Trait: allergic rhinitis

Experimental Factor Ontology (EFO) Information
Identifier EFO_0005854
Description Inflammation of the nasal mucous membranes caused by an IgE-mediated response to external allergens. The inflammation may also involve the mucous membranes of the sinuses, eyes, middle ear, and pharynx. Symptoms include sneezing, nasal congestion, rhinorrhea, and itching. It may lead to fatigue, drowsiness, and malaise thus causing impairment of the quality of life. [NCIT: C79532]
Trait category
Immune system disorder
Synonyms 10 synonyms
  • AR
  • Alrh
  • Perenial allergic rhinitis
  • allergic form of rhinitis
  • allergic rhinitis
  • atopic rhinitis
  • non-seasonal allergic rhinitis
  • perennial allergic rhinitis
  • pollenosis
  • seasonal allergic rhinitis
Mapped terms 16 mapped terms
  • DOID:4481
  • HP:0003193
  • ICD9:477
  • ICD9:477.8
  • ICD9:477.9
  • MEDGEN:382012
  • MONDO:0011786
  • MedDRA:10001723
  • MedDRA:10001727
  • NCIT:C79532
  • NCIt:C79532
  • OMIM:607154
  • SCTID:61582004
  • SNOMEDCT:61582004
  • UMLS:C2607914
  • icd11.foundation:1711769234
Child trait(s) 2 child traits

Associated Polygenic Score(s)

Filter PGS by Participant Ancestry
Individuals included in:
G - Source of Variant Associations (GWAS)
D - Score Development/Training
E - PGS Evaluation
List of ancestries includes:
Display options:
Ancestry legend
Multi-ancestry (including European)
Multi-ancestry (excluding European)
African
East Asian
South Asian
Additional Asian Ancestries
European
Greater Middle Eastern
Hispanic or Latin American
Additional Diverse Ancestries
Not Reported
Note: This table shows all PGS for "allergic rhinitis" and any child terms of this trait in the EFO hierarchy by default.
Polygenic Score ID & Name PGS Publication ID (PGP) Reported Trait Mapped Trait(s) (Ontology) Number of Variants Ancestry distribution
GWAS
Dev
Eval
 Scoring File (FTP Link)
PGS001109
(GBE_HC1021)
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
 Vasomotor and allergic rhinitis (time-to-event) allergic rhinitis,
vasomotor rhinitis		 1,910
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS001109/ScoringFiles/PGS001109.txt.gz
PGS001259
(GBE_HC49)
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
 Hayfever/allergic rhinitis seasonal allergic rhinitis 349
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS001259/ScoringFiles/PGS001259.txt.gz

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		Evaluated Score PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM008284 PGS001109
(GBE_HC1021)
 PSS004069|
African Ancestry|
6,497 individuals
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
 Reported Trait: TTE vasomotor and allergic rhinitis — AUROC: 0.5683 [0.54473, 0.59188] R²: 0.01206
Incremental AUROC (full-covars): 0.00409
PGS R2 (no covariates): 0.00275
PGS AUROC (no covariates): 0.53243 [0.50926, 0.55561]		 age, sex, UKB array type, Genotype PCs Full Model & PGS R2 is estimated using Nagelkerke's method
PPM008285 PGS001109
(GBE_HC1021)
 PSS004070|
East Asian Ancestry|
1,704 individuals
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
 Reported Trait: TTE vasomotor and allergic rhinitis — AUROC: 0.54528 [0.51116, 0.5794] R²: 0.01457
Incremental AUROC (full-covars): 0.00387
PGS R2 (no covariates): 0.00105
PGS AUROC (no covariates): 0.51375 [0.47834, 0.54917]		 age, sex, UKB array type, Genotype PCs Full Model & PGS R2 is estimated using Nagelkerke's method
PPM008286 PGS001109
(GBE_HC1021)
 PSS004071|
European Ancestry|
24,905 individuals
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
 Reported Trait: TTE vasomotor and allergic rhinitis — AUROC: 0.6003 [0.58786, 0.61273] R²: 0.0217
Incremental AUROC (full-covars): 0.02658
PGS R2 (no covariates): 0.00981
PGS AUROC (no covariates): 0.56712 [0.55454, 0.57969]		 age, sex, UKB array type, Genotype PCs Full Model & PGS R2 is estimated using Nagelkerke's method
PPM008287 PGS001109
(GBE_HC1021)
 PSS004072|
South Asian Ancestry|
7,831 individuals
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
 Reported Trait: TTE vasomotor and allergic rhinitis — AUROC: 0.55379 [0.53392, 0.57366] R²: 0.00762
Incremental AUROC (full-covars): 0.0079
PGS R2 (no covariates): 0.00254
PGS AUROC (no covariates): 0.53239 [0.51256, 0.55222]		 age, sex, UKB array type, Genotype PCs Full Model & PGS R2 is estimated using Nagelkerke's method
PPM008288 PGS001109
(GBE_HC1021)
 PSS004073|
European Ancestry|
67,425 individuals
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
 Reported Trait: TTE vasomotor and allergic rhinitis — AUROC: 0.59854 [0.59138, 0.6057] R²: 0.02303
Incremental AUROC (full-covars): 0.02878
PGS R2 (no covariates): 0.0118
PGS AUROC (no covariates): 0.56998 [0.56268, 0.57727]		 age, sex, UKB array type, Genotype PCs Full Model & PGS R2 is estimated using Nagelkerke's method
PPM008800 PGS001259
(GBE_HC49)
 PSS004511|
African Ancestry|
6,497 individuals
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
 Reported Trait: Hayfever/allergic rhinitis — AUROC: 0.58821 [0.55886, 0.61757] R²: 0.01784
Incremental AUROC (full-covars): -0.00253
PGS R2 (no covariates): 0.00082
PGS AUROC (no covariates): 0.51547 [0.48626, 0.54467]		 age, sex, UKB array type, Genotype PCs Full Model & PGS R2 is estimated using Nagelkerke's method
PPM008801 PGS001259
(GBE_HC49)
 PSS004512|
East Asian Ancestry|
1,704 individuals
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
 Reported Trait: Hayfever/allergic rhinitis — AUROC: 0.56313 [0.52505, 0.60122] R²: 0.02281
Incremental AUROC (full-covars): 0.00075
PGS R2 (no covariates): 0.0011
PGS AUROC (no covariates): 0.52627 [0.48539, 0.56716]		 age, sex, UKB array type, Genotype PCs Full Model & PGS R2 is estimated using Nagelkerke's method
PPM008802 PGS001259
(GBE_HC49)
 PSS004513|
European Ancestry|
24,905 individuals
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
 Reported Trait: Hayfever/allergic rhinitis — AUROC: 0.60641 [0.59175, 0.62107] R²: 0.02043
Incremental AUROC (full-covars): 0.01519
PGS R2 (no covariates): 0.00564
PGS AUROC (no covariates): 0.55414 [0.53891, 0.56936]		 age, sex, UKB array type, Genotype PCs Full Model & PGS R2 is estimated using Nagelkerke's method
PPM008803 PGS001259
(GBE_HC49)
 PSS004514|
South Asian Ancestry|
7,831 individuals
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
 Reported Trait: Hayfever/allergic rhinitis — AUROC: 0.60093 [0.57427, 0.6276] R²: 0.02041
Incremental AUROC (full-covars): 0.00631
PGS R2 (no covariates): 0.00266
PGS AUROC (no covariates): 0.54086 [0.51259, 0.56913]		 age, sex, UKB array type, Genotype PCs Full Model & PGS R2 is estimated using Nagelkerke's method
PPM008804 PGS001259
(GBE_HC49)
 PSS004515|
European Ancestry|
67,425 individuals
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
 Reported Trait: Hayfever/allergic rhinitis — AUROC: 0.60078 [0.59218, 0.60937] R²: 0.02042
Incremental AUROC (full-covars): 0.01922
PGS R2 (no covariates): 0.00737
PGS AUROC (no covariates): 0.5597 [0.55096, 0.56843]		 age, sex, UKB array type, Genotype PCs Full Model & PGS R2 is estimated using Nagelkerke's method

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS004511 — —
[
  • 393 cases
  • , 6,104 controls
]
 — African unspecified — UKB —
PSS004512 — —
[
  • 215 cases
  • , 1,489 controls
]
 — East Asian — UKB —
PSS004513 — —
[
  • 1,438 cases
  • , 23,467 controls
]
 — European non-white British ancestry UKB —
PSS004514 — —
[
  • 435 cases
  • , 7,396 controls
]
 — South Asian — UKB —
PSS004515 — —
[
  • 4,398 cases
  • , 63,027 controls
]
 — European white British ancestry UKB Testing cohort (heldout set)
PSS004069 — —
[
  • 648 cases
  • , 5,849 controls
]
 — African unspecified — UKB —
PSS004070 — —
[
  • 330 cases
  • , 1,374 controls
]
 — East Asian — UKB —
PSS004071 — —
[
  • 2,149 cases
  • , 22,756 controls
]
 — European non-white British ancestry UKB —
PSS004072 — —
[
  • 893 cases
  • , 6,938 controls
]
 — South Asian — UKB —
PSS004073 — —
[
  • 6,545 cases
  • , 60,880 controls
]
 — European white British ancestry UKB Testing cohort (heldout set)