Trait: superior frontal gyrus grey matter volume measurement

Experimental Factor Ontology (EFO) Information
Identifier EFO_0006516
Description quantification of the volume of grey matter in the superior frontal gyrus, usuallly through an MRI scan
Trait category
Other measurement

Associated Polygenic Score(s)

Filter PGS by Participant Ancestry
Individuals included in:
G - Source of Variant Associations (GWAS)
D - Score Development/Training
E - PGS Evaluation
List of ancestries includes:
Display options:
Ancestry legend
Multi-ancestry (including European)
Multi-ancestry (excluding European)
African
East Asian
South Asian
Additional Asian Ancestries
European
Greater Middle Eastern
Hispanic or Latin American
Additional Diverse Ancestries
Not Reported
Polygenic Score ID & Name PGS Publication ID (PGP) Reported Trait Mapped Trait(s) (Ontology) Number of Variants Ancestry distribution
GWAS
Dev
Eval
 Scoring File (FTP Link)
PGS001597
(GBE_INI25786)
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
 Volume of grey matter in Superior Frontal Gyrus (L) neuroimaging measurement,
superior frontal gyrus grey matter volume measurement		 1,049
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS001597/ScoringFiles/PGS001597.txt.gz
PGS001598
(GBE_INI25787)
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
 Volume of grey matter in Superior Frontal Gyrus (R) neuroimaging measurement,
superior frontal gyrus grey matter volume measurement		 5
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS001598/ScoringFiles/PGS001598.txt.gz

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		Evaluated Score PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM006620 PGS001597
(GBE_INI25786)
 PSS006456|
African Ancestry|
200 individuals
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
 Reported Trait: Vol. of grey matter in Superior Frontal Gyrus (L) — — R²: 0.09859 [0.08484, 0.11235]
Incremental R2 (full-covars): -0.00792
PGS R2 (no covariates): 1e-05 [-0.00014, 0.00016]		 age, sex, UKB array type, Genotype PCs —
PPM006621 PGS001597
(GBE_INI25786)
 PSS006457|
East Asian Ancestry|
113 individuals
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
 Reported Trait: Vol. of grey matter in Superior Frontal Gyrus (L) — — R²: 0.19477 [0.16109, 0.22844]
Incremental R2 (full-covars): 0.01272
PGS R2 (no covariates): 0.01399 [0.00294, 0.02504]		 age, sex, UKB array type, Genotype PCs —
PPM006622 PGS001597
(GBE_INI25786)
 PSS006458|
European Ancestry|
1,739 individuals
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
 Reported Trait: Vol. of grey matter in Superior Frontal Gyrus (L) — — R²: 0.13433 [0.12645, 0.14221]
Incremental R2 (full-covars): 0.00771
PGS R2 (no covariates): 0.00816 [0.00593, 0.01038]		 age, sex, UKB array type, Genotype PCs —
PPM006623 PGS001597
(GBE_INI25786)
 PSS006459|
South Asian Ancestry|
329 individuals
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
 Reported Trait: Vol. of grey matter in Superior Frontal Gyrus (L) — — R²: 0.12481 [0.11112, 0.1385]
Incremental R2 (full-covars): -0.00831
PGS R2 (no covariates): 0.00016 [-0.0004, 0.00073]		 age, sex, UKB array type, Genotype PCs —
PPM006624 PGS001597
(GBE_INI25786)
 PSS006460|
European Ancestry|
5,443 individuals
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
 Reported Trait: Vol. of grey matter in Superior Frontal Gyrus (L) — — R²: 0.11229 [0.1078, 0.11678]
Incremental R2 (full-covars): 0.00643
PGS R2 (no covariates): 0.00753 [0.00623, 0.00883]		 age, sex, UKB array type, Genotype PCs —
PPM006625 PGS001598
(GBE_INI25787)
 PSS006461|
African Ancestry|
200 individuals
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
 Reported Trait: Vol. of grey matter in Superior Frontal Gyrus (R) — — R²: 0.08072 [0.06802, 0.09341]
Incremental R2 (full-covars): 0.0004
PGS R2 (no covariates): 1e-05 [-0.00014, 0.00016]		 age, sex, UKB array type, Genotype PCs —
PPM006626 PGS001598
(GBE_INI25787)
 PSS006462|
East Asian Ancestry|
113 individuals
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
 Reported Trait: Vol. of grey matter in Superior Frontal Gyrus (R) — — R²: 0.25224 [0.21665, 0.28782]
Incremental R2 (full-covars): -0.00235
PGS R2 (no covariates): 0.02356 [0.00936, 0.03777]		 age, sex, UKB array type, Genotype PCs —
PPM006627 PGS001598
(GBE_INI25787)
 PSS006463|
European Ancestry|
1,739 individuals
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
 Reported Trait: Vol. of grey matter in Superior Frontal Gyrus (R) — — R²: 0.13093 [0.12312, 0.13874]
Incremental R2 (full-covars): 0.00227
PGS R2 (no covariates): 0.00362 [0.00213, 0.00511]		 age, sex, UKB array type, Genotype PCs —
PPM006628 PGS001598
(GBE_INI25787)
 PSS006464|
South Asian Ancestry|
329 individuals
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
 Reported Trait: Vol. of grey matter in Superior Frontal Gyrus (R) — — R²: 0.14935 [0.13479, 0.1639]
Incremental R2 (full-covars): 0.00133
PGS R2 (no covariates): 0.00125 [-0.00031, 0.00281]		 age, sex, UKB array type, Genotype PCs —
PPM006629 PGS001598
(GBE_INI25787)
 PSS006465|
European Ancestry|
5,443 individuals
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
 Reported Trait: Vol. of grey matter in Superior Frontal Gyrus (R) — — R²: 0.09939 [0.09511, 0.10368]
Incremental R2 (full-covars): 0.00223
PGS R2 (no covariates): 0.0033 [0.00243, 0.00416]		 age, sex, UKB array type, Genotype PCs —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS006460 — — 5,443 individuals — European white British ancestry UKB Testing cohort (heldout set)
PSS006461 — — 200 individuals — African unspecified — UKB —
PSS006462 — — 113 individuals — East Asian — UKB —
PSS006463 — — 1,739 individuals — European non-white British ancestry UKB —
PSS006464 — — 329 individuals — South Asian — UKB —
PSS006465 — — 5,443 individuals — European white British ancestry UKB Testing cohort (heldout set)
PSS006456 — — 200 individuals — African unspecified — UKB —
PSS006457 — — 113 individuals — East Asian — UKB —
PSS006458 — — 1,739 individuals — European non-white British ancestry UKB —
PSS006459 — — 329 individuals — South Asian — UKB —