Trait: number of treatments or medications taken, self-reported

Experimental Factor Ontology (EFO) Information
Identifier EFO_0009803
Description Number of treatments undergone by an individual (including medications taken), as reported by the individual.
Trait category
Other trait

Associated Polygenic Score(s)

Filter PGS by Participant Ancestry
Individuals included in:
G - Source of Variant Associations (GWAS)
D - Score Development/Training
E - PGS Evaluation
List of ancestries includes:
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Ancestry legend
Multi-ancestry (including European)
Multi-ancestry (excluding European)
African
East Asian
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Additional Asian Ancestries
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Greater Middle Eastern
Hispanic or Latin American
Additional Diverse Ancestries
Not Reported
Polygenic Score ID & Name PGS Publication ID (PGP) Reported Trait Mapped Trait(s) (Ontology) Number of Variants Ancestry distribution
GWAS
Dev
Eval
 Scoring File (FTP Link)
PGS001003
(GBE_INI137)
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
 Number of medications taken number of treatments or medications taken, self-reported 8,085
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS001003/ScoringFiles/PGS001003.txt.gz

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		Evaluated Score PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM007778 PGS001003
(GBE_INI137)
 PSS004836|
African Ancestry|
6,483 individuals
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
 Reported Trait: # of medications taken — — R²: 0.10873 [0.09444, 0.12301]
Incremental R2 (full-covars): -0.00564
PGS R2 (no covariates): 0.00035 [-0.00056, 0.00126]		 age, sex, UKB array type, Genotype PCs —
PPM007779 PGS001003
(GBE_INI137)
 PSS004837|
East Asian Ancestry|
1,702 individuals
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
 Reported Trait: # of medications taken — — R²: 0.10438 [0.07695, 0.1318]
Incremental R2 (full-covars): -0.01455
PGS R2 (no covariates): 3e-05 [-0.00047, 0.00053]		 age, sex, UKB array type, Genotype PCs —
PPM007780 PGS001003
(GBE_INI137)
 PSS004838|
European Ancestry|
24,894 individuals
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
 Reported Trait: # of medications taken — — R²: 0.09752 [0.09052, 0.10452]
Incremental R2 (full-covars): 0.01417
PGS R2 (no covariates): 0.01416 [0.01125, 0.01708]		 age, sex, UKB array type, Genotype PCs —
PPM007781 PGS001003
(GBE_INI137)
 PSS004839|
South Asian Ancestry|
7,812 individuals
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
 Reported Trait: # of medications taken — — R²: 0.13684 [0.1227, 0.15098]
Incremental R2 (full-covars): 0.00757
PGS R2 (no covariates): 0.00724 [0.0035, 0.01098]		 age, sex, UKB array type, Genotype PCs —
PPM007782 PGS001003
(GBE_INI137)
 PSS004840|
European Ancestry|
67,419 individuals
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
 Reported Trait: # of medications taken — — R²: 0.08553 [0.0815, 0.08957]
Incremental R2 (full-covars): 0.01548
PGS R2 (no covariates): 0.01558 [0.01372, 0.01743]		 age, sex, UKB array type, Genotype PCs —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS004836 — — 6,483 individuals — African unspecified — UKB —
PSS004837 — — 1,702 individuals — East Asian — UKB —
PSS004838 — — 24,894 individuals — European non-white British ancestry UKB —
PSS004839 — — 7,812 individuals — South Asian — UKB —
PSS004840 — — 67,419 individuals — European white British ancestry UKB Testing cohort (heldout set)