PGS Publication: PGP000077

Publication Information (EuropePMC)
Title Family history and polygenic risk of cardiovascular disease: Independent factors associated with secondary cardiovascular events in patients undergoing carotid endarterectomy.
PubMed ID 32624175(Europe PMC)
doi 10.1016/j.atherosclerosis.2020.04.013
Publication Date May 3, 2020
Journal Atherosclerosis
Author(s) Timmerman N, de Kleijn DPV, de Borst GJ, den Ruijter HM, Asselbergs FW, Pasterkamp G, Haitjema S, van der Laan SW.
Released in PGS Catalog: April 29, 2020

Associated Polygenic Score(s)

Filter PGS by Participant Ancestry
Individuals included in:
G - Source of Variant Associations (GWAS)
D - Score Development/Training
E - PGS Evaluation
List of ancestries includes:
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Ancestry legend
Multi-ancestry (including European)
Multi-ancestry (excluding European)
African
East Asian
South Asian
Additional Asian Ancestries
European
Greater Middle Eastern
Hispanic or Latin American
Additional Diverse Ancestries
Not Reported

External PGS Evaluated By This Publication

Polygenic Score ID & Name PGS Publication ID (PGP) Reported Trait Mapped Trait(s) (Ontology) Number of Variants Ancestry distribution
GWAS
Dev
Eval
 Scoring File (FTP Link)
PGS000018
(metaGRS_CAD)
 PGP000007 |
Inouye M et al. J Am Coll Cardiol (2018)
 Coronary artery disease coronary artery disease 1,745,179
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000018/ScoringFiles/PGS000018.txt.gz

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		Evaluated Score PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM000518 PGS000018
(metaGRS_CAD)
 PSS000287|
European Ancestry|
1,319 individuals
 PGP000077 |
Timmerman N et al. Atherosclerosis (2020)
|Ext.		 Reported Trait: Plaque vulnerability score β: 0.07 [0.003, 0.137] — — Age, sex, surgery year, type of cerebrovascular symptoms, array, 4 genetic PCs —
PPM000517 PGS000018
(metaGRS_CAD)
 PSS000287|
European Ancestry|
1,319 individuals
 PGP000077 |
Timmerman N et al. Atherosclerosis (2020)
|Ext.		 Reported Trait: Microvessels β: 0.037 [-0.006, 0.08] — — Age, sex, surgery year, type of cerebrovascular symptoms, array, 4 genetic PCs —
PPM000516 PGS000018
(metaGRS_CAD)
 PSS000287|
European Ancestry|
1,319 individuals
 PGP000077 |
Timmerman N et al. Atherosclerosis (2020)
|Ext.		 Reported Trait: Number of smoooth muscle cells β: -0.004 [-0.038, 0.031] — — Age, sex, surgery year, type of cerebrovascular symptoms, array, 4 genetic PCs —
PPM000515 PGS000018
(metaGRS_CAD)
 PSS000287|
European Ancestry|
1,319 individuals
 PGP000077 |
Timmerman N et al. Atherosclerosis (2020)
|Ext.		 Reported Trait: Number of macrophages β: 0.01 [-0.015, 0.036] — — Age, sex, surgery year, type of cerebrovascular symptoms, array, 4 genetic PCs —
PPM000514 PGS000018
(metaGRS_CAD)
 PSS000287|
European Ancestry|
1,319 individuals
 PGP000077 |
Timmerman N et al. Atherosclerosis (2020)
|Ext.		 Reported Trait: Moderate/heavy macrophages OR: 1.103 [0.983, 1.237] — — Age, sex, surgery year, type of cerebrovascular symptoms, array, 4 genetic PCs —
PPM000513 PGS000018
(metaGRS_CAD)
 PSS000287|
European Ancestry|
1,319 individuals
 PGP000077 |
Timmerman N et al. Atherosclerosis (2020)
|Ext.		 Reported Trait: Moderate/heavy smooth muscle cells OR: 1.004 [0.88, 1.145] — — Age, sex, surgery year, type of cerebrovascular symptoms, array, 4 genetic PCs —
PPM000512 PGS000018
(metaGRS_CAD)
 PSS000287|
European Ancestry|
1,319 individuals
 PGP000077 |
Timmerman N et al. Atherosclerosis (2020)
|Ext.		 Reported Trait: Presence of IPH OR: 1.126 [0.999, 1.27] — — Age, sex, surgery year, type of cerebrovascular symptoms, array, 4 genetic PCs —
PPM000511 PGS000018
(metaGRS_CAD)
 PSS000287|
European Ancestry|
1,319 individuals
 PGP000077 |
Timmerman N et al. Atherosclerosis (2020)
|Ext.		 Reported Trait: Presence of lipid core >10% OR: 1.171 [1.026, 1.337] — — Age, sex, surgery year, type of cerebrovascular symptoms, array, 4 genetic PCs —
PPM000510 PGS000018
(metaGRS_CAD)
 PSS000287|
European Ancestry|
1,319 individuals
 PGP000077 |
Timmerman N et al. Atherosclerosis (2020)
|Ext.		 Reported Trait: Moderate/heavy collagen OR: 1.064 [0.919, 1.231] — — Age, sex, surgery year, type of cerebrovascular symptoms, array, 4 genetic PCs —
PPM000509 PGS000018
(metaGRS_CAD)
 PSS000287|
European Ancestry|
1,319 individuals
 PGP000077 |
Timmerman N et al. Atherosclerosis (2020)
|Ext.		 Reported Trait: Moderate/heavy calficiations OR: 0.94 [0.826, 1.07] — — Age, sex, surgery year, type of cerebrovascular symptoms, array, 4 genetic PCs —
PPM000508 PGS000018
(metaGRS_CAD)
 PSS000287|
European Ancestry|
1,319 individuals
 PGP000077 |
Timmerman N et al. Atherosclerosis (2020)
|Ext.		 Reported Trait: Plaque vulnerability score OR: 0.198 [0.003, 0.364] — — Age, sex, surgery year, type of cerebrovascular symptoms, array, 4 genetic PCs —
PPM000507 PGS000018
(metaGRS_CAD)
 PSS000287|
European Ancestry|
1,319 individuals
 PGP000077 |
Timmerman N et al. Atherosclerosis (2020)
|Ext.		 Reported Trait: Microvessels — — Beta (top 20% vs. rest): 0.072 [-0.037, 0.182] Age, sex, surgery year, type of cerebrovascular symptoms, array, 4 genetic PCs —
PPM000506 PGS000018
(metaGRS_CAD)
 PSS000287|
European Ancestry|
1,319 individuals
 PGP000077 |
Timmerman N et al. Atherosclerosis (2020)
|Ext.		 Reported Trait: Number of smoooth muscle cells — — Beta (top 20% vs. rest): -0.056 [-0.143, 0.031] Age, sex, surgery year, type of cerebrovascular symptoms, array, 4 genetic PCs —
PPM000505 PGS000018
(metaGRS_CAD)
 PSS000287|
European Ancestry|
1,319 individuals
 PGP000077 |
Timmerman N et al. Atherosclerosis (2020)
|Ext.		 Reported Trait: Number of macrophages — — Beta (top 20% vs. rest): 0.55 [-0.012, 0.121] Age, sex, surgery year, type of cerebrovascular symptoms, array, 4 genetic PCs —
PPM000504 PGS000018
(metaGRS_CAD)
 PSS000287|
European Ancestry|
1,319 individuals
 PGP000077 |
Timmerman N et al. Atherosclerosis (2020)
|Ext.		 Reported Trait: Moderate/heavy macrophages — — Odds Ratio (OR; top 20% vs. rest): 1.49 [1.118, 1.986] Age, sex, surgery year, type of cerebrovascular symptoms, array, 4 genetic PCs —
PPM000503 PGS000018
(metaGRS_CAD)
 PSS000287|
European Ancestry|
1,319 individuals
 PGP000077 |
Timmerman N et al. Atherosclerosis (2020)
|Ext.		 Reported Trait: Moderate/heavy smooth muscle cells — — Odds Ratio (OR; top 20% vs. rest): 0.908 [0.652, 1.265] Age, sex, surgery year, type of cerebrovascular symptoms, array, 4 genetic PCs —
PPM000502 PGS000018
(metaGRS_CAD)
 PSS000287|
European Ancestry|
1,319 individuals
 PGP000077 |
Timmerman N et al. Atherosclerosis (2020)
|Ext.		 Reported Trait: Presence of IPH — — Odds Ratio (OR; top 20% vs. rest): 1.112 [0.821, 1.506] Age, sex, surgery year, type of cerebrovascular symptoms, array, 4 genetic PCs —
PPM000501 PGS000018
(metaGRS_CAD)
 PSS000287|
European Ancestry|
1,319 individuals
 PGP000077 |
Timmerman N et al. Atherosclerosis (2020)
|Ext.		 Reported Trait: Presence of lipid core >10% — — Odds Ratio (OR; top 20% vs. rest): 1.591 [1.105, 2.291] Age, sex, surgery year, type of cerebrovascular symptoms, array, 4 genetic PCs —
PPM000500 PGS000018
(metaGRS_CAD)
 PSS000287|
European Ancestry|
1,319 individuals
 PGP000077 |
Timmerman N et al. Atherosclerosis (2020)
|Ext.		 Reported Trait: Moderate/heavy collagen — — Odds Ratio (OR; top 20% vs. rest): 1.091 [0.755, 1.577] Age, sex, surgery year, type of cerebrovascular symptoms, array, 4 genetic PCs —
PPM000499 PGS000018
(metaGRS_CAD)
 PSS000287|
European Ancestry|
1,319 individuals
 PGP000077 |
Timmerman N et al. Atherosclerosis (2020)
|Ext.		 Reported Trait: Moderate/heavy calficiations — — Odds Ratio (OR; top 20% vs. rest): 1.001 [0.754, 1.33] Age, sex, surgery year, type of cerebrovascular symptoms, array, 4 genetic PCs —
PPM000498 PGS000018
(metaGRS_CAD)
 PSS000287|
European Ancestry|
1,319 individuals
 PGP000077 |
Timmerman N et al. Atherosclerosis (2020)
|Ext.		 Reported Trait: Secondary cardiovascular events HR: 1.15 [1.02, 1.29] — — Age, sex, diabetes, BMI, smoking, hypercholesterolemia, array, 4 genetics PCs —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS000287 (i) Secondary cardiovascular events (sCVE; incl myocardial infarction, stroke, ruptured abdominal aortic aneurysm, fatal cardiac failure, percuteneous of bypass surgery, leg amputation due to cardiovascular causes, cardiovascular death), (ii) atherosclerotic carotid plaque characteristics Mean = 3.0 years 1,319 individuals,
69.3 % Male samples
 Mean = 68.8 years
Sd = 9.3 years		 European
(Dutch)		 — AEGS1 —