Trait: age at menopause

Experimental Factor Ontology (EFO) Information
Identifier EFO_0004704
Description The age of onset of (human) menopause, the beginning of the first menstrual cycle in an individual
Trait category
Other measurement
Mapped term NCIt:C106497

Associated Polygenic Score(s)

Filter PGS by Participant Ancestry
Individuals included in:
G - Source of Variant Associations (GWAS)
D - Score Development/Training
E - PGS Evaluation
List of ancestries includes:
Display options:
Ancestry legend
Multi-ancestry (including European)
Multi-ancestry (excluding European)
African
East Asian
South Asian
Additional Asian Ancestries
European
Greater Middle Eastern
Hispanic or Latin American
Additional Diverse Ancestries
Not Reported
Polygenic Score ID & Name PGS Publication ID (PGP) Reported Trait Mapped Trait(s) (Ontology) Number of Variants Ancestry distribution
GWAS
Dev
Eval
 Scoring File (FTP Link)
PGS002820
(ExPRSweb_AgeAtMenopause_ieu-a-1004_LASSOSUM_UKB_20211120)
 PGP000393 |
Ma Y et al. Am J Hum Genet (2022)
 Age at menopause age at menopause 99,745
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS002820/ScoringFiles/PGS002820.txt.gz
PGS002821
(ExPRSweb_AgeAtMenopause_ieu-a-1004_PT_UKB_20211120)
 PGP000393 |
Ma Y et al. Am J Hum Genet (2022)
 Age at menopause age at menopause 159
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS002821/ScoringFiles/PGS002821.txt.gz
PGS002822
(ExPRSweb_AgeAtMenopause_ieu-a-1004_PLINK_UKB_20211120)
 PGP000393 |
Ma Y et al. Am J Hum Genet (2022)
 Age at menopause age at menopause 159
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS002822/ScoringFiles/PGS002822.txt.gz
PGS002823
(ExPRSweb_AgeAtMenopause_ieu-a-1004_DBSLMM_UKB_20211120)
 PGP000393 |
Ma Y et al. Am J Hum Genet (2022)
 Age at menopause age at menopause 1,379,304
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS002823/ScoringFiles/PGS002823.txt.gz
PGS002824
(ExPRSweb_AgeAtMenopause_ieu-a-1004_PRSCS_UKB_20211120)
 PGP000393 |
Ma Y et al. Am J Hum Genet (2022)
 Age at menopause age at menopause 894,484
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS002824/ScoringFiles/PGS002824.txt.gz

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		Evaluated Score PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM015609 PGS002820
(ExPRSweb_AgeAtMenopause_ieu-a-1004_LASSOSUM_UKB_20211120)
 PSS010022|
European Ancestry|
69,801 individuals
 PGP000393 |
Ma Y et al. Am J Hum Genet (2022)
 Reported Trait: Age at Menopause β: 0.492 (0.0508) — R²: 0.00118 Sex,birthYear,genotyping.array,PC1,PC2,PC3,PC4 —
PPM015612 PGS002821
(ExPRSweb_AgeAtMenopause_ieu-a-1004_PT_UKB_20211120)
 PSS010022|
European Ancestry|
69,801 individuals
 PGP000393 |
Ma Y et al. Am J Hum Genet (2022)
 Reported Trait: Age at Menopause β: 0.809 (0.0507) — R²: 0.00316 Sex,birthYear,genotyping.array,PC1,PC2,PC3,PC4 —
PPM015610 PGS002822
(ExPRSweb_AgeAtMenopause_ieu-a-1004_PLINK_UKB_20211120)
 PSS010022|
European Ancestry|
69,801 individuals
 PGP000393 |
Ma Y et al. Am J Hum Genet (2022)
 Reported Trait: Age at Menopause β: 0.809 (0.0507) — R²: 0.00316 Sex,birthYear,genotyping.array,PC1,PC2,PC3,PC4 —
PPM015608 PGS002823
(ExPRSweb_AgeAtMenopause_ieu-a-1004_DBSLMM_UKB_20211120)
 PSS010022|
European Ancestry|
69,801 individuals
 PGP000393 |
Ma Y et al. Am J Hum Genet (2022)
 Reported Trait: Age at Menopause β: 0.387 (0.0506) — R²: 0.00071 Sex,birthYear,genotyping.array,PC1,PC2,PC3,PC4 —
PPM015611 PGS002824
(ExPRSweb_AgeAtMenopause_ieu-a-1004_PRSCS_UKB_20211120)
 PSS010022|
European Ancestry|
69,801 individuals
 PGP000393 |
Ma Y et al. Am J Hum Genet (2022)
 Reported Trait: Age at Menopause β: 0.519 (0.0507) — R²: 0.00129 Sex,birthYear,genotyping.array,PC1,PC2,PC3,PC4 —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS010022 Field ID: 3581; Quantitative — 69,801 individuals — European — UKB —