Trait: bone density

Trait Information
Identifier OBA_1000110
Description The mass density of a bone tissue. [AUTO: patterns/patterns/entity_attribute]
Trait category
Other measurement
Synonyms 2 synonyms
  • bone tissue mass density trait
  • mass density of bone tissue

Associated Polygenic Score(s)

Filter PGS by Participant Ancestry
Individuals included in:
G - Source of Variant Associations (GWAS)
D - Score Development/Training
E - PGS Evaluation
List of ancestries includes:
Display options:
Ancestry legend
Multi-ancestry (including European)
Multi-ancestry (excluding European)
African
East Asian
South Asian
Additional Asian Ancestries
European
Greater Middle Eastern
Hispanic or Latin American
Additional Diverse Ancestries
Not Reported
Polygenic Score ID & Name PGS Publication ID (PGP) Reported Trait Mapped Trait(s) (Ontology) Number of Variants Ancestry distribution
GWAS
Dev
Eval
Scoring File (FTP Link)
PGS000121
(2018_BMD62_GRS.FN)
PGP000056 |
Ho-Le TP et al. J Bone Miner Res (2016)
Bone mineral density (BMD) bone density 62
-
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000121/ScoringFiles/PGS000121.txt.gz
PGS000122
(2018_BMD33_GRS.FN)
PGP000056 |
Ho-Le TP et al. J Bone Miner Res (2016)
Bone mineral density (BMD) bone density 33
-
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000122/ScoringFiles/PGS000122.txt.gz
PGS002315
(bmd_HEEL_TSCOREz.BOLT-LMM)
PGP000332 |
Weissbrod O et al. Nat Genet (2022)
Bone mineral density (BMD) bone density 1,109,311
-
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS002315/ScoringFiles/PGS002315.txt.gz
PGS002387
(bmd_HEEL_TSCOREz.P+T.0.0001)
PGP000332 |
Weissbrod O et al. Nat Genet (2022)
Bone mineral density (BMD) bone density 25,831
-
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS002387/ScoringFiles/PGS002387.txt.gz
PGS002436
(bmd_HEEL_TSCOREz.P+T.0.001)
PGP000332 |
Weissbrod O et al. Nat Genet (2022)
Bone mineral density (BMD) bone density 53,472
-
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS002436/ScoringFiles/PGS002436.txt.gz
PGS002485
(bmd_HEEL_TSCOREz.P+T.0.01)
PGP000332 |
Weissbrod O et al. Nat Genet (2022)
Bone mineral density (BMD) bone density 171,392
-
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS002485/ScoringFiles/PGS002485.txt.gz
PGS002534
(bmd_HEEL_TSCOREz.P+T.1e-06)
PGP000332 |
Weissbrod O et al. Nat Genet (2022)
Bone mineral density (BMD) bone density 11,440
-
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS002534/ScoringFiles/PGS002534.txt.gz
PGS002583
(bmd_HEEL_TSCOREz.P+T.5e-08)
PGP000332 |
Weissbrod O et al. Nat Genet (2022)
Bone mineral density (BMD) bone density 7,908
-
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS002583/ScoringFiles/PGS002583.txt.gz
PGS002632
(bmd_HEEL_TSCOREz.PolyFun-pred)
PGP000332 |
Weissbrod O et al. Nat Genet (2022)
Bone mineral density (BMD) bone density 432,286
-
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS002632/ScoringFiles/PGS002632.txt.gz
PGS002681
(bmd_HEEL_TSCOREz.SBayesR)
PGP000332 |
Weissbrod O et al. Nat Genet (2022)
Bone mineral density (BMD) bone density 984,276
-
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS002681/ScoringFiles/PGS002681.txt.gz

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM)
Evaluated Score PGS Sample Set ID
(PSS)
Performance Source Trait PGS Effect Sizes
(per SD change)
Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM000368 PGS000121
(2018_BMD62_GRS.FN)
PSS000215|
European Ancestry|
1,459 individuals
PGP000056 |
Ho-Le TP et al. J Bone Miner Res (2016)
Reported Trait: Vertebral fracture HR: 1.25 [1.02, 1.56] Age
PPM000376 PGS000121
(2018_BMD62_GRS.FN)
PSS000216|
European Ancestry|
1,459 individuals
PGP000056 |
Ho-Le TP et al. J Bone Miner Res (2016)
Reported Trait: Wrist fracture HR: 1.48 [1.07, 2.06] Age
PPM000377 PGS000121
(2018_BMD62_GRS.FN)
PSS000216|
European Ancestry|
1,459 individuals
PGP000056 |
Ho-Le TP et al. J Bone Miner Res (2016)
Reported Trait: Wrist fracture HR: 1.5 [1.08, 2.09] Age, sex, prior fracture or fall
PPM000378 PGS000121
(2018_BMD62_GRS.FN)
PSS000216|
European Ancestry|
1,459 individuals
PGP000056 |
Ho-Le TP et al. J Bone Miner Res (2016)
Reported Trait: Wrist fracture HR: 1.41 [1.01, 1.96] Age, sex, prior fracture or fall, femoral neck bone mineral density
PPM000360 PGS000121
(2018_BMD62_GRS.FN)
PSS000213|
European Ancestry|
1,459 individuals
PGP000056 |
Ho-Le TP et al. J Bone Miner Res (2016)
Reported Trait: Hip fracture HR: 1.21 [0.91, 1.59] Age
PPM000352 PGS000121
(2018_BMD62_GRS.FN)
PSS000214|
European Ancestry|
1,459 individuals
PGP000056 |
Ho-Le TP et al. J Bone Miner Res (2016)
Reported Trait: Total fracture HR: 1.19 [1.03, 1.37] Age
PPM000362 PGS000121
(2018_BMD62_GRS.FN)
PSS000213|
European Ancestry|
1,459 individuals
PGP000056 |
Ho-Le TP et al. J Bone Miner Res (2016)
Reported Trait: Hip fracture HR: 1.03 [0.77, 1.36] Age, sex, prior fracture or fall, femoral neck bone mineral density
PPM000354 PGS000121
(2018_BMD62_GRS.FN)
PSS000214|
European Ancestry|
1,459 individuals
PGP000056 |
Ho-Le TP et al. J Bone Miner Res (2016)
Reported Trait: Total fracture HR: 1.13 [0.98, 1.29] Age, sex, prior fracture or fall, femoral neck bone mineral density
PPM000367 PGS000121
(2018_BMD62_GRS.FN)
PSS000215|
European Ancestry|
1,459 individuals
PGP000056 |
Ho-Le TP et al. J Bone Miner Res (2016)
Reported Trait: Vertebral fracture HR: 1.28 [1.02, 1.59]
PPM000359 PGS000121
(2018_BMD62_GRS.FN)
PSS000213|
European Ancestry|
1,459 individuals
PGP000056 |
Ho-Le TP et al. J Bone Miner Res (2016)
Reported Trait: Hip fracture HR: 1.23 [0.92, 1.63]
PPM000351 PGS000121
(2018_BMD62_GRS.FN)
PSS000214|
European Ancestry|
1,459 individuals
PGP000056 |
Ho-Le TP et al. J Bone Miner Res (2016)
Reported Trait: Total fracture HR: 1.2 [1.04, 1.38]
PPM000350 PGS000121
(2018_BMD62_GRS.FN)
PSS000212|
European Ancestry|
1,459 individuals
PGP000056 |
Ho-Le TP et al. J Bone Miner Res (2016)
Reported Trait: Lumbar spine BMD β: -0.037 (0.007)
PPM000349 PGS000121
(2018_BMD62_GRS.FN)
PSS000212|
European Ancestry|
1,459 individuals
PGP000056 |
Ho-Le TP et al. J Bone Miner Res (2016)
Reported Trait: Femoral neck BMD β: -0.019 (0.004)
PPM000375 PGS000121
(2018_BMD62_GRS.FN)
PSS000216|
European Ancestry|
1,459 individuals
PGP000056 |
Ho-Le TP et al. J Bone Miner Res (2016)
Reported Trait: Wrist fracture HR: 1.51 [1.08, 2.1]
PPM000369 PGS000121
(2018_BMD62_GRS.FN)
PSS000215|
European Ancestry|
1,459 individuals
PGP000056 |
Ho-Le TP et al. J Bone Miner Res (2016)
Reported Trait: Vertebral fracture HR: 1.24 [1.0, 1.54] Age, sex, prior fracture or fall
PPM000361 PGS000121
(2018_BMD62_GRS.FN)
PSS000213|
European Ancestry|
1,459 individuals
PGP000056 |
Ho-Le TP et al. J Bone Miner Res (2016)
Reported Trait: Hip fracture HR: 1.19 [0.91, 1.57] Age, sex, prior fracture or fall
PPM000353 PGS000121
(2018_BMD62_GRS.FN)
PSS000214|
European Ancestry|
1,459 individuals
PGP000056 |
Ho-Le TP et al. J Bone Miner Res (2016)
Reported Trait: Total fracture HR: 1.18 [1.03, 1.36] Age, sex, prior fracture or fall
PPM000370 PGS000121
(2018_BMD62_GRS.FN)
PSS000215|
European Ancestry|
1,459 individuals
PGP000056 |
Ho-Le TP et al. J Bone Miner Res (2016)
Reported Trait: Vertebral fracture HR: 1.14 [0.92, 1.42] Age, sex, prior fracture or fall, femoral neck bone mineral density
PPM000372 PGS000122
(2018_BMD33_GRS.FN)
PSS000215|
European Ancestry|
1,459 individuals
PGP000056 |
Ho-Le TP et al. J Bone Miner Res (2016)
Reported Trait: Vertebral fracture HR: 1.36 [1.04, 1.78] Age
PPM000380 PGS000122
(2018_BMD33_GRS.FN)
PSS000216|
European Ancestry|
1,459 individuals
PGP000056 |
Ho-Le TP et al. J Bone Miner Res (2016)
Reported Trait: Wrist fracture HR: 1.62 [1.08, 2.43] Age
PPM000374 PGS000122
(2018_BMD33_GRS.FN)
PSS000215|
European Ancestry|
1,459 individuals
PGP000056 |
Ho-Le TP et al. J Bone Miner Res (2016)
Reported Trait: Vertebral fracture HR: 1.28 [0.97, 1.68] Age, sex, prior fracture or fall, femoral neck bone mineral density
PPM000364 PGS000122
(2018_BMD33_GRS.FN)
PSS000213|
European Ancestry|
1,459 individuals
PGP000056 |
Ho-Le TP et al. J Bone Miner Res (2016)
Reported Trait: Hip fracture HR: 1.11 [0.78, 1.57] Age
PPM000356 PGS000122
(2018_BMD33_GRS.FN)
PSS000214|
European Ancestry|
1,459 individuals
PGP000056 |
Ho-Le TP et al. J Bone Miner Res (2016)
Reported Trait: Total fracture HR: 1.26 [1.06, 1.5] Age
PPM000366 PGS000122
(2018_BMD33_GRS.FN)
PSS000213|
European Ancestry|
1,459 individuals
PGP000056 |
Ho-Le TP et al. J Bone Miner Res (2016)
Reported Trait: Hip fracture HR: 1.01 [0.65, 1.35] Age, sex, prior fracture or fall, femoral neck bone mineral density
PPM000358 PGS000122
(2018_BMD33_GRS.FN)
PSS000214|
European Ancestry|
1,459 individuals
PGP000056 |
Ho-Le TP et al. J Bone Miner Res (2016)
Reported Trait: Total fracture HR: 1.23 [1.02, 1.46] Age, sex, prior fracture or fall, femoral neck bone mineral density
PPM000371 PGS000122
(2018_BMD33_GRS.FN)
PSS000215|
European Ancestry|
1,459 individuals
PGP000056 |
Ho-Le TP et al. J Bone Miner Res (2016)
Reported Trait: Vertebral fracture HR: 1.39 [1.06, 1.82]
PPM000363 PGS000122
(2018_BMD33_GRS.FN)
PSS000213|
European Ancestry|
1,459 individuals
PGP000056 |
Ho-Le TP et al. J Bone Miner Res (2016)
Reported Trait: Hip fracture HR: 1.09 [0.77, 1.54]
PPM000355 PGS000122
(2018_BMD33_GRS.FN)
PSS000214|
European Ancestry|
1,459 individuals
PGP000056 |
Ho-Le TP et al. J Bone Miner Res (2016)
Reported Trait: Total fracture HR: 1.26 [1.06, 1.5]
PPM000379 PGS000122
(2018_BMD33_GRS.FN)
PSS000216|
European Ancestry|
1,459 individuals
PGP000056 |
Ho-Le TP et al. J Bone Miner Res (2016)
Reported Trait: Wrist fracture HR: 1.65 [1.09, 2.48]
PPM000381 PGS000122
(2018_BMD33_GRS.FN)
PSS000216|
European Ancestry|
1,459 individuals
PGP000056 |
Ho-Le TP et al. J Bone Miner Res (2016)
Reported Trait: Wrist fracture HR: 1.6 [1.06, 2.4] Age, sex, prior fracture or fall
PPM000373 PGS000122
(2018_BMD33_GRS.FN)
PSS000215|
European Ancestry|
1,459 individuals
PGP000056 |
Ho-Le TP et al. J Bone Miner Res (2016)
Reported Trait: Vertebral fracture HR: 1.35 [1.03, 1.78] Age, sex, prior fracture or fall
PPM000365 PGS000122
(2018_BMD33_GRS.FN)
PSS000213|
European Ancestry|
1,459 individuals
PGP000056 |
Ho-Le TP et al. J Bone Miner Res (2016)
Reported Trait: Hip fracture HR: 1.06 [0.74, 1.51] Age, sex, prior fracture or fall
PPM000357 PGS000122
(2018_BMD33_GRS.FN)
PSS000214|
European Ancestry|
1,459 individuals
PGP000056 |
Ho-Le TP et al. J Bone Miner Res (2016)
Reported Trait: Total fracture HR: 1.24 [1.04, 1.47] Age, sex, prior fracture or fall
PPM000382 PGS000122
(2018_BMD33_GRS.FN)
PSS000216|
European Ancestry|
1,459 individuals
PGP000056 |
Ho-Le TP et al. J Bone Miner Res (2016)
Reported Trait: Wrist fracture HR: 1.53 [1.01, 2.31] Age, sex, prior fracture or fall, femoral neck bone mineral density
PPM013129 PGS002315
(bmd_HEEL_TSCOREz.BOLT-LMM)
PSS009704|
East Asian Ancestry|
889 individuals
PGP000332 |
Weissbrod O et al. Nat Genet (2022)
Reported Trait: Bone Mineral Density Incremental R2 (full model vs. covariates alone): 0.087 age, sex, age*sex, assessment center, genotyping array, 10 PCs
PPM013080 PGS002315
(bmd_HEEL_TSCOREz.BOLT-LMM)
PSS009703|
African Ancestry|
5,639 individuals
PGP000332 |
Weissbrod O et al. Nat Genet (2022)
Reported Trait: Bone Mineral Density Incremental R2 (full model vs. covariates alone): 0.0299 age, sex, age*sex, assessment center, genotyping array, 10 PCs
PPM013178 PGS002315
(bmd_HEEL_TSCOREz.BOLT-LMM)
PSS009705|
European Ancestry|
42,030 individuals
PGP000332 |
Weissbrod O et al. Nat Genet (2022)
Reported Trait: Bone Mineral Density Incremental R2 (full model vs. covariates alone): 0.2324 age, sex, age*sex, assessment center, genotyping array, 10 PCs
PPM013227 PGS002315
(bmd_HEEL_TSCOREz.BOLT-LMM)
PSS009706|
South Asian Ancestry|
7,588 individuals
PGP000332 |
Weissbrod O et al. Nat Genet (2022)
Reported Trait: Bone Mineral Density Incremental R2 (full model vs. covariates alone): 0.1529 age, sex, age*sex, assessment center, genotyping array, 10 PCs
PPM013368 PGS002387
(bmd_HEEL_TSCOREz.P+T.0.0001)
PSS009703|
African Ancestry|
5,639 individuals
PGP000332 |
Weissbrod O et al. Nat Genet (2022)
Reported Trait: Bone Mineral Density Incremental R2 (full model vs. covariates alone): 0.0014 age, sex, age*sex, assessment center, genotyping array, 10 PCs
PPM013417 PGS002387
(bmd_HEEL_TSCOREz.P+T.0.0001)
PSS009704|
East Asian Ancestry|
889 individuals
PGP000332 |
Weissbrod O et al. Nat Genet (2022)
Reported Trait: Bone Mineral Density Incremental R2 (full model vs. covariates alone): 0.0509 age, sex, age*sex, assessment center, genotyping array, 10 PCs
PPM013515 PGS002387
(bmd_HEEL_TSCOREz.P+T.0.0001)
PSS009706|
South Asian Ancestry|
7,588 individuals
PGP000332 |
Weissbrod O et al. Nat Genet (2022)
Reported Trait: Bone Mineral Density Incremental R2 (full model vs. covariates alone): 0.0961 age, sex, age*sex, assessment center, genotyping array, 10 PCs
PPM013466 PGS002387
(bmd_HEEL_TSCOREz.P+T.0.0001)
PSS009705|
European Ancestry|
42,030 individuals
PGP000332 |
Weissbrod O et al. Nat Genet (2022)
Reported Trait: Bone Mineral Density Incremental R2 (full model vs. covariates alone): 0.1523 age, sex, age*sex, assessment center, genotyping array, 10 PCs
PPM013564 PGS002436
(bmd_HEEL_TSCOREz.P+T.0.001)
PSS009703|
African Ancestry|
5,639 individuals
PGP000332 |
Weissbrod O et al. Nat Genet (2022)
Reported Trait: Bone Mineral Density Incremental R2 (full model vs. covariates alone): 0.0008 age, sex, age*sex, assessment center, genotyping array, 10 PCs
PPM013613 PGS002436
(bmd_HEEL_TSCOREz.P+T.0.001)
PSS009704|
East Asian Ancestry|
889 individuals
PGP000332 |
Weissbrod O et al. Nat Genet (2022)
Reported Trait: Bone Mineral Density Incremental R2 (full model vs. covariates alone): 0.0318 age, sex, age*sex, assessment center, genotyping array, 10 PCs
PPM013662 PGS002436
(bmd_HEEL_TSCOREz.P+T.0.001)
PSS009705|
European Ancestry|
42,030 individuals
PGP000332 |
Weissbrod O et al. Nat Genet (2022)
Reported Trait: Bone Mineral Density Incremental R2 (full model vs. covariates alone): 0.1546 age, sex, age*sex, assessment center, genotyping array, 10 PCs
PPM013711 PGS002436
(bmd_HEEL_TSCOREz.P+T.0.001)
PSS009706|
South Asian Ancestry|
7,588 individuals
PGP000332 |
Weissbrod O et al. Nat Genet (2022)
Reported Trait: Bone Mineral Density Incremental R2 (full model vs. covariates alone): 0.0589 age, sex, age*sex, assessment center, genotyping array, 10 PCs
PPM013760 PGS002485
(bmd_HEEL_TSCOREz.P+T.0.01)
PSS009703|
African Ancestry|
5,639 individuals
PGP000332 |
Weissbrod O et al. Nat Genet (2022)
Reported Trait: Bone Mineral Density Incremental R2 (full model vs. covariates alone): 0.0001 age, sex, age*sex, assessment center, genotyping array, 10 PCs
PPM013809 PGS002485
(bmd_HEEL_TSCOREz.P+T.0.01)
PSS009704|
East Asian Ancestry|
889 individuals
PGP000332 |
Weissbrod O et al. Nat Genet (2022)
Reported Trait: Bone Mineral Density Incremental R2 (full model vs. covariates alone): 0.01 age, sex, age*sex, assessment center, genotyping array, 10 PCs
PPM013858 PGS002485
(bmd_HEEL_TSCOREz.P+T.0.01)
PSS009705|
European Ancestry|
42,030 individuals
PGP000332 |
Weissbrod O et al. Nat Genet (2022)
Reported Trait: Bone Mineral Density Incremental R2 (full model vs. covariates alone): 0.1186 age, sex, age*sex, assessment center, genotyping array, 10 PCs
PPM013907 PGS002485
(bmd_HEEL_TSCOREz.P+T.0.01)
PSS009706|
South Asian Ancestry|
7,588 individuals
PGP000332 |
Weissbrod O et al. Nat Genet (2022)
Reported Trait: Bone Mineral Density Incremental R2 (full model vs. covariates alone): 0.0253 age, sex, age*sex, assessment center, genotyping array, 10 PCs
PPM013956 PGS002534
(bmd_HEEL_TSCOREz.P+T.1e-06)
PSS009703|
African Ancestry|
5,639 individuals
PGP000332 |
Weissbrod O et al. Nat Genet (2022)
Reported Trait: Bone Mineral Density Incremental R2 (full model vs. covariates alone): 0.0195 age, sex, age*sex, assessment center, genotyping array, 10 PCs
PPM014005 PGS002534
(bmd_HEEL_TSCOREz.P+T.1e-06)
PSS009704|
East Asian Ancestry|
889 individuals
PGP000332 |
Weissbrod O et al. Nat Genet (2022)
Reported Trait: Bone Mineral Density Incremental R2 (full model vs. covariates alone): 0.046 age, sex, age*sex, assessment center, genotyping array, 10 PCs
PPM014054 PGS002534
(bmd_HEEL_TSCOREz.P+T.1e-06)
PSS009705|
European Ancestry|
42,030 individuals
PGP000332 |
Weissbrod O et al. Nat Genet (2022)
Reported Trait: Bone Mineral Density Incremental R2 (full model vs. covariates alone): 0.1395 age, sex, age*sex, assessment center, genotyping array, 10 PCs
PPM014103 PGS002534
(bmd_HEEL_TSCOREz.P+T.1e-06)
PSS009706|
South Asian Ancestry|
7,588 individuals
PGP000332 |
Weissbrod O et al. Nat Genet (2022)
Reported Trait: Bone Mineral Density Incremental R2 (full model vs. covariates alone): 0.0891 age, sex, age*sex, assessment center, genotyping array, 10 PCs
PPM014152 PGS002583
(bmd_HEEL_TSCOREz.P+T.5e-08)
PSS009703|
African Ancestry|
5,639 individuals
PGP000332 |
Weissbrod O et al. Nat Genet (2022)
Reported Trait: Bone Mineral Density Incremental R2 (full model vs. covariates alone): 0.0203 age, sex, age*sex, assessment center, genotyping array, 10 PCs
PPM014201 PGS002583
(bmd_HEEL_TSCOREz.P+T.5e-08)
PSS009704|
East Asian Ancestry|
889 individuals
PGP000332 |
Weissbrod O et al. Nat Genet (2022)
Reported Trait: Bone Mineral Density Incremental R2 (full model vs. covariates alone): 0.0426 age, sex, age*sex, assessment center, genotyping array, 10 PCs
PPM014250 PGS002583
(bmd_HEEL_TSCOREz.P+T.5e-08)
PSS009705|
European Ancestry|
42,030 individuals
PGP000332 |
Weissbrod O et al. Nat Genet (2022)
Reported Trait: Bone Mineral Density Incremental R2 (full model vs. covariates alone): 0.1328 age, sex, age*sex, assessment center, genotyping array, 10 PCs
PPM014299 PGS002583
(bmd_HEEL_TSCOREz.P+T.5e-08)
PSS009706|
South Asian Ancestry|
7,588 individuals
PGP000332 |
Weissbrod O et al. Nat Genet (2022)
Reported Trait: Bone Mineral Density Incremental R2 (full model vs. covariates alone): 0.0836 age, sex, age*sex, assessment center, genotyping array, 10 PCs
PPM014348 PGS002632
(bmd_HEEL_TSCOREz.PolyFun-pred)
PSS009703|
African Ancestry|
5,639 individuals
PGP000332 |
Weissbrod O et al. Nat Genet (2022)
Reported Trait: Bone Mineral Density Incremental R2 (full model when combined with BOLT-LMM vs. covariates alone): 0.0416 age, sex, age*sex, assessment center, genotyping array, 10 PCs See bmd_HEEL_TSCOREz.mixweights file at http://data.broadinstitute.org/alkesgroup/polypred_results for combination weights
PPM014397 PGS002632
(bmd_HEEL_TSCOREz.PolyFun-pred)
PSS009704|
East Asian Ancestry|
889 individuals
PGP000332 |
Weissbrod O et al. Nat Genet (2022)
Reported Trait: Bone Mineral Density Incremental R2 (full model when combined with BOLT-LMM vs. covariates alone): 0.0991 age, sex, age*sex, assessment center, genotyping array, 10 PCs See bmd_HEEL_TSCOREz.mixweights file at http://data.broadinstitute.org/alkesgroup/polypred_results for combination weights
PPM014446 PGS002632
(bmd_HEEL_TSCOREz.PolyFun-pred)
PSS009705|
European Ancestry|
42,030 individuals
PGP000332 |
Weissbrod O et al. Nat Genet (2022)
Reported Trait: Bone Mineral Density Incremental R2 (full model when combined with BOLT-LMM vs. covariates alone): 0.2504 age, sex, age*sex, assessment center, genotyping array, 10 PCs See bmd_HEEL_TSCOREz.mixweights file at http://data.broadinstitute.org/alkesgroup/polypred_results for combination weights
PPM014495 PGS002632
(bmd_HEEL_TSCOREz.PolyFun-pred)
PSS009706|
South Asian Ancestry|
7,588 individuals
PGP000332 |
Weissbrod O et al. Nat Genet (2022)
Reported Trait: Bone Mineral Density Incremental R2 (full model when combined with BOLT-LMM vs. covariates alone): 0.1707 age, sex, age*sex, assessment center, genotyping array, 10 PCs See bmd_HEEL_TSCOREz.mixweights file at http://data.broadinstitute.org/alkesgroup/polypred_results for combination weights
PPM014544 PGS002681
(bmd_HEEL_TSCOREz.SBayesR)
PSS009703|
African Ancestry|
5,639 individuals
PGP000332 |
Weissbrod O et al. Nat Genet (2022)
Reported Trait: Bone Mineral Density Incremental R2 (full model vs. covariates alone): 0.0298 age, sex, age*sex, assessment center, genotyping array, 10 PCs
PPM014593 PGS002681
(bmd_HEEL_TSCOREz.SBayesR)
PSS009704|
East Asian Ancestry|
889 individuals
PGP000332 |
Weissbrod O et al. Nat Genet (2022)
Reported Trait: Bone Mineral Density Incremental R2 (full model vs. covariates alone): 0.0805 age, sex, age*sex, assessment center, genotyping array, 10 PCs
PPM014642 PGS002681
(bmd_HEEL_TSCOREz.SBayesR)
PSS009705|
European Ancestry|
42,030 individuals
PGP000332 |
Weissbrod O et al. Nat Genet (2022)
Reported Trait: Bone Mineral Density Incremental R2 (full model vs. covariates alone): 0.228 age, sex, age*sex, assessment center, genotyping array, 10 PCs
PPM014691 PGS002681
(bmd_HEEL_TSCOREz.SBayesR)
PSS009706|
South Asian Ancestry|
7,588 individuals
PGP000332 |
Weissbrod O et al. Nat Genet (2022)
Reported Trait: Bone Mineral Density Incremental R2 (full model vs. covariates alone): 0.1583 age, sex, age*sex, assessment center, genotyping array, 10 PCs

Evaluated Samples

PGS Sample Set ID
(PSS)
Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS000212 902 individuals,
0.0 % Male samples
Mean = 70.1 years
Sd = 7.0 years
European DOES
PSS000212 557 individuals,
100.0 % Male samples
Mean = 69.5 years
Sd = 5.9 years
European DOES
PSS000213
[
  • 95 cases
  • , 807 controls
]
,
0.0 % Male samples
Mean = 70.1 years
Sd = 7.0 years
European DOES
PSS000213
[
  • 135 cases
  • , 422 controls
]
,
100.0 % Male samples
Mean = 69.5 years
Sd = 5.9 years
European DOES
PSS000214
[
  • 395 cases
  • , 507 controls
]
,
0.0 % Male samples
Mean = 70.1 years
Sd = 7.0 years
European DOES
PSS000214
[
  • 135 cases
  • , 422 controls
]
,
100.0 % Male samples
Mean = 69.5 years
Sd = 5.9 years
European DOES
PSS000215
[
  • 166 cases
  • , 736 controls
]
,
0.0 % Male samples
Mean = 70.1 years
Sd = 7.0 years
European DOES
PSS000215
[
  • 53 cases
  • , 504 controls
]
,
100.0 % Male samples
Mean = 69.5 years
Sd = 5.9 years
European DOES
PSS000216
[
  • 103 cases
  • , 799 controls
]
,
0.0 % Male samples
Mean = 70.1 years
Sd = 7.0 years
European DOES
PSS000216
[
  • 9 cases
  • , 548 controls
]
,
100.0 % Male samples
Mean = 69.5 years
Sd = 5.9 years
European DOES
PSS009703 5,639 individuals African unspecified UKB
PSS009704 889 individuals East Asian UKB
PSS009705 42,030 individuals European Non-British European UKB
PSS009706 7,588 individuals South Asian UKB