PGS Publication: PGP000021

Publication Information (EuropePMC)
Title Longitudinal Analysis of Genetic Susceptibility and BMI Throughout Adult Life.
PubMed ID 29212779(Europe PMC)
doi 10.2337/db17-1156
Publication Date Dec. 6, 2017
Journal Diabetes
Author(s) Song M, Zheng Y, Qi L, Hu FB, Chan AT, Giovannucci EL.
Released in PGS Catalog: Oct. 14, 2019

Associated Polygenic Score(s)

Filter PGS by Participant Ancestry
Individuals included in:
G - Source of Variant Associations (GWAS)
D - Score Development/Training
E - PGS Evaluation
List of ancestries includes:
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Multi-ancestry (excluding European)
African
East Asian
South Asian
Additional Asian Ancestries
European
Greater Middle Eastern
Hispanic or Latin American
Additional Diverse Ancestries
Not Reported

PGS Developed By This Publication

Polygenic Score ID & Name PGS Publication ID (PGP) Reported Trait Mapped Trait(s) (Ontology) Number of Variants Ancestry distribution
GWAS
Dev
Eval
 Scoring File (FTP Link)
PGS000034
(GRS_BMI)
 PGP000021 |
Song M et al. Diabetes (2017)
 Adult body mass index (BMI) body mass index 97
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000034/ScoringFiles/PGS000034.txt.gz

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		Evaluated Score PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM000072 PGS000034
(GRS_BMI)
 PSS000050|
European Ancestry|
5,640 individuals
 PGP000021 |
Song M et al. Diabetes (2017)
 Reported Trait: mean BMI difference — — β (per 10-allele increment): 0.17 [0.03, 0.31] — —
PPM000071 PGS000034
(GRS_BMI)
 PSS000048|
European Ancestry|
5,956 individuals
 PGP000021 |
Song M et al. Diabetes (2017)
 Reported Trait: mean BMI difference — — β (per 10-allele increment): 0.54 [0.38, 0.71] — —
PPM000073 PGS000034
(GRS_BMI)
 PSS000051|
European Ancestry|
2,942 individuals
 PGP000021 |
Song M et al. Diabetes (2017)
 Reported Trait: mean BMI difference — — β (per 10-allele increment): -0.22 [-0.39, -0.05] — —
PPM000074 PGS000034
(GRS_BMI)
 PSS000049|
European Ancestry|
6,705 individuals
 PGP000021 |
Song M et al. Diabetes (2017)
 Reported Trait: mean BMI difference — — β (per 10-allele increment): 0.6 [0.42, 0.77] — —
PPM000075 PGS000034
(GRS_BMI)
 PSS000052|
European Ancestry|
6,436 individuals
 PGP000021 |
Song M et al. Diabetes (2017)
 Reported Trait: mean BMI difference — — β (per 10-allele increment): 0.07 [-0.04, 0.19] — —
PPM000076 PGS000034
(GRS_BMI)
 PSS000045|
European Ancestry|
1,699 individuals
 PGP000021 |
Song M et al. Diabetes (2017)
 Reported Trait: mean BMI difference — — β (per 10-allele increment): 0.23 [0.02, 0.44] — —
PPM000077 PGS000034
(GRS_BMI)
 PSS000046|
European Ancestry|
1,634 individuals
 PGP000021 |
Song M et al. Diabetes (2017)
 Reported Trait: mean BMI difference — — β (per 10-allele increment): -0.1 [-0.29, 0.09] — —
PPM000078 PGS000034
(GRS_BMI)
 PSS000047|
European Ancestry|
2,020 individuals
 PGP000021 |
Song M et al. Diabetes (2017)
 Reported Trait: mean BMI difference — — β (per 10-allele increment): -0.01 [-0.16, 0.14] — —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS000049 BMI difference between age 18 and Menopause — 6,705 individuals,
0.0 % Male samples
 — European — NHS —
PSS000050 BMI difference between ages 45 and 65 — 5,640 individuals,
0.0 % Male samples
 — European — NHS —
PSS000051 BMI difference between ages 65 and 80 — 2,942 individuals,
0.0 % Male samples
 — European — NHS —
PSS000052 BMI difference between Menopause and age 65 — 6,436 individuals,
0.0 % Male samples
 — European — NHS —
PSS000045 BMI difference between ages 21 and 45 — 1,699 individuals,
100.0 % Male samples
 — European — HPFS —
PSS000046 BMI difference between ages 45 and 65 — 1,634 individuals,
100.0 % Male samples
 — European — HPFS —
PSS000047 BMI difference between ages 65 and 80 — 2,020 individuals,
100.0 % Male samples
 — European — HPFS —
PSS000048 BMI difference between ages 18 and 45 — 5,956 individuals,
0.0 % Male samples
 — European — NHS —