Trait: tiredness measurement

Experimental Factor Ontology (EFO) Information
Identifier EFO_0007946
Description Quantification an individual's level of tiredness, generally via a standardised questionnaire or structured interview.
Trait category
Other measurement
Mapped term PMID:28194004

Associated Polygenic Score(s)

Filter PGS by Participant Ancestry
Individuals included in:
G - Source of Variant Associations (GWAS)
D - Score Development/Training
E - PGS Evaluation
List of ancestries includes:
Display options:
Ancestry legend
Multi-ancestry (including European)
Multi-ancestry (excluding European)
African
East Asian
South Asian
Additional Asian Ancestries
European
Greater Middle Eastern
Hispanic or Latin American
Additional Diverse Ancestries
Not Reported
Polygenic Score ID & Name PGS Publication ID (PGP) Reported Trait Mapped Trait(s) (Ontology) Number of Variants Ancestry distribution
GWAS
Dev
Eval
 Scoring File (FTP Link)
PGS001080
(GBE_QT_FC1002080)
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
 Freq. of tiredness / lethargy in last 2 weeks tiredness measurement 5,594
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS001080/ScoringFiles/PGS001080.txt.gz

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		Evaluated Score PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM008160 PGS001080
(GBE_QT_FC1002080)
 PSS007588|
European Ancestry|
24,093 individuals
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
 Reported Trait: Freq. of tiredness / lethargy in last 2 weeks — — R²: 0.02527 [0.02142, 0.02912]
Incremental R2 (full-covars): 0.00661
PGS R2 (no covariates): 0.00678 [0.00475, 0.00881]		 age, sex, UKB array type, Genotype PCs —
PPM008158 PGS001080
(GBE_QT_FC1002080)
 PSS007586|
African Ancestry|
5,943 individuals
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
 Reported Trait: Freq. of tiredness / lethargy in last 2 weeks — — R²: 0.02179 [0.01477, 0.02881]
Incremental R2 (full-covars): -0.00162
PGS R2 (no covariates): 0.0004 [-0.00057, 0.00137]		 age, sex, UKB array type, Genotype PCs —
PPM008159 PGS001080
(GBE_QT_FC1002080)
 PSS007587|
East Asian Ancestry|
1,554 individuals
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
 Reported Trait: Freq. of tiredness / lethargy in last 2 weeks — — R²: 0.04117 [0.02273, 0.0596]
Incremental R2 (full-covars): -0.00538
PGS R2 (no covariates): 8e-05 [-0.00075, 0.00091]		 age, sex, UKB array type, Genotype PCs —
PPM008161 PGS001080
(GBE_QT_FC1002080)
 PSS007589|
South Asian Ancestry|
6,965 individuals
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
 Reported Trait: Freq. of tiredness / lethargy in last 2 weeks — — R²: 0.04134 [0.03271, 0.04997]
Incremental R2 (full-covars): 0.00197
PGS R2 (no covariates): 0.00195 [0.0, 0.0039]		 age, sex, UKB array type, Genotype PCs —
PPM008162 PGS001080
(GBE_QT_FC1002080)
 PSS007590|
European Ancestry|
65,570 individuals
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
 Reported Trait: Freq. of tiredness / lethargy in last 2 weeks — — R²: 0.03173 [0.02913, 0.03434]
Incremental R2 (full-covars): 0.00645
PGS R2 (no covariates): 0.007 [0.00574, 0.00825]		 age, sex, UKB array type, Genotype PCs —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS007586 — — 5,943 individuals — African unspecified — UKB —
PSS007587 — — 1,554 individuals — East Asian — UKB —
PSS007588 — — 24,093 individuals — European non-white British ancestry UKB —
PSS007589 — — 6,965 individuals — South Asian — UKB —
PSS007590 — — 65,570 individuals — European white British ancestry UKB Testing cohort (heldout set)