Trait: insulin use measurement

Experimental Factor Ontology (EFO) Information
Identifier EFO_0600082
Description Quantification of some aspect of the use of insulin.
Trait category
Other measurement
Mapped terms 2 mapped terms
  • https://biobank.ctsu.ox.ac.uk/crystal/field.cgi?id=2986
  • https://doi.org/10.1101/2021.09.02.21262942

Associated Polygenic Score(s)

Filter PGS by Participant Ancestry
Individuals included in:
G - Source of Variant Associations (GWAS)
D - Score Development/Training
E - PGS Evaluation
List of ancestries includes:
Display options:
Ancestry legend
Multi-ancestry (including European)
Multi-ancestry (excluding European)
African
East Asian
South Asian
Additional Asian Ancestries
European
Greater Middle Eastern
Hispanic or Latin American
Additional Diverse Ancestries
Not Reported
Polygenic Score ID & Name PGS Publication ID (PGP) Reported Trait Mapped Trait(s) (Ontology) Number of Variants Ancestry distribution
GWAS
Dev
Eval
 Scoring File (FTP Link)
PGS001117
(GBE_BIN_FC10002986)
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
 Started insulin within one year diagnosis of diabetes insulin use measurement 68
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS001117/ScoringFiles/PGS001117.txt.gz

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		Evaluated Score PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM008323 PGS001117
(GBE_BIN_FC10002986)
 PSS003731|
African Ancestry|
705 individuals
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
 Reported Trait: Started insulin within one year diagnosis of diabetes — AUROC: 0.6057 [0.54935, 0.66205] R²: 0.03335
Incremental AUROC (full-covars): 0.01803
PGS R2 (no covariates): 0.00453
PGS AUROC (no covariates): 0.54401 [0.48567, 0.60235]		 age, sex, UKB array type, Genotype PCs Full Model & PGS R2 is estimated using Nagelkerke's method
PPM008324 PGS001117
(GBE_BIN_FC10002986)
 PSS003732|
East Asian Ancestry|
86 individuals
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
 Reported Trait: Started insulin within one year diagnosis of diabetes — AUROC: 0.71573 [0.51412, 0.91734] R²: 0.15018
Incremental AUROC (full-covars): -0.09668
PGS R2 (no covariates): 0.11116
PGS AUROC (no covariates): 0.29582 [0.14557, 0.44606]		 age, sex, UKB array type, Genotype PCs Full Model & PGS R2 is estimated using Nagelkerke's method
PPM008325 PGS001117
(GBE_BIN_FC10002986)
 PSS003733|
European Ancestry|
1,089 individuals
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
 Reported Trait: Started insulin within one year diagnosis of diabetes — AUROC: 0.80203 [0.75876, 0.8453] R²: 0.28861
Incremental AUROC (full-covars): 0.05722
PGS R2 (no covariates): 0.17586
PGS AUROC (no covariates): 0.72657 [0.67703, 0.77611]		 age, sex, UKB array type, Genotype PCs Full Model & PGS R2 is estimated using Nagelkerke's method
PPM008326 PGS001117
(GBE_BIN_FC10002986)
 PSS003734|
South Asian Ancestry|
1,358 individuals
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
 Reported Trait: Started insulin within one year diagnosis of diabetes — AUROC: 0.62878 [0.57833, 0.67923] R²: 0.03294
Incremental AUROC (full-covars): 0.02324
PGS R2 (no covariates): 0.01621
PGS AUROC (no covariates): 0.58662 [0.53076, 0.64248]		 age, sex, UKB array type, Genotype PCs Full Model & PGS R2 is estimated using Nagelkerke's method
PPM008327 PGS001117
(GBE_BIN_FC10002986)
 PSS003735|
European Ancestry|
3,243 individuals
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
 Reported Trait: Started insulin within one year diagnosis of diabetes — AUROC: 0.74056 [0.71173, 0.76938] R²: 0.17764
Incremental AUROC (full-covars): 0.0941
PGS R2 (no covariates): 0.12982
PGS AUROC (no covariates): 0.71086 [0.68153, 0.74018]		 age, sex, UKB array type, Genotype PCs Full Model & PGS R2 is estimated using Nagelkerke's method

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS003731 — —
[
  • 115 cases
  • , 590 controls
]
 — African unspecified — UKB —
PSS003732 — —
[
  • 9 cases
  • , 77 controls
]
 — East Asian — UKB —
PSS003733 — —
[
  • 143 cases
  • , 946 controls
]
 — European non-white British ancestry UKB —
PSS003734 — —
[
  • 120 cases
  • , 1,238 controls
]
 — South Asian — UKB —
PSS003735 — —
[
  • 397 cases
  • , 2,846 controls
]
 — European white British ancestry UKB Testing cohort (heldout set)