Polygenic Score (PGS) ID: PGS000034

Predicted Trait
Reported Trait Adult body mass index (BMI)
Mapped Trait(s) body mass index (EFO_0004340)
Released in PGS Catalog: Oct. 14, 2019
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Score Details

Score Construction
PGS Name GRS_BMI
Development Method
Name Genome-wide significant variants
Parameters The GRS is normalized by multiplying the weighted allele counts by the number of SNPs and their weights (97/sum( βi))
Variants
Original Genome Build NR
Number of Variants 97
Effect Weight Type NR
PGS Source
PGS Catalog Publication (PGP) ID PGP000021
Citation (link to publication) Song M et al. Diabetes (2017)
Ancestry Distribution
Source of Variant
Associations (GWAS)
European: 99.1%
Hispanic or Latin American: 0.5%
African: 0.4%
238,944 individuals (100%)
PGS Evaluation
European: 88.9%
Multi-ancestry (including European): 11.1%
  • European
  • Not Reported
9 Sample Sets

Development Samples

Source of Variant Associations (GWAS)
Study Identifiers Sample Numbers Sample Ancestry Cohort(s)
GWAS Catalog: GCST002783
Europe PMC: 25673413
 236,781 individuals European NR
GWAS Catalog: GCST002783
Europe PMC: 25673413
 887 individuals African American or Afro-Caribbean NR
GWAS Catalog: GCST002783
Europe PMC: 25673413
 1,276 individuals Hispanic or Latin American NR

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM000072 PSS000050|
European Ancestry|
5,640 individuals
 PGP000021 |
Song M et al. Diabetes (2017)
 Reported Trait: mean BMI difference — — β (per 10-allele increment): 0.17 [0.03, 0.31] — —
PPM000071 PSS000048|
European Ancestry|
5,956 individuals
 PGP000021 |
Song M et al. Diabetes (2017)
 Reported Trait: mean BMI difference — — β (per 10-allele increment): 0.54 [0.38, 0.71] — —
PPM000073 PSS000051|
European Ancestry|
2,942 individuals
 PGP000021 |
Song M et al. Diabetes (2017)
 Reported Trait: mean BMI difference — — β (per 10-allele increment): -0.22 [-0.39, -0.05] — —
PPM000074 PSS000049|
European Ancestry|
6,705 individuals
 PGP000021 |
Song M et al. Diabetes (2017)
 Reported Trait: mean BMI difference — — β (per 10-allele increment): 0.6 [0.42, 0.77] — —
PPM000075 PSS000052|
European Ancestry|
6,436 individuals
 PGP000021 |
Song M et al. Diabetes (2017)
 Reported Trait: mean BMI difference — — β (per 10-allele increment): 0.07 [-0.04, 0.19] — —
PPM000076 PSS000045|
European Ancestry|
1,699 individuals
 PGP000021 |
Song M et al. Diabetes (2017)
 Reported Trait: mean BMI difference — — β (per 10-allele increment): 0.23 [0.02, 0.44] — —
PPM000077 PSS000046|
European Ancestry|
1,634 individuals
 PGP000021 |
Song M et al. Diabetes (2017)
 Reported Trait: mean BMI difference — — β (per 10-allele increment): -0.1 [-0.29, 0.09] — —
PPM000078 PSS000047|
European Ancestry|
2,020 individuals
 PGP000021 |
Song M et al. Diabetes (2017)
 Reported Trait: mean BMI difference — — β (per 10-allele increment): -0.01 [-0.16, 0.14] — —
PPM021770 PSS011792|
Multi-ancestry (including European)|
236 individuals
 PGP000677 |
Renier TJ et al. Int J Obes (Lond) (2023)
|Ext.		 Reported Trait: BMI in children HR: 0.23 [0.12, 0.35] — — Age, sex, ancestry, parent education, and study —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS000049 BMI difference between age 18 and Menopause — 6,705 individuals,
0.0 % Male samples
 — European — NHS —
PSS000050 BMI difference between ages 45 and 65 — 5,640 individuals,
0.0 % Male samples
 — European — NHS —
PSS000051 BMI difference between ages 65 and 80 — 2,942 individuals,
0.0 % Male samples
 — European — NHS —
PSS000052 BMI difference between Menopause and age 65 — 6,436 individuals,
0.0 % Male samples
 — European — NHS —
PSS011792 — — 213 individuals — European — NR —
PSS011792 — — 23 individuals — Not reported — NR —
PSS000045 BMI difference between ages 21 and 45 — 1,699 individuals,
100.0 % Male samples
 — European — HPFS —
PSS000046 BMI difference between ages 45 and 65 — 1,634 individuals,
100.0 % Male samples
 — European — HPFS —
PSS000047 BMI difference between ages 65 and 80 — 2,020 individuals,
100.0 % Male samples
 — European — HPFS —
PSS000048 BMI difference between ages 18 and 45 — 5,956 individuals,
0.0 % Male samples
 — European — NHS —