| Experimental Factor Ontology (EFO) Information | |
| Identifier | EFO_0007462 |
| Description | A disorder characterized by episodes of vigorous and often violent motor activity during rem sleep (... sleep, rem). The affected individual may inflict self injury or harm others, and is difficult to awaken from this condition. Episodes are usually followed by a vivid recollection of a dream that is consistent with the aggressive behavior. This condition primarily affects adult males. (From Adams et al., Principles of Neurology, 6th ed, p393) [MESH: D020187]Show more |
| Trait category |
Neurological disorder
|
| Synonyms |
5 synonyms
|
| Mapped terms |
10 mapped terms
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Polygenic Score ID & Name
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PGS Publication ID (PGP)
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Reported Trait
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Mapped Trait(s) (Ontology)
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Number of Variants
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Ancestry distribution GWAS Dev Eval |
Scoring File (FTP Link)
|
|---|---|---|---|---|---|---|
| PGS003414 (PRS47_RBD) | PGP000427 | Krohn L et al. Nat Commun (2022) | REM sleep behavior disorder | REM sleep behavior disorder | 47 | - | https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS003414/ScoringFiles/PGS003414.txt.gz |
PGS Performance Metric ID (PPM) |
Evaluated Score
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PGS Sample Set ID (PSS) |
Performance Source
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Trait
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PGS Effect Sizes (per SD change) |
Classification Metrics
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Other Metrics
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Covariates Included in the Model
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PGS Performance: Other Relevant Information |
|---|---|---|---|---|---|---|---|---|---|
| PPM017064 | PGS003414 (PRS47_RBD) | PSS010109| European Ancestry| 1,477 individuals | PGP000427 | Krohn L et al. Nat Commun (2022) | Reported Trait: Isolated REM sleep behavior disorder | — | AUROC: 0.614 [0.575, 0.654] | — | — | — |
| PPM017065 | PGS003414 (PRS47_RBD) | PSS010110| European Ancestry| 1,192 individuals | PGP000427 | Krohn L et al. Nat Commun (2022) | Reported Trait: Probabable REM sleep behavior disorder (with Parkinson disease) | — | AUROC: 0.597 [0.56, 0.634] | — | — | — |
| PPM017066 | PGS003414 (PRS47_RBD) | PSS010111| European Ancestry| 1,124 individuals | PGP000427 | Krohn L et al. Nat Commun (2022) | Reported Trait: Probabable REM sleep behavior disorder | — | AUROC: 0.548 [0.505, 0.59] | — | — | — |
PGS Sample Set ID (PSS) |
Phenotype Definitions and Methods
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Participant Follow-up Time
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Sample Numbers
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Age of Study Participants
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Sample Ancestry
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Additional Ancestry Description
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Cohort(s)
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Additional Sample/Cohort Information
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|---|---|---|---|---|---|---|---|---|
| PSS010109 | — | — | [
| — | European | — | 23andMe, WTCCC | — |
| PSS010110 | — | — | [
| — | European | — | 23andMe, WTCCC | — |
| PSS010111 | — | — | [
| — | European | — | 23andMe, WTCCC | — |