Publication Information (EuropePMC) | |
Title | Prediction of Bone Mineral Density and Fragility Fracture by Genetic Profiling. |
PubMed ID | 27649491(Europe PMC) |
doi | 10.1002/jbmr.2998 |
Publication Date | Oct. 26, 2016 |
Journal | J Bone Miner Res |
Author(s) | Ho-Le TP, Center JR, Eisman JA, Nguyen HT, Nguyen TV. |
Polygenic Score ID & Name
|
PGS Publication ID (PGP)
|
Reported Trait
|
Mapped Trait(s) (Ontology)
|
Number of Variants
|
Ancestry distribution GWAS Dev Eval |
Scoring File (FTP Link)
|
---|---|---|---|---|---|---|
PGS000121 (2018_BMD62_GRS.FN) | PGP000056 | Ho-Le TP et al. J Bone Miner Res (2016) | Bone mineral density (BMD) | bone density | 62 | - | https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000121/ScoringFiles/PGS000121.txt.gz |
PGS000122 (2018_BMD33_GRS.FN) | PGP000056 | Ho-Le TP et al. J Bone Miner Res (2016) | Bone mineral density (BMD) | bone density | 33 | - | https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000122/ScoringFiles/PGS000122.txt.gz |
PGS Performance Metric ID (PPM) |
Evaluated Score
|
PGS Sample Set ID (PSS) |
Performance Source
|
Trait
|
PGS Effect Sizes (per SD change) |
Classification Metrics
|
Other Metrics
|
Covariates Included in the Model
|
PGS Performance: Other Relevant Information |
---|---|---|---|---|---|---|---|---|---|
PPM000349 | PGS000121 (2018_BMD62_GRS.FN) | PSS000212| European Ancestry| 1,459 individuals | PGP000056 | Ho-Le TP et al. J Bone Miner Res (2016) | Reported Trait: Femoral neck BMD | β: -0.019 (0.004) | — | — | — | — |
PPM000350 | PGS000121 (2018_BMD62_GRS.FN) | PSS000212| European Ancestry| 1,459 individuals | PGP000056 | Ho-Le TP et al. J Bone Miner Res (2016) | Reported Trait: Lumbar spine BMD | β: -0.037 (0.007) | — | — | — | — |
PPM000351 | PGS000121 (2018_BMD62_GRS.FN) | PSS000214| European Ancestry| 1,459 individuals | PGP000056 | Ho-Le TP et al. J Bone Miner Res (2016) | Reported Trait: Total fracture | HR: 1.2 [1.04, 1.38] | — | — | — | — |
PPM000352 | PGS000121 (2018_BMD62_GRS.FN) | PSS000214| European Ancestry| 1,459 individuals | PGP000056 | Ho-Le TP et al. J Bone Miner Res (2016) | Reported Trait: Total fracture | HR: 1.19 [1.03, 1.37] | — | — | Age | — |
PPM000353 | PGS000121 (2018_BMD62_GRS.FN) | PSS000214| European Ancestry| 1,459 individuals | PGP000056 | Ho-Le TP et al. J Bone Miner Res (2016) | Reported Trait: Total fracture | HR: 1.18 [1.03, 1.36] | — | — | Age, sex, prior fracture or fall | — |
PPM000354 | PGS000121 (2018_BMD62_GRS.FN) | PSS000214| European Ancestry| 1,459 individuals | PGP000056 | Ho-Le TP et al. J Bone Miner Res (2016) | Reported Trait: Total fracture | HR: 1.13 [0.98, 1.29] | — | — | Age, sex, prior fracture or fall, femoral neck bone mineral density | — |
PPM000355 | PGS000122 (2018_BMD33_GRS.FN) | PSS000214| European Ancestry| 1,459 individuals | PGP000056 | Ho-Le TP et al. J Bone Miner Res (2016) | Reported Trait: Total fracture | HR: 1.26 [1.06, 1.5] | — | — | — | — |
PPM000356 | PGS000122 (2018_BMD33_GRS.FN) | PSS000214| European Ancestry| 1,459 individuals | PGP000056 | Ho-Le TP et al. J Bone Miner Res (2016) | Reported Trait: Total fracture | HR: 1.26 [1.06, 1.5] | — | — | Age | — |
PPM000357 | PGS000122 (2018_BMD33_GRS.FN) | PSS000214| European Ancestry| 1,459 individuals | PGP000056 | Ho-Le TP et al. J Bone Miner Res (2016) | Reported Trait: Total fracture | HR: 1.24 [1.04, 1.47] | — | — | Age, sex, prior fracture or fall | — |
PPM000358 | PGS000122 (2018_BMD33_GRS.FN) | PSS000214| European Ancestry| 1,459 individuals | PGP000056 | Ho-Le TP et al. J Bone Miner Res (2016) | Reported Trait: Total fracture | HR: 1.23 [1.02, 1.46] | — | — | Age, sex, prior fracture or fall, femoral neck bone mineral density | — |
PPM000359 | PGS000121 (2018_BMD62_GRS.FN) | PSS000213| European Ancestry| 1,459 individuals | PGP000056 | Ho-Le TP et al. J Bone Miner Res (2016) | Reported Trait: Hip fracture | HR: 1.23 [0.92, 1.63] | — | — | — | — |
PPM000360 | PGS000121 (2018_BMD62_GRS.FN) | PSS000213| European Ancestry| 1,459 individuals | PGP000056 | Ho-Le TP et al. J Bone Miner Res (2016) | Reported Trait: Hip fracture | HR: 1.21 [0.91, 1.59] | — | — | Age | — |
PPM000361 | PGS000121 (2018_BMD62_GRS.FN) | PSS000213| European Ancestry| 1,459 individuals | PGP000056 | Ho-Le TP et al. J Bone Miner Res (2016) | Reported Trait: Hip fracture | HR: 1.19 [0.91, 1.57] | — | — | Age, sex, prior fracture or fall | — |
PPM000362 | PGS000121 (2018_BMD62_GRS.FN) | PSS000213| European Ancestry| 1,459 individuals | PGP000056 | Ho-Le TP et al. J Bone Miner Res (2016) | Reported Trait: Hip fracture | HR: 1.03 [0.77, 1.36] | — | — | Age, sex, prior fracture or fall, femoral neck bone mineral density | — |
PPM000363 | PGS000122 (2018_BMD33_GRS.FN) | PSS000213| European Ancestry| 1,459 individuals | PGP000056 | Ho-Le TP et al. J Bone Miner Res (2016) | Reported Trait: Hip fracture | HR: 1.09 [0.77, 1.54] | — | — | — | — |
PGS Sample Set ID (PSS) |
Phenotype Definitions and Methods
|
Participant Follow-up Time
|
Sample Numbers
|
Age of Study Participants
|
Sample Ancestry
|
Additional Ancestry Description
|
Cohort(s)
|
Additional Sample/Cohort Information
|
---|---|---|---|---|---|---|---|---|
PSS000212 | — | — | 902 individuals, 0.0 % Male samples | Mean = 70.1 years Sd = 7.0 years | European | — | DOES | — |
PSS000212 | — | — | 557 individuals, 100.0 % Male samples | Mean = 69.5 years Sd = 5.9 years | European | — | DOES | — |
PSS000213 | — | — | [ ,
0.0 % Male samples | Mean = 70.1 years Sd = 7.0 years | European | — | DOES | — |
PSS000213 | — | — | [ ,
100.0 % Male samples | Mean = 69.5 years Sd = 5.9 years | European | — | DOES | — |
PSS000214 | — | — | [ ,
0.0 % Male samples | Mean = 70.1 years Sd = 7.0 years | European | — | DOES | — |
PSS000214 | — | — | [ ,
100.0 % Male samples | Mean = 69.5 years Sd = 5.9 years | European | — | DOES | — |
PSS000215 | — | — | [ ,
0.0 % Male samples | Mean = 70.1 years Sd = 7.0 years | European | — | DOES | — |
PSS000215 | — | — | [ ,
100.0 % Male samples | Mean = 69.5 years Sd = 5.9 years | European | — | DOES | — |
PSS000216 | — | — | [ ,
0.0 % Male samples | Mean = 70.1 years Sd = 7.0 years | European | — | DOES | — |
PSS000216 | — | — | [ ,
100.0 % Male samples | Mean = 69.5 years Sd = 5.9 years | European | — | DOES | — |