Trait: Tinnitus

Trait Information
Identifier HP_0000360
Description Tinnitus is an auditory perception that can be described as the experience of sound, in the ear or in the head, in the absence of external acoustic stimulation.
Trait category
Other trait
Synonyms 2 synonyms
  • Ringing in ears
  • Ringing in the ears
Mapped terms 4 mapped terms
  • SNOMEDCT_US:162349004
  • SNOMEDCT_US:162352007
  • SNOMEDCT_US:60862001
  • UMLS:C0040264

Associated Polygenic Score(s)

Filter PGS by Participant Ancestry
Individuals included in:
G - Source of Variant Associations (GWAS)
D - Score Development/Training
E - PGS Evaluation
List of ancestries includes:
Display options:
Ancestry legend
Multi-ancestry (including European)
Multi-ancestry (excluding European)
African
East Asian
South Asian
Additional Asian Ancestries
European
Greater Middle Eastern
Hispanic or Latin American
Additional Diverse Ancestries
Not Reported
Polygenic Score ID & Name PGS Publication ID (PGP) Reported Trait Mapped Trait(s) (Ontology) Number of Variants Ancestry distribution
GWAS
Dev
Eval
 Scoring File (FTP Link)
PGS001533
(GBE_QT_FC1004803)
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
 Tinnitus severity Tinnitus 343
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS001533/ScoringFiles/PGS001533.txt.gz

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		Evaluated Score PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM007260 PGS001533
(GBE_QT_FC1004803)
 PSS007611|
African Ancestry|
3,651 individuals
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
 Reported Trait: Tinnitus severity — — R²: 0.00963 [0.00491, 0.01435]
Incremental R2 (full-covars): 0.00027
PGS R2 (no covariates): 0.00038 [-0.00057, 0.00132]		 age, sex, UKB array type, Genotype PCs —
PPM007261 PGS001533
(GBE_QT_FC1004803)
 PSS007612|
East Asian Ancestry|
770 individuals
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
 Reported Trait: Tinnitus severity — — R²: 0.04047 [0.02218, 0.05877]
Incremental R2 (full-covars): 0.0031
PGS R2 (no covariates): 0.00478 [-0.00174, 0.01131]		 age, sex, UKB array type, Genotype PCs —
PPM007262 PGS001533
(GBE_QT_FC1004803)
 PSS007613|
European Ancestry|
11,174 individuals
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
 Reported Trait: Tinnitus severity — — R²: 0.01906 [0.0157, 0.02243]
Incremental R2 (full-covars): 0.00143
PGS R2 (no covariates): 0.00167 [0.00066, 0.00268]		 age, sex, UKB array type, Genotype PCs —
PPM007263 PGS001533
(GBE_QT_FC1004803)
 PSS007614|
South Asian Ancestry|
4,731 individuals
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
 Reported Trait: Tinnitus severity — — R²: 0.02195 [0.01553, 0.02837]
Incremental R2 (full-covars): 0.00113
PGS R2 (no covariates): 0.00165 [-0.00014, 0.00345]		 age, sex, UKB array type, Genotype PCs —
PPM007264 PGS001533
(GBE_QT_FC1004803)
 PSS007615|
European Ancestry|
27,484 individuals
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
 Reported Trait: Tinnitus severity — — R²: 0.01575 [0.01388, 0.01761]
Incremental R2 (full-covars): 0.0008
PGS R2 (no covariates): 0.00073 [0.00032, 0.00114]		 age, sex, UKB array type, Genotype PCs —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS007612 — — 770 individuals — East Asian — UKB —
PSS007613 — — 11,174 individuals — European non-white British ancestry UKB —
PSS007614 — — 4,731 individuals — South Asian — UKB —
PSS007615 — — 27,484 individuals — European white British ancestry UKB Testing cohort (heldout set)
PSS007611 — — 3,651 individuals — African unspecified — UKB —