Trait: putamen volume

Experimental Factor Ontology (EFO) Information
Identifier EFO_0006932
Description quantification of the volume of the putamen, a round structure located at the base of the forebrain
Trait category
Other measurement

Associated Polygenic Score(s)

Filter PGS by Participant Ancestry
Individuals included in:
G - Source of Variant Associations (GWAS)
D - Score Development/Training
E - PGS Evaluation
List of ancestries includes:
Display options:
Ancestry legend
Multi-ancestry (including European)
Multi-ancestry (excluding European)
African
East Asian
South Asian
Additional Asian Ancestries
European
Greater Middle Eastern
Hispanic or Latin American
Additional Diverse Ancestries
Not Reported
Polygenic Score ID & Name PGS Publication ID (PGP) Reported Trait Mapped Trait(s) (Ontology) Number of Variants Ancestry distribution
GWAS
Dev
Eval
 Scoring File (FTP Link)
PGS001635
(GBE_INI25015)
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
 Volume of putamen (L) neuroimaging measurement,
putamen volume		 747
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS001635/ScoringFiles/PGS001635.txt.gz
PGS001636
(GBE_INI25016)
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
 Volume of putamen (R) neuroimaging measurement,
putamen volume		 2,048
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS001636/ScoringFiles/PGS001636.txt.gz

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		Evaluated Score PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM005420 PGS001635
(GBE_INI25015)
 PSS005256|
African Ancestry|
200 individuals
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
 Reported Trait: Vol. of putamen (L) — — R²: 0.33965 [0.32095, 0.35836]
Incremental R2 (full-covars): 0.00697
PGS R2 (no covariates): 0.00173 [-0.00029, 0.00375]		 age, sex, UKB array type, Genotype PCs —
PPM005421 PGS001635
(GBE_INI25015)
 PSS005257|
East Asian Ancestry|
113 individuals
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
 Reported Trait: Vol. of putamen (L) — — R²: 0.30984 [0.27344, 0.34625]
Incremental R2 (full-covars): -0.01626
PGS R2 (no covariates): 0.01874 [0.00601, 0.03146]		 age, sex, UKB array type, Genotype PCs —
PPM005422 PGS001635
(GBE_INI25015)
 PSS005258|
European Ancestry|
1,739 individuals
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
 Reported Trait: Vol. of putamen (L) — — R²: 0.31778 [0.30823, 0.32733]
Incremental R2 (full-covars): 0.01379
PGS R2 (no covariates): 0.01037 [0.00787, 0.01288]		 age, sex, UKB array type, Genotype PCs —
PPM005423 PGS001635
(GBE_INI25015)
 PSS005259|
South Asian Ancestry|
328 individuals
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
 Reported Trait: Vol. of putamen (L) — — R²: 0.36514 [0.34815, 0.38212]
Incremental R2 (full-covars): 0.00063
PGS R2 (no covariates): 0.00157 [-0.00018, 0.00333]		 age, sex, UKB array type, Genotype PCs —
PPM005424 PGS001635
(GBE_INI25015)
 PSS005260|
European Ancestry|
5,443 individuals
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
 Reported Trait: Vol. of putamen (L) — — R²: 0.25509 [0.24941, 0.26077]
Incremental R2 (full-covars): 0.01846
PGS R2 (no covariates): 0.0242 [0.0219, 0.02649]		 age, sex, UKB array type, Genotype PCs —
PPM005425 PGS001636
(GBE_INI25016)
 PSS005261|
African Ancestry|
200 individuals
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
 Reported Trait: Vol. of putamen (R) — — R²: 0.39088 [0.37237, 0.40939]
Incremental R2 (full-covars): -0.01331
PGS R2 (no covariates): 0.00077 [-0.00058, 0.00213]		 age, sex, UKB array type, Genotype PCs —
PPM005426 PGS001636
(GBE_INI25016)
 PSS005262|
East Asian Ancestry|
113 individuals
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
 Reported Trait: Vol. of putamen (R) — — R²: 0.21046 [0.17614, 0.24479]
Incremental R2 (full-covars): 0.00709
PGS R2 (no covariates): 0.01057 [0.00093, 0.02021]		 age, sex, UKB array type, Genotype PCs —
PPM005427 PGS001636
(GBE_INI25016)
 PSS005263|
European Ancestry|
1,739 individuals
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
 Reported Trait: Vol. of putamen (R) — — R²: 0.306 [0.29646, 0.31553]
Incremental R2 (full-covars): 0.01075
PGS R2 (no covariates): 0.00831 [0.00606, 0.01055]		 age, sex, UKB array type, Genotype PCs —
PPM005428 PGS001636
(GBE_INI25016)
 PSS005264|
South Asian Ancestry|
328 individuals
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
 Reported Trait: Vol. of putamen (R) — — R²: 0.38833 [0.37146, 0.40521]
Incremental R2 (full-covars): -0.02573
PGS R2 (no covariates): 1e-05 [-0.0001, 0.00011]		 age, sex, UKB array type, Genotype PCs —
PPM005429 PGS001636
(GBE_INI25016)
 PSS005265|
European Ancestry|
5,443 individuals
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
 Reported Trait: Vol. of putamen (R) — — R²: 0.27752 [0.27178, 0.28327]
Incremental R2 (full-covars): 0.02342
PGS R2 (no covariates): 0.02816 [0.0257, 0.03062]		 age, sex, UKB array type, Genotype PCs —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS005256 — — 200 individuals — African unspecified — UKB —
PSS005257 — — 113 individuals — East Asian — UKB —
PSS005258 — — 1,739 individuals — European non-white British ancestry UKB —
PSS005259 — — 328 individuals — South Asian — UKB —
PSS005260 — — 5,443 individuals — European white British ancestry UKB Testing cohort (heldout set)
PSS005261 — — 200 individuals — African unspecified — UKB —
PSS005262 — — 113 individuals — East Asian — UKB —
PSS005263 — — 1,739 individuals — European non-white British ancestry UKB —
PSS005264 — — 328 individuals — South Asian — UKB —
PSS005265 — — 5,443 individuals — European white British ancestry UKB Testing cohort (heldout set)