Trait: bipolar II disorder

Experimental Factor Ontology (EFO) Information
Identifier EFO_0009964
Description A bipolar disorder that is characterized by at least one hypomanic episode and at least one major depressive episode; with this disorder, depressive episodes are more frequent and more intense than manic episodes.
Trait category
Neurological disorder
Mapped terms 3 mapped terms
  • DOID:0060166
  • MedDRA:10004940
  • PMID:31043756

Associated Polygenic Score(s)

Filter PGS by Participant Ancestry
Individuals included in:
G - Source of Variant Associations (GWAS)
D - Score Development/Training
E - PGS Evaluation
List of ancestries includes:
Display options:
Ancestry legend
Multi-ancestry (including European)
Multi-ancestry (excluding European)
African
East Asian
South Asian
Additional Asian Ancestries
European
Greater Middle Eastern
Hispanic or Latin American
Additional Diverse Ancestries
Not Reported
Polygenic Score ID & Name PGS Publication ID (PGP) Reported Trait Mapped Trait(s) (Ontology) Number of Variants Ancestry distribution
GWAS
Dev
Eval
 Scoring File (FTP Link)
PGS002788
(BD2_SDPR)
 PGP000370 |
Gui Y et al. Transl Psychiatry (2022)
 Type 2 bipolar disorder bipolar II disorder 935,292
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS002788/ScoringFiles/PGS002788.txt.gz

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		Evaluated Score PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM015179 PGS002788
(BD2_SDPR)
 PSS009950|
European Ancestry|
2,524 individuals
 PGP000370 |
Gui Y et al. Transl Psychiatry (2022)
 Reported Trait: Psychiatric behavior (withdrawn) — — partial R²: 3e-05 age, PCs1-3 —
PPM015180 PGS002788
(BD2_SDPR)
 PSS009950|
European Ancestry|
2,524 individuals
 PGP000370 |
Gui Y et al. Transl Psychiatry (2022)
 Reported Trait: Psychiatric behavior (somatic symptoms) — — partial R²: 0.00065 age, PCs1-3 —
PPM015181 PGS002788
(BD2_SDPR)
 PSS009950|
European Ancestry|
2,524 individuals
 PGP000370 |
Gui Y et al. Transl Psychiatry (2022)
 Reported Trait: Psychiatric behavior (social problems) — — partial R²: 0.00039 age, PCs1-3 —
PPM015182 PGS002788
(BD2_SDPR)
 PSS009950|
European Ancestry|
2,524 individuals
 PGP000370 |
Gui Y et al. Transl Psychiatry (2022)
 Reported Trait: Psychiatric behavior (thought problems) — — partial R²: 0.00024 age, PCs1-3 —
PPM015183 PGS002788
(BD2_SDPR)
 PSS009950|
European Ancestry|
2,524 individuals
 PGP000370 |
Gui Y et al. Transl Psychiatry (2022)
 Reported Trait: Psychiatric behavior (attention problems) — — partial R²: 0.00092 age, PCs1-3 —
PPM015185 PGS002788
(BD2_SDPR)
 PSS009950|
European Ancestry|
2,524 individuals
 PGP000370 |
Gui Y et al. Transl Psychiatry (2022)
 Reported Trait: Psychiatric behavior (aggressive behaviour) — — partial R²: 0.00217 age, PCs1-3 —
PPM015186 PGS002788
(BD2_SDPR)
 PSS009950|
European Ancestry|
2,524 individuals
 PGP000370 |
Gui Y et al. Transl Psychiatry (2022)
 Reported Trait: Psychiatric behavior (internalising) — — partial R²: 0.00055 age, PCs1-3 —
PPM015187 PGS002788
(BD2_SDPR)
 PSS009950|
European Ancestry|
2,524 individuals
 PGP000370 |
Gui Y et al. Transl Psychiatry (2022)
 Reported Trait: Psychiatric behavior (externalising) — — partial R²: 0.00192 age, PCs1-3 —
PPM015188 PGS002788
(BD2_SDPR)
 PSS009950|
European Ancestry|
2,524 individuals
 PGP000370 |
Gui Y et al. Transl Psychiatry (2022)
 Reported Trait: Psychiatric behavior (total problems) — — partial R²: 0.00114 age, PCs1-3 —
PPM015189 PGS002788
(BD2_SDPR)
 PSS009950|
European Ancestry|
2,524 individuals
 PGP000370 |
Gui Y et al. Transl Psychiatry (2022)
 Reported Trait: Psychiatric behavior (Dsm5 depression) — — partial R²: 2.60e-06 age, PCs1-3 —
PPM015190 PGS002788
(BD2_SDPR)
 PSS009950|
European Ancestry|
2,524 individuals
 PGP000370 |
Gui Y et al. Transl Psychiatry (2022)
 Reported Trait: Psychiatric behavior (Dsm5 anxety disorder) — — partial R²: 0.00045 age, PCs1-3 —
PPM015191 PGS002788
(BD2_SDPR)
 PSS009950|
European Ancestry|
2,524 individuals
 PGP000370 |
Gui Y et al. Transl Psychiatry (2022)
 Reported Trait: Psychiatric behavior (Dsm5 somatic problem) — — partial R²: 0.00071 age, PCs1-3 —
PPM015192 PGS002788
(BD2_SDPR)
 PSS009950|
European Ancestry|
2,524 individuals
 PGP000370 |
Gui Y et al. Transl Psychiatry (2022)
 Reported Trait: Psychiatric behavior (Dsm5 adhd) — — partial R²: 0.0006 age, PCs1-3 —
PPM015193 PGS002788
(BD2_SDPR)
 PSS009950|
European Ancestry|
2,524 individuals
 PGP000370 |
Gui Y et al. Transl Psychiatry (2022)
 Reported Trait: Psychiatric behavior (Dsm5 opppsit) — — partial R²: 0.00195 age, PCs1-3 —
PPM015194 PGS002788
(BD2_SDPR)
 PSS009950|
European Ancestry|
2,524 individuals
 PGP000370 |
Gui Y et al. Transl Psychiatry (2022)
 Reported Trait: Psychiatric behavior (Dsm5 conduct) — — partial R²: 0.00088 age, PCs1-3 —
PPM015196 PGS002788
(BD2_SDPR)
 PSS009950|
European Ancestry|
2,524 individuals
 PGP000370 |
Gui Y et al. Transl Psychiatry (2022)
 Reported Trait: Psychiatric behavior (Obsessive compulsive disorder) — — partial R²: 0.00097 age, PCs1-3 —
PPM015197 PGS002788
(BD2_SDPR)
 PSS009950|
European Ancestry|
2,524 individuals
 PGP000370 |
Gui Y et al. Transl Psychiatry (2022)
 Reported Trait: Psychiatric behavior (stress) — — partial R²: 0.00138 age, PCs1-3 —
PPM015198 PGS002788
(BD2_SDPR)
 PSS009950|
European Ancestry|
2,524 individuals
 PGP000370 |
Gui Y et al. Transl Psychiatry (2022)
 Reported Trait: Cognitive function (Picture vocabulary) — — partial R²: 0.00049 age, PCs1-3 —
PPM015199 PGS002788
(BD2_SDPR)
 PSS009950|
European Ancestry|
2,524 individuals
 PGP000370 |
Gui Y et al. Transl Psychiatry (2022)
 Reported Trait: Cognitive function (Flanker test) — — partial R²: 0.00024 age, PCs1-3 —
PPM015200 PGS002788
(BD2_SDPR)
 PSS009950|
European Ancestry|
2,524 individuals
 PGP000370 |
Gui Y et al. Transl Psychiatry (2022)
 Reported Trait: Cognitive function (list sorting) — — partial R²: 0.00036 age, PCs1-3 —
PPM015201 PGS002788
(BD2_SDPR)
 PSS009950|
European Ancestry|
2,524 individuals
 PGP000370 |
Gui Y et al. Transl Psychiatry (2022)
 Reported Trait: Cognitive function (card sorting) — — partial R²: 0.00014 age, PCs1-3 —
PPM015202 PGS002788
(BD2_SDPR)
 PSS009950|
European Ancestry|
2,524 individuals
 PGP000370 |
Gui Y et al. Transl Psychiatry (2022)
 Reported Trait: Cognitive function (pattern comparison) — — partial R²: 6e-05 age, PCs1-3 —
PPM015203 PGS002788
(BD2_SDPR)
 PSS009950|
European Ancestry|
2,524 individuals
 PGP000370 |
Gui Y et al. Transl Psychiatry (2022)
 Reported Trait: Cognitive function (Picture sequence) — — partial R²: 0.00011 age, PCs1-3 —
PPM015204 PGS002788
(BD2_SDPR)
 PSS009950|
European Ancestry|
2,524 individuals
 PGP000370 |
Gui Y et al. Transl Psychiatry (2022)
 Reported Trait: Cognitive function (reading) — — partial R²: 1e-05 age, PCs1-3 —
PPM015205 PGS002788
(BD2_SDPR)
 PSS009950|
European Ancestry|
2,524 individuals
 PGP000370 |
Gui Y et al. Transl Psychiatry (2022)
 Reported Trait: Cognitive function (fluid composite) — — partial R²: 0.0003 age, PCs1-3 —
PPM015206 PGS002788
(BD2_SDPR)
 PSS009950|
European Ancestry|
2,524 individuals
 PGP000370 |
Gui Y et al. Transl Psychiatry (2022)
 Reported Trait: Cognitive function (Crystallized composite) — — partial R²: 6e-05 age, PCs1-3 —
PPM015207 PGS002788
(BD2_SDPR)
 PSS009950|
European Ancestry|
2,524 individuals
 PGP000370 |
Gui Y et al. Transl Psychiatry (2022)
 Reported Trait: Cognitive function (Cognitive total) — — partial R²: 0.00026 age, PCs1-3 —
PPM015209 PGS002788
(BD2_SDPR)
 PSS009949|
European Ancestry|
2,198 individuals
 PGP000370 |
Gui Y et al. Transl Psychiatry (2022)
 Reported Trait: Psychiatric behavior (anxious/depressed) — — partial R²: 0.00163 age, PCs1-3 —
PPM015210 PGS002788
(BD2_SDPR)
 PSS009949|
European Ancestry|
2,198 individuals
 PGP000370 |
Gui Y et al. Transl Psychiatry (2022)
 Reported Trait: Psychiatric behavior (withdrawn) — — partial R²: 0.00156 age, PCs1-3 —
PPM015211 PGS002788
(BD2_SDPR)
 PSS009949|
European Ancestry|
2,198 individuals
 PGP000370 |
Gui Y et al. Transl Psychiatry (2022)
 Reported Trait: Psychiatric behavior (somatic symptoms) — — partial R²: 0.00085 age, PCs1-3 —
PPM015212 PGS002788
(BD2_SDPR)
 PSS009949|
European Ancestry|
2,198 individuals
 PGP000370 |
Gui Y et al. Transl Psychiatry (2022)
 Reported Trait: Psychiatric behavior (social problems) — — partial R²: 0.00123 age, PCs1-3 —
PPM015213 PGS002788
(BD2_SDPR)
 PSS009949|
European Ancestry|
2,198 individuals
 PGP000370 |
Gui Y et al. Transl Psychiatry (2022)
 Reported Trait: Psychiatric behavior (thought problems) — — partial R²: 8e-05 age, PCs1-3 —
PPM015214 PGS002788
(BD2_SDPR)
 PSS009949|
European Ancestry|
2,198 individuals
 PGP000370 |
Gui Y et al. Transl Psychiatry (2022)
 Reported Trait: Psychiatric behavior (attention problems) — — partial R²: 3e-05 age, PCs1-3 —
PPM015215 PGS002788
(BD2_SDPR)
 PSS009949|
European Ancestry|
2,198 individuals
 PGP000370 |
Gui Y et al. Transl Psychiatry (2022)
 Reported Trait: Psychiatric behavior (rule breaking) — — partial R²: 0.00057 age, PCs1-3 —
PPM015216 PGS002788
(BD2_SDPR)
 PSS009949|
European Ancestry|
2,198 individuals
 PGP000370 |
Gui Y et al. Transl Psychiatry (2022)
 Reported Trait: Psychiatric behavior (aggressive behaviour) — — partial R²: 5e-05 age, PCs1-3 —
PPM015217 PGS002788
(BD2_SDPR)
 PSS009949|
European Ancestry|
2,198 individuals
 PGP000370 |
Gui Y et al. Transl Psychiatry (2022)
 Reported Trait: Psychiatric behavior (internalising) — — partial R²: 0.00197 age, PCs1-3 —
PPM015218 PGS002788
(BD2_SDPR)
 PSS009949|
European Ancestry|
2,198 individuals
 PGP000370 |
Gui Y et al. Transl Psychiatry (2022)
 Reported Trait: Psychiatric behavior (externalising) — — partial R²: 0.00016 age, PCs1-3 —
PPM015220 PGS002788
(BD2_SDPR)
 PSS009949|
European Ancestry|
2,198 individuals
 PGP000370 |
Gui Y et al. Transl Psychiatry (2022)
 Reported Trait: Psychiatric behavior (Dsm5 depression) — — partial R²: 0.0006 age, PCs1-3 —
PPM015221 PGS002788
(BD2_SDPR)
 PSS009949|
European Ancestry|
2,198 individuals
 PGP000370 |
Gui Y et al. Transl Psychiatry (2022)
 Reported Trait: Psychiatric behavior (Dsm5 anxety disorder) — — partial R²: 0.00145 age, PCs1-3 —
PPM015222 PGS002788
(BD2_SDPR)
 PSS009949|
European Ancestry|
2,198 individuals
 PGP000370 |
Gui Y et al. Transl Psychiatry (2022)
 Reported Trait: Psychiatric behavior (Dsm5 somatic problem) — — partial R²: 0.00071 age, PCs1-3 —
PPM015223 PGS002788
(BD2_SDPR)
 PSS009949|
European Ancestry|
2,198 individuals
 PGP000370 |
Gui Y et al. Transl Psychiatry (2022)
 Reported Trait: Psychiatric behavior (Dsm5 adhd) — — partial R²: 3e-05 age, PCs1-3 —
PPM015224 PGS002788
(BD2_SDPR)
 PSS009949|
European Ancestry|
2,198 individuals
 PGP000370 |
Gui Y et al. Transl Psychiatry (2022)
 Reported Trait: Psychiatric behavior (Dsm5 opppsit) — — partial R²: 3e-05 age, PCs1-3 —
PPM015225 PGS002788
(BD2_SDPR)
 PSS009949|
European Ancestry|
2,198 individuals
 PGP000370 |
Gui Y et al. Transl Psychiatry (2022)
 Reported Trait: Psychiatric behavior (Dsm5 conduct) — — partial R²: 4e-05 age, PCs1-3 —
PPM015226 PGS002788
(BD2_SDPR)
 PSS009949|
European Ancestry|
2,198 individuals
 PGP000370 |
Gui Y et al. Transl Psychiatry (2022)
 Reported Trait: Psychiatric behavior (Sluggish cognitive tempo) — — partial R²: 0.0001 age, PCs1-3 —
PPM015227 PGS002788
(BD2_SDPR)
 PSS009949|
European Ancestry|
2,198 individuals
 PGP000370 |
Gui Y et al. Transl Psychiatry (2022)
 Reported Trait: Psychiatric behavior (Obsessive compulsive disorder) — — partial R²: 0.00125 age, PCs1-3 —
PPM015228 PGS002788
(BD2_SDPR)
 PSS009949|
European Ancestry|
2,198 individuals
 PGP000370 |
Gui Y et al. Transl Psychiatry (2022)
 Reported Trait: Psychiatric behavior (stress) — — partial R²: 0.00025 age, PCs1-3 —
PPM015230 PGS002788
(BD2_SDPR)
 PSS009949|
European Ancestry|
2,198 individuals
 PGP000370 |
Gui Y et al. Transl Psychiatry (2022)
 Reported Trait: Cognitive function (Flanker test) — — partial R²: 1.91e-06 age, PCs1-3 —
PPM015231 PGS002788
(BD2_SDPR)
 PSS009949|
European Ancestry|
2,198 individuals
 PGP000370 |
Gui Y et al. Transl Psychiatry (2022)
 Reported Trait: Cognitive function (list sorting) — — partial R²: 3.47e-06 age, PCs1-3 —
PPM015232 PGS002788
(BD2_SDPR)
 PSS009949|
European Ancestry|
2,198 individuals
 PGP000370 |
Gui Y et al. Transl Psychiatry (2022)
 Reported Trait: Cognitive function (card sorting) — — partial R²: 8.67e-06 age, PCs1-3 —
PPM015233 PGS002788
(BD2_SDPR)
 PSS009949|
European Ancestry|
2,198 individuals
 PGP000370 |
Gui Y et al. Transl Psychiatry (2022)
 Reported Trait: Cognitive function (pattern comparison) — — partial R²: 9.91e-06 age, PCs1-3 —
PPM015234 PGS002788
(BD2_SDPR)
 PSS009949|
European Ancestry|
2,198 individuals
 PGP000370 |
Gui Y et al. Transl Psychiatry (2022)
 Reported Trait: Cognitive function (Picture sequence) — — partial R²: 7e-05 age, PCs1-3 —
PPM015235 PGS002788
(BD2_SDPR)
 PSS009949|
European Ancestry|
2,198 individuals
 PGP000370 |
Gui Y et al. Transl Psychiatry (2022)
 Reported Trait: Cognitive function (reading) — — partial R²: 0.0001 age, PCs1-3 —
PPM015236 PGS002788
(BD2_SDPR)
 PSS009949|
European Ancestry|
2,198 individuals
 PGP000370 |
Gui Y et al. Transl Psychiatry (2022)
 Reported Trait: Cognitive function (fluid composite) — — partial R²: 3e-05 age, PCs1-3 —
PPM015237 PGS002788
(BD2_SDPR)
 PSS009949|
European Ancestry|
2,198 individuals
 PGP000370 |
Gui Y et al. Transl Psychiatry (2022)
 Reported Trait: Cognitive function (Crystallized composite) — — partial R²: 7e-05 age, PCs1-3 —
PPM015238 PGS002788
(BD2_SDPR)
 PSS009949|
European Ancestry|
2,198 individuals
 PGP000370 |
Gui Y et al. Transl Psychiatry (2022)
 Reported Trait: Cognitive function (Cognitive total) — — partial R²: 3.27e-06 age, PCs1-3 —
PPM015239 PGS002788
(BD2_SDPR)
 PSS009951|
European Ancestry|
78,561 individuals
 PGP000370 |
Gui Y et al. Transl Psychiatry (2022)
 Reported Trait: Cognitive function (fluid composite) — — partial R²: 5.36e-06 age, PCs1-10 —
PPM015178 PGS002788
(BD2_SDPR)
 PSS009950|
European Ancestry|
2,524 individuals
 PGP000370 |
Gui Y et al. Transl Psychiatry (2022)
 Reported Trait: Psychiatric behavior (anxious/depressed) — — partial R²: 0.00052 age, PCs1-3 —
PPM015184 PGS002788
(BD2_SDPR)
 PSS009950|
European Ancestry|
2,524 individuals
 PGP000370 |
Gui Y et al. Transl Psychiatry (2022)
 Reported Trait: Psychiatric behavior (rule breaking) — — partial R²: 0.00084 age, PCs1-3 —
PPM015195 PGS002788
(BD2_SDPR)
 PSS009950|
European Ancestry|
2,524 individuals
 PGP000370 |
Gui Y et al. Transl Psychiatry (2022)
 Reported Trait: Psychiatric behavior (Sluggish cognitive tempo) — — partial R²: 0.00307 age, PCs1-3 —
PPM015208 PGS002788
(BD2_SDPR)
 PSS009953|
European Ancestry|
68,614 individuals
 PGP000370 |
Gui Y et al. Transl Psychiatry (2022)
 Reported Trait: Cognitive function (fluid composite) — — partial R²: 9.85e-06 age, PCs1-10 —
PPM015219 PGS002788
(BD2_SDPR)
 PSS009949|
European Ancestry|
2,198 individuals
 PGP000370 |
Gui Y et al. Transl Psychiatry (2022)
 Reported Trait: Psychiatric behavior (total problems) — — partial R²: 0.00068 age, PCs1-3 —
PPM015229 PGS002788
(BD2_SDPR)
 PSS009949|
European Ancestry|
2,198 individuals
 PGP000370 |
Gui Y et al. Transl Psychiatry (2022)
 Reported Trait: Cognitive function (Picture vocabulary) — — partial R²: 0.00035 age, PCs1-3 —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS009949 NIH Toolbox was used to measure cognition in ABCD. Children’s problems and competencies were rated using the parent-reported Children Behavior Checklist (CBCL). Details of the ABCD MRI data acquisition and analysis have been published previously. — 2,198 individuals,
0.0 % Male samples
 Mean = 9.89 years
Sd = 0.61 years		 European — ABCD —
PSS009950 NIH Toolbox was used to measure cognition in ABCD. Children’s problems and competencies were rated using the parent-reported Children Behavior Checklist (CBCL). Details of the ABCD MRI data acquisition and analysis have been published previously. — 2,524 individuals,
100.0 % Male samples
 Mean = 9.92 years
Sd = 0.62 years		 European — ABCD —
PSS009951 Fluid intelligence test — 78,561 individuals,
0.0 % Male samples
 Mean = 57.46 years
Sd = 8.08 years		 European — UKB —
PSS009953 Fluid intelligence test — 68,614 individuals,
100.0 % Male samples
 Mean = 58.39 years
Sd = 8.36 years		 European — UKB —