Trait: drug allergy

Experimental Factor Ontology (EFO) Information
Identifier EFO_0009482
Description Immunologically mediated adverse reactions to medicinal substances used legally or illegally. [MESH: D004342]
Trait category
Immune system disorder
Synonyms 4 synonyms
  • allergy of exposure to drug
  • drug allergy
  • drug hypersensitivity
  • exposure to drug allergic disease
Mapped terms 7 mapped terms
  • DOID:0060500
  • MEDGEN:41663
  • MESH:D004342
  • MONDO:0000775
  • MeSH:D004342
  • MedDRA:10013661
  • UMLS:C0013182

Associated Polygenic Score(s)

Filter PGS by Participant Ancestry
Individuals included in:
G - Source of Variant Associations (GWAS)
D - Score Development/Training
E - PGS Evaluation
List of ancestries includes:
Display options:
Ancestry legend
Multi-ancestry (including European)
Multi-ancestry (excluding European)
African
East Asian
South Asian
Additional Asian Ancestries
European
Greater Middle Eastern
Hispanic or Latin American
Additional Diverse Ancestries
Not Reported
Polygenic Score ID & Name PGS Publication ID (PGP) Reported Trait Mapped Trait(s) (Ontology) Number of Variants Ancestry distribution
GWAS
Dev
Eval
 Scoring File (FTP Link)
PGS001885
(portability-PLR_960.2)
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Allergy/adverse effect of penicillin drug allergy 95
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS001885/ScoringFiles/PGS001885.txt.gz
PGS002097
(portability-ldpred2_960.2)
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Allergy/adverse effect of penicillin drug allergy 742,904
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS002097/ScoringFiles/PGS002097.txt.gz

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		Evaluated Score PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM009964 PGS001885
(portability-PLR_960.2)
 PSS009362|
European Ancestry|
19,352 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Allergy/adverse effect of penicillin — — Partial Correlation (partial-r): 0.0296 [0.0155, 0.0436] sex, age, birth date, deprivation index, 16 PCs —
PPM009966 PGS001885
(portability-PLR_960.2)
 PSS008690|
European Ancestry|
6,493 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Allergy/adverse effect of penicillin — — Partial Correlation (partial-r): 0.0196 [-0.0047, 0.044] sex, age, birth date, deprivation index, 16 PCs —
PPM009967 PGS001885
(portability-PLR_960.2)
 PSS008464|
Greater Middle Eastern Ancestry|
1,172 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Allergy/adverse effect of penicillin — — Partial Correlation (partial-r): -0.0358 [-0.0933, 0.022] sex, age, birth date, deprivation index, 16 PCs —
PPM009968 PGS001885
(portability-PLR_960.2)
 PSS008244|
South Asian Ancestry|
6,180 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Allergy/adverse effect of penicillin — — Partial Correlation (partial-r): -0.0111 [-0.036, 0.0139] sex, age, birth date, deprivation index, 16 PCs —
PPM009969 PGS001885
(portability-PLR_960.2)
 PSS008022|
East Asian Ancestry|
1,773 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Allergy/adverse effect of penicillin — — Partial Correlation (partial-r): -0.0272 [-0.0739, 0.0196] sex, age, birth date, deprivation index, 16 PCs —
PPM009970 PGS001885
(portability-PLR_960.2)
 PSS007808|
African Ancestry|
2,406 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Allergy/adverse effect of penicillin — — Partial Correlation (partial-r): 0.0141 [-0.0261, 0.0542] sex, age, birth date, deprivation index, 16 PCs —
PPM009971 PGS001885
(portability-PLR_960.2)
 PSS008912|
African Ancestry|
3,818 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Allergy/adverse effect of penicillin — — Partial Correlation (partial-r): 0.0003 [-0.0315, 0.0321] sex, age, birth date, deprivation index, 16 PCs —
PPM009965 PGS001885
(portability-PLR_960.2)
 PSS009136|
European Ancestry|
4,025 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Allergy/adverse effect of penicillin — — Partial Correlation (partial-r): 0.0128 [-0.0182, 0.0437] sex, age, birth date, deprivation index, 16 PCs —
PPM011632 PGS002097
(portability-ldpred2_960.2)
 PSS009362|
European Ancestry|
19,352 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Allergy/adverse effect of penicillin — — Partial Correlation (partial-r): 0.0397 [0.0256, 0.0537] sex, age, birth date, deprivation index, 16 PCs —
PPM011633 PGS002097
(portability-ldpred2_960.2)
 PSS009136|
European Ancestry|
4,025 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Allergy/adverse effect of penicillin — — Partial Correlation (partial-r): 0.0394 [0.0085, 0.0703] sex, age, birth date, deprivation index, 16 PCs —
PPM011635 PGS002097
(portability-ldpred2_960.2)
 PSS008464|
Greater Middle Eastern Ancestry|
1,172 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Allergy/adverse effect of penicillin — — Partial Correlation (partial-r): -0.0396 [-0.0971, 0.0182] sex, age, birth date, deprivation index, 16 PCs —
PPM011636 PGS002097
(portability-ldpred2_960.2)
 PSS008244|
South Asian Ancestry|
6,180 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Allergy/adverse effect of penicillin — — Partial Correlation (partial-r): 0.0264 [0.0015, 0.0514] sex, age, birth date, deprivation index, 16 PCs —
PPM011637 PGS002097
(portability-ldpred2_960.2)
 PSS008022|
East Asian Ancestry|
1,773 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Allergy/adverse effect of penicillin — — Partial Correlation (partial-r): -0.0013 [-0.0481, 0.0455] sex, age, birth date, deprivation index, 16 PCs —
PPM011638 PGS002097
(portability-ldpred2_960.2)
 PSS007808|
African Ancestry|
2,406 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Allergy/adverse effect of penicillin — — Partial Correlation (partial-r): -0.0128 [-0.0529, 0.0273] sex, age, birth date, deprivation index, 16 PCs —
PPM011639 PGS002097
(portability-ldpred2_960.2)
 PSS008912|
African Ancestry|
3,818 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Allergy/adverse effect of penicillin — — Partial Correlation (partial-r): 0.0043 [-0.0275, 0.0361] sex, age, birth date, deprivation index, 16 PCs —
PPM011634 PGS002097
(portability-ldpred2_960.2)
 PSS008690|
European Ancestry|
6,493 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Allergy/adverse effect of penicillin — — Partial Correlation (partial-r): 0.0313 [0.0069, 0.0556] sex, age, birth date, deprivation index, 16 PCs —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS008464 — — 1,172 individuals — Greater Middle Eastern (Middle Eastern, North African or Persian) Iran (Middle East) UKB —
PSS008912 — — 3,818 individuals — African unspecified Nigeria (West Africa) UKB —
PSS008690 — — 6,493 individuals — European Italy (South Europe) UKB —
PSS009362 — — 19,352 individuals — European UK (+ Ireland) UKB —
PSS008244 — — 6,180 individuals — South Asian India (South Asia) UKB —
PSS009136 — — 4,025 individuals — European Poland (NE Europe) UKB —
PSS008022 — — 1,773 individuals — East Asian China (East Asia) UKB —
PSS007808 — — 2,406 individuals — African American or Afro-Caribbean Carribean UKB —