Trait: handedness

Experimental Factor Ontology (EFO) Information
Identifier EFO_0009902
Description A better, faster, or more precise performance or individual preference for use of a hand, known as the dominant hand; the less capable or less preferred hand is called the non-dominant hand. Dominance typically applies to all tasks, but in rare cases may be task-specific (known as cross-handedness or mixed-dominance) Ambidexterity is the ability to do any task equally well with either hand.
Trait category
Neurological disorder
Synonyms 5 synonyms
  • Ambidexterity
  • Mirror Writing
  • Mirror Writings
  • Writing, Mirror
  • Writings, Mirror

Associated Polygenic Score(s)

Filter PGS by Participant Ancestry
Individuals included in:
G - Source of Variant Associations (GWAS)
D - Score Development/Training
E - PGS Evaluation
List of ancestries includes:
Display options:
Ancestry legend
Multi-ancestry (including European)
Multi-ancestry (excluding European)
African
East Asian
South Asian
Additional Asian Ancestries
European
Greater Middle Eastern
Hispanic or Latin American
Additional Diverse Ancestries
Not Reported
Polygenic Score ID & Name PGS Publication ID (PGP) Reported Trait Mapped Trait(s) (Ontology) Number of Variants Ancestry distribution
GWAS
Dev
Eval
 Scoring File (FTP Link)
PGS002151
(portability-ldpred2_left_handed)
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Handedness (chirality/laterality) handedness 734,236
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS002151/ScoringFiles/PGS002151.txt.gz

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		Evaluated Score PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM012055 PGS002151
(portability-ldpred2_left_handed)
 PSS009420|
European Ancestry|
19,662 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Handedness (chirality/laterality) — — Partial Correlation (partial-r): 0.0253 [0.0113, 0.0392] sex, age, birth date, deprivation index, 16 PCs —
PPM012056 PGS002151
(portability-ldpred2_left_handed)
 PSS009194|
European Ancestry|
4,015 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Handedness (chirality/laterality) — — Partial Correlation (partial-r): -0.0105 [-0.0415, 0.0205] sex, age, birth date, deprivation index, 16 PCs —
PPM012057 PGS002151
(portability-ldpred2_left_handed)
 PSS008748|
European Ancestry|
6,485 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Handedness (chirality/laterality) — — Partial Correlation (partial-r): 0.0171 [-0.0072, 0.0415] sex, age, birth date, deprivation index, 16 PCs —
PPM012058 PGS002151
(portability-ldpred2_left_handed)
 PSS008522|
Greater Middle Eastern Ancestry|
1,137 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Handedness (chirality/laterality) — — Partial Correlation (partial-r): 0.0424 [-0.0163, 0.1008] sex, age, birth date, deprivation index, 16 PCs —
PPM012059 PGS002151
(portability-ldpred2_left_handed)
 PSS008300|
South Asian Ancestry|
6,079 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Handedness (chirality/laterality) — — Partial Correlation (partial-r): 0.0255 sex, age, birth date, deprivation index, 16 PCs —
PPM012060 PGS002151
(portability-ldpred2_left_handed)
 PSS008077|
East Asian Ancestry|
1,737 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Handedness (chirality/laterality) — — Partial Correlation (partial-r): 0.033 [-0.0143, 0.0802] sex, age, birth date, deprivation index, 16 PCs —
PPM012061 PGS002151
(portability-ldpred2_left_handed)
 PSS007864|
African Ancestry|
2,424 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Handedness (chirality/laterality) — — Partial Correlation (partial-r): 0.0368 [-0.0031, 0.0767] sex, age, birth date, deprivation index, 16 PCs —
PPM012062 PGS002151
(portability-ldpred2_left_handed)
 PSS008968|
African Ancestry|
3,788 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Handedness (chirality/laterality) — — Partial Correlation (partial-r): 0.0029 [-0.029, 0.0349] sex, age, birth date, deprivation index, 16 PCs —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS008968 — — 3,788 individuals — African unspecified Nigeria (West Africa) UKB —
PSS008522 — — 1,137 individuals — Greater Middle Eastern (Middle Eastern, North African or Persian) Iran (Middle East) UKB —
PSS009194 — — 4,015 individuals — European Poland (NE Europe) UKB —
PSS009420 — — 19,662 individuals — European UK (+ Ireland) UKB —
PSS008748 — — 6,485 individuals — European Italy (South Europe) UKB —
PSS008300 — — 6,079 individuals — South Asian India (South Asia) UKB —
PSS008077 — — 1,737 individuals — East Asian China (East Asia) UKB —
PSS007864 — — 2,424 individuals — African American or Afro-Caribbean Carribean UKB —