Trait: nucleus accumbens volume

Experimental Factor Ontology (EFO) Information
Identifier EFO_0006931
Description quantification of the volume of the nucleus accumbens, a region of the basal forebrain rostral to the preoptic area of the hypothalamus and which together with the olfactory tubercle forms the ventral striatum
Trait category
Other measurement

Associated Polygenic Score(s)

Filter PGS by Participant Ancestry
Individuals included in:
G - Source of Variant Associations (GWAS)
D - Score Development/Training
E - PGS Evaluation
List of ancestries includes:
Display options:
Ancestry legend
Multi-ancestry (including European)
Multi-ancestry (excluding European)
African
East Asian
South Asian
Additional Asian Ancestries
European
Greater Middle Eastern
Hispanic or Latin American
Additional Diverse Ancestries
Not Reported
Polygenic Score ID & Name PGS Publication ID (PGP) Reported Trait Mapped Trait(s) (Ontology) Number of Variants Ancestry distribution
GWAS
Dev
Eval
 Scoring File (FTP Link)
PGS001537
(GBE_INI25023)
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
 Volume of accumbens (L) neuroimaging measurement,
nucleus accumbens volume		 647
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS001537/ScoringFiles/PGS001537.txt.gz
PGS001538
(GBE_INI25024)
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
 Volume of accumbens (R) neuroimaging measurement,
nucleus accumbens volume		 643
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS001538/ScoringFiles/PGS001538.txt.gz

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		Evaluated Score PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM005445 PGS001537
(GBE_INI25023)
 PSS005281|
African Ancestry|
200 individuals
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
 Reported Trait: Vol. of accumbens (L) — — R²: 0.22724 [0.20933, 0.24514]
Incremental R2 (full-covars): 0.00582
PGS R2 (no covariates): 0.0189 [0.01234, 0.02546]		 age, sex, UKB array type, Genotype PCs —
PPM005446 PGS001537
(GBE_INI25023)
 PSS005282|
East Asian Ancestry|
113 individuals
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
 Reported Trait: Vol. of accumbens (L) — — R²: 0.1475 [0.11648, 0.17853]
Incremental R2 (full-covars): -0.00779
PGS R2 (no covariates): 0.00255 [-0.00222, 0.00733]		 age, sex, UKB array type, Genotype PCs —
PPM005447 PGS001537
(GBE_INI25023)
 PSS005283|
European Ancestry|
1,739 individuals
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
 Reported Trait: Vol. of accumbens (L) — — R²: 0.2189 [0.20982, 0.22797]
Incremental R2 (full-covars): 0.00532
PGS R2 (no covariates): 0.00656 [0.00456, 0.00856]		 age, sex, UKB array type, Genotype PCs —
PPM005448 PGS001537
(GBE_INI25023)
 PSS005284|
South Asian Ancestry|
328 individuals
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
 Reported Trait: Vol. of accumbens (L) — — R²: 0.26307 [0.24633, 0.2798]
Incremental R2 (full-covars): -0.00549
PGS R2 (no covariates): 0.0 [-0.00008, 0.00008]		 age, sex, UKB array type, Genotype PCs —
PPM005449 PGS001537
(GBE_INI25023)
 PSS005285|
European Ancestry|
5,443 individuals
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
 Reported Trait: Vol. of accumbens (L) — — R²: 0.15316 [0.14816, 0.15817]
Incremental R2 (full-covars): 0.00598
PGS R2 (no covariates): 0.00546 [0.00435, 0.00657]		 age, sex, UKB array type, Genotype PCs —
PPM005450 PGS001538
(GBE_INI25024)
 PSS005286|
African Ancestry|
200 individuals
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
 Reported Trait: Vol. of accumbens (R) — — R²: 0.29382 [0.27521, 0.31242]
Incremental R2 (full-covars): -0.00191
PGS R2 (no covariates): 0.00137 [-0.00043, 0.00316]		 age, sex, UKB array type, Genotype PCs —
PPM005451 PGS001538
(GBE_INI25024)
 PSS005287|
East Asian Ancestry|
113 individuals
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
 Reported Trait: Vol. of accumbens (R) — — R²: 0.18368 [0.15052, 0.21683]
Incremental R2 (full-covars): 0.008
PGS R2 (no covariates): 0.00588 [-0.00134, 0.0131]		 age, sex, UKB array type, Genotype PCs —
PPM005452 PGS001538
(GBE_INI25024)
 PSS005288|
European Ancestry|
1,739 individuals
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
 Reported Trait: Vol. of accumbens (R) — — R²: 0.19982 [0.19094, 0.2087]
Incremental R2 (full-covars): 0.0024
PGS R2 (no covariates): 0.00717 [0.00508, 0.00926]		 age, sex, UKB array type, Genotype PCs —
PPM005453 PGS001538
(GBE_INI25024)
 PSS005289|
South Asian Ancestry|
328 individuals
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
 Reported Trait: Vol. of accumbens (R) — — R²: 0.30769 [0.29069, 0.3247]
Incremental R2 (full-covars): 0.00789
PGS R2 (no covariates): 0.00434 [0.00143, 0.00724]		 age, sex, UKB array type, Genotype PCs —
PPM005454 PGS001538
(GBE_INI25024)
 PSS005290|
European Ancestry|
5,443 individuals
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
 Reported Trait: Vol. of accumbens (R) — — R²: 0.17591 [0.17069, 0.18113]
Incremental R2 (full-covars): 0.0067
PGS R2 (no covariates): 0.0065 [0.00529, 0.0077]		 age, sex, UKB array type, Genotype PCs —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS005281 — — 200 individuals — African unspecified — UKB —
PSS005282 — — 113 individuals — East Asian — UKB —
PSS005283 — — 1,739 individuals — European non-white British ancestry UKB —
PSS005284 — — 328 individuals — South Asian — UKB —
PSS005285 — — 5,443 individuals — European white British ancestry UKB Testing cohort (heldout set)
PSS005286 — — 200 individuals — African unspecified — UKB —
PSS005287 — — 113 individuals — East Asian — UKB —
PSS005288 — — 1,739 individuals — European non-white British ancestry UKB —
PSS005289 — — 328 individuals — South Asian — UKB —
PSS005290 — — 5,443 individuals — European white British ancestry UKB Testing cohort (heldout set)