| Experimental Factor Ontology (EFO) Information | |
| Identifier | EFO_0008373 |
| Description | quantification of the volumetric fraction of blood pumped out of the left ventricle |
| Trait category |
Cardiovascular measurement
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| Mapped term | PMID:28763429 |
Polygenic Score ID & Name
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PGS Publication ID (PGP)
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Reported Trait
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Mapped Trait(s) (Ontology)
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Number of Variants
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Ancestry distribution GWAS Dev Eval |
Scoring File (FTP Link)
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|---|---|---|---|---|---|---|
| PGS001412 (GBE_INI22420) | PGP000244 | Tanigawa Y et al. PLoS Genet (2022) | LV ejection fraction | left ventricular ejection fraction measurement | 266 | - | https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS001412/ScoringFiles/PGS001412.txt.gz |
| PGS002278 (GRS16_snLVEF) | PGP000307 | Forrest IS et al. Eur J Heart Fail (2022) | Supranormal left ventricular ejection fraction | left ventricular ejection fraction measurement | 16 | - | https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS002278/ScoringFiles/PGS002278.txt.gz |
| PGS002279 (GRS22_rLVEF) | PGP000307 | Forrest IS et al. Eur J Heart Fail (2022) | Reduced left ventricular ejection fraction | left ventricular ejection fraction measurement | 22 | - | https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS002279/ScoringFiles/PGS002279.txt.gz |
PGS Performance Metric ID (PPM) |
Evaluated Score
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PGS Sample Set ID (PSS) |
Performance Source
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Trait
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PGS Effect Sizes (per SD change) |
Classification Metrics
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Other Metrics
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Covariates Included in the Model
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PGS Performance: Other Relevant Information |
|---|---|---|---|---|---|---|---|---|---|
| PPM005315 | PGS001412 (GBE_INI22420) | PSS004986| African Ancestry| 192 individuals | PGP000244 | Tanigawa Y et al. PLoS Genet (2022) | Reported Trait: LV ejection fraction | — | — | R²: 0.07902 [0.06643, 0.0916] Incremental R2 (full-covars): 0.0065 PGS R2 (no covariates): 0.00921 [0.00459, 0.01383] | age, sex, UKB array type, Genotype PCs | — |
| PPM005316 | PGS001412 (GBE_INI22420) | PSS004987| East Asian Ancestry| 110 individuals | PGP000244 | Tanigawa Y et al. PLoS Genet (2022) | Reported Trait: LV ejection fraction | — | — | R²: 0.21638 [0.18183, 0.25092] Incremental R2 (full-covars): 0.00243 PGS R2 (no covariates): 0.0051 [-0.00163, 0.01183] | age, sex, UKB array type, Genotype PCs | — |
| PPM005317 | PGS001412 (GBE_INI22420) | PSS004988| European Ancestry| 1,708 individuals | PGP000244 | Tanigawa Y et al. PLoS Genet (2022) | Reported Trait: LV ejection fraction | — | — | R²: 0.07182 [0.06564, 0.07799] Incremental R2 (full-covars): 0.0014 PGS R2 (no covariates): 0.00189 [0.00081, 0.00297] | age, sex, UKB array type, Genotype PCs | — |
| PPM005318 | PGS001412 (GBE_INI22420) | PSS004989| South Asian Ancestry| 319 individuals | PGP000244 | Tanigawa Y et al. PLoS Genet (2022) | Reported Trait: LV ejection fraction | — | — | R²: 0.06719 [0.05648, 0.07789] Incremental R2 (full-covars): 0.00348 PGS R2 (no covariates): 0.00252 [0.00031, 0.00474] | age, sex, UKB array type, Genotype PCs | — |
| PPM005319 | PGS001412 (GBE_INI22420) | PSS004990| European Ancestry| 5,528 individuals | PGP000244 | Tanigawa Y et al. PLoS Genet (2022) | Reported Trait: LV ejection fraction | — | — | R²: 0.04862 [0.04545, 0.05179] Incremental R2 (full-covars): 0.00384 PGS R2 (no covariates): 0.00375 [0.00283, 0.00468] | age, sex, UKB array type, Genotype PCs | — |
| PPM012952 | PGS002278 (GRS16_snLVEF) | PSS009631| Multi-ancestry (including European)| 486,754 individuals | PGP000307 | Forrest IS et al. Eur J Heart Fail (2022) | Reported Trait: All-cause mortality | — | — | HR (top 10% vs bottom 10%): 1.11 [1.04, 1.18] | Age, sex, body mass index (BMI; except for obesity),10 principal components of ancestry | — |
| PPM012953 | PGS002279 (GRS22_rLVEF) | PSS009631| Multi-ancestry (including European)| 486,754 individuals | PGP000307 | Forrest IS et al. Eur J Heart Fail (2022) | Reported Trait: All-cause mortality | — | — | HR (top 10% vs bottom 10%): 1.1 [1.02, 1.12] | Age, sex, body mass index (BMI; except for obesity),10 principal components of ancestry | — |
| PPM012954 | PGS002278 (GRS16_snLVEF) | PSS009631| Multi-ancestry (including European)| 486,754 individuals | PGP000307 | Forrest IS et al. Eur J Heart Fail (2022) | Reported Trait: All-cause mortality (with heart failure) | — | — | HR (top 10% vs bottom 10%): 1.26 [1.05, 1.5] | Age, sex, body mass index (BMI; except for obesity),10 principal components of ancestry | — |
| PPM012955 | PGS002279 (GRS22_rLVEF) | PSS009631| Multi-ancestry (including European)| 486,754 individuals | PGP000307 | Forrest IS et al. Eur J Heart Fail (2022) | Reported Trait: All-cause mortality (with heart failure) | — | — | HR (top 10% vs bottom 10%): 1.31 [1.09, 1.58] | Age, sex, body mass index (BMI; except for obesity),10 principal components of ancestry | — |
| PPM012956 | PGS002278 (GRS16_snLVEF) | PSS009631| Multi-ancestry (including European)| 486,754 individuals | PGP000307 | Forrest IS et al. Eur J Heart Fail (2022) | Reported Trait: All-cause mortality (without heart failure) | — | — | HR (top 10% vs bottom 10%): 1.09 [1.02, 1.17] | Age, sex, body mass index (BMI; except for obesity),10 principal components of ancestry | — |
| PPM012957 | PGS002278 (GRS16_snLVEF) | PSS009631| Multi-ancestry (including European)| 486,754 individuals | PGP000307 | Forrest IS et al. Eur J Heart Fail (2022) | Reported Trait: Heart failure diagnosis | OR: 0.97 [0.95, 0.99] | — | — | Age, sex, body mass index,10 principal components of ancestry | — |
| PPM012958 | PGS002278 (GRS16_snLVEF) | PSS009631| Multi-ancestry (including European)| 486,754 individuals | PGP000307 | Forrest IS et al. Eur J Heart Fail (2022) | Reported Trait: Brain natriuretic peptide level | — | — | Median (top 10% vs bottom 10%): 146.0 [79, 228] pg/ml | — | — |
| PPM012959 | PGS002278 (GRS16_snLVEF) | PSS009631| Multi-ancestry (including European)| 486,754 individuals | PGP000307 | Forrest IS et al. Eur J Heart Fail (2022) | Reported Trait: Prevalence of dyspnoea | — | — | OR (top 10% vs bottom 10%): 1.17 [1.01, 1.37] | — | — |
| PPM012960 | PGS002278 (GRS16_snLVEF) | PSS009631| Multi-ancestry (including European)| 486,754 individuals | PGP000307 | Forrest IS et al. Eur J Heart Fail (2022) | Reported Trait: Exertional dyspnoea | — | — | OR (top 10% vs bottom 10%): 1.39 [1.12, 1.74] | — | — |
| PPM012961 | PGS002278 (GRS16_snLVEF) | PSS009631| Multi-ancestry (including European)| 486,754 individuals | PGP000307 | Forrest IS et al. Eur J Heart Fail (2022) | Reported Trait: Peperipheral oedema | — | — | OR (top 10% vs bottom 10%): 1.07 [1.01, 1.13] | — | — |
PGS Sample Set ID (PSS) |
Phenotype Definitions and Methods
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Participant Follow-up Time
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Sample Numbers
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Age of Study Participants
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Sample Ancestry
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Additional Ancestry Description
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Cohort(s)
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Additional Sample/Cohort Information
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|---|---|---|---|---|---|---|---|---|
| PSS004986 | — | — | 192 individuals | — | African unspecified | — | UKB | — |
| PSS004987 | — | — | 110 individuals | — | East Asian | — | UKB | — |
| PSS004988 | — | — | 1,708 individuals | — | European | non-white British ancestry | UKB | — |
| PSS004989 | — | — | 319 individuals | — | South Asian | — | UKB | — |
| PSS004990 | — | — | 5,528 individuals | — | European | white British ancestry | UKB | Testing cohort (heldout set) |
| PSS009631 | ICD-10 diagnosis code for hypertensive heart disease with heart failure, hypertensive heart and chro... nic kidney disease with heart failure and stage 1 through stage 4 chronic kidney disease, hypertensive heart and chronic kidney disease with heart failure and with stage 5 chronic kidney disease, or heart failure (I11.0, I13.0, I13.2, I50) in BioMe biobank and ICD-10 diagnosis code for hypertensive heart disease with heart failure, hypertensive heart and chronic kidney disease with heart failure and stage 1 through stage 4 chronic kidney disease, hypertensive heart and chronic kidney disease with heart failure and with stage 5 chronic kidney disease, or heart failure (I11.0, I13.0, I13.2, I50) in UKB; ICD-10 diagnosis code for exertional dyspnea (R06.09) and/or physician-documented exertional dyspnea in the problem list; ICD-10 diagnosis code for peripheral edema (R60) and/or physician-documented peripheral edema in the problem list (e.g., “ankle swelling”, “lower extremity swelling”); (e.g., “shortness of breath”, “difficulty breathing”; and “on exertion”, “when exercising”); ICD-10 diagnosis code for dyspnea (R06.0) and/or physician-documented dyspnea in the problem list (e.g., “shortness of breath”, “trouble breathing”)Show more | — | 486,754 individuals, 46.0 % Male samples | Median = 58.0 years | African unspecified, Hispanic or Latin American, European, Asian unspecified, NR | African, Hispanic/Latino, European, Asian, Other ancestry | BioMe, UKB | — |