PGS Publication: PGP000054

Publication Information (EuropePMC)
Title Predictive Accuracy of a Polygenic Risk Score-Enhanced Prediction Model vs a Clinical Risk Score for Coronary Artery Disease.
PubMed ID 32068818(Europe PMC)
doi 10.1001/jama.2019.22241
Publication Date Feb. 1, 2020
Journal JAMA
Author(s) Elliott J, Bodinier B, Bond TA, Chadeau-Hyam M, Evangelou E, Moons KGM, Dehghan A, Muller DC, Elliott P, Tzoulaki I.
Released in PGS Catalog: March 27, 2020

Associated Polygenic Score(s)

Filter PGS by Participant Ancestry
Individuals included in:
G - Source of Variant Associations (GWAS)
D - Score Development/Training
E - PGS Evaluation
List of ancestries includes:
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Ancestry legend
Multi-ancestry (including European)
Multi-ancestry (excluding European)
African
East Asian
South Asian
Additional Asian Ancestries
European
Greater Middle Eastern
Hispanic or Latin American
Additional Diverse Ancestries
Not Reported

PGS Developed By This Publication

Polygenic Score ID & Name PGS Publication ID (PGP) Reported Trait Mapped Trait(s) (Ontology) Number of Variants Ancestry distribution
GWAS
Dev
Eval
 Scoring File (FTP Link)
PGS000116
(CAD_EJ2020)
 PGP000054 |
Elliott J et al. JAMA (2020)
 Coronary artery disease coronary artery disease 40,079
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000116/ScoringFiles/PGS000116.txt.gz - Check Terms/Licenses
PGS000117
(CVD_EJ2020)
 PGP000054 |
Elliott J et al. JAMA (2020)
 Cardiovascular disease cardiovascular disease 297,862
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000117/ScoringFiles/PGS000117.txt.gz - Check Terms/Licenses

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		Evaluated Score PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM000825 PGS000117
(CVD_EJ2020)
 PSS000388|
Multi-ancestry (including European)|
204,675 individuals
 PGP000054 |
Elliott J et al. JAMA (2020)
 Reported Trait: Incident cardiovascular disease (under age 55) — C-index: 0.66 [0.65, 0.66] — age,sex —
PPM000826 PGS000117
(CVD_EJ2020)
 PSS000388|
Multi-ancestry (including European)|
204,675 individuals
 PGP000054 |
Elliott J et al. JAMA (2020)
 Reported Trait: Incident cardiovascular disease (under age 55) — C-index: 0.7 [0.7, 0.71] — pooled cohort equations —
PPM000828 PGS000117
(CVD_EJ2020)
 PSS000384|
Multi-ancestry (including European)|
147,985 individuals
 PGP000054 |
Elliott J et al. JAMA (2020)
 Reported Trait: Incident cardiovascular disease (over age 55) — C-index: 0.7 [0.69, 0.71] — age,sex —
PPM000829 PGS000117
(CVD_EJ2020)
 PSS000384|
Multi-ancestry (including European)|
147,985 individuals
 PGP000054 |
Elliott J et al. JAMA (2020)
 Reported Trait: Incident cardiovascular disease (over age 55) — C-index: 0.77 [0.76, 0.78] — pooled cohort equations —
PPM000831 PGS000117
(CVD_EJ2020)
 PSS000392|
Multi-ancestry (including European)|
147,363 individuals
 PGP000054 |
Elliott J et al. JAMA (2020)
 Reported Trait: Incident cardiovascular disease (in males) — C-index: 0.67 [0.66, 0.67] — age,sex —
PPM000832 PGS000117
(CVD_EJ2020)
 PSS000392|
Multi-ancestry (including European)|
147,363 individuals
 PGP000054 |
Elliott J et al. JAMA (2020)
 Reported Trait: Incident cardiovascular disease (in males) — C-index: 0.71 [0.71, 0.72] — pooled cohort equations —
PPM000834 PGS000117
(CVD_EJ2020)
 PSS000396|
Multi-ancestry (including European)|
205,297 individuals
 PGP000054 |
Elliott J et al. JAMA (2020)
 Reported Trait: Incident cardiovascular disease (in females) — C-index: 0.69 [0.68, 0.7] — age,sex —
PPM000835 PGS000117
(CVD_EJ2020)
 PSS000396|
Multi-ancestry (including European)|
205,297 individuals
 PGP000054 |
Elliott J et al. JAMA (2020)
 Reported Trait: Incident cardiovascular disease (in females) — C-index: 0.74 [0.73, 0.75] — pooled cohort equations —
PPM000823 PGS000117
(CVD_EJ2020)
 PSS000400|
Multi-ancestry (including European)|
352,660 individuals
 PGP000054 |
Elliott J et al. JAMA (2020)
 Reported Trait: Incident cardiovascular disease — C-index: 0.75 [0.75, 0.76] — pooled cohort equations —
PPM000836 PGS000116
(CAD_EJ2020)
 PSS000401|
Multi-ancestry (including European)|
350,730 individuals
 PGP000054 |
Elliott J et al. JAMA (2020)
 Reported Trait: Incident coronary artery disease — C-index: 0.74 [0.73, 0.75] — QRISK3 —
PPM000837 PGS000116
(CAD_EJ2020)
 PSS000389|
Multi-ancestry (including European)|
203,620 individuals
 PGP000054 |
Elliott J et al. JAMA (2020)
 Reported Trait: Incident coronary artery disease (over age 55) — C-index: 0.75 [0.74, 0.76] — QRISK3 —
PPM000838 PGS000116
(CAD_EJ2020)
 PSS000385|
Multi-ancestry (including European)|
147,110 individuals
 PGP000054 |
Elliott J et al. JAMA (2020)
 Reported Trait: Incident coronary artery disease (under age 55) — C-index: 0.83 [0.81, 0.84] — QRISK3 —
PPM000839 PGS000116
(CAD_EJ2020)
 PSS000393|
Multi-ancestry (including European)|
146,573 individuals
 PGP000054 |
Elliott J et al. JAMA (2020)
 Reported Trait: Incident coronary artery disease (in males) — C-index: 0.73 [0.72, 0.74] — QRISK3 —
PPM000840 PGS000116
(CAD_EJ2020)
 PSS000397|
Multi-ancestry (including European)|
204,157 individuals
 PGP000054 |
Elliott J et al. JAMA (2020)
 Reported Trait: Incident coronary artery disease (in females) — C-index: 0.78 [0.76, 0.79] — QRISK3 —
PPM000841 PGS000117
(CVD_EJ2020)
 PSS000402|
Multi-ancestry (including European)|
350,730 individuals
 PGP000054 |
Elliott J et al. JAMA (2020)
 Reported Trait: Incident cardiovascular disease — C-index: 0.75 [0.75, 0.76] — QRISK3 —
PPM000842 PGS000117
(CVD_EJ2020)
 PSS000390|
Multi-ancestry (including European)|
203,620 individuals
 PGP000054 |
Elliott J et al. JAMA (2020)
 Reported Trait: Incident cardiovascular disease (over age 55) — C-index: 0.7 [0.7, 0.71] — QRISK3 —
PPM000843 PGS000117
(CVD_EJ2020)
 PSS000386|
Multi-ancestry (including European)|
147,110 individuals
 PGP000054 |
Elliott J et al. JAMA (2020)
 Reported Trait: Incident cardiovascular disease (under age 55) — C-index: 0.77 [0.76, 0.78] — QRISK3 —
PPM000844 PGS000117
(CVD_EJ2020)
 PSS000394|
Multi-ancestry (including European)|
146,573 individuals
 PGP000054 |
Elliott J et al. JAMA (2020)
 Reported Trait: Incident cardiovascular disease (in males) — C-index: 0.71 [0.71, 0.72] — QRISK3 —
PPM000845 PGS000117
(CVD_EJ2020)
 PSS000398|
Multi-ancestry (including European)|
204,157 individuals
 PGP000054 |
Elliott J et al. JAMA (2020)
 Reported Trait: Incident cardiovascular disease (in females) — C-index: 0.74 [0.73, 0.75] — QRISK3 —
PPM000807 PGS000116
(CAD_EJ2020)
 PSS000399|
Multi-ancestry (including European)|
352,660 individuals
 PGP000054 |
Elliott J et al. JAMA (2020)
 Reported Trait: Incident coronary artery disease — C-index: 0.76 [0.75, 0.76] — age,sex —
PPM000808 PGS000116
(CAD_EJ2020)
 PSS000399|
Multi-ancestry (including European)|
352,660 individuals
 PGP000054 |
Elliott J et al. JAMA (2020)
 Reported Trait: Incident coronary artery disease — C-index: 0.78 [0.77, 0.79] — pooled cohort equations —
PPM000810 PGS000116
(CAD_EJ2020)
 PSS000387|
Multi-ancestry (including European)|
204,675 individuals
 PGP000054 |
Elliott J et al. JAMA (2020)
 Reported Trait: Incident coronary artery disease (over age 55) — C-index: 0.71 [0.7, 0.72] — age,sex —
PPM000811 PGS000116
(CAD_EJ2020)
 PSS000387|
Multi-ancestry (including European)|
204,675 individuals
 PGP000054 |
Elliott J et al. JAMA (2020)
 Reported Trait: Incident coronary artery disease (over age 55) — C-index: 0.74 [0.73, 0.74] — pooled cohort equations —
PPM000813 PGS000116
(CAD_EJ2020)
 PSS000383|
Multi-ancestry (including European)|
147,985 individuals
 PGP000054 |
Elliott J et al. JAMA (2020)
 Reported Trait: Incident coronary artery disease (under age 55) — C-index: 0.76 [0.75, 0.78] — age,sex —
PPM000814 PGS000116
(CAD_EJ2020)
 PSS000383|
Multi-ancestry (including European)|
147,985 individuals
 PGP000054 |
Elliott J et al. JAMA (2020)
 Reported Trait: Incident coronary artery disease (under age 55) — C-index: 0.8 [0.79, 0.82] — pooled cohort equations —
PPM000816 PGS000116
(CAD_EJ2020)
 PSS000391|
Multi-ancestry (including European)|
147,363 individuals
 PGP000054 |
Elliott J et al. JAMA (2020)
 Reported Trait: Incident coronary artery disease (in males) — C-index: 0.68 [0.67, 0.69] — age,sex —
PPM000817 PGS000116
(CAD_EJ2020)
 PSS000391|
Multi-ancestry (including European)|
147,363 individuals
 PGP000054 |
Elliott J et al. JAMA (2020)
 Reported Trait: Incident coronary artery disease (in males) — C-index: 0.71 [0.7, 0.72] — pooled cohort equations —
PPM000819 PGS000116
(CAD_EJ2020)
 PSS000395|
Multi-ancestry (including European)|
205,297 individuals
 PGP000054 |
Elliott J et al. JAMA (2020)
 Reported Trait: Incident coronary artery disease (in females) — C-index: 0.71 [0.7, 0.73] — age,sex —
PPM000820 PGS000116
(CAD_EJ2020)
 PSS000395|
Multi-ancestry (including European)|
205,297 individuals
 PGP000054 |
Elliott J et al. JAMA (2020)
 Reported Trait: Incident coronary artery disease (in females) — C-index: 0.76 [0.74, 0.77] — pooled cohort equations —
PPM000822 PGS000117
(CVD_EJ2020)
 PSS000400|
Multi-ancestry (including European)|
352,660 individuals
 PGP000054 |
Elliott J et al. JAMA (2020)
 Reported Trait: Incident cardiovascular disease — C-index: 0.71 [0.71, 0.72] — age,sex —
PPM000824 PGS000117
(CVD_EJ2020)
 PSS000388|
Multi-ancestry (including European)|
204,675 individuals
 PGP000054 |
Elliott J et al. JAMA (2020)
 Reported Trait: Incident cardiovascular disease (under age 55) — C-index: 0.56 [0.55, 0.56] — — —
PPM000827 PGS000117
(CVD_EJ2020)
 PSS000384|
Multi-ancestry (including European)|
147,985 individuals
 PGP000054 |
Elliott J et al. JAMA (2020)
 Reported Trait: Incident cardiovascular disease (over age 55) — C-index: 0.59 [0.58, 0.61] — — —
PPM000830 PGS000117
(CVD_EJ2020)
 PSS000392|
Multi-ancestry (including European)|
147,363 individuals
 PGP000054 |
Elliott J et al. JAMA (2020)
 Reported Trait: Incident cardiovascular disease (in males) — C-index: 0.57 [0.56, 0.57] — — —
PPM000833 PGS000117
(CVD_EJ2020)
 PSS000396|
Multi-ancestry (including European)|
205,297 individuals
 PGP000054 |
Elliott J et al. JAMA (2020)
 Reported Trait: Incident cardiovascular disease (in females) — C-index: 0.56 [0.55, 0.57] — — —
PPM000806 PGS000116
(CAD_EJ2020)
 PSS000399|
Multi-ancestry (including European)|
352,660 individuals
 PGP000054 |
Elliott J et al. JAMA (2020)
 Reported Trait: Incident coronary artery disease HR: 1.32 [1.3, 1.34] C-index: 0.61 [0.6, 0.62] — — —
PPM000809 PGS000116
(CAD_EJ2020)
 PSS000387|
Multi-ancestry (including European)|
204,675 individuals
 PGP000054 |
Elliott J et al. JAMA (2020)
 Reported Trait: Incident coronary artery disease (over age 55) — C-index: 0.6 [0.59, 0.61] — — —
PPM000812 PGS000116
(CAD_EJ2020)
 PSS000383|
Multi-ancestry (including European)|
147,985 individuals
 PGP000054 |
Elliott J et al. JAMA (2020)
 Reported Trait: Incident coronary artery disease (under age 55) — C-index: 0.64 [0.63, 0.66] — — —
PPM000815 PGS000116
(CAD_EJ2020)
 PSS000391|
Multi-ancestry (including European)|
147,363 individuals
 PGP000054 |
Elliott J et al. JAMA (2020)
 Reported Trait: Incident coronary artery disease (in males) — C-index: 0.61 [0.6, 0.62] — — —
PPM000818 PGS000116
(CAD_EJ2020)
 PSS000395|
Multi-ancestry (including European)|
205,297 individuals
 PGP000054 |
Elliott J et al. JAMA (2020)
 Reported Trait: Incident coronary artery disease (in females) — C-index: 0.61 [0.6, 0.63] — — —
PPM000821 PGS000117
(CVD_EJ2020)
 PSS000400|
Multi-ancestry (including European)|
352,660 individuals
 PGP000054 |
Elliott J et al. JAMA (2020)
 Reported Trait: Incident cardiovascular disease — C-index: 0.56 [0.56, 0.57] — — —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS000383 Coronary artery disease was defined as myocardial infarction and its related sequelae (coronary angioplasty, and coronary artery bypass grafts). ICD-10 codes: I21, I22, I23, I24.1, I25.2 ICD-9 codes: 410, 411, 412, 429.79 OPCS-4 codes: K40.1-4, K41.1-4, K45.1-5, K49.1-2, K49.8-9, K50.2, K75.1-4, K54.8-9 UKBiobank field 20002 code: 1075 UKBiobank field 20004 codes: 1070, 1095 UKBiobank field 6150 code: 1 See eTable 1 for risk factor codings Mean = 8.01 years
Sd = 1.04 years
[
  • 1,350 cases
  • , 146,635 controls
]
 Range = [40.0, 55.0] years European, African unspecified, NR 98.3% White European, 1.7% Black/Other UKB PCE Prospective Cohort (lipid-lowering treatment performed)
PSS000384 Cardiovascular disease was defined as coronary artery disease, and additionally includes angina, nonhemorrhagic stroke, and transient ischemic attack. ICD-10 codes: G45, I20, I21, I22, I23, I24.1, I25, I63. I64 ICD-9 codes: 410, 411, 412, 413, 414, 434, 436 OPCS-4 codes: K40, K41, K42, K43, K44, K45, K46, K47.1, K49, K50, K75 UKBiobank field 20002 codes: 1074, 1075, 1082, 1548 UKBiobank field 20004 codes: 1070, 1071, 1095, 1105, 1109, 1514 UKBiobank field 6150 codes: 1, 2, 3 See eTable 1 for risk factor codings Mean = 8.01 years
Sd = 1.04 years
[
  • 10,899 cases
  • , 137,086 controls
]
 Range = [40.0, 55.0] years European, African unspecified, NR 98.3% White European, 1.7% Black/Other UKB PCE Prospective Cohort (lipid-lowering treatment performed)
PSS000385 Coronary artery disease was defined as myocardial infarction and its related sequelae (coronary angioplasty, and coronary artery bypass grafts). ICD-10 codes: I21, I22, I23, I24.1, I25.2 ICD-9 codes: 410, 411, 412, 429.79 OPCS-4 codes: K40.1-4, K41.1-4, K45.1-5, K49.1-2, K49.8-9, K50.2, K75.1-4, K54.8-9 UKBiobank field 20002 code: 1075 UKBiobank field 20004 codes: 1070, 1095 UKBiobank field 6150 code: 1 See eTable 1 for risk factor codings Mean = 8.01 years
Sd = 1.04 years
[
  • 1,339 cases
  • , 145,771 controls
]
 Range = [40.0, 55.0] years European, South Asian, African American or Afro-Caribbean, African unspecified, East Asian, Asian unspecified 2,332 Africans, 145 Bangladeshi, 3,165 Carribeans, 1,136 Chinese, 3,790 Indians, 1,258 Other Asians, 1,182 Pakistani, 332,326 White Europeans and Unkown ancestry UKB QRISK3 Prospective Cohort/Testing Set (lipid-lowering treatment performed)
PSS000386 Cardiovascular disease was defined as coronary artery disease, and additionally includes angina, nonhemorrhagic stroke, and transient ischemic attack. ICD-10 codes: G45, I20, I21, I22, I23, I24.1, I25, I63. I64 ICD-9 codes: 410, 411, 412, 413, 414, 434, 436 OPCS-4 codes: K40, K41, K42, K43, K44, K45, K46, K47.1, K49, K50, K75 UKBiobank field 20002 codes: 1074, 1075, 1082, 1548 UKBiobank field 20004 codes: 1070, 1071, 1095, 1105, 1109, 1514 UKBiobank field 6150 codes: 1, 2, 3 See eTable 1 for risk factor codings Mean = 8.01 years
Sd = 1.04 years
[
  • 2,826 cases
  • , 144,284 controls
]
 Range = [40.0, 55.0] years European, South Asian, African American or Afro-Caribbean, African unspecified, East Asian, Asian unspecified 2,332 Africans, 145 Bangladeshi, 3,165 Carribeans, 1,136 Chinese, 3,790 Indians, 1,258 Other Asians, 1,182 Pakistani, 332,326 White Europeans and Unkown ancestry UKB QRISK3 Prospective Cohort/Testing Set (lipid-lowering treatment performed)
PSS000387 Coronary artery disease was defined as myocardial infarction and its related sequelae (coronary angioplasty, and coronary artery bypass grafts). ICD-10 codes: I21, I22, I23, I24.1, I25.2 ICD-9 codes: 410, 411, 412, 429.79 OPCS-4 codes: K40.1-4, K41.1-4, K45.1-5, K49.1-2, K49.8-9, K50.2, K75.1-4, K54.8-9 UKBiobank field 20002 code: 1075 UKBiobank field 20004 codes: 1070, 1095 UKBiobank field 6150 code: 1 See eTable 1 for risk factor codings Mean = 8.01 years
Sd = 1.04 years
[
  • 4,922 cases
  • , 199,753 controls
]
 Range = [55.0, 69.0] years European, African unspecified, NR 98.3% White European, 1.7% Black/Other UKB PCE Prospective Cohort (lipid-lowering treatment performed)
PSS000388 Cardiovascular disease was defined as coronary artery disease, and additionally includes angina, nonhemorrhagic stroke, and transient ischemic attack. ICD-10 codes: G45, I20, I21, I22, I23, I24.1, I25, I63. I64 ICD-9 codes: 410, 411, 412, 413, 414, 434, 436 OPCS-4 codes: K40, K41, K42, K43, K44, K45, K46, K47.1, K49, K50, K75 UKBiobank field 20002 codes: 1074, 1075, 1082, 1548 UKBiobank field 20004 codes: 1070, 1071, 1095, 1105, 1109, 1514 UKBiobank field 6150 codes: 1, 2, 3 See eTable 1 for risk factor codings Mean = 8.01 years
Sd = 1.04 years
[
  • 2,854 cases
  • , 201,821 controls
]
 Range = [55.0, 69.0] years European, African unspecified, NR 98.3% White European, 1.7% Black/Other UKB PCE Prospective Cohort (lipid-lowering treatment performed)
PSS000389 Coronary artery disease was defined as myocardial infarction and its related sequelae (coronary angioplasty, and coronary artery bypass grafts). ICD-10 codes: I21, I22, I23, I24.1, I25.2 ICD-9 codes: 410, 411, 412, 429.79 OPCS-4 codes: K40.1-4, K41.1-4, K45.1-5, K49.1-2, K49.8-9, K50.2, K75.1-4, K54.8-9 UKBiobank field 20002 code: 1075 UKBiobank field 20004 codes: 1070, 1095 UKBiobank field 6150 code: 1 See eTable 1 for risk factor codings Mean = 8.01 years
Sd = 1.04 years
[
  • 4,900 cases
  • , 198,720 controls
]
 Range = [55.0, 69.0] years European, South Asian, African American or Afro-Caribbean, African unspecified, East Asian, Asian unspecified 2,332 Africans, 145 Bangladeshi, 3,165 Carribeans, 1,136 Chinese, 3,790 Indians, 1,258 Other Asians, 1,182 Pakistani, 332,326 White Europeans and Unkown ancestry UKB QRISK3 Prospective Cohort/Testing Set (lipid-lowering treatment performed)
PSS000390 Cardiovascular disease was defined as coronary artery disease, and additionally includes angina, nonhemorrhagic stroke, and transient ischemic attack. ICD-10 codes: G45, I20, I21, I22, I23, I24.1, I25, I63. I64 ICD-9 codes: 410, 411, 412, 413, 414, 434, 436 OPCS-4 codes: K40, K41, K42, K43, K44, K45, K46, K47.1, K49, K50, K75 UKBiobank field 20002 codes: 1074, 1075, 1082, 1548 UKBiobank field 20004 codes: 1070, 1071, 1095, 1105, 1109, 1514 UKBiobank field 6150 codes: 1, 2, 3 See eTable 1 for risk factor codings Mean = 8.01 years
Sd = 1.04 years
[
  • 10,824 cases
  • , 192,796 controls
]
 Range = [55.0, 69.0] years European, South Asian, African American or Afro-Caribbean, African unspecified, East Asian, Asian unspecified 2,332 Africans, 145 Bangladeshi, 3,165 Carribeans, 1,136 Chinese, 3,790 Indians, 1,258 Other Asians, 1,182 Pakistani, 332,326 White Europeans and Unkown ancestry UKB QRISK3 Prospective Cohort/Testing Set (lipid-lowering treatment performed)
PSS000391 Coronary artery disease was defined as myocardial infarction and its related sequelae (coronary angioplasty, and coronary artery bypass grafts). ICD-10 codes: I21, I22, I23, I24.1, I25.2 ICD-9 codes: 410, 411, 412, 429.79 OPCS-4 codes: K40.1-4, K41.1-4, K45.1-5, K49.1-2, K49.8-9, K50.2, K75.1-4, K54.8-9 UKBiobank field 20002 code: 1075 UKBiobank field 20004 codes: 1070, 1095 UKBiobank field 6150 code: 1 See eTable 1 for risk factor codings Mean = 8.01 years
Sd = 1.04 years
[
  • 4,493 cases
  • , 142,870 controls
]
,
100.0 % Male samples
 Mean = 55.79 years
Sd = 8.35 years		 European, African unspecified, NR 98.3% White European, 1.7% Black/Other UKB PCE Prospective Cohort (lipid-lowering treatment performed)
PSS000392 Cardiovascular disease was defined as coronary artery disease, and additionally includes angina, nonhemorrhagic stroke, and transient ischemic attack. ICD-10 codes: G45, I20, I21, I22, I23, I24.1, I25, I63. I64 ICD-9 codes: 410, 411, 412, 413, 414, 434, 436 OPCS-4 codes: K40, K41, K42, K43, K44, K45, K46, K47.1, K49, K50, K75 UKBiobank field 20002 codes: 1074, 1075, 1082, 1548 UKBiobank field 20004 codes: 1070, 1071, 1095, 1105, 1109, 1514 UKBiobank field 6150 codes: 1, 2, 3 See eTable 1 for risk factor codings Mean = 8.01 years
Sd = 1.04 years
[
  • 8,595 cases
  • , 138,768 controls
]
,
100.0 % Male samples
 Mean = 55.79 years
Sd = 8.35 years		 European, African unspecified, NR 98.3% White European, 1.7% Black/Other UKB PCE Prospective Cohort (lipid-lowering treatment performed)
PSS000393 Coronary artery disease was defined as myocardial infarction and its related sequelae (coronary angioplasty, and coronary artery bypass grafts). ICD-10 codes: I21, I22, I23, I24.1, I25.2 ICD-9 codes: 410, 411, 412, 429.79 OPCS-4 codes: K40.1-4, K41.1-4, K45.1-5, K49.1-2, K49.8-9, K50.2, K75.1-4, K54.8-9 UKBiobank field 20002 code: 1075 UKBiobank field 20004 codes: 1070, 1095 UKBiobank field 6150 code: 1 See eTable 1 for risk factor codings Mean = 8.01 years
Sd = 1.04 years
[
  • 4,471 cases
  • , 142,102 controls
]
,
100.0 % Male samples
 Mean = 55.8 years
Sd = 8.3 years		 European, South Asian, African American or Afro-Caribbean, African unspecified, East Asian, Asian unspecified 2,332 Africans, 145 Bangladeshi, 3,165 Carribeans, 1,136 Chinese, 3,790 Indians, 1,258 Other Asians, 1,182 Pakistani, 332,326 White Europeans and Unkown ancestry UKB QRISK3 Prospective Cohort/Testing Set (lipid-lowering treatment performed)
PSS000394 Cardiovascular disease was defined as coronary artery disease, and additionally includes angina, nonhemorrhagic stroke, and transient ischemic attack. ICD-10 codes: G45, I20, I21, I22, I23, I24.1, I25, I63. I64 ICD-9 codes: 410, 411, 412, 413, 414, 434, 436 OPCS-4 codes: K40, K41, K42, K43, K44, K45, K46, K47.1, K49, K50, K75 UKBiobank field 20002 codes: 1074, 1075, 1082, 1548 UKBiobank field 20004 codes: 1070, 1071, 1095, 1105, 1109, 1514 UKBiobank field 6150 codes: 1, 2, 3 See eTable 1 for risk factor codings Mean = 8.01 years
Sd = 1.04 years
[
  • 8,536 cases
  • , 138,037 controls
]
,
100.0 % Male samples
 Mean = 55.8 years
Sd = 8.3 years		 European, South Asian, African American or Afro-Caribbean, African unspecified, East Asian, Asian unspecified 2,332 Africans, 145 Bangladeshi, 3,165 Carribeans, 1,136 Chinese, 3,790 Indians, 1,258 Other Asians, 1,182 Pakistani, 332,326 White Europeans and Unkown ancestry UKB QRISK3 Prospective Cohort/Testing Set (lipid-lowering treatment performed)
PSS000395 Coronary artery disease was defined as myocardial infarction and its related sequelae (coronary angioplasty, and coronary artery bypass grafts). ICD-10 codes: I21, I22, I23, I24.1, I25.2 ICD-9 codes: 410, 411, 412, 429.79 OPCS-4 codes: K40.1-4, K41.1-4, K45.1-5, K49.1-2, K49.8-9, K50.2, K75.1-4, K54.8-9 UKBiobank field 20002 code: 1075 UKBiobank field 20004 codes: 1070, 1095 UKBiobank field 6150 code: 1 See eTable 1 for risk factor codings Mean = 8.01 years
Sd = 1.04 years
[
  • 1,779 cases
  • , 203,518 controls
]
,
0.0 % Male samples
 Mean = 56.0 years
Sd = 8.01 years		 European, African unspecified, NR 98.3% White European, 1.7% Black/Other UKB PCE Prospective Cohort (lipid-lowering treatment performed)
PSS000396 Cardiovascular disease was defined as coronary artery disease, and additionally includes angina, nonhemorrhagic stroke, and transient ischemic attack. ICD-10 codes: G45, I20, I21, I22, I23, I24.1, I25, I63. I64 ICD-9 codes: 410, 411, 412, 413, 414, 434, 436 OPCS-4 codes: K40, K41, K42, K43, K44, K45, K46, K47.1, K49, K50, K75 UKBiobank field 20002 codes: 1074, 1075, 1082, 1548 UKBiobank field 20004 codes: 1070, 1071, 1095, 1105, 1109, 1514 UKBiobank field 6150 codes: 1, 2, 3 See eTable 1 for risk factor codings Mean = 8.01 years
Sd = 1.04 years
[
  • 5,158 cases
  • , 200,139 controls
]
,
0.0 % Male samples
 Mean = 56.0 years
Sd = 8.01 years		 European, African unspecified, NR 98.3% White European, 1.7% Black/Other UKB PCE Prospective Cohort (lipid-lowering treatment performed)
PSS000397 Coronary artery disease was defined as myocardial infarction and its related sequelae (coronary angioplasty, and coronary artery bypass grafts). ICD-10 codes: I21, I22, I23, I24.1, I25.2 ICD-9 codes: 410, 411, 412, 429.79 OPCS-4 codes: K40.1-4, K41.1-4, K45.1-5, K49.1-2, K49.8-9, K50.2, K75.1-4, K54.8-9 UKBiobank field 20002 code: 1075 UKBiobank field 20004 codes: 1070, 1095 UKBiobank field 6150 code: 1 See eTable 1 for risk factor codings Mean = 8.01 years
Sd = 1.04 years
[
  • 1,768 cases
  • , 202,389 controls
]
,
0.0 % Male samples
 Mean = 56.0 years
Sd = 8.0 years		 European, South Asian, African American or Afro-Caribbean, African unspecified, East Asian, Asian unspecified 2,332 Africans, 145 Bangladeshi, 3,165 Carribeans, 1,136 Chinese, 3,790 Indians, 1,258 Other Asians, 1,182 Pakistani, 332,326 White Europeans and Unkown ancestry UKB QRISK3 Prospective Cohort/Testing Set (lipid-lowering treatment performed)
PSS000398 Cardiovascular disease was defined as coronary artery disease, and additionally includes angina, nonhemorrhagic stroke, and transient ischemic attack. ICD-10 codes: G45, I20, I21, I22, I23, I24.1, I25, I63. I64 ICD-9 codes: 410, 411, 412, 413, 414, 434, 436 OPCS-4 codes: K40, K41, K42, K43, K44, K45, K46, K47.1, K49, K50, K75 UKBiobank field 20002 codes: 1074, 1075, 1082, 1548 UKBiobank field 20004 codes: 1070, 1071, 1095, 1105, 1109, 1514 UKBiobank field 6150 codes: 1, 2, 3 See eTable 1 for risk factor codings Mean = 8.01 years
Sd = 1.04 years
[
  • 5,114 cases
  • , 199,043 controls
]
,
0.0 % Male samples
 Mean = 56.0 years
Sd = 8.0 years		 European, South Asian, African American or Afro-Caribbean, African unspecified, East Asian, Asian unspecified 2,332 Africans, 145 Bangladeshi, 3,165 Carribeans, 1,136 Chinese, 3,790 Indians, 1,258 Other Asians, 1,182 Pakistani, 332,326 White Europeans and Unkown ancestry UKB QRISK3 Prospective Cohort/Testing Set (lipid-lowering treatment performed)
PSS000399 Coronary artery disease was defined as myocardial infarction and its related sequelae (coronary angioplasty, and coronary artery bypass grafts). ICD-10 codes: I21, I22, I23, I24.1, I25.2 ICD-9 codes: 410, 411, 412, 429.79 OPCS-4 codes: K40.1-4, K41.1-4, K45.1-5, K49.1-2, K49.8-9, K50.2, K75.1-4, K54.8-9 UKBiobank field 20002 code: 1075 UKBiobank field 20004 codes: 1070, 1095 UKBiobank field 6150 code: 1 See eTable 1 for risk factor codings Mean = 8.01 years
Sd = 1.04 years
[
  • 6,272 cases
  • , 346,388 controls
]
,
41.8 % Male samples
 Mean = 55.9 years
Range = [40.0, 69.0] years		 European, African unspecified, NR 98.3% White European, 1.7% Black/Other UKB PCE Prospective Cohort (lipid-lowering treatment performed)
PSS000400 Cardiovascular disease was defined as coronary artery disease, and additionally includes angina, nonhemorrhagic stroke, and transient ischemic attack. ICD-10 codes: G45, I20, I21, I22, I23, I24.1, I25, I63. I64 ICD-9 codes: 410, 411, 412, 413, 414, 434, 436 OPCS-4 codes: K40, K41, K42, K43, K44, K45, K46, K47.1, K49, K50, K75 UKBiobank field 20002 codes: 1074, 1075, 1082, 1548 UKBiobank field 20004 codes: 1070, 1071, 1095, 1105, 1109, 1514 UKBiobank field 6150 codes: 1, 2, 3 See eTable 1 for risk factor codings Mean = 8.01 years
Sd = 1.04 years
[
  • 13,753 cases
  • , 338,907 controls
]
,
41.8 % Male samples
 Mean = 55.9 years
Range = [40.0, 69.0] years		 European, African unspecified, NR 98.3% White European, 1.7% Black/Other UKB PCE Prospective Cohort (lipid-lowering treatment performed)
PSS000401 Coronary artery disease was defined as myocardial infarction and its related sequelae (coronary angioplasty, and coronary artery bypass grafts). ICD-10 codes: I21, I22, I23, I24.1, I25.2 ICD-9 codes: 410, 411, 412, 429.79 OPCS-4 codes: K40.1-4, K41.1-4, K45.1-5, K49.1-2, K49.8-9, K50.2, K75.1-4, K54.8-9 UKBiobank field 20002 code: 1075 UKBiobank field 20004 codes: 1070, 1095 UKBiobank field 6150 code: 1 See eTable 1 for risk factor codings Mean = 8.01 years
Sd = 1.04 years
[
  • 6,239 cases
  • , 344,491 controls
]
,
41.0 % Male samples
 Range = [40.0, 69.0] years European, South Asian, African American or Afro-Caribbean, African unspecified, East Asian, Asian unspecified 2,332 Africans, 145 Bangladeshi, 3,165 Carribeans, 1,136 Chinese, 3,790 Indians, 1,258 Other Asians, 1,182 Pakistani, 332,326 White Europeans and Unkown ancestry UKB QRISK3 Prospective Cohort/Testing Set (lipid-lowering treatment performed)
PSS000402 Cardiovascular disease was defined as coronary artery disease, and additionally includes angina, nonhemorrhagic stroke, and transient ischemic attack. ICD-10 codes: G45, I20, I21, I22, I23, I24.1, I25, I63. I64 ICD-9 codes: 410, 411, 412, 413, 414, 434, 436 OPCS-4 codes: K40, K41, K42, K43, K44, K45, K46, K47.1, K49, K50, K75 UKBiobank field 20002 codes: 1074, 1075, 1082, 1548 UKBiobank field 20004 codes: 1070, 1071, 1095, 1105, 1109, 1514 UKBiobank field 6150 codes: 1, 2, 3 See eTable 1 for risk factor codings Mean = 8.01 years
Sd = 1.04 years
[
  • 13,650 cases
  • , 337,080 controls
]
,
41.0 % Male samples
 Range = [40.0, 69.0] years European, South Asian, African American or Afro-Caribbean, African unspecified, East Asian, Asian unspecified 2,332 Africans, 145 Bangladeshi, 3,165 Carribeans, 1,136 Chinese, 3,790 Indians, 1,258 Other Asians, 1,182 Pakistani, 332,326 White Europeans and Unkown ancestry UKB QRISK3 Prospective Cohort/Testing Set (lipid-lowering treatment performed)