Trait: Epstein Barr virus nuclear antigen-1 seropositivity

Experimental Factor Ontology (EFO) Information
Identifier EFO_0009271
Description The result of a measurement of circulating Epstein Barr virus nuclear antigen-1 antibodies used in the diagnosis of latent Epstein-Barr virus infection
Trait category
Other measurement
Synonyms 2 synonyms
  • EBNA seropositivity
  • EBNA-1 seropositivity
Mapped term PMID:29868224

Associated Polygenic Score(s)

Filter PGS by Participant Ancestry
Individuals included in:
G - Source of Variant Associations (GWAS)
D - Score Development/Training
E - PGS Evaluation
List of ancestries includes:
Display options:
Ancestry legend
Multi-ancestry (including European)
Multi-ancestry (excluding European)
African
East Asian
South Asian
Additional Asian Ancestries
European
Greater Middle Eastern
Hispanic or Latin American
Additional Diverse Ancestries
Not Reported
Polygenic Score ID & Name PGS Publication ID (PGP) Reported Trait Mapped Trait(s) (Ontology) Number of Variants Ancestry distribution
GWAS
Dev
Eval
 Scoring File (FTP Link)
PGS001036
(GBE_INI23004)
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
 Epstein Barr virus nuclear antigen 1 IgG seropositivity Epstein Barr virus nuclear antigen-1 seropositivity 38
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS001036/ScoringFiles/PGS001036.txt.gz

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		Evaluated Score PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM007938 PGS001036
(GBE_INI23004)
 PSS005011|
African Ancestry|
119 individuals
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
 Reported Trait: EBNA-1 antigen for Epstein-Barr Virus — — R²: 0.08991 [0.07665, 0.10318]
Incremental R2 (full-covars): 0.0329
PGS R2 (no covariates): 0.04656 [0.03656, 0.05656]		 age, sex, UKB array type, Genotype PCs —
PPM007939 PGS001036
(GBE_INI23004)
 PSS005012|
East Asian Ancestry|
41 individuals
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
 Reported Trait: EBNA-1 antigen for Epstein-Barr Virus — — R²: 0.50637 [0.47308, 0.53966]
Incremental R2 (full-covars): 0.00658
PGS R2 (no covariates): 0.00013 [-0.00095, 0.00122]		 age, sex, UKB array type, Genotype PCs —
PPM007940 PGS001036
(GBE_INI23004)
 PSS005013|
European Ancestry|
471 individuals
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
 Reported Trait: EBNA-1 antigen for Epstein-Barr Virus — — R²: 0.11391 [0.10648, 0.12134]
Incremental R2 (full-covars): 0.07089
PGS R2 (no covariates): 0.07891 [0.07248, 0.08533]		 age, sex, UKB array type, Genotype PCs —
PPM007941 PGS001036
(GBE_INI23004)
 PSS005014|
South Asian Ancestry|
164 individuals
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
 Reported Trait: EBNA-1 antigen for Epstein-Barr Virus — — R²: 0.10651 [0.0936, 0.11942]
Incremental R2 (full-covars): 0.02856
PGS R2 (no covariates): 0.02783 [0.02065, 0.03501]		 age, sex, UKB array type, Genotype PCs —
PPM007942 PGS001036
(GBE_INI23004)
 PSS005015|
European Ancestry|
1,275 individuals
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
 Reported Trait: EBNA-1 antigen for Epstein-Barr Virus — — R²: 0.06244 [0.05891, 0.06598]
Incremental R2 (full-covars): 0.06217
PGS R2 (no covariates): 0.07143 [0.06768, 0.07518]		 age, sex, UKB array type, Genotype PCs —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS005011 — — 119 individuals — African unspecified — UKB —
PSS005012 — — 41 individuals — East Asian — UKB —
PSS005013 — — 471 individuals — European non-white British ancestry UKB —
PSS005014 — — 164 individuals — South Asian — UKB —
PSS005015 — — 1,275 individuals — European white British ancestry UKB Testing cohort (heldout set)