Genet (2022)
 Reported Trait: Age of Menarche — — Incremental R2 (full model vs. covariates alone): 0.0001 age, sex, age*sex, assessment center, genotyping array, 10 PCs —
PPM013951 PGS002529
(repro_MENARCHE_AGE.P+T.1e-06)
 PSS009683|
African Ancestry|
3,392 individuals
 PGP000332 |
Weissbrod O et al. Nat Genet (2022)
 Reported Trait: Age of Menarche — — Incremental R2 (full model vs. covariates alone): 0.0018 age, sex, age*sex, assessment center, genotyping array, 10 PCs —
PPM014000 PGS002529
(repro_MENARCHE_AGE.P+T.1e-06)
 PSS009684|
East Asian Ancestry|
554 individuals
 PGP000332 |
Weissbrod O et al. Nat Genet (2022)
 Reported Trait: Age of Menarche — — Incremental R2 (full model vs. covariates alone): 0.0271 age, sex, age*sex, assessment center, genotyping array, 10 PCs —
PPM014049 PGS002529
(repro_MENARCHE_AGE.P+T.1e-06)
 PSS009685|
European Ancestry|
23,774 individuals
 PGP000332 |
Weissbrod O et al. Nat Genet (2022)
 Reported Trait: Age of Menarche — — Incremental R2 (full model vs. covariates alone): 0.0399 age, sex, age*sex, assessment center, genotyping array, 10 PCs —
PPM014098 PGS002529
(repro_MENARCHE_AGE.P+T.1e-06)
 PSS009686|
South Asian Ancestry|
3,465 individuals
 PGP000332 |
Weissbrod O et al. Nat Genet (2022)
 Reported Trait: Age of Menarche — — Incremental R2 (full model vs. covariates alone): 0.0103 age, sex, age*sex, assessment center, genotyping array, 10 PCs —
PPM014147 PGS002578
(repro_MENARCHE_AGE.P+T.5e-08)
 PSS009683|
African Ancestry|
3,392 individuals
 PGP000332 |
Weissbrod O et al. Nat Genet (2022)
 Reported Trait: Age of Menarche — — Incremental R2 (full model vs. covariates alone): 0.002 age, sex, age*sex, assessment center, genotyping array, 10 PCs —
PPM014196 PGS002578
(repro_MENARCHE_AGE.P+T.5e-08)
 PSS009684|
East Asian Ancestry|
554 individuals
 PGP000332 |
Weissbrod O et al. Nat Genet (2022)
 Reported Trait: Age of Menarche — — Incremental R2 (full model vs. covariates alone): 0.0207 age, sex, age*sex, assessment center, genotyping array, 10 PCs —
PPM014245 PGS002578
(repro_MENARCHE_AGE.P+T.5e-08)
 PSS009685|
European Ancestry|
23,774 individuals
 PGP000332 |
Weissbrod O et al. Nat Genet (2022)
 Reported Trait: Age of Menarche — — Incremental R2 (full model vs. covariates alone): 0.0338 age, sex, age*sex, assessment center, genotyping array, 10 PCs —
PPM014294 PGS002578
(repro_MENARCHE_AGE.P+T.5e-08)
 PSS009686|
South Asian Ancestry|
3,465 individuals
 PGP000332 |
Weissbrod O et al. Nat Genet (2022)
 Reported Trait: Age of Menarche — — Incremental R2 (full model vs. covariates alone): 0.0084 age, sex, age*sex, assessment center, genotyping array, 10 PCs —
PPM014343 PGS002627
(repro_MENARCHE_AGE.PolyFun-pred)
 PSS009683|
African Ancestry|
3,392 individuals
 PGP000332 |
Weissbrod O et al. Nat Genet (2022)
 Reported Trait: Age of Menarche — — Incremental R2 (full model when combined with BOLT-LMM vs. covariates alone): 0.0078 age, sex, age*sex, assessment center, genotyping array, 10 PCs See repro_MENARCHE_AGE.mixweights file at http://data.broadinstitute.org/alkesgroup/polypred_results for combination weights
PPM014392 PGS002627
(repro_MENARCHE_AGE.PolyFun-pred)
 PSS009684|
East Asian Ancestry|
554 individuals
 PGP000332 |
Weissbrod O et al. Nat Genet (2022)
 Reported Trait: Age of Menarche — — Incremental R2 (full model when combined with BOLT-LMM vs. covariates alone): 0.007 age, sex, age*sex, assessment center, genotyping array, 10 PCs See repro_MENARCHE_AGE.mixweights file at http://data.broadinstitute.org/alkesgroup/polypred_results for combination weights
PPM014441 PGS002627
(repro_MENARCHE_AGE.PolyFun-pred)
 PSS009685|
European Ancestry|
23,774 individuals
 PGP000332 |
Weissbrod O et al. Nat Genet (2022)
 Reported Trait: Age of Menarche — — Incremental R2 (full model when combined with BOLT-LMM vs. covariates alone): 0.1008 age, sex, age*sex, assessment center, genotyping array, 10 PCs See repro_MENARCHE_AGE.mixweights file at http://data.broadinstitute.org/alkesgroup/polypred_results for combination weights
PPM014490 PGS002627
(repro_MENARCHE_AGE.PolyFun-pred)
 PSS009686|
South Asian Ancestry|
3,465 individuals
 PGP000332 |
Weissbrod O et al. Nat Genet (2022)
 Reported Trait: Age of Menarche — — Incremental R2 (full model when combined with BOLT-LMM vs. covariates alone): 0.0318 age, sex, age*sex, assessment center, genotyping array, 10 PCs See repro_MENARCHE_AGE.mixweights file at http://data.broadinstitute.org/alkesgroup/polypred_results for combination weights
PPM014588 PGS002676
(repro_MENARCHE_AGE.SBayesR)
 PSS009684|
East Asian Ancestry|
554 individuals
 PGP000332 |
Weissbrod O et al. Nat Genet (2022)
 Reported Trait: Age of Menarche — — Incremental R2 (full model vs. covariates alone): 0.0072 age, sex, age*sex, assessment center, genotyping array, 10 PCs —
PPM014539 PGS002676
(repro_MENARCHE_AGE.SBayesR)
 PSS009683|
African Ancestry|
3,392 individuals
 PGP000332 |
Weissbrod O et al. Nat Genet (2022)
 Reported Trait: Age of Menarche — — Incremental R2 (full model vs. covariates alone): 0.0158 age, sex, age*sex, assessment center, genotyping array, 10 PCs —
PPM014637 PGS002676
(repro_MENARCHE_AGE.SBayesR)
 PSS009685|
European Ancestry|
23,774 individuals
 PGP000332 |
Weissbrod O et al. Nat Genet (2022)
 Reported Trait: Age of Menarche — — Incremental R2 (full model vs. covariates alone): 0.0972 age, sex, age*sex, assessment center, genotyping array, 10 PCs —
PPM014686 PGS002676
(repro_MENARCHE_AGE.SBayesR)
 PSS009686|
South Asian Ancestry|
3,465 individuals
 PGP000332 |
Weissbrod O et al. Nat Genet (2022)
 Reported Trait: Age of Menarche — — Incremental R2 (full model vs. covariates alone): 0.0311 age, sex, age*sex, assessment center, genotyping array, 10 PCs —
PPM015604 PGS002815
(ExPRSweb_AgeAtMenarche_ieu-a-1095_LASSOSUM_UKB_20211120)
 PSS010021|
European Ancestry|
110,333 individuals
 PGP000393 |
Ma Y et al. Am J Hum Genet (2022)
 Reported Trait: Age at Menarche β: 0.265 (0.0083) — R²: 0.00922 Sex,birthYear,genotyping.array,PC1,PC2,PC3,PC4 —
PPM015607 PGS002816
(ExPRSweb_AgeAtMenarche_ieu-a-1095_PT_UKB_20211120)
 PSS010021|
European Ancestry|
110,333 individuals
 PGP000393 |
Ma Y et al. Am J Hum Genet (2022)
 Reported Trait: Age at Menarche β: 0.3 (0.00831) — R²: 0.0118 Sex,birthYear,genotyping.array,PC1,PC2,PC3,PC4 —
PPM015605 PGS002817
(ExPRSweb_AgeAtMenarche_ieu-a-1095_PLINK_UKB_20211120)
 PSS010021|
European Ancestry|
110,333 individuals
 PGP000393 |
Ma Y et al. Am J Hum Genet (2022)
 Reported Trait: Age at Menarche β: 0.3 (0.00831) — R²: 0.0118 Sex,birthYear,genotyping.array,PC1,PC2,PC3,PC4 —
PPM015603 PGS002818
(ExPRSweb_AgeAtMenarche_ieu-a-1095_DBSLMM_UKB_20211120)
 PSS010021|
European Ancestry|
110,333 individuals
 PGP000393 |
Ma Y et al. Am J Hum Genet (2022)
 Reported Trait: Age at Menarche β: 0.159 (0.00835) — R²: 0.00332 Sex,birthYear,genotyping.array,PC1,PC2,PC3,PC4 —
PPM015606 PGS002819
(ExPRSweb_AgeAtMenarche_ieu-a-1095_PRSCS_UKB_20211120)
 PSS010021|
European Ancestry|
110,333 individuals
 PGP000393 |
Ma Y et al. Am J Hum Genet (2022)
 Reported Trait: Age at Menarche β: 0.298 (0.00831) — R²: 0.0117 Sex,birthYear,genotyping.array,PC1,PC2,PC3,PC4 —
PPM017436 PGS003508
(cont-decay-F_menarche)
 PSS010869|
European Ancestry|
10,448 individuals
 PGP000457 |
Ding Y et al. bioRxiv (2022)
|Pre		 Reported Trait: Age when periods started (menarche) — — partial-R2: 0.1 sex, age, deprivation index, PC1-16 —
PPM017520 PGS003508
(cont-decay-F_menarche)
 PSS010785|
European Ancestry|
2,448 individuals
 PGP000457 |
Ding Y et al. bioRxiv (2022)
|Pre		 Reported Trait: Age when periods started (menarche) — — partial-R2: 0.08 sex, age, deprivation index, PC1-16 —
PPM017604 PGS003508
(cont-decay-F_menarche)
 PSS010617|
European Ancestry|
3,478 individuals
 PGP000457 |
Ding Y et al. bioRxiv (2022)
|Pre		 Reported Trait: Age when periods started (menarche) — — partial-R2: 0.08 sex, age, deprivation index, PC1-16 —
PPM017688 PGS003508
(cont-decay-F_menarche)
 PSS010533|
Greater Middle Eastern Ancestry|
442 individuals
 PGP000457 |
Ding Y et al. bioRxiv (2022)
|Pre		 Reported Trait: Age when periods started (menarche) — — partial-R2: 0.05 sex, age, deprivation index, PC1-16 —
PPM017772 PGS003508
(cont-decay-F_menarche)
 PSS010197|
European Ancestry|
1,248 individuals
 PGP000457 |
Ding Y et al. bioRxiv (2022)
|Pre		 Reported Trait: Age when periods started (menarche) — — partial-R2: 0.1 sex, age, deprivation index, PC1-16 —
PPM017856 PGS003508
(cont-decay-F_menarche)
 PSS010449|
South Asian Ancestry|
2,633 individuals
 PGP000457 |
Ding Y et al. bioRxiv (2022)
|Pre		 Reported Trait: Age when periods started (menarche) — — partial-R2: 0.03 sex, age, deprivation index, PC1-16 —
PPM017940 PGS003508
(cont-decay-F_menarche)
 PSS010365|
East Asian Ancestry|
1,138 individuals
 PGP000457 |
Ding Y et al. bioRxiv (2022)
|Pre		 Reported Trait: Age when periods started (menarche) — — partial-R2: 0.02 sex, age, deprivation index, PC1-16 —
PPM018024 PGS003508
(cont-decay-F_menarche)
 PSS010281|
African Ancestry|
1,469 individuals
 PGP000457 |
Ding Y et al. bioRxiv (2022)
|Pre		 Reported Trait: Age when periods started (menarche) — — partial-R2: 0.03 sex, age, deprivation index, PC1-16 —
PPM018108 PGS003508
(cont-decay-F_menarche)
 PSS010701|
African Ancestry|
1,905 individuals
 PGP000457 |
Ding Y et al. bioRxiv (2022)
|Pre		 Reported Trait: Age when periods started (menarche) — — partial-R2: 0.01 sex, age, deprivation index, PC1-16 —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS010785 — — 2,448 individuals,
0.0 % Male samples
 Mean = 54.5 years
Sd = 7.6 years		 European Polish UKB —
PSS010533 — — 442 individuals,
0.0 % Male samples
 Mean = 52.2 years
Sd = 8.0 years		 Greater Middle Eastern (Middle Eastern, North African or Persian) Iranian UKB —
PSS010281 — — 1,469 individuals,
0.0 % Male samples
 Mean = 52.2 years
Sd = 7.9 years		 African American or Afro-Caribbean Caribbean UKB —
PSS008923 — — 994 individuals — African unspecified Nigeria (West Africa) UKB —
PSS008033 — — 611 individuals — East Asian China (East Asia) UKB —
PSS010701 — — 1,905 individuals,
0.0 % Male samples
 Mean = 52.3 years
Sd = 8.0 years		 African unspecified Nigerian UKB —
PSS010449 — — 2,633 individuals,
0.0 % Male samples
 Mean = 52.8 years
Sd = 8.0 years		 South Asian Indian UKB —
PSS010197 — — 1,248 individuals,
0.0 % Male samples
 Mean = 57.8 years
Sd = 7.0 years		 European Ashkenazi UKB —
PSS008703 — — 1,920 individuals — European Italy (South Europe) UKB —
PSS010021 Field ID: 2714; Quantitative — 110,333 individuals — European — UKB —
PSS007819 — — 771 individuals — African American or Afro-Caribbean Carribean UKB —
PSS009684 — — 554 individuals — East Asian — UKB —
PSS009685 — — 23,774 individuals — European Non-British European UKB —
PSS009686 — — 3,465 individuals — South Asian — UKB —
PSS009683 — — 3,392 individuals — African unspecified — UKB —
PSS010869 — — 10,448 individuals,
0.0 % Male samples
 Mean = 56.7 years
Sd = 7.8 years		 European white British UKB —
PSS008477 — — 221 individuals — Greater Middle Eastern (Middle Eastern, North African or Persian) Iran (Middle East) UKB —
PSS009375 — — 5,746 individuals — European UK (+ Ireland) UKB —
PSS010617 — — 3,478 individuals,
0.0 % Male samples
 Mean = 54.2 years
Sd = 8.3 years		 European Italian UKB —
PSS010365 — — 1,138 individuals,
0.0 % Male samples
 Mean = 52.4 years
Sd = 7.5 years		 East Asian Chinese UKB —
PSS009149 — — 1,292 individuals — European Poland (NE Europe) UKB —
PSS008255 — — 1,460 individuals — South Asian India (South Asia) UKB —