Trait: follicular lymphoma

Trait Information
Identifier MONDO_0018906
Description Follicular lymphoma is a form of non-Hodgkin lymphoma characterized by a proliferation of B cells whose nodular structure of follicular architecture is preserved. [Orphanet: 545]
Trait categories
Cancer
Immune system disorder
Synonyms 10 synonyms
  • follicle center lymphoma
  • follicle centre lymphoma
  • follicular center cell lymphoma
  • follicular centre cell lymphoma
  • follicular non-Hodgkin lymphoma
  • follicular non-Hodgkin's lymphoma
  • lymphoma, follicular
  • lymphoma, follicular center cell
  • lymphoma, follicular centre cell
  • lymphoma, follicular, malignant
Mapped terms 13 mapped terms
  • DOID:0050873
  • GARD:2356
  • HGNC:990
  • ICDO:9690/3
  • MEDGEN:7417
  • MESH:D008224
  • NCIT:C3209
  • NORD:1983
  • ONCOTREE:FL
  • Orphanet:545
  • SCTID:308121000
  • UMLS:C0024301
  • icd11.foundation:797822185

Associated Polygenic Score(s)

Filter PGS by Participant Ancestry
Individuals included in:
G - Source of Variant Associations (GWAS)
D - Score Development/Training
E - PGS Evaluation
List of ancestries includes:
Display options:
Ancestry legend
Multi-ancestry (including European)
Multi-ancestry (excluding European)
African
East Asian
South Asian
Additional Asian Ancestries
European
Greater Middle Eastern
Hispanic or Latin American
Additional Diverse Ancestries
Not Reported
Polygenic Score ID & Name PGS Publication ID (PGP) Reported Trait Mapped Trait(s) (Ontology) Number of Variants Ancestry distribution
GWAS
Dev
Eval
 Scoring File (FTP Link)
PGS000643
(PRSWEB_PHECODE202.21_C-FOLLICULAR-LYMPHOMA_PRS-CS_MGI_20200608)
 PGP000118 |
Fritsche LG et al. Am J Hum Genet (2020)
 Nodular lymphoma follicular lymphoma 1,048,780
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000643/ScoringFiles/PGS000643.txt.gz
PGS000644
(PRSWEB_PHECODE202.21_C-FOLLICULAR-LYMPHOMA_LASSOSUM_MGI_20200608)
 PGP000118 |
Fritsche LG et al. Am J Hum Genet (2020)
 Nodular lymphoma follicular lymphoma 2,209,179
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000644/ScoringFiles/PGS000644.txt.gz
PGS002304
(PRS6_FL)
 PGP000328 |
Choi J et al. Int J Cancer (2020)
 Follicular lymphoma follicular lymphoma 6
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS002304/ScoringFiles/PGS002304.txt.gz
PGS003455
(PRS7_FL)
 PGP000448 |
Berndt SI et al. Leukemia (2022)
 Follicular lymphoma follicular lymphoma 7
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS003455/ScoringFiles/PGS003455.txt.gz

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		Evaluated Score PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM001328 PGS000643
(PRSWEB_PHECODE202.21_C-FOLLICULAR-LYMPHOMA_PRS-CS_MGI_20200608)
 PSS000560|
European Ancestry|
3,256 individuals
 PGP000118 |
Fritsche LG et al. Am J Hum Genet (2020)
 Reported Trait: Nodular lymphoma OR: 1.133 [1.005, 1.277]
β: 0.125 (0.061)		 AUROC: 0.532 [0.497, 0.568] Nagelkerke's Pseudo-R²: 0.00282
Brier score: 0.0825
Odds Ratio (OR, top 1% vs. Rest): 2.49 [1.1, 5.65]		 age, sex, batch PCs 1-4 Cancer PRSweb PheWAS Results: PRSWEB_PHECODE202.21_C-FOLLICULAR-LYMPHOMA_PRS-CS_MGI_20200608
PPM001329 PGS000644
(PRSWEB_PHECODE202.21_C-FOLLICULAR-LYMPHOMA_LASSOSUM_MGI_20200608)
 PSS000560|
European Ancestry|
3,256 individuals
 PGP000118 |
Fritsche LG et al. Am J Hum Genet (2020)
 Reported Trait: Nodular lymphoma OR: 1.149 [1.021, 1.294]
β: 0.139 (0.0606)		 AUROC: 0.538 [0.504, 0.573] Nagelkerke's Pseudo-R²: 0.00349
Brier score: 0.0825
Odds Ratio (OR, top 1% vs. Rest): 1.48 [0.538, 4.05]		 age, sex, batch PCs 1-4 Cancer PRSweb PheWAS Results: PRSWEB_PHECODE202.21_C-FOLLICULAR-LYMPHOMA_LASSOSUM_MGI_20200608
PPM013033 PGS002304
(PRS6_FL)
 PSS009658|
European Ancestry|
197 individuals
 PGP000328 |
Choi J et al. Int J Cancer (2020)
 Reported Trait: Follicular lymphoma — AUROC: 0.61 [0.59, 0.63] — — —
PPM013041 PGS002304
(PRS6_FL)
 PSS009658|
European Ancestry|
197 individuals
 PGP000328 |
Choi J et al. Int J Cancer (2020)
 Reported Trait: Follicular lymphoma — — Hazard ratio (HR top 5% vs average): 2.33 [1.38, 3.93] Age, birth cohort, genotyping array, top 10 PCs for ancestry and sex (for nonsex specific cancer only) —
PPM017226 PGS003455
(PRS7_FL)
 PSS010176|
European Ancestry|
20,134 individuals
 PGP000448 |
Berndt SI et al. Leukemia (2022)
 Reported Trait: Chronic lymphocytic leukemia OR: 1.07 [0.98, 1.17] — — — —
PPM017234 PGS003455
(PRS7_FL)
 PSS010176|
European Ancestry|
20,134 individuals
 PGP000448 |
Berndt SI et al. Leukemia (2022)
 Reported Trait: Diffuse large B-cell lymphoma OR: 1.28 [1.19, 1.39] — — — —
PPM017242 PGS003455
(PRS7_FL)
 PSS010176|
European Ancestry|
20,134 individuals
 PGP000448 |
Berndt SI et al. Leukemia (2022)
 Reported Trait: Follicular lymphoma OR: 2.77 [2.52, 3.04] — — — —
PPM017250 PGS003455
(PRS7_FL)
 PSS010176|
European Ancestry|
20,134 individuals
 PGP000448 |
Berndt SI et al. Leukemia (2022)
 Reported Trait: Marginal zone lymphoma OR: 0.94 [0.81, 1.09] — — — —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS009658 follicular lymphoma (ICD- 10 = C82 or ICD-O: 9690) — 197 individuals — European — UKB —
PSS010176 — —
[
  • 10,629 cases
  • , 9,505 controls
]
 — European — NR Inter- Lymph Consortium
PSS000560 PheCode:202.21; ICD9CM:202.00, 202.01, 202.02, 202.03, 202.04, 202.05, 202.06, 202.07, 202.08; ICD10CM:C82, C82.0, C82.00, C82.01, C82.02, C82.03, C82.04, C82.05, C82.06, C82.07, C82.08, C82.09, C82.1, C82.10, C82.11, C82.12, C82.13, C82.14, C82.15, C82.16, C82.17, C82.18, C82.19, C82.2, C82.20, C82.21, C82.22, C82.23, C82.24, C82.25, C82.26, C82.27, C82.28, C82.29, C82.3, C82.30, C82.31, C82.32, C82.33, C82.34, C82.35, C82.36, C82.37, C82.38, C82.39, C82.4, C82.40, C82.41, C82.42, C82.43, C82.44, C82.45, C82.46, C82.47, C82.48, C82.49, C82.5, C82.50, C82.51, C82.52, C82.53, C82.54, C82.55, C82.56, C82.57, C82.58, C82.59, C82.6, C82.60, C82.61, C82.62, C82.63, C82.64, C82.65, C82.66, C82.67, C82.68, C82.69, C82.8, C82.80, C82.81, C82.82, C82.83, C82.84, C82.85, C82.86, C82.87, C82.88, C82.89, C82.9, C82.90, C82.91, C82.92, C82.93, C82.94, C82.95, C82.96, C82.97, C82.98, C82.99 —
[
  • 296 cases
  • , 2,960 controls
]
 — European — MGI —