PGS Publication: PGP000141

Publication Information (EuropePMC)
Title Genetic associations with temporal shifts in obesity and severe obesity during the obesity epidemic in Norway: A longitudinal population-based cohort (the HUNT Study).
PubMed ID 33315864(Europe PMC)
doi 10.1371/journal.pmed.1003452
Publication Date Dec. 14, 2020
Journal PLoS Med
Author(s) Brandkvist M, Bjørngaard JH, Ødegård RA, Brumpton B, Smith GD, Åsvold BO, Sund ER, Kvaløy K, Willer CJ, Vie GÅ.
Released in PGS Catalog: Feb. 23, 2021

Associated Polygenic Score(s)

Filter PGS by Participant Ancestry
Individuals included in:
G - Source of Variant Associations (GWAS)
D - Score Development/Training
E - PGS Evaluation
List of ancestries includes:
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Additional Diverse Ancestries
Not Reported

External PGS Evaluated By This Publication

Polygenic Score ID & Name PGS Publication ID (PGP) Reported Trait Mapped Trait(s) (Ontology) Number of Variants Ancestry distribution
GWAS
Dev
Eval
 Scoring File (FTP Link)
PGS000027
(GPS_BMI)
 PGP000017 |
Khera AV et al. Cell (2019)
 Body mass index (BMI) body mass index 2,100,302
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000027/ScoringFiles/PGS000027.txt.gz - Check Terms/Licenses

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		Evaluated Score PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM001725 PGS000027
(GPS_BMI)
 PSS000885|
European Ancestry|
19,588 individuals
 PGP000141 |
Brandkvist M et al. PLoS Med (2020)
|Ext.		 Reported Trait: Obesity between male siblings OR: 2.21 [1.92, 2.54] — — Sex, time of measurement, age, PCs (1-20), genotyping batch 2.07 million of the 2.1 milliion common variants (excluding those with insufficient quality of genotyping or imputation (r^2 < 0.8) in the HUNT cohort) were included in the polygenic score previously developed by Khera et al (2019).
PPM001726 PGS000027
(GPS_BMI)
 PSS000886|
European Ancestry|
21,499 individuals
 PGP000141 |
Brandkvist M et al. PLoS Med (2020)
|Ext.		 Reported Trait: Obesity within female siblings OR: 2.09 [1.74, 2.51] — — Sex, time of measurement, age, PCs (1-20), genotyping batch 2.07 million of the 2.1 milliion common variants (excluding those with insufficient quality of genotyping or imputation (r^2 < 0.8) in the HUNT cohort) were included in the polygenic score previously developed by Khera et al (2019).
PPM001727 PGS000027
(GPS_BMI)
 PSS000886|
European Ancestry|
21,499 individuals
 PGP000141 |
Brandkvist M et al. PLoS Med (2020)
|Ext.		 Reported Trait: Obesity between female siblings OR: 2.13 [1.87, 2.43] — — Sex, time of measurement, age, PCs (1-20), genotyping batch 2.07 million of the 2.1 milliion common variants (excluding those with insufficient quality of genotyping or imputation (r^2 < 0.8) in the HUNT cohort) were included in the polygenic score previously developed by Khera et al (2019).
PPM001728 PGS000027
(GPS_BMI)
 PSS000887|
European Ancestry|
26,323 individuals
 PGP000141 |
Brandkvist M et al. PLoS Med (2020)
|Ext.		 Reported Trait: Obesity within male siblings OR: 2.15 [1.91, 2.41] — — Sex, time of measurement, age, PCs (1-20), genotyping batch 2.07 million of the 2.1 milliion common variants (excluding those with insufficient quality of genotyping or imputation (r^2 < 0.8) in the HUNT cohort) were included in the polygenic score previously developed by Khera et al (2019).
PPM001730 PGS000027
(GPS_BMI)
 PSS000888|
European Ancestry|
29,527 individuals
 PGP000141 |
Brandkvist M et al. PLoS Med (2020)
|Ext.		 Reported Trait: Obesity within female siblings OR: 1.87 [1.68, 2.09] — — Sex, time of measurement, age, PCs (1-20), genotyping batch 2.07 million of the 2.1 milliion common variants (excluding those with insufficient quality of genotyping or imputation (r^2 < 0.8) in the HUNT cohort) were included in the polygenic score previously developed by Khera et al (2019).
PPM001731 PGS000027
(GPS_BMI)
 PSS000888|
European Ancestry|
29,527 individuals
 PGP000141 |
Brandkvist M et al. PLoS Med (2020)
|Ext.		 Reported Trait: Obesity between female siblings OR: 2.05 [1.89, 2.22] — — Sex, time of measurement, age, PCs (1-20), genotyping batch 2.07 million of the 2.1 milliion common variants (excluding those with insufficient quality of genotyping or imputation (r^2 < 0.8) in the HUNT cohort) were included in the polygenic score previously developed by Khera et al (2019).
PPM001732 PGS000027
(GPS_BMI)
 PSS000889|
European Ancestry|
21,187 individuals
 PGP000141 |
Brandkvist M et al. PLoS Med (2020)
|Ext.		 Reported Trait: Obesity within male siblings OR: 2.0 [1.79, 2.23] — — Sex, time of measurement, age, PCs (1-20), genotyping batch 2.07 million of the 2.1 milliion common variants (excluding those with insufficient quality of genotyping or imputation (r^2 < 0.8) in the HUNT cohort) were included in the polygenic score previously developed by Khera et al (2019).
PPM001733 PGS000027
(GPS_BMI)
 PSS000889|
European Ancestry|
21,187 individuals
 PGP000141 |
Brandkvist M et al. PLoS Med (2020)
|Ext.		 Reported Trait: Obesity between male siblings OR: 2.12 [1.96, 2.3] — — Sex, time of measurement, age, PCs (1-20), genotyping batch 2.07 million of the 2.1 milliion common variants (excluding those with insufficient quality of genotyping or imputation (r^2 < 0.8) in the HUNT cohort) were included in the polygenic score previously developed by Khera et al (2019).
PPM001734 PGS000027
(GPS_BMI)
 PSS000890|
European Ancestry|
25,096 individuals
 PGP000141 |
Brandkvist M et al. PLoS Med (2020)
|Ext.		 Reported Trait: Obesity within female siblings OR: 2.0 [1.8, 2.21] — — Sex, time of measurement, age, PCs (1-20), genotyping batch 2.07 million of the 2.1 milliion common variants (excluding those with insufficient quality of genotyping or imputation (r^2 < 0.8) in the HUNT cohort) were included in the polygenic score previously developed by Khera et al (2019).
PPM001735 PGS000027
(GPS_BMI)
 PSS000890|
European Ancestry|
25,096 individuals
 PGP000141 |
Brandkvist M et al. PLoS Med (2020)
|Ext.		 Reported Trait: Obesity between female siblings OR: 2.03 [1.88, 2.19] — — Sex, time of measurement, age, PCs (1-20), genotyping batch 2.07 million of the 2.1 milliion common variants (excluding those with insufficient quality of genotyping or imputation (r^2 < 0.8) in the HUNT cohort) were included in the polygenic score previously developed by Khera et al (2019).
PPM001736 PGS000027
(GPS_BMI)
 PSS000891|
European Ancestry|
14,487 individuals
 PGP000141 |
Brandkvist M et al. PLoS Med (2020)
|Ext.		 Reported Trait: Obesity within male siblings OR: 1.9 [1.68, 2.14] — — Sex, time of measurement, age, PCs (1-20), genotyping batch 2.07 million of the 2.1 milliion common variants (excluding those with insufficient quality of genotyping or imputation (r^2 < 0.8) in the HUNT cohort) were included in the polygenic score previously developed by Khera et al (2019).
PPM001737 PGS000027
(GPS_BMI)
 PSS000891|
European Ancestry|
14,487 individuals
 PGP000141 |
Brandkvist M et al. PLoS Med (2020)
|Ext.		 Reported Trait: Obesity between male siblings OR: 2.0 [1.83, 2.19] — — Sex, time of measurement, age, PCs (1-20), genotyping batch 2.07 million of the 2.1 milliion common variants (excluding those with insufficient quality of genotyping or imputation (r^2 < 0.8) in the HUNT cohort) were included in the polygenic score previously developed by Khera et al (2019).
PPM001738 PGS000027
(GPS_BMI)
 PSS000892|
European Ancestry|
17,740 individuals
 PGP000141 |
Brandkvist M et al. PLoS Med (2020)
|Ext.		 Reported Trait: Obesity within female siblings OR: 1.72 [1.53, 1.93] — — Sex, time of measurement, age, PCs (1-20), genotyping batch 2.07 million of the 2.1 milliion common variants (excluding those with insufficient quality of genotyping or imputation (r^2 < 0.8) in the HUNT cohort) were included in the polygenic score previously developed by Khera et al (2019).
PPM001739 PGS000027
(GPS_BMI)
 PSS000892|
European Ancestry|
17,740 individuals
 PGP000141 |
Brandkvist M et al. PLoS Med (2020)
|Ext.		 Reported Trait: Obesity between female siblings OR: 1.89 [1.74, 2.05] — — Sex, time of measurement, age, PCs (1-20), genotyping batch 2.07 million of the 2.1 milliion common variants (excluding those with insufficient quality of genotyping or imputation (r^2 < 0.8) in the HUNT cohort) were included in the polygenic score previously developed by Khera et al (2019).
PPM001724 PGS000027
(GPS_BMI)
 PSS000885|
European Ancestry|
19,588 individuals
 PGP000141 |
Brandkvist M et al. PLoS Med (2020)
|Ext.		 Reported Trait: Obesity within male siblings OR: 2.02 [1.66, 2.46] — — Sex, time of measurement, age, PCs (1-20), genotyping batch 2.07 million of the 2.1 milliion common variants (excluding those with insufficient quality of genotyping or imputation (r^2 < 0.8) in the HUNT cohort) were included in the polygenic score previously developed by Khera et al (2019).
PPM001729 PGS000027
(GPS_BMI)
 PSS000887|
European Ancestry|
26,323 individuals
 PGP000141 |
Brandkvist M et al. PLoS Med (2020)
|Ext.		 Reported Trait: Obesity between male siblings OR: 2.15 [1.97, 2.34] — — Sex, time of measurement, age, PCs (1-20), genotyping batch 2.07 million of the 2.1 milliion common variants (excluding those with insufficient quality of genotyping or imputation (r^2 < 0.8) in the HUNT cohort) were included in the polygenic score previously developed by Khera et al (2019).

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS000892 Body mass index (BMI) measurements were standardized with weight measured to the nearest half kilogram with the participants wearing light clothes and no shoes, and height was measured to the nearest centimeter. BMI was calculated using the formula weight in kilograms per meter squared. As defined by the World Health Organization (WHO), the authors rrefer to overweight as having BMI greater than or equal to 25 and obesity as having BMI greater than or equal to 30. Severe obesity was defined as having BMI greater than or equal to 35. —
[
  • 17,740 cases
]
,
0.0 % Male samples
 Mean = 58.9 years
Sd = 11.9 years		 European — HUNT number o cases = number of observations (more than 1 pp)
PSS000885 Body mass index (BMI) measurements were standardized with weight measured to the nearest half kilogram with the participants wearing light clothes and no shoes, and height was measured to the nearest centimeter. BMI was calculated using the formula weight in kilograms per meter squared. As defined by the World Health Organization (WHO), the authors rrefer to overweight as having BMI greater than or equal to 25 and obesity as having BMI greater than or equal to 30. Severe obesity was defined as having BMI greater than or equal to 35. —
[
  • 19,588 cases
]
,
100.0 % Male samples
 Mean = 42.4 years
Sd = 12.6 years		 European — HUNT number o cases = number of observations (more than 1 pp)
PSS000886 Body mass index (BMI) measurements were standardized with weight measured to the nearest half kilogram with the participants wearing light clothes and no shoes, and height was measured to the nearest centimeter. BMI was calculated using the formula weight in kilograms per meter squared. As defined by the World Health Organization (WHO), the authors rrefer to overweight as having BMI greater than or equal to 25 and obesity as having BMI greater than or equal to 30. Severe obesity was defined as having BMI greater than or equal to 35. —
[
  • 21,499 cases
]
,
0.0 % Male samples
 Mean = 42.6 years
Sd = 12.8 years		 European — HUNT number o cases = number of observations (more than 1 pp)
PSS000887 Body mass index (BMI) measurements were standardized with weight measured to the nearest half kilogram with the participants wearing light clothes and no shoes, and height was measured to the nearest centimeter. BMI was calculated using the formula weight in kilograms per meter squared. As defined by the World Health Organization (WHO), the authors rrefer to overweight as having BMI greater than or equal to 25 and obesity as having BMI greater than or equal to 30. Severe obesity was defined as having BMI greater than or equal to 35. —
[
  • 26,336 cases
]
,
100.0 % Male samples
 Mean = 47.6 years
Sd = 16.1 years		 European — HUNT number o cases = number of observations (more than 1 pp)
PSS000888 Body mass index (BMI) measurements were standardized with weight measured to the nearest half kilogram with the participants wearing light clothes and no shoes, and height was measured to the nearest centimeter. BMI was calculated using the formula weight in kilograms per meter squared. As defined by the World Health Organization (WHO), the authors rrefer to overweight as having BMI greater than or equal to 25 and obesity as having BMI greater than or equal to 30. Severe obesity was defined as having BMI greater than or equal to 35. —
[
  • 29,545 cases
]
,
0.0 % Male samples
 Mean = 47.1 years
Sd = 16.5 years		 European — HUNT number o cases = number of observations (more than 1 pp)
PSS000889 Body mass index (BMI) measurements were standardized with weight measured to the nearest half kilogram with the participants wearing light clothes and no shoes, and height was measured to the nearest centimeter. BMI was calculated using the formula weight in kilograms per meter squared. As defined by the World Health Organization (WHO), the authors rrefer to overweight as having BMI greater than or equal to 25 and obesity as having BMI greater than or equal to 30. Severe obesity was defined as having BMI greater than or equal to 35. —
[
  • 21,192 cases
]
,
100.0 % Male samples
 Mean = 52.3 years
Sd = 14.5 years		 European — HUNT number o cases = number of observations (more than 1 pp)
PSS000890 Body mass index (BMI) measurements were standardized with weight measured to the nearest half kilogram with the participants wearing light clothes and no shoes, and height was measured to the nearest centimeter. BMI was calculated using the formula weight in kilograms per meter squared. As defined by the World Health Organization (WHO), the authors rrefer to overweight as having BMI greater than or equal to 25 and obesity as having BMI greater than or equal to 30. Severe obesity was defined as having BMI greater than or equal to 35. —
[
  • 25,108 cases
]
,
0.0 % Male samples
 Mean = 51.2 years
Sd = 15.0 years		 European — HUNT number o cases = number of observations (more than 1 pp)
PSS000891 Body mass index (BMI) measurements were standardized with weight measured to the nearest half kilogram with the participants wearing light clothes and no shoes, and height was measured to the nearest centimeter. BMI was calculated using the formula weight in kilograms per meter squared. As defined by the World Health Organization (WHO), the authors rrefer to overweight as having BMI greater than or equal to 25 and obesity as having BMI greater than or equal to 30. Severe obesity was defined as having BMI greater than or equal to 35. —
[
  • 14,487 cases
]
,
100.0 % Male samples
 Mean = 60.2 years
Sd = 11.5 years		 European — HUNT number o cases = number of observations (more than 1 pp)