Trait: left ventricular stroke volume measurement

Experimental Factor Ontology (EFO) Information
Identifier EFO_0010555
Description Quantification of the volume of blood pumped from the left ventricle of the heart with each beat, calculated by subtracting the volume of blood in the ventricle at the end of a beat (end-systolic volume) from the volume of blood just prior to the beat (end-diastolic volume).
Trait category
Cardiovascular measurement
Mapped term PMID:31554410

Associated Polygenic Score(s)

Filter PGS by Participant Ancestry
Individuals included in:
G - Source of Variant Associations (GWAS)
D - Score Development/Training
E - PGS Evaluation
List of ancestries includes:
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Ancestry legend
Multi-ancestry (including European)
Multi-ancestry (excluding European)
African
East Asian
South Asian
Additional Asian Ancestries
European
Greater Middle Eastern
Hispanic or Latin American
Additional Diverse Ancestries
Not Reported
Polygenic Score ID & Name PGS Publication ID (PGP) Reported Trait Mapped Trait(s) (Ontology) Number of Variants Ancestry distribution
GWAS
Dev
Eval
 Scoring File (FTP Link)
PGS001413
(GBE_INI22423)
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
 LV stroke volume left ventricular stroke volume measurement 26
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS001413/ScoringFiles/PGS001413.txt.gz

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		Evaluated Score PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM005320 PGS001413
(GBE_INI22423)
 PSS004991|
African Ancestry|
192 individuals
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
 Reported Trait: LV stroke volume — — R²: 0.2894 [0.27082, 0.30798]
Incremental R2 (full-covars): 0.00042
PGS R2 (no covariates): 2e-05 [-0.00021, 0.00026]		 age, sex, UKB array type, Genotype PCs —
PPM005321 PGS001413
(GBE_INI22423)
 PSS004992|
East Asian Ancestry|
110 individuals
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
 Reported Trait: LV stroke volume — — R²: 0.24626 [0.21082, 0.28171]
Incremental R2 (full-covars): 0.00076
PGS R2 (no covariates): 0.00073 [-0.00183, 0.00328]		 age, sex, UKB array type, Genotype PCs —
PPM005322 PGS001413
(GBE_INI22423)
 PSS004993|
European Ancestry|
1,708 individuals
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
 Reported Trait: LV stroke volume — — R²: 0.27363 [0.26419, 0.28306]
Incremental R2 (full-covars): -0.00044
PGS R2 (no covariates): 8e-05 [-0.00014, 0.00031]		 age, sex, UKB array type, Genotype PCs —
PPM005323 PGS001413
(GBE_INI22423)
 PSS004994|
South Asian Ancestry|
319 individuals
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
 Reported Trait: LV stroke volume — — R²: 0.21177 [0.19571, 0.22783]
Incremental R2 (full-covars): -0.00201
PGS R2 (no covariates): 0.00017 [-0.00041, 0.00074]		 age, sex, UKB array type, Genotype PCs —
PPM005324 PGS001413
(GBE_INI22423)
 PSS004995|
European Ancestry|
5,528 individuals
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
 Reported Trait: LV stroke volume — — R²: 0.20777 [0.20231, 0.21322]
Incremental R2 (full-covars): 0.00246
PGS R2 (no covariates): 0.00431 [0.00333, 0.0053]		 age, sex, UKB array type, Genotype PCs —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS004991 — — 192 individuals — African unspecified — UKB —
PSS004992 — — 110 individuals — East Asian — UKB —
PSS004993 — — 1,708 individuals — European non-white British ancestry UKB —
PSS004994 — — 319 individuals — South Asian — UKB —
PSS004995 — — 5,528 individuals — European white British ancestry UKB Testing cohort (heldout set)