Trait: depressive episode measurement

Experimental Factor Ontology (EFO) Information
Identifier EFO_0007704
Description quantification of some aspect, eg frequency or severity, of depressive episodes in patients with mental or behavioural disorders such as bipolar disorder or clinical depression
Trait category
Other measurement

Associated Polygenic Score(s)

Filter PGS by Participant Ancestry
Individuals included in:
G - Source of Variant Associations (GWAS)
D - Score Development/Training
E - PGS Evaluation
List of ancestries includes:
Display options:
Ancestry legend
Multi-ancestry (including European)
Multi-ancestry (excluding European)
African
East Asian
South Asian
Additional Asian Ancestries
European
Greater Middle Eastern
Hispanic or Latin American
Additional Diverse Ancestries
Not Reported
Polygenic Score ID & Name PGS Publication ID (PGP) Reported Trait Mapped Trait(s) (Ontology) Number of Variants Ancestry distribution
GWAS
Dev
Eval
 Scoring File (FTP Link)
PGS002113
(portability-ldpred2_depression_stress_trauma)
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Depression possibly related to stressful or traumatic event depressive episode measurement,
trauma exposure measurement		 545,334
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS002113/ScoringFiles/PGS002113.txt.gz
PGS003497
(cont-decay-depressed_for_1w)
 PGP000457 |
Ding Y et al. bioRxiv (2022)
|Pre		 Ever depressed for a whole week depressive episode measurement 979,739
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS003497/ScoringFiles/PGS003497.txt.gz

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		Evaluated Score PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM011760 PGS002113
(portability-ldpred2_depression_stress_trauma)
 PSS009170|
European Ancestry|
741 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Depression possibly related to stressful or traumatic event — — Partial Correlation (partial-r): 0.0272 [-0.0459, 0.1001] sex, age, birth date, deprivation index, 16 PCs —
PPM011759 PGS002113
(portability-ldpred2_depression_stress_trauma)
 PSS009396|
European Ancestry|
3,597 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Depression possibly related to stressful or traumatic event — — Partial Correlation (partial-r): 0.0378 [0.005, 0.0705] sex, age, birth date, deprivation index, 16 PCs —
PPM011761 PGS002113
(portability-ldpred2_depression_stress_trauma)
 PSS008724|
European Ancestry|
1,364 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Depression possibly related to stressful or traumatic event — — Partial Correlation (partial-r): 0.0391 [-0.0144, 0.0924] sex, age, birth date, deprivation index, 16 PCs —
PPM011762 PGS002113
(portability-ldpred2_depression_stress_trauma)
 PSS008498|
Greater Middle Eastern Ancestry|
100 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Depression possibly related to stressful or traumatic event — — Partial Correlation (partial-r): -0.0739 [-0.2889, 0.1482] sex, age, birth date, deprivation index, 16 PCs —
PPM011763 PGS002113
(portability-ldpred2_depression_stress_trauma)
 PSS008276|
South Asian Ancestry|
425 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Depression possibly related to stressful or traumatic event — — Partial Correlation (partial-r): 0.1438 [0.0471, 0.238] sex, age, birth date, deprivation index, 16 PCs —
PPM011764 PGS002113
(portability-ldpred2_depression_stress_trauma)
 PSS008053|
East Asian Ancestry|
215 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Depression possibly related to stressful or traumatic event — — Partial Correlation (partial-r): 0.0141 [-0.1267, 0.1543] sex, age, birth date, deprivation index, 16 PCs —
PPM011765 PGS002113
(portability-ldpred2_depression_stress_trauma)
 PSS007840|
African Ancestry|
215 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Depression possibly related to stressful or traumatic event — — Partial Correlation (partial-r): -0.0269 [-0.1668, 0.114] sex, age, birth date, deprivation index, 16 PCs —
PPM011766 PGS002113
(portability-ldpred2_depression_stress_trauma)
 PSS008944|
African Ancestry|
214 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Depression possibly related to stressful or traumatic event — — Partial Correlation (partial-r): -0.0334 [-0.1734, 0.108] sex, age, birth date, deprivation index, 16 PCs —
PPM017425 PGS003497
(cont-decay-depressed_for_1w)
 PSS010936|
European Ancestry|
6,610 individuals
 PGP000457 |
Ding Y et al. bioRxiv (2022)
|Pre		 Reported Trait: Ever depressed for a whole week — — partial-R2: 0.01 sex, age, deprivation index, PC1-16 —
PPM017509 PGS003497
(cont-decay-depressed_for_1w)
 PSS010852|
European Ancestry|
1,520 individuals
 PGP000457 |
Ding Y et al. bioRxiv (2022)
|Pre		 Reported Trait: Ever depressed for a whole week — — partial-R2: 0.01 sex, age, deprivation index, PC1-16 —
PPM017593 PGS003497
(cont-decay-depressed_for_1w)
 PSS010684|
European Ancestry|
2,449 individuals
 PGP000457 |
Ding Y et al. bioRxiv (2022)
|Pre		 Reported Trait: Ever depressed for a whole week — — partial-R2: 0.01 sex, age, deprivation index, PC1-16 —
PPM017677 PGS003497
(cont-decay-depressed_for_1w)
 PSS010600|
Greater Middle Eastern Ancestry|
505 individuals
 PGP000457 |
Ding Y et al. bioRxiv (2022)
|Pre		 Reported Trait: Ever depressed for a whole week — — partial-R2: 0.0 sex, age, deprivation index, PC1-16 —
PPM017761 PGS003497
(cont-decay-depressed_for_1w)
 PSS010264|
European Ancestry|
593 individuals
 PGP000457 |
Ding Y et al. bioRxiv (2022)
|Pre		 Reported Trait: Ever depressed for a whole week — — partial-R2: 0.0 sex, age, deprivation index, PC1-16 —
PPM017845 PGS003497
(cont-decay-depressed_for_1w)
 PSS010516|
South Asian Ancestry|
3,525 individuals
 PGP000457 |
Ding Y et al. bioRxiv (2022)
|Pre		 Reported Trait: Ever depressed for a whole week — — partial-R2: 0.0 sex, age, deprivation index, PC1-16 —
PPM017929 PGS003497
(cont-decay-depressed_for_1w)
 PSS010432|
East Asian Ancestry|
751 individuals
 PGP000457 |
Ding Y et al. bioRxiv (2022)
|Pre		 Reported Trait: Ever depressed for a whole week — — partial-R2: 0.0 sex, age, deprivation index, PC1-16 —
PPM018013 PGS003497
(cont-decay-depressed_for_1w)
 PSS010348|
African Ancestry|
1,457 individuals
 PGP000457 |
Ding Y et al. bioRxiv (2022)
|Pre		 Reported Trait: Ever depressed for a whole week — — partial-R2: 0.0 sex, age, deprivation index, PC1-16 —
PPM018097 PGS003497
(cont-decay-depressed_for_1w)
 PSS010768|
African Ancestry|
2,067 individuals
 PGP000457 |
Ding Y et al. bioRxiv (2022)
|Pre		 Reported Trait: Ever depressed for a whole week — — partial-R2: 0.0 sex, age, deprivation index, PC1-16 —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS010432 — — 751 individuals,
30.0 % Male samples
 Mean = 53.5 years
Sd = 8.1 years		 East Asian Chinese UKB —
PSS010852 — — 1,520 individuals,
35.0 % Male samples
 Mean = 54.5 years
Sd = 8.0 years		 European Polish UKB —
PSS010264 — — 593 individuals,
43.0 % Male samples
 Mean = 58.7 years
Sd = 6.9 years		 European Ashkenazi UKB —
PSS010600 — — 505 individuals,
55.0 % Male samples
 Mean = 53.4 years
Sd = 8.3 years		 Greater Middle Eastern (Middle Eastern, North African or Persian) Iranian UKB —
PSS008944 — — 214 individuals — African unspecified Nigeria (West Africa) UKB —
PSS008498 — — 100 individuals — Greater Middle Eastern (Middle Eastern, North African or Persian) Iran (Middle East) UKB —
PSS009170 — — 741 individuals — European Poland (NE Europe) UKB —
PSS009396 — — 3,597 individuals — European UK (+ Ireland) UKB —
PSS008724 — — 1,364 individuals — European Italy (South Europe) UKB —
PSS008276 — — 425 individuals — South Asian India (South Asia) UKB —
PSS008053 — — 215 individuals — East Asian China (East Asia) UKB —
PSS010348 — — 1,457 individuals,
37.0 % Male samples
 Mean = 52.6 years
Sd = 7.9 years		 African American or Afro-Caribbean Caribbean UKB —
PSS010768 — — 2,067 individuals,
42.0 % Male samples
 Mean = 52.2 years
Sd = 8.0 years		 African unspecified Nigerian UKB —
PSS010516 — — 3,525 individuals,
53.0 % Male samples
 Mean = 53.7 years
Sd = 8.5 years		 South Asian Indian UKB —
PSS010936 — — 6,610 individuals,
48.0 % Male samples
 Mean = 57.1 years
Sd = 8.0 years		 European white British UKB —
PSS007840 — — 215 individuals — African American or Afro-Caribbean Carribean UKB —
PSS010684 — — 2,449 individuals,
43.0 % Male samples
 Mean = 54.5 years
Sd = 8.7 years		 European Italian UKB —