Trait: eye inflammation

Experimental Factor Ontology (EFO) Information
Identifier EFO_0005752
Description an inflammation in the eye(s)
Trait category
Other trait
Mapped term MedDRA:10015943

Associated Polygenic Score(s)

Filter PGS by Participant Ancestry
Individuals included in:
G - Source of Variant Associations (GWAS)
D - Score Development/Training
E - PGS Evaluation
List of ancestries includes:
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Ancestry legend
Multi-ancestry (including European)
Multi-ancestry (excluding European)
African
East Asian
South Asian
Additional Asian Ancestries
European
Greater Middle Eastern
Hispanic or Latin American
Additional Diverse Ancestries
Not Reported
Polygenic Score ID & Name PGS Publication ID (PGP) Reported Trait Mapped Trait(s) (Ontology) Number of Variants Ancestry distribution
GWAS
Dev
Eval
 Scoring File (FTP Link)
PGS002045
(portability-ldpred2_371)
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Inflammation of the eye eye disease,
eye inflammation		 527,030
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS002045/ScoringFiles/PGS002045.txt.gz

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		Evaluated Score PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM011225 PGS002045
(portability-ldpred2_371)
 PSS009082|
European Ancestry|
4,069 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Inflammation of the eye — — Partial Correlation (partial-r): -0.007 [-0.0378, 0.0238] sex, age, birth date, deprivation index, 16 PCs —
PPM011227 PGS002045
(portability-ldpred2_371)
 PSS008410|
Greater Middle Eastern Ancestry|
1,183 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Inflammation of the eye — — Partial Correlation (partial-r): 0.0226 [-0.0349, 0.08] sex, age, birth date, deprivation index, 16 PCs —
PPM011228 PGS002045
(portability-ldpred2_371)
 PSS008190|
South Asian Ancestry|
6,184 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Inflammation of the eye — — Partial Correlation (partial-r): 0.01 [-0.015, 0.0349] sex, age, birth date, deprivation index, 16 PCs —
PPM011229 PGS002045
(portability-ldpred2_371)
 PSS007973|
East Asian Ancestry|
1,779 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Inflammation of the eye — — Partial Correlation (partial-r): -0.0042 [-0.0509, 0.0426] sex, age, birth date, deprivation index, 16 PCs —
PPM011230 PGS002045
(portability-ldpred2_371)
 PSS007755|
African Ancestry|
2,428 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Inflammation of the eye — — Partial Correlation (partial-r): -0.0067 [-0.0466, 0.0333] sex, age, birth date, deprivation index, 16 PCs —
PPM011231 PGS002045
(portability-ldpred2_371)
 PSS008860|
African Ancestry|
3,820 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Inflammation of the eye — — Partial Correlation (partial-r): -0.008 [-0.0397, 0.0238] sex, age, birth date, deprivation index, 16 PCs —
PPM011224 PGS002045
(portability-ldpred2_371)
 PSS009308|
European Ancestry|
19,618 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Inflammation of the eye — — Partial Correlation (partial-r): 0.0162 [0.0022, 0.0302] sex, age, birth date, deprivation index, 16 PCs —
PPM011226 PGS002045
(portability-ldpred2_371)
 PSS008636|
European Ancestry|
6,561 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Inflammation of the eye — — Partial Correlation (partial-r): 0.0309 [0.0067, 0.0551] sex, age, birth date, deprivation index, 16 PCs —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS007973 — — 1,779 individuals — East Asian China (East Asia) UKB —
PSS007755 — — 2,428 individuals — African American or Afro-Caribbean Carribean UKB —
PSS008636 — — 6,561 individuals — European Italy (South Europe) UKB —
PSS009082 — — 4,069 individuals — European Poland (NE Europe) UKB —
PSS008410 — — 1,183 individuals — Greater Middle Eastern (Middle Eastern, North African or Persian) Iran (Middle East) UKB —
PSS008860 — — 3,820 individuals — African unspecified Nigeria (West Africa) UKB —
PSS008190 — — 6,184 individuals — South Asian India (South Asia) UKB —
PSS009308 — — 19,618 individuals — European UK (+ Ireland) UKB —