| Trait Information | |
| Identifier | HP_0001279 |
| Description | Syncope is a syndrome in which loss of consciousness is of relatively sudden onset, temporary (usual... ly less than 1 to 2 minutes), self-terminating, and of usually rapid recovery. Syncope leads to a generalized weakness of muscles with loss of postural tone, inability to stand upright, and loss of consciousness. Once the patient is in a horizontal position, blood flow to the brain is no longer hindered by gravitation and consciousness is regained. Unconsciousness usually lasts for seconds to minutes. Headache and drowsiness (which usually follow seizures) do not follow a syncopal attack. Syncope results from a sudden impairment of brain metabolism usually due to a reduction in cerebral blood flow. [PMID: 29255499]Show more |
| Trait category |
Cardiovascular disease
|
| Synonym | Fainting spell |
| Mapped terms |
4 mapped terms
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Polygenic Score ID & Name
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PGS Publication ID (PGP)
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Reported Trait
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Mapped Trait(s) (Ontology)
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Number of Variants
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Ancestry distribution GWAS Dev Eval |
Scoring File (FTP Link)
|
|---|---|---|---|---|---|---|
| PGS004498 (disease.R55.score) | PGP000561 | Jung H et al. Commun Biol (2024) | R55 (Syncope and collapse) | Syncope | 1,059,939 | - | https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004498/ScoringFiles/PGS004498.txt.gz |
| PGS004568 (meta.R55.score) | PGP000561 | Jung H et al. Commun Biol (2024) | R55 (Syncope and collapse) | Syncope | 1,059,939 | - | https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004568/ScoringFiles/PGS004568.txt.gz |
PGS Performance Metric ID (PPM) |
Evaluated Score
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PGS Sample Set ID (PSS) |
Performance Source
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Trait
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PGS Effect Sizes (per SD change) |
Classification Metrics
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Other Metrics
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Covariates Included in the Model
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PGS Performance: Other Relevant Information |
|---|---|---|---|---|---|---|---|---|---|
| PPM020613 | PGS004498 (disease.R55.score) | PSS011364| European Ancestry| 56,192 individuals | PGP000561 | Jung H et al. Commun Biol (2024) | Reported Trait: R55 (Syncope and collapse) | OR: 1.12311 | — | — | — | — |
| PPM020683 | PGS004568 (meta.R55.score) | PSS011364| European Ancestry| 56,192 individuals | PGP000561 | Jung H et al. Commun Biol (2024) | Reported Trait: R55 (Syncope and collapse) | OR: 1.1647 | — | — | — | — |
PGS Sample Set ID (PSS) |
Phenotype Definitions and Methods
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Participant Follow-up Time
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Sample Numbers
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Age of Study Participants
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Sample Ancestry
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Additional Ancestry Description
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Cohort(s)
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Additional Sample/Cohort Information
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|---|---|---|---|---|---|---|---|---|
| PSS011364 | — | — | 56,192 individuals | — | European | — | UKB | — |