Trait: urea measurement

Experimental Factor Ontology (EFO) Information
Identifier EFO_0011005
Description Quantification of urea in a sample.
Trait category
Other measurement
Mapped term PMID:33283231

Associated Polygenic Score(s)

Filter PGS by Participant Ancestry
Individuals included in:
G - Source of Variant Associations (GWAS)
D - Score Development/Training
E - PGS Evaluation
List of ancestries includes:
Display options:
Ancestry legend
Multi-ancestry (including European)
Multi-ancestry (excluding European)
African
East Asian
South Asian
Additional Asian Ancestries
European
Greater Middle Eastern
Hispanic or Latin American
Additional Diverse Ancestries
Not Reported
Polygenic Score ID & Name PGS Publication ID (PGP) Reported Trait Mapped Trait(s) (Ontology) Number of Variants Ancestry distribution
GWAS
Dev
Eval
 Scoring File (FTP Link)
PGS001980
(portability-PLR_log_urea)
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Urea urea measurement 56,782
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS001980/ScoringFiles/PGS001980.txt.gz
PGS002198
(portability-ldpred2_log_urea)
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Urea urea measurement 820,118
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS002198/ScoringFiles/PGS002198.txt.gz
PGS003553
(cont-decay-log_urea)
 PGP000457 |
Ding Y et al. bioRxiv (2022)
|Pre		 Urea urea measurement 979,739
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS003553/ScoringFiles/PGS003553.txt.gz
PGS004331
(X30670.score)
 PGP000561 |
Jung H et al. Commun Biol (2024)
 Urea (mmol/L) urea measurement 1,059,939
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004331/ScoringFiles/PGS004331.txt.gz
PGS004739
(BUN_PRSmix_eur)
 PGP000604 |
Truong B et al. Cell Genom (2024)
 Urea urea measurement 587,237
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004739/ScoringFiles/PGS004739.txt.gz
PGS004740
(BUN_PRSmix_sas)
 PGP000604 |
Truong B et al. Cell Genom (2024)
 Urea urea measurement 1,499,858
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004740/ScoringFiles/PGS004740.txt.gz
PGS004741
(BUN_PRSmixPlus_eur)
 PGP000604 |
Truong B et al. Cell Genom (2024)
 Urea urea measurement 1,178,386
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004741/ScoringFiles/PGS004741.txt.gz
PGS004742
(BUN_PRSmixPlus_sas)
 PGP000604 |
Truong B et al. Cell Genom (2024)
 Urea urea measurement 1,499,858
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004742/ScoringFiles/PGS004742.txt.gz

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		Evaluated Score PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM010715 PGS001980
(portability-PLR_log_urea)
 PSS009468|
European Ancestry|
18,989 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Urea — — Partial Correlation (partial-r): 0.2537 [0.2404, 0.267] sex, age, birth date, deprivation index, 16 PCs —
PPM010717 PGS001980
(portability-PLR_log_urea)
 PSS008796|
European Ancestry|
6,320 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Urea — — Partial Correlation (partial-r): 0.2435 [0.2201, 0.2665] sex, age, birth date, deprivation index, 16 PCs —
PPM010718 PGS001980
(portability-PLR_log_urea)
 PSS008570|
Greater Middle Eastern Ancestry|
1,124 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Urea — — Partial Correlation (partial-r): 0.2276 [0.1709, 0.2828] sex, age, birth date, deprivation index, 16 PCs —
PPM010719 PGS001980
(portability-PLR_log_urea)
 PSS008348|
South Asian Ancestry|
6,003 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Urea — — Partial Correlation (partial-r): 0.2101 [0.1858, 0.2342] sex, age, birth date, deprivation index, 16 PCs —
PPM010720 PGS001980
(portability-PLR_log_urea)
 PSS008125|
East Asian Ancestry|
1,715 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Urea — — Partial Correlation (partial-r): 0.1944 [0.1481, 0.2398] sex, age, birth date, deprivation index, 16 PCs —
PPM010721 PGS001980
(portability-PLR_log_urea)
 PSS007912|
African Ancestry|
2,345 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Urea — — Partial Correlation (partial-r): 0.16 [0.1202, 0.1994] sex, age, birth date, deprivation index, 16 PCs —
PPM010722 PGS001980
(portability-PLR_log_urea)
 PSS009016|
African Ancestry|
3,655 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Urea — — Partial Correlation (partial-r): 0.0842 [0.0518, 0.1164] sex, age, birth date, deprivation index, 16 PCs —
PPM010716 PGS001980
(portability-PLR_log_urea)
 PSS009242|
European Ancestry|
3,950 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Urea — — Partial Correlation (partial-r): 0.2562 [0.2268, 0.2852] sex, age, birth date, deprivation index, 16 PCs —
PPM012431 PGS002198
(portability-ldpred2_log_urea)
 PSS009468|
European Ancestry|
18,989 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Urea — — Partial Correlation (partial-r): 0.2506 [0.2372, 0.2639] sex, age, birth date, deprivation index, 16 PCs —
PPM012432 PGS002198
(portability-ldpred2_log_urea)
 PSS009242|
European Ancestry|
3,950 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Urea — — Partial Correlation (partial-r): 0.2538 [0.2243, 0.2828] sex, age, birth date, deprivation index, 16 PCs —
PPM012433 PGS002198
(portability-ldpred2_log_urea)
 PSS008796|
European Ancestry|
6,320 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Urea — — Partial Correlation (partial-r): 0.2434 [0.2201, 0.2665] sex, age, birth date, deprivation index, 16 PCs —
PPM012434 PGS002198
(portability-ldpred2_log_urea)
 PSS008570|
Greater Middle Eastern Ancestry|
1,124 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Urea — — Partial Correlation (partial-r): 0.229 [0.1723, 0.2842] sex, age, birth date, deprivation index, 16 PCs —
PPM012436 PGS002198
(portability-ldpred2_log_urea)
 PSS008125|
East Asian Ancestry|
1,715 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Urea — — Partial Correlation (partial-r): 0.1944 [0.1482, 0.2398] sex, age, birth date, deprivation index, 16 PCs —
PPM012437 PGS002198
(portability-ldpred2_log_urea)
 PSS007912|
African Ancestry|
2,345 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Urea — — Partial Correlation (partial-r): 0.1588 [0.1189, 0.1982] sex, age, birth date, deprivation index, 16 PCs —
PPM012438 PGS002198
(portability-ldpred2_log_urea)
 PSS009016|
African Ancestry|
3,655 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Urea — — Partial Correlation (partial-r): 0.0872 [0.0548, 0.1194] sex, age, birth date, deprivation index, 16 PCs —
PPM012435 PGS002198
(portability-ldpred2_log_urea)
 PSS008348|
South Asian Ancestry|
6,003 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Urea — — Partial Correlation (partial-r): 0.2054 [0.181, 0.2296] sex, age, birth date, deprivation index, 16 PCs —
PPM017481 PGS003553
(cont-decay-log_urea)
 PSS010919|
European Ancestry|
19,108 individuals
 PGP000457 |
Ding Y et al. bioRxiv (2022)
|Pre		 Reported Trait: Urea — — partial-R2: 0.06 sex, age, deprivation index, PC1-16 —
PPM017565 PGS003553
(cont-decay-log_urea)
 PSS010835|
European Ancestry|
3,939 individuals
 PGP000457 |
Ding Y et al. bioRxiv (2022)
|Pre		 Reported Trait: Urea — — partial-R2: 0.07 sex, age, deprivation index, PC1-16 —
PPM017649 PGS003553
(cont-decay-log_urea)
 PSS010667|
European Ancestry|
6,168 individuals
 PGP000457 |
Ding Y et al. bioRxiv (2022)
|Pre		 Reported Trait: Urea — — partial-R2: 0.06 sex, age, deprivation index, PC1-16 —
PPM017733 PGS003553
(cont-decay-log_urea)
 PSS010583|
Greater Middle Eastern Ancestry|
1,095 individuals
 PGP000457 |
Ding Y et al. bioRxiv (2022)
|Pre		 Reported Trait: Urea — — partial-R2: 0.05 sex, age, deprivation index, PC1-16 —
PPM017817 PGS003553
(cont-decay-log_urea)
 PSS010247|
European Ancestry|
2,235 individuals
 PGP000457 |
Ding Y et al. bioRxiv (2022)
|Pre		 Reported Trait: Urea — — partial-R2: 0.06 sex, age, deprivation index, PC1-16 —
PPM017901 PGS003553
(cont-decay-log_urea)
 PSS010499|
South Asian Ancestry|
5,949 individuals
 PGP000457 |
Ding Y et al. bioRxiv (2022)
|Pre		 Reported Trait: Urea — — partial-R2: 0.04 sex, age, deprivation index, PC1-16 —
PPM017985 PGS003553
(cont-decay-log_urea)
 PSS010415|
East Asian Ancestry|
1,704 individuals
 PGP000457 |
Ding Y et al. bioRxiv (2022)
|Pre		 Reported Trait: Urea — — partial-R2: 0.04 sex, age, deprivation index, PC1-16 —
PPM018069 PGS003553
(cont-decay-log_urea)
 PSS010331|
African Ancestry|
2,333 individuals
 PGP000457 |
Ding Y et al. bioRxiv (2022)
|Pre		 Reported Trait: Urea — — partial-R2: 0.02 sex, age, deprivation index, PC1-16 —
PPM018153 PGS003553
(cont-decay-log_urea)
 PSS010751|
African Ancestry|
3,626 individuals
 PGP000457 |
Ding Y et al. bioRxiv (2022)
|Pre		 Reported Trait: Urea — — partial-R2: 0.01 sex, age, deprivation index, PC1-16 —
PPM020446 PGS004331
(X30670.score)
 PSS011364|
European Ancestry|
56,192 individuals
 PGP000561 |
Jung H et al. Commun Biol (2024)
 Reported Trait: Urea (mmol/L) — — PGS R2 (no covariates): 0.16618 — —
PPM020964 PGS004739
(BUN_PRSmix_eur)
 PSS011461|
European Ancestry|
5,760 individuals
 PGP000604 |
Truong B et al. Cell Genom (2024)
 Reported Trait: Urea — — Incremental R2 (Full model versus model with only covariates): 0.023 [0.016, 0.031] age, sex, PC1, PC2, PC3, PC4, PC5, PC6, PC7, PC8, PC9, PC10 Incremental R2 (Full model versus model with only covariates)
PPM020965 PGS004740
(BUN_PRSmix_sas)
 PSS011462|
South Asian Ancestry|
6,087 individuals
 PGP000604 |
Truong B et al. Cell Genom (2024)
 Reported Trait: Urea — — Incremental R2 (Full model versus model with only covariates): 0.014 [0.008, 0.019] age, sex, PC1, PC2, PC3, PC4, PC5, PC6, PC7, PC8, PC9, PC10 Incremental R2 (Full model versus model with only covariates)
PPM020966 PGS004741
(BUN_PRSmixPlus_eur)
 PSS011461|
European Ancestry|
5,760 individuals
 PGP000604 |
Truong B et al. Cell Genom (2024)
 Reported Trait: Urea — — Incremental R2 (Full model versus model with only covariates): 0.028 [0.019, 0.036] age, sex, PC1, PC2, PC3, PC4, PC5, PC6, PC7, PC8, PC9, PC10 Incremental R2 (Full model versus model with only covariates)
PPM020967 PGS004742
(BUN_PRSmixPlus_sas)
 PSS011462|
South Asian Ancestry|
6,087 individuals
 PGP000604 |
Truong B et al. Cell Genom (2024)
 Reported Trait: Urea — — Incremental R2 (Full model versus model with only covariates): 0.016 [0.009, 0.022] age, sex, PC1, PC2, PC3, PC4, PC5, PC6, PC7, PC8, PC9, PC10 Incremental R2 (Full model versus model with only covariates)

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS010919 — — 19,108 individuals,
46.0 % Male samples
 Mean = 56.9 years
Sd = 7.9 years		 European white British UKB —
PSS010667 — — 6,168 individuals,
45.0 % Male samples
 Mean = 54.5 years
Sd = 8.4 years		 European Italian UKB —
PSS010415 — — 1,704 individuals,
33.0 % Male samples
 Mean = 52.4 years
Sd = 7.8 years		 East Asian Chinese UKB —
PSS011461 — — 5,760 individuals — European — AllofUs —
PSS011462 — — 6,087 individuals — South Asian — G&H —
PSS008796 — — 6,320 individuals — European Italy (South Europe) UKB —
PSS007912 — — 2,345 individuals — African American or Afro-Caribbean Carribean UKB —
PSS010835 — — 3,939 individuals,
38.0 % Male samples
 Mean = 54.4 years
Sd = 7.5 years		 European Polish UKB —
PSS008570 — — 1,124 individuals — Greater Middle Eastern (Middle Eastern, North African or Persian) Iran (Middle East) UKB —
PSS009468 — — 18,989 individuals — European UK (+ Ireland) UKB —
PSS010583 — — 1,095 individuals,
60.0 % Male samples
 Mean = 51.9 years
Sd = 8.0 years		 Greater Middle Eastern (Middle Eastern, North African or Persian) Iranian UKB —
PSS010331 — — 2,333 individuals,
37.0 % Male samples
 Mean = 52.5 years
Sd = 8.1 years		 African American or Afro-Caribbean Caribbean UKB —
PSS009242 — — 3,950 individuals — European Poland (NE Europe) UKB —
PSS008348 — — 6,003 individuals — South Asian India (South Asia) UKB —
PSS011364 — — 56,192 individuals — European — UKB —
PSS010751 — — 3,626 individuals,
46.0 % Male samples
 Mean = 51.9 years
Sd = 8.1 years		 African unspecified Nigerian UKB —
PSS010499 — — 5,949 individuals,
54.0 % Male samples
 Mean = 53.3 years
Sd = 8.4 years		 South Asian Indian UKB —
PSS010247 — — 2,235 individuals,
45.0 % Male samples
 Mean = 58.1 years
Sd = 7.1 years		 European Ashkenazi UKB —
PSS009016 — — 3,655 individuals — African unspecified Nigeria (West Africa) UKB —
PSS008125 — — 1,715 individuals — East Asian China (East Asia) UKB —