Trait: Headache

Trait Information
Identifier HP_0002315
Description Cephalgia, or pain sensed in various parts of the head, not confined to the area of distribution of any nerve. [PMID: 15304572]
Trait category
Neurological disorder
Synonyms 2 synonyms
  • Headache
  • Headaches
Mapped terms 3 mapped terms
  • ICD10:R51
  • SNOMEDCT_US:25064002
  • UMLS:C0018681

Associated Polygenic Score(s)

Filter PGS by Participant Ancestry
Individuals included in:
G - Source of Variant Associations (GWAS)
D - Score Development/Training
E - PGS Evaluation
List of ancestries includes:
Display options:
Ancestry legend
Multi-ancestry (including European)
Multi-ancestry (excluding European)
African
East Asian
South Asian
Additional Asian Ancestries
European
Greater Middle Eastern
Hispanic or Latin American
Additional Diverse Ancestries
Not Reported
Polygenic Score ID & Name PGS Publication ID (PGP) Reported Trait Mapped Trait(s) (Ontology) Number of Variants Ancestry distribution
GWAS
Dev
Eval
 Scoring File (FTP Link)
PGS000909
(PRS_Headaches)
 PGP000238 |
Campos AI et al. Commun Med (Lond) (2021)
 Headache Headache 2,862,172
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000909/ScoringFiles/PGS000909.txt.gz

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		Evaluated Score PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM002940 PGS000909
(PRS_Headaches)
 PSS001283|
European Ancestry|
5,719 individuals
 PGP000238 |
Campos AI et al. Commun Med (Lond) (2021)
 Reported Trait: Headaches in Sertraline takers OR: 1.16 [1.08, 1.25] — Variance explained (Nagelkerke's R2*100): 0.49 sex, age at study enrollment, genetic PCs 1-20 —
PPM002941 PGS000909
(PRS_Headaches)
 PSS001279|
European Ancestry|
4,365 individuals
 PGP000238 |
Campos AI et al. Commun Med (Lond) (2021)
 Reported Trait: Headaches in Escitalopram takers OR: 1.06 [0.97, 1.16] — Variance explained (Nagelkerke's R2*100): 0.08 sex, age at study enrollment, genetic PCs 1-20 —
PPM002942 PGS000909
(PRS_Headaches)
 PSS001284|
European Ancestry|
3,967 individuals
 PGP000238 |
Campos AI et al. Commun Med (Lond) (2021)
 Reported Trait: Headaches in Venlafaxine takers OR: 1.11 [1.01, 1.21] — Variance explained (Nagelkerke's R2*100): 0.22 sex, age at study enrollment, genetic PCs 1-20 —
PPM002943 PGS000909
(PRS_Headaches)
 PSS001275|
European Ancestry|
1,657 individuals
 PGP000238 |
Campos AI et al. Commun Med (Lond) (2021)
 Reported Trait: Headaches in Amitriptyline takers OR: 1.09 [0.93, 1.28] — Variance explained (Nagelkerke's R2*100): 0.15 sex, age at study enrollment, genetic PCs 1-20 —
PPM002944 PGS000909
(PRS_Headaches)
 PSS001281|
European Ancestry|
1,987 individuals
 PGP000238 |
Campos AI et al. Commun Med (Lond) (2021)
 Reported Trait: Headaches in Mirtazapine takers OR: 1.04 [0.9, 1.2] — Variance explained (Nagelkerke's R2*100): 0.04 sex, age at study enrollment, genetic PCs 1-20 —
PPM002945 PGS000909
(PRS_Headaches)
 PSS001277|
European Ancestry|
2,524 individuals
 PGP000238 |
Campos AI et al. Commun Med (Lond) (2021)
 Reported Trait: Headaches in Desvenlafaxine takers OR: 1.08 [0.98, 1.2] — Variance explained (Nagelkerke's R2*100): 0.16 sex, age at study enrollment, genetic PCs 1-20 —
PPM002946 PGS000909
(PRS_Headaches)
 PSS001276|
European Ancestry|
2,585 individuals
 PGP000238 |
Campos AI et al. Commun Med (Lond) (2021)
 Reported Trait: Headaches in Citalopram takers OR: 1.11 [0.98, 1.26] — Variance explained (Nagelkerke's R2*100): 0.23 sex, age at study enrollment, genetic PCs 1-20 —
PPM002947 PGS000909
(PRS_Headaches)
 PSS001280|
European Ancestry|
3,670 individuals
 PGP000238 |
Campos AI et al. Commun Med (Lond) (2021)
 Reported Trait: Headaches in Fluoxetine takers OR: 1.02 [0.93, 1.12] — Variance explained (Nagelkerke's R2*100): 0.01 sex, age at study enrollment, genetic PCs 1-20 —
PPM002948 PGS000909
(PRS_Headaches)
 PSS001278|
European Ancestry|
1,995 individuals
 PGP000238 |
Campos AI et al. Commun Med (Lond) (2021)
 Reported Trait: Headaches in Duloxetine takers OR: 1.03 [0.92, 1.15] — Variance explained (Nagelkerke's R2*100): 0.02 sex, age at study enrollment, genetic PCs 1-20 —
PPM002949 PGS000909
(PRS_Headaches)
 PSS001282|
European Ancestry|
1,580 individuals
 PGP000238 |
Campos AI et al. Commun Med (Lond) (2021)
 Reported Trait: Headaches in Paroxetine takers OR: 1.16 [1.0, 1.35] — Variance explained (Nagelkerke's R2*100): 0.46 sex, age at study enrollment, genetic PCs 1-20 —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS001275 — —
[
  • 140 cases
  • , 1,517 controls
]
 — European — AGDS —
PSS001276 — —
[
  • 367 cases
  • , 2,218 controls
]
 — European — AGDS —
PSS001277 — —
[
  • 489 cases
  • , 2,035 controls
]
 — European — AGDS —
PSS001278 — —
[
  • 382 cases
  • , 1,613 controls
]
 — European — AGDS —
PSS001279 — —
[
  • 712 cases
  • , 3,653 controls
]
 — European — AGDS —
PSS001280 — —
[
  • 583 cases
  • , 3,087 controls
]
 — European — AGDS —
PSS001281 — —
[
  • 186 cases
  • , 1,801 controls
]
 — European — AGDS —
PSS001282 — —
[
  • 236 cases
  • , 1,344 controls
]
 — European — AGDS —
PSS001283 — —
[
  • 1,020 cases
  • , 4,699 controls
]
 — European — AGDS —
PSS001284 — —
[
  • 794 cases
  • , 3,173 controls
]
 — European — AGDS —