Trait: occlusion precerebral artery

Experimental Factor Ontology (EFO) Information
Identifier EFO_0009677
Description Occlusion of a precerebral artery.
Trait categories
Cardiovascular disease
Neurological disorder
Synonyms 3 synonyms
  • occlusion and stenosis of multiple and bilateral precerebral arteries
  • occlusion and stenosis of precerebral artery
  • occlusion precerebral artery
Mapped terms 11 mapped terms
  • DOID:5976
  • ICD10:I65
  • ICD9:433
  • ICD9:433.3
  • ICD9:433.80
  • ICD9:433.81
  • ICD9:433.9
  • MEDGEN:539069
  • MONDO:0003718
  • SCTID:28790007
  • UMLS:C0265090

Associated Polygenic Score(s)

Filter PGS by Participant Ancestry
Individuals included in:
G - Source of Variant Associations (GWAS)
D - Score Development/Training
E - PGS Evaluation
List of ancestries includes:
Display options:
Ancestry legend
Multi-ancestry (including European)
Multi-ancestry (excluding European)
African
East Asian
South Asian
Additional Asian Ancestries
European
Greater Middle Eastern
Hispanic or Latin American
Additional Diverse Ancestries
Not Reported
Polygenic Score ID & Name PGS Publication ID (PGP) Reported Trait Mapped Trait(s) (Ontology) Number of Variants Ancestry distribution
GWAS
Dev
Eval
 Scoring File (FTP Link)
PGS002052
(portability-ldpred2_433.1)
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Occlusion and stenosis of precerebral arteries occlusion precerebral artery 490,459
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS002052/ScoringFiles/PGS002052.txt.gz

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		Evaluated Score PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM011278 PGS002052
(portability-ldpred2_433.1)
 PSS009316|
European Ancestry|
19,445 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Occlusion and stenosis of precerebral arteries — — Partial Correlation (partial-r): 0.0199 [0.0058, 0.034] sex, age, birth date, deprivation index, 16 PCs —
PPM011279 PGS002052
(portability-ldpred2_433.1)
 PSS009090|
European Ancestry|
4,046 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Occlusion and stenosis of precerebral arteries — — Partial Correlation (partial-r): 0.0001 [-0.0308, 0.031] sex, age, birth date, deprivation index, 16 PCs —
PPM011280 PGS002052
(portability-ldpred2_433.1)
 PSS008644|
European Ancestry|
6,521 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Occlusion and stenosis of precerebral arteries — — Partial Correlation (partial-r): 0.0191 [-0.0052, 0.0434] sex, age, birth date, deprivation index, 16 PCs —
PPM011282 PGS002052
(portability-ldpred2_433.1)
 PSS008198|
South Asian Ancestry|
6,173 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Occlusion and stenosis of precerebral arteries — — Partial Correlation (partial-r): 0.0003 [-0.0247, 0.0253] sex, age, birth date, deprivation index, 16 PCs —
PPM011283 PGS002052
(portability-ldpred2_433.1)
 PSS007980|
East Asian Ancestry|
1,789 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Occlusion and stenosis of precerebral arteries — — Partial Correlation (partial-r): -0.0132 [-0.0598, 0.0334] sex, age, birth date, deprivation index, 16 PCs —
PPM011284 PGS002052
(portability-ldpred2_433.1)
 PSS007763|
African Ancestry|
2,407 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Occlusion and stenosis of precerebral arteries — — Partial Correlation (partial-r): 0.0003 [-0.0398, 0.0404] sex, age, birth date, deprivation index, 16 PCs —
PPM011285 PGS002052
(portability-ldpred2_433.1)
 PSS008867|
African Ancestry|
3,806 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Occlusion and stenosis of precerebral arteries — — Partial Correlation (partial-r): 0.0054 [-0.0265, 0.0372] sex, age, birth date, deprivation index, 16 PCs —
PPM011281 PGS002052
(portability-ldpred2_433.1)
 PSS008418|
Greater Middle Eastern Ancestry|
1,183 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Occlusion and stenosis of precerebral arteries — — Partial Correlation (partial-r): -0.0093 [-0.0667, 0.0482] sex, age, birth date, deprivation index, 16 PCs —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS009316 — — 19,445 individuals — European UK (+ Ireland) UKB —
PSS008644 — — 6,521 individuals — European Italy (South Europe) UKB —
PSS008198 — — 6,173 individuals — South Asian India (South Asia) UKB —
PSS007980 — — 1,789 individuals — East Asian China (East Asia) UKB —
PSS008418 — — 1,183 individuals — Greater Middle Eastern (Middle Eastern, North African or Persian) Iran (Middle East) UKB —
PSS007763 — — 2,407 individuals — African American or Afro-Caribbean Carribean UKB —
PSS009090 — — 4,046 individuals — European Poland (NE Europe) UKB —
PSS008867 — — 3,806 individuals — African unspecified Nigeria (West Africa) UKB —