PGS Publication: PGP000153

Publication Information (EuropePMC)
Title A Polygenic Risk Score as a Risk Factor for Medication-Associated Fractures.
PubMed ID 32511779(Europe PMC)
doi 10.1002/jbmr.4104
Publication Date July 20, 2020
Journal J Bone Miner Res
Author(s) Manousaki D, Forgetta V, Keller-Baruch J, Zhao K, Greenwood CM, Mooser V, Bassett JD, Leslie WD, Richards JB.
Released in PGS Catalog: March 22, 2021

Associated Polygenic Score(s)

Filter PGS by Participant Ancestry
Individuals included in:
G - Source of Variant Associations (GWAS)
D - Score Development/Training
E - PGS Evaluation
List of ancestries includes:
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Additional Diverse Ancestries
Not Reported

External PGS Evaluated By This Publication

Polygenic Score ID & Name PGS Publication ID (PGP) Reported Trait Mapped Trait(s) (Ontology) Number of Variants Ancestry distribution
GWAS
Dev
Eval
 Scoring File (FTP Link)
PGS000657
(gSOS)
 PGP000120 |
Forgetta V et al. PLoS Med (2020)
 Heel quantitative ultrasound speed of sound (SOS) calcaneal bone quantitative ultrasound measurement 21,716
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000657/ScoringFiles/PGS000657.txt.gz - Check Terms/Licenses

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		Evaluated Score PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM001852 PGS000657
(gSOS)
 PSS000937|
European Ancestry|
80,014 individuals
 PGP000153 |
Manousaki D et al. J Bone Miner Res (2020)
|Ext.		 Reported Trait: Incident major osteoporotic fracture OR: 0.69 [0.65, 0.71] — — — —
PPM001853 PGS000657
(gSOS)
 PSS000937|
European Ancestry|
80,014 individuals
 PGP000153 |
Manousaki D et al. J Bone Miner Res (2020)
|Ext.		 Reported Trait: Incident major osteoporotic fracture OR: 0.68 [0.64, 0.73] — Odds ratio (OR, bottom 50% vs top 50%): 1.86 [1.62, 2.13] Baseline fracture risk (FRAX), fracture-related drug use, fracture-related drug use*gSOS —
PPM001854 PGS000657
(gSOS)
 PSS000936|
European Ancestry|
80,014 individuals
 PGP000153 |
Manousaki D et al. J Bone Miner Res (2020)
|Ext.		 Reported Trait: Incident hip fracture OR: 0.76 [0.67, 0.87] — Odds ratio (OR, bottom 50% vs top 50%): 1.42 [1.08, 1.88] Basline fracture risk (FRAX), fracture-related drug use —
PPM001855 PGS000657
(gSOS)
 PSS000936|
European Ancestry|
80,014 individuals
 PGP000153 |
Manousaki D et al. J Bone Miner Res (2020)
|Ext.		 Reported Trait: Incident hip fracture OR: 0.74 [0.64, 0.78] — — — —
PPM001856 PGS000657
(gSOS)
 PSS000936|
European Ancestry|
80,014 individuals
 PGP000153 |
Manousaki D et al. J Bone Miner Res (2020)
|Ext.		 Reported Trait: Incident hip fracture OR: 0.76 [0.64, 0.89] — — Baseline fracture risk (FRAX), fracture-related drug use, fracture-related drug use*gSOS —
PPM001857 PGS000657
(gSOS)
 PSS000933|
European Ancestry|
12,678 individuals
 PGP000153 |
Manousaki D et al. J Bone Miner Res (2020)
|Ext.		 Reported Trait: Incident major osteoporotic fracture in fracture-related drug users OR: 0.78 [0.68, 0.88] — Odds ratio (OR, bottom 50% vs top 50%): 1.54 [1.19, 1.99] Basline fracture risk (FRAX) —
PPM001858 PGS000657
(gSOS)
 PSS000932|
European Ancestry|
12,678 individuals
 PGP000153 |
Manousaki D et al. J Bone Miner Res (2020)
|Ext.		 Reported Trait: incident hip fracture in fracture-related drug users OR: 0.77 [0.61, 0.98] — Odds ratio (OR, bottom 50% vs top 50%): 1.99 [1.19, 3.31] Basline fracture risk (FRAX) —
PPM001859 PGS000657
(gSOS)
 PSS000935|
European Ancestry|
67,336 individuals
 PGP000153 |
Manousaki D et al. J Bone Miner Res (2020)
|Ext.		 Reported Trait: Incident major osteoporotic fracture in individuals who don’t use fracture-related drugs OR: 0.57 [0.54, 0.61] — Odds ratio (OR, bottom 50% vs top 50%): 1.75 [1.65, 1.86] Basline fracture risk (FRAX) —
PPM001860 PGS000657
(gSOS)
 PSS000934|
European Ancestry|
67,336 individuals
 PGP000153 |
Manousaki D et al. J Bone Miner Res (2020)
|Ext.		 Reported Trait: Incident hip fracture in individuals who don’t use fracture-related drugs OR: 0.36 [0.3, 0.43] — Odds ratio (OR, bottom 50% vs top 50%): 2.81 [2.35, 3.36] Basline fracture risk (FRAX) —
PPM001851 PGS000657
(gSOS)
 PSS000937|
European Ancestry|
80,014 individuals
 PGP000153 |
Manousaki D et al. J Bone Miner Res (2020)
|Ext.		 Reported Trait: Incident major osteoporotic fracture OR: 0.7 [0.66, 0.75] — Odds Ratio (OR, bottom 50% vs top 50%): 1.79 [1.58, 2.01] Basline fracture risk (FRAX), fracture-related drug use —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS000932 Incident major osteoporotic fractures (MOF; composite of hip, clinical spine, forearm, humerus)(16) were identified from ques- tionnaire data from UK Biobank from the baseline assessment and ICD-10 codes from hospital admissions (primary diagnoses). ICD codes used to identify Fracture cases include: M8002, M8003, M8082, M8083, S422, S423, S424, S520, S521, S522, S523, S525, S526, S529, M8005, M8085, S720, S721,S722, M8008, M8088, S220, S320 —
[
  • 68 cases
  • , 12,610 controls
]
,
40.52 % Male samples
 Mean = 58.6 years
Sd = 7.7 years		 European — UKB —
PSS000933 Incident major osteoporotic fractures (MOF; composite of hip, clinical spine, forearm, humerus)(16) were identified from ques- tionnaire data from UK Biobank from the baseline assessment and ICD-10 codes from hospital admissions (primary diagnoses). ICD codes used to identify Fracture cases include: M8002, M8003, M8082, M8083, S422, S423, S424, S520, S521, S522, S523, S525, S526, S529, M8005, M8085, S720, S721,S722, M8008, M8088, S220, S320 —
[
  • 256 cases
  • , 12,422 controls
]
,
40.52 % Male samples
 Mean = 58.6 years
Sd = 7.6 years		 European — UKB —
PSS000934 Incident major osteoporotic fractures (MOF; composite of hip, clinical spine, forearm, humerus)(16) were identified from ques- tionnaire data from UK Biobank from the baseline assessment and ICD-10 codes from hospital admissions (primary diagnoses). ICD codes used to identify Fracture cases include: M8002, M8003, M8082, M8083, S422, S423, S424, S520, S521, S522, S523, S525, S526, S529, M8005, M8085, S720, S721,S722, M8008, M8088, S220, S322 —
[
  • 141 cases
  • , 67,195 controls
]
,
46.27 % Male samples
 Mean = 56.5 years
Sd = 8.2 years		 European — UKB —
PSS000935 Incident major osteoporotic fractures (MOF; composite of hip, clinical spine, forearm, humerus)(16) were identified from ques- tionnaire data from UK Biobank from the baseline assessment and ICD-10 codes from hospital admissions (primary diagnoses). ICD codes used to identify Fracture cases include: M8002, M8003, M8082, M8083, S422, S423, S424, S520, S521, S522, S523, S525, S526, S529, M8005, M8085, S720, S721,S722, M8008, M8088, S220, S321 —
[
  • 933 cases
  • , 66,403 controls
]
,
46.27 % Male samples
 Mean = 56.5 years
Sd = 8.1 years		 European — UKB —
PSS000936 Incident major osteoporotic fractures (MOF; composite of hip, clinical spine, forearm, humerus)(16) were identified from ques- tionnaire data from UK Biobank from the baseline assessment and ICD-10 codes from hospital admissions (primary diagnoses). ICD codes used to identify Fracture cases include: M8002, M8003, M8082, M8083, S422, S423, S424, S520, S521, S522, S523, S525, S526, S529, M8005, M8085, S720, S721,S722, M8008, M8088, S220, S320 —
[
  • 209 cases
  • , 79,805 controls
]
,
45.36 % Male samples
 Mean = 56.8 years
Sd = 8.1 years		 European — UKB —
PSS000937 Incident major osteoporotic fractures (MOF; composite of hip, clinical spine, forearm, humerus)(16) were identified from ques- tionnaire data from UK Biobank from the baseline assessment and ICD-10 codes from hospital admissions (primary diagnoses). ICD codes used to identify Fracture cases include: M8002, M8003, M8082, M8083, S422, S423, S424, S520, S521, S522, S523, S525, S526, S529, M8005, M8085, S720, S721,S722, M8008, M8088, S220, S320 —
[
  • 1,189 cases
  • , 78,825 controls
]
,
45.36 % Male samples
 Mean = 56.8 years
Sd = 8.0 years		 European — UKB —