Trait: mean reticulocyte volume

Experimental Factor Ontology (EFO) Information
Identifier EFO_0010701
Description Mean volume of reticulocyte cells
Trait category
Hematological measurement

Associated Polygenic Score(s)

Filter PGS by Participant Ancestry
Individuals included in:
G - Source of Variant Associations (GWAS)
D - Score Development/Training
E - PGS Evaluation
List of ancestries includes:
Display options:
Ancestry legend
Multi-ancestry (including European)
Multi-ancestry (excluding European)
African
East Asian
South Asian
Additional Asian Ancestries
European
Greater Middle Eastern
Hispanic or Latin American
Additional Diverse Ancestries
Not Reported
Polygenic Score ID & Name PGS Publication ID (PGP) Reported Trait Mapped Trait(s) (Ontology) Number of Variants Ancestry distribution
GWAS
Dev
Eval
 Scoring File (FTP Link)
PGS000180
(mrv)
 PGP000078 |
Vuckovic D et al. Cell (2020)
 Mean reticulocyte volume mean reticulocyte volume 629
-
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000180/ScoringFiles/PGS000180.txt.gz
PGS000987
(GBE_INI30260)
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
 Mean reticulocyte volume mean reticulocyte volume 13,277
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000987/ScoringFiles/PGS000987.txt.gz
PGS002003
(portability-PLR_reticulocyte_volume)
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Mean reticulocyte volume mean reticulocyte volume 24,536
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS002003/ScoringFiles/PGS002003.txt.gz
PGS002221
(portability-ldpred2_reticulocyte_volume)
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Mean reticulocyte volume mean reticulocyte volume 523,074
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS002221/ScoringFiles/PGS002221.txt.gz
PGS003567
(cont-decay-reticulocyte_volume)
 PGP000457 |
Ding Y et al. bioRxiv (2022)
|Pre		 Mean reticulocyte volume mean reticulocyte volume 979,739
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS003567/ScoringFiles/PGS003567.txt.gz
PGS003948
(INI30260)
 PGP000502 |
Tanigawa Y et al. AJHG (2023)
 Mean reticulocyte volume mean reticulocyte volume 18,832
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS003948/ScoringFiles/PGS003948.txt.gz
PGS004365
(X30260.score)
 PGP000561 |
Jung H et al. Commun Biol (2024)
 Mean reticulocyte volume mean reticulocyte volume 1,059,939
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004365/ScoringFiles/PGS004365.txt.gz

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		Evaluated Score PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM007703 PGS000987
(GBE_INI30260)
 PSS007026|
African Ancestry|
5,973 individuals
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
 Reported Trait: Mean reticulocyte volume — — R²: 0.03718 [0.02815, 0.0462]
Incremental R2 (full-covars): 0.02777
PGS R2 (no covariates): 0.02867 [0.02068, 0.03667]		 age, sex, UKB array type, Genotype PCs —
PPM007704 PGS000987
(GBE_INI30260)
 PSS007027|
East Asian Ancestry|
1,623 individuals
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
 Reported Trait: Mean reticulocyte volume — — R²: 0.08812 [0.06247, 0.11377]
Incremental R2 (full-covars): 0.07173
PGS R2 (no covariates): 0.07447 [0.05053, 0.0984]		 age, sex, UKB array type, Genotype PCs —
PPM007705 PGS000987
(GBE_INI30260)
 PSS007028|
European Ancestry|
23,687 individuals
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
 Reported Trait: Mean reticulocyte volume — — R²: 0.1616 [0.15323, 0.16997]
Incremental R2 (full-covars): 0.14435
PGS R2 (no covariates): 0.1455 [0.1374, 0.15359]		 age, sex, UKB array type, Genotype PCs —
PPM007706 PGS000987
(GBE_INI30260)
 PSS007029|
South Asian Ancestry|
7,323 individuals
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
 Reported Trait: Mean reticulocyte volume — — R²: 0.13294 [0.11894, 0.14694]
Incremental R2 (full-covars): 0.09343
PGS R2 (no covariates): 0.09786 [0.08537, 0.11036]		 age, sex, UKB array type, Genotype PCs —
PPM007707 PGS000987
(GBE_INI30260)
 PSS007030|
European Ancestry|
64,570 individuals
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
 Reported Trait: Mean reticulocyte volume — — R²: 0.15675 [0.15171, 0.16179]
Incremental R2 (full-covars): 0.14554
PGS R2 (no covariates): 0.14631 [0.14138, 0.15124]		 age, sex, UKB array type, Genotype PCs —
PPM010898 PGS002003
(portability-PLR_reticulocyte_volume)
 PSS009487|
European Ancestry|
19,120 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Mean reticulocyte volume — — Partial Correlation (partial-r): 0.3934 [0.3814, 0.4054] sex, age, birth date, deprivation index, 16 PCs —
PPM010899 PGS002003
(portability-PLR_reticulocyte_volume)
 PSS009261|
European Ancestry|
3,924 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Mean reticulocyte volume — — Partial Correlation (partial-r): 0.3882 [0.3612, 0.4145] sex, age, birth date, deprivation index, 16 PCs —
PPM010900 PGS002003
(portability-PLR_reticulocyte_volume)
 PSS008815|
European Ancestry|
6,298 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Mean reticulocyte volume — — Partial Correlation (partial-r): 0.3774 [0.356, 0.3984] sex, age, birth date, deprivation index, 16 PCs —
PPM010901 PGS002003
(portability-PLR_reticulocyte_volume)
 PSS008589|
Greater Middle Eastern Ancestry|
1,127 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Mean reticulocyte volume — — Partial Correlation (partial-r): 0.3348 [0.2815, 0.3861] sex, age, birth date, deprivation index, 16 PCs —
PPM010902 PGS002003
(portability-PLR_reticulocyte_volume)
 PSS008367|
South Asian Ancestry|
5,935 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Mean reticulocyte volume — — Partial Correlation (partial-r): 0.3217 [0.2986, 0.3443] sex, age, birth date, deprivation index, 16 PCs —
PPM010903 PGS002003
(portability-PLR_reticulocyte_volume)
 PSS008143|
East Asian Ancestry|
1,722 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Mean reticulocyte volume — — Partial Correlation (partial-r): 0.2638 [0.219, 0.3074] sex, age, birth date, deprivation index, 16 PCs —
PPM010904 PGS002003
(portability-PLR_reticulocyte_volume)
 PSS007931|
African Ancestry|
2,293 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Mean reticulocyte volume — — Partial Correlation (partial-r): 0.2125 [0.1729, 0.2514] sex, age, birth date, deprivation index, 16 PCs —
PPM010905 PGS002003
(portability-PLR_reticulocyte_volume)
 PSS009035|
African Ancestry|
3,602 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Mean reticulocyte volume — — Partial Correlation (partial-r): 0.1616 [0.1296, 0.1934] sex, age, birth date, deprivation index, 16 PCs —
PPM012614 PGS002221
(portability-ldpred2_reticulocyte_volume)
 PSS009487|
European Ancestry|
19,120 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Mean reticulocyte volume — — Partial Correlation (partial-r): 0.3894 [0.3773, 0.4014] sex, age, birth date, deprivation index, 16 PCs —
PPM012615 PGS002221
(portability-ldpred2_reticulocyte_volume)
 PSS009261|
European Ancestry|
3,924 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Mean reticulocyte volume — — Partial Correlation (partial-r): 0.3877 [0.3608, 0.4141] sex, age, birth date, deprivation index, 16 PCs —
PPM012616 PGS002221
(portability-ldpred2_reticulocyte_volume)
 PSS008815|
European Ancestry|
6,298 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Mean reticulocyte volume — — Partial Correlation (partial-r): 0.3736 [0.3521, 0.3947] sex, age, birth date, deprivation index, 16 PCs —
PPM012617 PGS002221
(portability-ldpred2_reticulocyte_volume)
 PSS008589|
Greater Middle Eastern Ancestry|
1,127 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Mean reticulocyte volume — — Partial Correlation (partial-r): 0.3308 [0.2773, 0.3823] sex, age, birth date, deprivation index, 16 PCs —
PPM012618 PGS002221
(portability-ldpred2_reticulocyte_volume)
 PSS008367|
South Asian Ancestry|
5,935 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Mean reticulocyte volume — — Partial Correlation (partial-r): 0.3152 [0.2921, 0.338] sex, age, birth date, deprivation index, 16 PCs —
PPM012619 PGS002221
(portability-ldpred2_reticulocyte_volume)
 PSS008143|
East Asian Ancestry|
1,722 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Mean reticulocyte volume — — Partial Correlation (partial-r): 0.2541 [0.2091, 0.298] sex, age, birth date, deprivation index, 16 PCs —
PPM012620 PGS002221
(portability-ldpred2_reticulocyte_volume)
 PSS007931|
African Ancestry|
2,293 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Mean reticulocyte volume — — Partial Correlation (partial-r): 0.2118 [0.1722, 0.2507] sex, age, birth date, deprivation index, 16 PCs —
PPM012621 PGS002221
(portability-ldpred2_reticulocyte_volume)
 PSS009035|
African Ancestry|
3,602 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Mean reticulocyte volume — — Partial Correlation (partial-r): 0.1834 [0.1516, 0.2149] sex, age, birth date, deprivation index, 16 PCs —
PPM017495 PGS003567
(cont-decay-reticulocyte_volume)
 PSS010934|
European Ancestry|
19,112 individuals
 PGP000457 |
Ding Y et al. bioRxiv (2022)
|Pre		 Reported Trait: Mean reticulocyte volume — — partial-R2: 0.15 sex, age, deprivation index, PC1-16 —
PPM017579 PGS003567
(cont-decay-reticulocyte_volume)
 PSS010850|
European Ancestry|
3,913 individuals
 PGP000457 |
Ding Y et al. bioRxiv (2022)
|Pre		 Reported Trait: Mean reticulocyte volume — — partial-R2: 0.15 sex, age, deprivation index, PC1-16 —
PPM017663 PGS003567
(cont-decay-reticulocyte_volume)
 PSS010682|
European Ancestry|
6,144 individuals
 PGP000457 |
Ding Y et al. bioRxiv (2022)
|Pre		 Reported Trait: Mean reticulocyte volume — — partial-R2: 0.13 sex, age, deprivation index, PC1-16 —
PPM017747 PGS003567
(cont-decay-reticulocyte_volume)
 PSS010598|
Greater Middle Eastern Ancestry|
1,097 individuals
 PGP000457 |
Ding Y et al. bioRxiv (2022)
|Pre		 Reported Trait: Mean reticulocyte volume — — partial-R2: 0.1 sex, age, deprivation index, PC1-16 —
PPM017831 PGS003567
(cont-decay-reticulocyte_volume)
 PSS010262|
European Ancestry|
2,221 individuals
 PGP000457 |
Ding Y et al. bioRxiv (2022)
|Pre		 Reported Trait: Mean reticulocyte volume — — partial-R2: 0.16 sex, age, deprivation index, PC1-16 —
PPM017915 PGS003567
(cont-decay-reticulocyte_volume)
 PSS010514|
South Asian Ancestry|
5,886 individuals
 PGP000457 |
Ding Y et al. bioRxiv (2022)
|Pre		 Reported Trait: Mean reticulocyte volume — — partial-R2: 0.1 sex, age, deprivation index, PC1-16 —
PPM017999 PGS003567
(cont-decay-reticulocyte_volume)
 PSS010430|
East Asian Ancestry|
1,711 individuals
 PGP000457 |
Ding Y et al. bioRxiv (2022)
|Pre		 Reported Trait: Mean reticulocyte volume — — partial-R2: 0.06 sex, age, deprivation index, PC1-16 —
PPM018083 PGS003567
(cont-decay-reticulocyte_volume)
 PSS010346|
African Ancestry|
2,281 individuals
 PGP000457 |
Ding Y et al. bioRxiv (2022)
|Pre		 Reported Trait: Mean reticulocyte volume — — partial-R2: 0.04 sex, age, deprivation index, PC1-16 —
PPM018167 PGS003567
(cont-decay-reticulocyte_volume)
 PSS010766|
African Ancestry|
3,574 individuals
 PGP000457 |
Ding Y et al. bioRxiv (2022)
|Pre		 Reported Trait: Mean reticulocyte volume — — partial-R2: 0.03 sex, age, deprivation index, PC1-16 —
PPM019059 PGS003948
(INI30260)
 PSS011140|
European Ancestry|
64,861 individuals
 PGP000502 |
Tanigawa Y et al. AJHG (2023)
 Reported Trait: Mean reticulocyte volume — — R²: 0.16087 [0.1558, 0.16594]
PGS R2 (no covariates): 0.14603 [0.14111, 0.15095]
Incremental R2 (full-covars): 0.14515		 age, sex, age^2, age*sex, Townsend deprivation index, genotype PCs (PC1-PC18) —
PPM019060 PGS003948
(INI30260)
 PSS011099|
European Ancestry|
2,770 individuals
 PGP000502 |
Tanigawa Y et al. AJHG (2023)
 Reported Trait: Mean reticulocyte volume — — R²: 0.17217 [0.14717, 0.19717]
PGS R2 (no covariates): 0.14414 [0.1205, 0.16779]
Incremental R2 (full-covars): 0.14281		 age, sex, age^2, age*sex, Townsend deprivation index, genotype PCs (PC1-PC18) —
PPM019061 PGS003948
(INI30260)
 PSS011111|
South Asian Ancestry|
1,393 individuals
 PGP000502 |
Tanigawa Y et al. AJHG (2023)
 Reported Trait: Mean reticulocyte volume — — R²: 0.13781 [0.10535, 0.17027]
PGS R2 (no covariates): 0.11019 [0.08024, 0.14015]
Incremental R2 (full-covars): 0.10391		 age, sex, age^2, age*sex, Townsend deprivation index, genotype PCs (PC1-PC18) —
PPM019062 PGS003948
(INI30260)
 PSS011152|
African Ancestry|
1,124 individuals
 PGP000502 |
Tanigawa Y et al. AJHG (2023)
 Reported Trait: Mean reticulocyte volume — — R²: 0.03874 [0.01751, 0.05997]
PGS R2 (no covariates): 0.03349 [0.01364, 0.05333]
Incremental R2 (full-covars): 0.033		 age, sex, age^2, age*sex, Townsend deprivation index, genotype PCs (PC1-PC18) —
PPM019063 PGS003948
(INI30260)
 PSS011169|
Multi-ancestry (excluding European)|
7,578 individuals
 PGP000502 |
Tanigawa Y et al. AJHG (2023)
 Reported Trait: Mean reticulocyte volume — — R²: 0.15509 [0.14052, 0.16966]
PGS R2 (no covariates): 0.13046 [0.11671, 0.14422]
Incremental R2 (full-covars): 0.11887		 age, sex, age^2, age*sex, Townsend deprivation index, genotype PCs (PC1-PC18) —
PPM020480 PGS004365
(X30260.score)
 PSS011364|
European Ancestry|
56,192 individuals
 PGP000561 |
Jung H et al. Commun Biol (2024)
 Reported Trait: Mean reticulocyte volume — — PGS R2 (no covariates): 0.26343 — —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS011140 — — 64,861 individuals — European
(white British ancestry)		 — UKB —
PSS009035 — — 3,602 individuals — African unspecified Nigeria (West Africa) UKB —
PSS008143 — — 1,722 individuals — East Asian China (East Asia) UKB —
PSS011152 — — 1,124 individuals — African unspecified — UKB —
PSS010934 — — 19,112 individuals,
46.0 % Male samples
 Mean = 56.9 years
Sd = 7.9 years		 European white British UKB —
PSS010682 — — 6,144 individuals,
45.0 % Male samples
 Mean = 54.4 years
Sd = 8.4 years		 European Italian UKB —
PSS011169 — — 7,578 individuals — East Asian, Other admixed ancestry East Asian, Other admixed ancestry UKB —
PSS010430 — — 1,711 individuals,
33.0 % Male samples
 Mean = 52.4 years
Sd = 7.8 years		 East Asian Chinese UKB —
PSS008815 — — 6,298 individuals — European Italy (South Europe) UKB —
PSS007026 — — 5,973 individuals — African unspecified — UKB —
PSS007931 — — 2,293 individuals — African American or Afro-Caribbean Carribean UKB —
PSS007027 — — 1,623 individuals — East Asian — UKB —
PSS007028 — — 23,687 individuals — European non-white British ancestry UKB —
PSS007029 — — 7,323 individuals — South Asian — UKB —
PSS007030 — — 64,570 individuals — European white British ancestry UKB Testing cohort (heldout set)
PSS010850 — — 3,913 individuals,
38.0 % Male samples
 Mean = 54.3 years
Sd = 7.5 years		 European Polish UKB —
PSS010598 — — 1,097 individuals,
59.0 % Male samples
 Mean = 52.0 years
Sd = 8.0 years		 Greater Middle Eastern (Middle Eastern, North African or Persian) Iranian UKB —
PSS008589 — — 1,127 individuals — Greater Middle Eastern (Middle Eastern, North African or Persian) Iran (Middle East) UKB —
PSS009487 — — 19,120 individuals — European UK (+ Ireland) UKB —
PSS010346 — — 2,281 individuals,
37.0 % Male samples
 Mean = 52.4 years
Sd = 8.0 years		 African American or Afro-Caribbean Caribbean UKB —
PSS011099 — — 2,770 individuals — European
(non-white British ancestry)		 — UKB —
PSS011364 — — 56,192 individuals — European — UKB —
PSS011111 — — 1,393 individuals — South Asian — UKB —
PSS009261 — — 3,924 individuals — European Poland (NE Europe) UKB —
PSS008367 — — 5,935 individuals — South Asian India (South Asia) UKB —
PSS010766 — — 3,574 individuals,
47.0 % Male samples
 Mean = 51.9 years
Sd = 8.1 years		 African unspecified Nigerian UKB —
PSS010514 — — 5,886 individuals,
55.0 % Male samples
 Mean = 53.3 years
Sd = 8.4 years		 South Asian Indian UKB —
PSS010262 — — 2,221 individuals,
45.0 % Male samples
 Mean = 58.0 years
Sd = 7.1 years		 European Ashkenazi UKB —