Trait: hippocampal CA1 volume

Experimental Factor Ontology (EFO) Information
Identifier EFO_0009394
Description Volume of hippocampal CA1, which is the part of hippocampus proper bounded by CA2 and the subiculum, characterized by pyramidal neurons that receive projections from pyramidal neurons of CA3 via the Schaffer collaterals.
Trait category
Other measurement

Associated Polygenic Score(s)

Filter PGS by Participant Ancestry
Individuals included in:
G - Source of Variant Associations (GWAS)
D - Score Development/Training
E - PGS Evaluation
List of ancestries includes:
Display options:
Ancestry legend
Multi-ancestry (including European)
Multi-ancestry (excluding European)
African
East Asian
South Asian
Additional Asian Ancestries
European
Greater Middle Eastern
Hispanic or Latin American
Additional Diverse Ancestries
Not Reported
Polygenic Score ID & Name PGS Publication ID (PGP) Reported Trait Mapped Trait(s) (Ontology) Number of Variants Ancestry distribution
GWAS
Dev
Eval
 Scoring File (FTP Link)
PGS003609
(L_CA1_body_trans_ancestry_meta_analysis)
 PGP000464 |
Liu N et al. Nat Genet (2023)
 Left CA1 body volume hippocampal CA1 volume 40,494
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS003609/ScoringFiles/PGS003609.txt.gz
PGS003610
(L_CA1_head_trans_ancestry_meta_analysis)
 PGP000464 |
Liu N et al. Nat Genet (2023)
 Left CA1 head volume hippocampal CA1 volume 792
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS003610/ScoringFiles/PGS003610.txt.gz
PGS003611
(R_CA1_body_trans_ancestry_meta_analysis)
 PGP000464 |
Liu N et al. Nat Genet (2023)
 Right CA1 body volume hippocampal CA1 volume 7,104
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS003611/ScoringFiles/PGS003611.txt.gz
PGS003612
(R_CA1_head_trans_ancestry_meta_analysis)
 PGP000464 |
Liu N et al. Nat Genet (2023)
 Right CA1 head volume hippocampal CA1 volume 6,252
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS003612/ScoringFiles/PGS003612.txt.gz
PGS003613
(L_CA1_body_UKBB_EUR_GWAS)
 PGP000464 |
Liu N et al. Nat Genet (2023)
 Left CA1 body volume hippocampal CA1 volume 8
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS003613/ScoringFiles/PGS003613.txt.gz
PGS003614
(L_CA1_head_UKBB_EUR_GWAS)
 PGP000464 |
Liu N et al. Nat Genet (2023)
 Left CA1 head volume hippocampal CA1 volume 8,634
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS003614/ScoringFiles/PGS003614.txt.gz
PGS003615
(R_CA1_body_UKBB_EUR_GWAS)
 PGP000464 |
Liu N et al. Nat Genet (2023)
 Right CA1 body volume hippocampal CA1 volume 123,648
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS003615/ScoringFiles/PGS003615.txt.gz
PGS003616
(R_CA1_head_UKBB_EUR_GWAS)
 PGP000464 |
Liu N et al. Nat Genet (2023)
 Right CA1 head volume hippocampal CA1 volume 19,937
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS003616/ScoringFiles/PGS003616.txt.gz
PGS003617
(L_CA1_body_CHIMGEN_EAS_GWAS)
 PGP000464 |
Liu N et al. Nat Genet (2023)
 Left CA1 body volume hippocampal CA1 volume 205
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS003617/ScoringFiles/PGS003617.txt.gz
PGS003618
(L_CA1_head_CHIMGEN_EAS_GWAS)
 PGP000464 |
Liu N et al. Nat Genet (2023)
 Left CA1 head volume hippocampal CA1 volume 57
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS003618/ScoringFiles/PGS003618.txt.gz
PGS003619
(R_CA1_body_CHIMGEN_EAS_GWAS)
 PGP000464 |
Liu N et al. Nat Genet (2023)
 Right CA1 body volume hippocampal CA1 volume 189
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS003619/ScoringFiles/PGS003619.txt.gz
PGS003620
(R_CA1_head_CHIMGEN_EAS_GWAS)
 PGP000464 |
Liu N et al. Nat Genet (2023)
 Right CA1 head volume hippocampal CA1 volume 19,628
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS003620/ScoringFiles/PGS003620.txt.gz

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		Evaluated Score PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM018289 PGS003609
(L_CA1_body_trans_ancestry_meta_analysis)
 PSS010958|
East Asian Ancestry|
1,999 individuals
 PGP000464 |
Liu N et al. Nat Genet (2023)
 Reported Trait: Left CA1 body volume — — R²: 0.01292 sex, age, age2, age × sex, total intracranial volume, and top six genetic principal components —
PPM018293 PGS003610
(L_CA1_head_trans_ancestry_meta_analysis)
 PSS010958|
East Asian Ancestry|
1,999 individuals
 PGP000464 |
Liu N et al. Nat Genet (2023)
 Reported Trait: Left CA1 head volume — — R²: 0.01741 sex, age, age2, age × sex, total intracranial volume, and top six genetic principal components —
PPM018310 PGS003611
(R_CA1_body_trans_ancestry_meta_analysis)
 PSS010958|
East Asian Ancestry|
1,999 individuals
 PGP000464 |
Liu N et al. Nat Genet (2023)
 Reported Trait: Right CA1 body volume — — R²: 0.02285 sex, age, age2, age × sex, total intracranial volume, and top six genetic principal components —
PPM018314 PGS003612
(R_CA1_head_trans_ancestry_meta_analysis)
 PSS010958|
East Asian Ancestry|
1,999 individuals
 PGP000464 |
Liu N et al. Nat Genet (2023)
 Reported Trait: Right CA1 head volume — — R²: 0.01716 sex, age, age2, age × sex, total intracranial volume, and top six genetic principal components —
PPM018333 PGS003613
(L_CA1_body_UKBB_EUR_GWAS)
 PSS010958|
East Asian Ancestry|
1,999 individuals
 PGP000464 |
Liu N et al. Nat Genet (2023)
 Reported Trait: Left CA1 body volume — — R²: 0.00563 sex, age, age2, age × sex, total intracranial volume, and top six genetic principal components —
PPM018337 PGS003614
(L_CA1_head_UKBB_EUR_GWAS)
 PSS010958|
East Asian Ancestry|
1,999 individuals
 PGP000464 |
Liu N et al. Nat Genet (2023)
 Reported Trait: Left CA1 head volume — — R²: 0.00629 sex, age, age2, age × sex, total intracranial volume, and top six genetic principal components —
PPM018354 PGS003615
(R_CA1_body_UKBB_EUR_GWAS)
 PSS010958|
East Asian Ancestry|
1,999 individuals
 PGP000464 |
Liu N et al. Nat Genet (2023)
 Reported Trait: Right CA1 body volume — — R²: 0.00771 sex, age, age2, age × sex, total intracranial volume, and top six genetic principal components —
PPM018358 PGS003616
(R_CA1_head_UKBB_EUR_GWAS)
 PSS010958|
East Asian Ancestry|
1,999 individuals
 PGP000464 |
Liu N et al. Nat Genet (2023)
 Reported Trait: Right CA1 head volume — — R²: 0.01234 sex, age, age2, age × sex, total intracranial volume, and top six genetic principal components —
PPM018377 PGS003617
(L_CA1_body_CHIMGEN_EAS_GWAS)
 PSS010958|
East Asian Ancestry|
1,999 individuals
 PGP000464 |
Liu N et al. Nat Genet (2023)
 Reported Trait: Left CA1 body volume — — R²: 0.00468 sex, age, age2, age × sex, total intracranial volume, and top six genetic principal components —
PPM018381 PGS003618
(L_CA1_head_CHIMGEN_EAS_GWAS)
 PSS010958|
East Asian Ancestry|
1,999 individuals
 PGP000464 |
Liu N et al. Nat Genet (2023)
 Reported Trait: Left CA1 head volume — — R²: 0.00364 sex, age, age2, age × sex, total intracranial volume, and top six genetic principal components —
PPM018398 PGS003619
(R_CA1_body_CHIMGEN_EAS_GWAS)
 PSS010958|
East Asian Ancestry|
1,999 individuals
 PGP000464 |
Liu N et al. Nat Genet (2023)
 Reported Trait: Right CA1 body volume — — R²: 0.00624 sex, age, age2, age × sex, total intracranial volume, and top six genetic principal components —
PPM018402 PGS003620
(R_CA1_head_CHIMGEN_EAS_GWAS)
 PSS010958|
East Asian Ancestry|
1,999 individuals
 PGP000464 |
Liu N et al. Nat Genet (2023)
 Reported Trait: Right CA1 head volume — — R²: 0.00515 sex, age, age2, age × sex, total intracranial volume, and top six genetic principal components —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS010958 — — 1,999 individuals — East Asian — CHIMGEN —