Trait: aspartate aminotransferase to alanine aminotransferase ratio

Experimental Factor Ontology (EFO) Information
Identifier EFO_0010934
Description The ratio between the levels of aspartate aminotransferase (AST) and alanine aminotransferase (ALT).
Trait category
Other measurement
Synonym AST:ALT ratio
Mapped term PMID:33004991

Associated Polygenic Score(s)

Filter PGS by Participant Ancestry
Individuals included in:
G - Source of Variant Associations (GWAS)
D - Score Development/Training
E - PGS Evaluation
List of ancestries includes:
Display options:
Ancestry legend
Multi-ancestry (including European)
Multi-ancestry (excluding European)
African
East Asian
South Asian
Additional Asian Ancestries
European
Greater Middle Eastern
Hispanic or Latin American
Additional Diverse Ancestries
Not Reported
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Polygenic Score ID & Name
PGS Publication ID (PGP)
Reported Trait
Mapped Trait(s) (Ontology)
Number of Variants
Ancestry distribution
GWAS
Dev
Eval
Scoring File (FTP Link)
PGS000674
(snpnet.AST_ALT_ratio)
PGP000128 |
Sinnott-Armstrong N et al. Nat Genet (2021)
AST to ALT ratioaspartate aminotransferase to alanine aminotransferase ratio15,548
-
D
E
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000674/ScoringFiles/PGS000674.txt.gz - Check Terms/Licenses
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Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

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PGS Performance
Metric ID (PPM)
Evaluated Score
PGS Sample Set ID
(PSS)
Performance Source
Trait
PGS Effect Sizes
(per SD change)
Classification Metrics
Other Metrics
Covariates Included in the Model
PGS Performance:
Other Relevant Information
PPM001402PGS000674
(snpnet.AST_ALT_ratio)
PSS000617|
African Ancestry|
5,981 individuals
PGP000128 |
Sinnott-Armstrong N et al. Nat Genet (2021)
Reported Trait: AST to ALT ratio——R²: 0.10039
Spearman's ρ: 0.108		Age, sex, PCs(1-40)—
PPM001437PGS000674
(snpnet.AST_ALT_ratio)
PSS000618|
East Asian Ancestry|
1,069 individuals
PGP000128 |
Sinnott-Armstrong N et al. Nat Genet (2021)
Reported Trait: AST to ALT ratio——Spearman's ρ: 0.14
R²: 0.16003		Age, sex, PCs(1-40)—
PPM001472PGS000674
(snpnet.AST_ALT_ratio)
PSS000619|
European Ancestry|
23,478 individuals
PGP000128 |
Sinnott-Armstrong N et al. Nat Genet (2021)
Reported Trait: AST to ALT ratio——R²: 0.17913
Spearman's ρ: 0.256		Age, sex, PCs(1-40)—
PPM001507PGS000674
(snpnet.AST_ALT_ratio)
PSS000620|
South Asian Ancestry|
7,309 individuals
PGP000128 |
Sinnott-Armstrong N et al. Nat Genet (2021)
Reported Trait: AST to ALT ratio——R²: 0.16338
Spearman's ρ: 0.204		Age, sex, PCs(1-40)—
PPM001542PGS000674
(snpnet.AST_ALT_ratio)
PSS000621|
European Ancestry|
63,545 individuals
PGP000128 |
Sinnott-Armstrong N et al. Nat Genet (2021)
Reported Trait: AST to ALT ratio——R²: 0.16733
Spearman's ρ: 0.272		Age, sex, PCs(1-40)—
PPM007295PGS000674
(snpnet.AST_ALT_ratio)
PSS006906|
African Ancestry|
5,981 individuals
PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
|Ext.		Reported Trait: AST to ALT ratio——R²: 0.01466 [0.00886, 0.02046]
Incremental R2 (full-covars): 0.00987
PGS R2 (no covariates): 0.01069 [0.00572, 0.01566]		age, sex, UKB array type, Genotype PCs—
PPM007296PGS000674
(snpnet.AST_ALT_ratio)
PSS006907|
East Asian Ancestry|
1,564 individuals
PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
|Ext.		Reported Trait: AST to ALT ratio——R²: 0.02597 [0.01109, 0.04085]
Incremental R2 (full-covars): 0.01695
PGS R2 (no covariates): 0.01781 [0.00539, 0.03023]		age, sex, UKB array type, Genotype PCs—
PPM007297PGS000674
(snpnet.AST_ALT_ratio)
PSS006908|
European Ancestry|
23,476 individuals
PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
|Ext.		Reported Trait: AST to ALT ratio——R²: 0.0729 [0.06668, 0.07911]
Incremental R2 (full-covars): 0.07099
PGS R2 (no covariates): 0.07181 [0.06563, 0.07799]		age, sex, UKB array type, Genotype PCs—
PPM007298PGS000674
(snpnet.AST_ALT_ratio)
PSS006909|
South Asian Ancestry|
7,258 individuals
PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
|Ext.		Reported Trait: AST to ALT ratio——R²: 0.04818 [0.03893, 0.05743]
Incremental R2 (full-covars): 0.04091
PGS R2 (no covariates): 0.04147 [0.03283, 0.05012]		age, sex, UKB array type, Genotype PCs—
PPM007299PGS000674
(snpnet.AST_ALT_ratio)
PSS006910|
European Ancestry|
63,540 individuals
PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
|Ext.		Reported Trait: AST to ALT ratio——R²: 0.07733 [0.07346, 0.08121]
Incremental R2 (full-covars): 0.07732
PGS R2 (no covariates): 0.07746 [0.07358, 0.08133]		age, sex, UKB array type, Genotype PCs—
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Evaluated Samples

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PGS Sample Set ID
(PSS)
Phenotype Definitions and Methods
Participant Follow-up Time
Sample Numbers
Age of Study Participants
Sample Ancestry
Additional Ancestry Description
Cohort(s)
Additional Sample/Cohort Information
PSS000617——5,981 individuals—African unspecified—UKB—
PSS000618——1,069 individuals—East Asian—UKB—
PSS000619——23,478 individuals—EuropeanNon-British WhiteUKB—
PSS000620——7,309 individuals—South Asian—UKB—
PSS000621——63,545 individuals—European
(British)		—UKB—
PSS006906——5,981 individuals—African unspecified—UKB—
PSS006907——1,564 individuals—East Asian—UKB—
PSS006908——23,476 individuals—Europeannon-white British ancestryUKB—
PSS006909——7,258 individuals—South Asian—UKB—
PSS006910——63,540 individuals—Europeanwhite British ancestryUKBTesting cohort (heldout set)
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