PGS Catalog - Renier TJ, Int J Obes (Lond) (2023) (Publication)

PGS Publication: PGP000677

Publication Information (EuropePMC)
Title	Elucidating pathways to pediatric obesity: a study evaluating obesity polygenic risk scores related to appetitive traits in children.
PubMed ID	37736781(Europe PMC)
doi	10.1038/s41366-023-01385-3
Publication Date	Sept. 22, 2023
Journal	*Int J Obes (Lond)*
Author(s)	Renier TJ, Yeum D, Emond JA, Lansigan RK, Ballarino GA, Carlson DD, Loos RJF, Gilbert-Diamond D.

Released in PGS Catalog: Sept. 19, 2024

Associated Polygenic Score(s)

External PGS Evaluated By This Publication

Polygenic Score ID & Name	PGS Publication ID (PGP)	Reported Trait	Mapped Trait(s) (Ontology)	Number of Variants	Ancestry distribution GWAS Dev Eval	Scoring File (FTP Link)
PGS000034 (GRS_BMI)	PGP000021 \| Song M et al. Diabetes (2017)	Adult body mass index (BMI)	body mass index	97	-	https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000034/ScoringFiles/PGS000034.txt.gz
PGS000027 (GPS_BMI)	PGP000017 \| Khera AV et al. Cell (2019)	Body mass index (BMI)	body mass index	2,100,302		https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000027/ScoringFiles/PGS000027.txt.gz - Check Terms/Licenses
PGS000716 (PGS295_elbs)	PGP000132 \| Richardson TG et al. BMJ (2020)	Early life body size	comparative body size at age 10, self-reported, body mass index	295	-	https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000716/ScoringFiles/PGS000716.txt.gz
PGS000717 (PGS557_albs)	PGP000132 \| Richardson TG et al. BMJ (2020)	Adult life body size	body mass index	557	-	https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000717/ScoringFiles/PGS000717.txt.gz

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance Metric ID (PPM)	Evaluated Score	PGS Sample Set ID (PSS)	Performance Source	Trait	PGS Effect Sizes (per SD change)	Classification Metrics	Other Metrics	Covariates Included in the Model	PGS Performance: Other Relevant Information
PPM021770	PGS000034 (GRS_BMI)	PSS011792\| Multi-ancestry (including European)\| 236 individuals	PGP000677 \| Renier TJ et al. Int J Obes (Lond) (2023) \|Ext.	Reported Trait: BMI in children	HR: 0.23 [0.12, 0.35]	—	—	Age, sex, ancestry, parent education, and study	—
PPM021771	PGS000716 (PGS295_elbs)	PSS011792\| Multi-ancestry (including European)\| 236 individuals	PGP000677 \| Renier TJ et al. Int J Obes (Lond) (2023) \|Ext.	Reported Trait: BMI in children	HR: 0.23 [0.11, 0.34]	—	—	Age, sex, ancestry, parent education, and study	—
PPM021772	PGS000717 (PGS557_albs)	PSS011792\| Multi-ancestry (including European)\| 236 individuals	PGP000677 \| Renier TJ et al. Int J Obes (Lond) (2023) \|Ext.	Reported Trait: BMI in children	HR: 0.12 [0.0, 0.24]	—	—	Age, sex, ancestry, parent education, and study	—
PPM021773	PGS000027 (GPS_BMI)	PSS011792\| Multi-ancestry (including European)\| 236 individuals	PGP000677 \| Renier TJ et al. Int J Obes (Lond) (2023) \|Ext.	Reported Trait: BMI in children	HR: 0.33 [0.2, 0.45]	—	—	Age, sex, ancestry, parent education, and study	—

Evaluated Samples

PGS Sample Set ID (PSS)	Phenotype Definitions and Methods	Participant Follow-up Time	Sample Numbers	Age of Study Participants	Sample Ancestry	Additional Ancestry Description	Cohort(s)	Additional Sample/Cohort Information
PSS011792	—	—	213 individuals	—	European	—	NR	—
PSS011792	—	—	23 individuals	—	Not reported	—	NR	—