Trait: Colonic diverticula

Trait Information
Identifier HP_0002253
Description The presence of multiple diverticula of the colon.
Trait category
Other trait
Synonyms 2 synonyms
  • Colon diverticula
  • Colonic diverticulosis
Mapped terms 4 mapped terms
  • MEDDRA:10009993
  • SNOMEDCT_US:398050005
  • UMLS:C0012811
  • UMLS:C0012819

Associated Polygenic Score(s)

Filter PGS by Participant Ancestry
Individuals included in:
G - Source of Variant Associations (GWAS)
D - Score Development/Training
E - PGS Evaluation
List of ancestries includes:
Display options:
Ancestry legend
Multi-ancestry (including European)
Multi-ancestry (excluding European)
African
East Asian
South Asian
Additional Asian Ancestries
European
Greater Middle Eastern
Hispanic or Latin American
Additional Diverse Ancestries
Not Reported
Polygenic Score ID & Name PGS Publication ID (PGP) Reported Trait Mapped Trait(s) (Ontology) Number of Variants Ancestry distribution
GWAS
Dev
Eval
 Scoring File (FTP Link)
PGS001857
(portability-PLR_562.1)
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Diverticulosis Colonic diverticula 23,800
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS001857/ScoringFiles/PGS001857.txt.gz
PGS002068
(portability-ldpred2_562.1)
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Diverticulosis Colonic diverticula 831,212
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS002068/ScoringFiles/PGS002068.txt.gz

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		Evaluated Score PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM009745 PGS001857
(portability-PLR_562.1)
 PSS009332|
European Ancestry|
17,645 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Diverticulosis — — Partial Correlation (partial-r): 0.0896 [0.0749, 0.1042] sex, age, birth date, deprivation index, 16 PCs —
PPM009746 PGS001857
(portability-PLR_562.1)
 PSS009106|
European Ancestry|
3,723 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Diverticulosis — — Partial Correlation (partial-r): 0.1026 [0.0706, 0.1343] sex, age, birth date, deprivation index, 16 PCs —
PPM009747 PGS001857
(portability-PLR_562.1)
 PSS008660|
European Ancestry|
5,841 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Diverticulosis — — Partial Correlation (partial-r): 0.0849 [0.0593, 0.1104] sex, age, birth date, deprivation index, 16 PCs —
PPM009748 PGS001857
(portability-PLR_562.1)
 PSS008434|
Greater Middle Eastern Ancestry|
1,057 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Diverticulosis — — Partial Correlation (partial-r): 0.1413 [0.0811, 0.2004] sex, age, birth date, deprivation index, 16 PCs —
PPM009749 PGS001857
(portability-PLR_562.1)
 PSS008214|
South Asian Ancestry|
5,515 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Diverticulosis — — Partial Correlation (partial-r): 0.068 [0.0416, 0.0942] sex, age, birth date, deprivation index, 16 PCs —
PPM009750 PGS001857
(portability-PLR_562.1)
 PSS007995|
East Asian Ancestry|
1,638 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Diverticulosis — — Partial Correlation (partial-r): -0.0033 [-0.052, 0.0454] sex, age, birth date, deprivation index, 16 PCs —
PPM009751 PGS001857
(portability-PLR_562.1)
 PSS007779|
African Ancestry|
2,211 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Diverticulosis — — Partial Correlation (partial-r): 0.0777 [0.0359, 0.1192] sex, age, birth date, deprivation index, 16 PCs —
PPM009752 PGS001857
(portability-PLR_562.1)
 PSS008883|
African Ancestry|
3,605 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Diverticulosis — — Partial Correlation (partial-r): 0.0342 [0.0015, 0.0669] sex, age, birth date, deprivation index, 16 PCs —
PPM011405 PGS002068
(portability-ldpred2_562.1)
 PSS009332|
European Ancestry|
17,645 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Diverticulosis — — Partial Correlation (partial-r): 0.1006 [0.0859, 0.1152] sex, age, birth date, deprivation index, 16 PCs —
PPM011406 PGS002068
(portability-ldpred2_562.1)
 PSS009106|
European Ancestry|
3,723 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Diverticulosis — — Partial Correlation (partial-r): 0.1198 [0.0879, 0.1514] sex, age, birth date, deprivation index, 16 PCs —
PPM011407 PGS002068
(portability-ldpred2_562.1)
 PSS008660|
European Ancestry|
5,841 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Diverticulosis — — Partial Correlation (partial-r): 0.0853 [0.0598, 0.1108] sex, age, birth date, deprivation index, 16 PCs —
PPM011408 PGS002068
(portability-ldpred2_562.1)
 PSS008434|
Greater Middle Eastern Ancestry|
1,057 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Diverticulosis — — Partial Correlation (partial-r): 0.1177 [0.0572, 0.1773] sex, age, birth date, deprivation index, 16 PCs —
PPM011409 PGS002068
(portability-ldpred2_562.1)
 PSS008214|
South Asian Ancestry|
5,515 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Diverticulosis — — Partial Correlation (partial-r): 0.0814 [0.055, 0.1076] sex, age, birth date, deprivation index, 16 PCs —
PPM011410 PGS002068
(portability-ldpred2_562.1)
 PSS007995|
East Asian Ancestry|
1,638 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Diverticulosis — — Partial Correlation (partial-r): -0.0042 [-0.0529, 0.0445] sex, age, birth date, deprivation index, 16 PCs —
PPM011411 PGS002068
(portability-ldpred2_562.1)
 PSS007779|
African Ancestry|
2,211 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Diverticulosis — — Partial Correlation (partial-r): 0.0636 [0.0217, 0.1052] sex, age, birth date, deprivation index, 16 PCs —
PPM011412 PGS002068
(portability-ldpred2_562.1)
 PSS008883|
African Ancestry|
3,605 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Diverticulosis — — Partial Correlation (partial-r): 0.0582 [0.0255, 0.0907] sex, age, birth date, deprivation index, 16 PCs —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS009106 — — 3,723 individuals — European Poland (NE Europe) UKB —
PSS008434 — — 1,057 individuals — Greater Middle Eastern (Middle Eastern, North African or Persian) Iran (Middle East) UKB —
PSS009332 — — 17,645 individuals — European UK (+ Ireland) UKB —
PSS008660 — — 5,841 individuals — European Italy (South Europe) UKB —
PSS008214 — — 5,515 individuals — South Asian India (South Asia) UKB —
PSS008883 — — 3,605 individuals — African unspecified Nigeria (West Africa) UKB —
PSS007995 — — 1,638 individuals — East Asian China (East Asia) UKB —
PSS007779 — — 2,211 individuals — African American or Afro-Caribbean Carribean UKB —