PGS Publication: PGP000087

Publication Information (EuropePMC)
Title A cumulative genetic risk score predicts progression in Parkinson's disease.
PubMed ID 26853697(Europe PMC)
doi 10.1002/mds.26505
Publication Date Feb. 8, 2016
Journal Mov Disord
Author(s) Pihlstrøm L, Morset KR, Grimstad E, Vitelli V, Toft M.
Released in PGS Catalog: July 1, 2020

Associated Polygenic Score(s)

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Individuals included in:
G - Source of Variant Associations (GWAS)
D - Score Development/Training
E - PGS Evaluation
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Not Reported

PGS Developed By This Publication

Polygenic Score ID & Name PGS Publication ID (PGP) Reported Trait Mapped Trait(s) (Ontology) Number of Variants Ancestry distribution
GWAS
Dev
Eval
 Scoring File (FTP Link)
PGS000211
(PD19)
 PGP000087 |
Pihlstrøm L et al. Mov Disord (2016)
 Parkinson's disease Parkinson disease 19
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000211/ScoringFiles/PGS000211.txt.gz

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		Evaluated Score PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM000648 PGS000211
(PD19)
 PSS000358|
European Ancestry|
336 individuals
 PGP000087 |
Pihlstrøm L et al. Mov Disord (2016)
 Reported Trait: Motor decline (time to Hoehn & Yahr ≥ 3) HR: 1.29 [1.06, 1.56] — — sex, age at diagnosis —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS000358 UPDRS motor severity was estimated as a mean value acrosseach patient’s recordings, relative to the rest of the data Mean = 5946.0 days
Sd = 2299.0 days
Range = [1574.0, 13992.0] days
[
  • 336 cases
  • , 0 controls
]
,
66.0 % Male samples
 Range = [35.0, 85.0] years European — NR Testing dataset genotyped as part of a larger study of a total of 1380 patients with idiopathic PD and 1295 control subjects by 5 collaborating groups in Norway and Sweden. (https://www.sciencedirect.com/science/article/abs/pii/S0197458012005301?showall%3Dtrue%26via%3Dihub)