Trait: corneal resistance factor

Experimental Factor Ontology (EFO) Information
Identifier EFO_0010067
Description A measure of the biomechanical properties of the cornea. Low corneal resistance factor may be indicative of keratoconus.
Trait category
Other measurement
Mapped term PMID:31246245

Associated Polygenic Score(s)

Filter PGS by Participant Ancestry
Individuals included in:
G - Source of Variant Associations (GWAS)
D - Score Development/Training
E - PGS Evaluation
List of ancestries includes:
Display options:
Ancestry legend
Multi-ancestry (including European)
Multi-ancestry (excluding European)
African
East Asian
South Asian
Additional Asian Ancestries
European
Greater Middle Eastern
Hispanic or Latin American
Additional Diverse Ancestries
Not Reported
Polygenic Score ID & Name PGS Publication ID (PGP) Reported Trait Mapped Trait(s) (Ontology) Number of Variants Ancestry distribution
GWAS
Dev
Eval
 Scoring File (FTP Link)
PGS001382
(GBE_INI5265)
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
 Corneal resistance factor (L) corneal resistance factor 2,390
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS001382/ScoringFiles/PGS001382.txt.gz
PGS001383
(GBE_INI5257)
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
 Corneal resistance factor (R) corneal resistance factor 3,941
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS001383/ScoringFiles/PGS001383.txt.gz

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		Evaluated Score PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM007215 PGS001382
(GBE_INI5265)
 PSS007471|
African Ancestry|
3,212 individuals
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
 Reported Trait: Corneal resistance factor (L) — — R²: 0.0128 [0.00737, 0.01823]
Incremental R2 (full-covars): 0.00811
PGS R2 (no covariates): 0.0089 [0.00436, 0.01345]		 age, sex, UKB array type, Genotype PCs —
PPM007216 PGS001382
(GBE_INI5265)
 PSS007472|
East Asian Ancestry|
583 individuals
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
 Reported Trait: Corneal resistance factor (L) — — R²: 0.0417 [0.02316, 0.06025]
Incremental R2 (full-covars): 0.01915
PGS R2 (no covariates): 0.02245 [0.00857, 0.03633]		 age, sex, UKB array type, Genotype PCs —
PPM007217 PGS001382
(GBE_INI5265)
 PSS007473|
European Ancestry|
7,806 individuals
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
 Reported Trait: Corneal resistance factor (L) — — R²: 0.04343 [0.03848, 0.04838]
Incremental R2 (full-covars): 0.03796
PGS R2 (no covariates): 0.03864 [0.03394, 0.04333]		 age, sex, UKB array type, Genotype PCs —
PPM007218 PGS001382
(GBE_INI5265)
 PSS007474|
South Asian Ancestry|
3,565 individuals
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
 Reported Trait: Corneal resistance factor (L) — — R²: 0.03432 [0.0264, 0.04224]
Incremental R2 (full-covars): 0.0261
PGS R2 (no covariates): 0.02734 [0.02022, 0.03446]		 age, sex, UKB array type, Genotype PCs —
PPM007219 PGS001382
(GBE_INI5265)
 PSS007475|
European Ancestry|
16,274 individuals
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
 Reported Trait: Corneal resistance factor (L) — — R²: 0.05817 [0.05474, 0.0616]
Incremental R2 (full-covars): 0.05402
PGS R2 (no covariates): 0.05488 [0.05153, 0.05822]		 age, sex, UKB array type, Genotype PCs —
PPM007195 PGS001383
(GBE_INI5257)
 PSS007451|
African Ancestry|
1,002 individuals
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
 Reported Trait: Corneal resistance factor (R) — — R²: 0.02531 [0.01192, 0.03869]
Incremental R2 (full-covars): 0.01226
PGS R2 (no covariates): 0.0127 [0.0031, 0.02231]		 age, sex, UKB array type, Genotype PCs —
PPM007196 PGS001383
(GBE_INI5257)
 PSS007452|
East Asian Ancestry|
161 individuals
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
 Reported Trait: Corneal resistance factor (R) — — R²: 0.19696 [0.13534, 0.25858]
Incremental R2 (full-covars): 0.02804
PGS R2 (no covariates): 0.02639 [-0.00095, 0.05374]		 age, sex, UKB array type, Genotype PCs —
PPM007197 PGS001383
(GBE_INI5257)
 PSS007453|
European Ancestry|
2,380 individuals
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
 Reported Trait: Corneal resistance factor (R) — — R²: 0.05219 [0.04244, 0.06193]
Incremental R2 (full-covars): 0.04314
PGS R2 (no covariates): 0.0443 [0.03524, 0.05336]		 age, sex, UKB array type, Genotype PCs —
PPM007198 PGS001383
(GBE_INI5257)
 PSS007454|
South Asian Ancestry|
1,090 individuals
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
 Reported Trait: Corneal resistance factor (R) — — R²: 0.03596 [0.02131, 0.05061]
Incremental R2 (full-covars): 0.02434
PGS R2 (no covariates): 0.02524 [0.01283, 0.03765]		 age, sex, UKB array type, Genotype PCs —
PPM007199 PGS001383
(GBE_INI5257)
 PSS007455|
European Ancestry|
5,012 individuals
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
 Reported Trait: Corneal resistance factor (R) — — R²: 0.07286 [0.06607, 0.07966]
Incremental R2 (full-covars): 0.06589
PGS R2 (no covariates): 0.06647 [0.05993, 0.073]		 age, sex, UKB array type, Genotype PCs —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS007452 — — 161 individuals — East Asian — UKB —
PSS007453 — — 2,380 individuals — European non-white British ancestry UKB —
PSS007454 — — 1,090 individuals — South Asian — UKB —
PSS007455 — — 5,012 individuals — European white British ancestry UKB Testing cohort (heldout set)
PSS007471 — — 3,212 individuals — African unspecified — UKB —
PSS007472 — — 583 individuals — East Asian — UKB —
PSS007473 — — 7,806 individuals — European non-white British ancestry UKB —
PSS007474 — — 3,565 individuals — South Asian — UKB —
PSS007475 — — 16,274 individuals — European white British ancestry UKB Testing cohort (heldout set)
PSS007451 — — 1,002 individuals — African unspecified — UKB —