Trait: response to statin

Trait Information
Identifier GO_0036273
Description Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a statin stimulus. Statins are organooxygen compounds whose structure is related to compactin (mevastatin) and which may be used as an anticholesteremic drug due its EC:1.1.1.34/EC:1.1.1.88 (hydroxymethylglutaryl-CoA reductase) inhibitory properties. [GOC: hp]
Trait category
Biological process
Synonyms 2 synonyms
  • response to HMG-CoA reductase inhibitor
  • response to hydroxymethylglutaryl-CoA reductase inhibitor

Associated Polygenic Score(s)

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Individuals included in:
G - Source of Variant Associations (GWAS)
D - Score Development/Training
E - PGS Evaluation
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Not Reported
Polygenic Score ID & Name PGS Publication ID (PGP) Reported Trait Mapped Trait(s) (Ontology) Number of Variants Ancestry distribution
GWAS
Dev
Eval
 Scoring File (FTP Link)
PGS002730
(GRSlipid_35)
 PGP000337 |
Mayerhofer E et al. Brain (2022)
 LDL lowering in response to statin low density lipoprotein cholesterol measurement,
response to statin		 35
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS002730/ScoringFiles/PGS002730.txt.gz

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		Evaluated Score PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM014797 PGS002730
(GRSlipid_35)
 PSS009892|
European Ancestry|
75,973 individuals
 PGP000337 |
Mayerhofer E et al. Brain (2022)
 Reported Trait: On-statin LDL decrease β: -0.05 [-0.07, -0.02] — — — —
PPM014798 PGS002730
(GRSlipid_35)
 PSS009892|
European Ancestry|
75,973 individuals
 PGP000337 |
Mayerhofer E et al. Brain (2022)
 Reported Trait: Incident intracerebral hemorrhage HR: 1.16 [1.05, 1.28] — — — —
PPM014799 PGS002730
(GRSlipid_35)
 PSS009892|
European Ancestry|
75,973 individuals
 PGP000337 |
Mayerhofer E et al. Brain (2022)
 Reported Trait: Incident myocardial infarction HR: 0.98 [0.96, 0.99] — — — —
PPM014800 PGS002730
(GRSlipid_35)
 PSS009892|
European Ancestry|
75,973 individuals
 PGP000337 |
Mayerhofer E et al. Brain (2022)
 Reported Trait: Incident Peripheral Artery Disease HR: 0.93 [0.87, 0.99] — — — —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS009892 — — 75,973 individuals,
57.2 % Male samples
 Mean = 60.4 years
Sd = 6.6 years		 European — UKB —