Trait: heel bone mineral density

Experimental Factor Ontology (EFO) Information
Identifier EFO_0009270
Description Quantification of the mineral density of the heel bone
Trait category
Other measurement
Mapped term PMID:28869591

Associated Polygenic Score(s)

Filter PGS by Participant Ancestry
Individuals included in:
G - Source of Variant Associations (GWAS)
D - Score Development/Training
E - PGS Evaluation
List of ancestries includes:
Display options:
Ancestry legend
Multi-ancestry (including European)
Multi-ancestry (excluding European)
African
East Asian
South Asian
Additional Asian Ancestries
European
Greater Middle Eastern
Hispanic or Latin American
Additional Diverse Ancestries
Not Reported
Polygenic Score ID & Name PGS Publication ID (PGP) Reported Trait Mapped Trait(s) (Ontology) Number of Variants Ancestry distribution
GWAS
Dev
Eval
 Scoring File (FTP Link)
PGS000657
(gSOS)
 PGP000120 |
Forgetta V et al. PLoS Med (2020)
 Heel quantitative ultrasound speed of sound (SOS) heel bone mineral density 21,716
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000657/ScoringFiles/PGS000657.txt.gz - Check Terms/Licenses
PGS001037
(GBE_INI78)
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
 Heel bone mineral density (BMD) T-score, automated heel bone mineral density 14,310
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS001037/ScoringFiles/PGS001037.txt.gz
PGS001038
(GBE_INI4106)
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
 Left heel bone mineral density (BMD) T-score, automated heel bone mineral density 9,275
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS001038/ScoringFiles/PGS001038.txt.gz
PGS001039
(GBE_INI4125)
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
 Right heel bone mineral density (BMD) T-score, automated heel bone mineral density 9,753
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS001039/ScoringFiles/PGS001039.txt.gz
PGS001402
(GBE_INI3148)
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
 Heel bone mineral density (BMD) heel bone mineral density 14,251
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS001402/ScoringFiles/PGS001402.txt.gz
PGS001403
(GBE_INI4105)
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
 Heel bone mineral density (BMD) (L) heel bone mineral density 8,285
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS001403/ScoringFiles/PGS001403.txt.gz
PGS001404
(GBE_INI4124)
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
 Heel bone mineral density (BMD) (R) heel bone mineral density 9,637
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS001404/ScoringFiles/PGS001404.txt.gz
PGS001529
(GBE_INI3146)
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
 Speed of sound through heel heel bone mineral density 13,172
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS001529/ScoringFiles/PGS001529.txt.gz
PGS001530
(GBE_INI4103)
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
 Speed of sound through heel (L) heel bone mineral density 8,419
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS001530/ScoringFiles/PGS001530.txt.gz
PGS001531
(GBE_INI4122)
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
 Speed of sound through heel (R) heel bone mineral density 8,912
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS001531/ScoringFiles/PGS001531.txt.gz
PGS001955
(portability-PLR_log_heel_BMD)
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Heel bone mineral density (BMD) heel bone mineral density 73,565
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS001955/ScoringFiles/PGS001955.txt.gz
PGS001956
(portability-PLR_log_heel_BUA)
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Heel Broadband ultrasound attenuation, direct entry heel bone mineral density 69,537
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS001956/ScoringFiles/PGS001956.txt.gz
PGS002173
(portability-ldpred2_log_heel_BMD)
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Heel bone mineral density (BMD) heel bone mineral density 729,074
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS002173/ScoringFiles/PGS002173.txt.gz
PGS002174
(portability-ldpred2_log_heel_BUA)
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Heel Broadband ultrasound attenuation, direct entry heel bone mineral density 732,595
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS002174/ScoringFiles/PGS002174.txt.gz
PGS002768
(BMD_prscs)
 PGP000364 |
Mars N et al. Am J Hum Genet (2022)
 Osteoporosis osteoporosis,
heel bone mineral density		 1,091,549
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS002768/ScoringFiles/PGS002768.txt.gz
PGS003535
(cont-decay-log_heel_BMD)
 PGP000457 |
Ding Y et al. bioRxiv (2022)
|Pre		 Heel bone mineral density (BMD) heel bone mineral density 979,739
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS003535/ScoringFiles/PGS003535.txt.gz
PGS004411
(X78.score)
 PGP000561 |
Jung H et al. Commun Biol (2024)
 Heel bone mineral density (BMD) T-score, automated heel bone mineral density 1,059,939
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004411/ScoringFiles/PGS004411.txt.gz
PGS004415
(X3148.score)
 PGP000561 |
Jung H et al. Commun Biol (2024)
 Heel bone mineral density (BMD) heel bone mineral density 1,059,939
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004415/ScoringFiles/PGS004415.txt.gz
PGS004419
(X4105.score)
 PGP000561 |
Jung H et al. Commun Biol (2024)
 Heel bone mineral density (BMD) (left) heel bone mineral density 1,059,939
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004419/ScoringFiles/PGS004419.txt.gz
PGS004420
(X4106.score)
 PGP000561 |
Jung H et al. Commun Biol (2024)
 Heel bone mineral density (BMD) T-score, automated (left) heel bone mineral density 1,059,939
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004420/ScoringFiles/PGS004420.txt.gz
PGS004424
(X4124.score)
 PGP000561 |
Jung H et al. Commun Biol (2024)
 Heel bone mineral density (BMD) (right) heel bone mineral density 1,059,939
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004424/ScoringFiles/PGS004424.txt.gz
PGS004425
(X4125.score)
 PGP000561 |
Jung H et al. Commun Biol (2024)
 Heel bone mineral density (BMD) T-score, automated (right) heel bone mineral density 1,059,939
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004425/ScoringFiles/PGS004425.txt.gz

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		Evaluated Score PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM001343 PGS000657
(gSOS)
 PSS000586|
European Ancestry|
80,027 individuals
 PGP000120 |
Forgetta V et al. PLoS Med (2020)
 Reported Trait: Heel bone speed of sound — — R²: 0.2318 [0.2266, 0.2369] — —
PPM001344 PGS000657
(gSOS)
 PSS000585|
Multi-ancestry (including European)|
21,408 individuals
 PGP000120 |
Forgetta V et al. PLoS Med (2020)
 Reported Trait: Screening incorporating a gSOS-based screening step — — Positive Predictive Value (PPV): 0.954
Reduction in individuals requiring Clinical-Risk-Factor FRAX tests (%): 37.0
Percent reduction in individuals requiring BMD FRAX Tests (%): 41.0		 — —
PPM001862 PGS000657
(gSOS)
 PSS000950|
European Ancestry|
90,172 individuals
 PGP000154 |
Lu T et al. Genome Med (2021)
|Ext.		 Reported Trait: Incident hip fracture — AUROC: 0.798 [0.791, 0.805] Odds ratio (OR, bottom 25% vs. remaining 75%): 1.2 [1.02, 1.41] Age, sex —
PPM001863 PGS000657
(gSOS)
 PSS000944|
European Ancestry|
8,278 individuals
 PGP000154 |
Lu T et al. Genome Med (2021)
|Ext.		 Reported Trait: Incident major osteoporotic fracture — C-index: 0.623 [0.603, 0.642] — Sex —
PPM001864 PGS000657
(gSOS)
 PSS000943|
European Ancestry|
8,278 individuals
 PGP000154 |
Lu T et al. Genome Med (2021)
|Ext.		 Reported Trait: Incident hip fracture — C-index: 0.672 [0.65, 0.695] — Sex —
PPM001861 PGS000657
(gSOS)
 PSS000951|
European Ancestry|
90,172 individuals
 PGP000154 |
Lu T et al. Genome Med (2021)
|Ext.		 Reported Trait: Incident major osteoporotic fracture — AUROC: 0.734 [0.727, 0.74] Odds ratio (OR, bottom 25% vs. remaining 75%): 1.68 [1.47, 1.89] Age, sex —
PPM001867 PGS000657
(gSOS)
 PSS000942|
European Ancestry|
4,663 individuals
 PGP000154 |
Lu T et al. Genome Med (2021)
|Ext.		 Reported Trait: Incident major osteoporotic fracture OR: 0.72 [0.66, 0.79] — — Age, sex —
PPM001852 PGS000657
(gSOS)
 PSS000937|
European Ancestry|
80,014 individuals
 PGP000153 |
Manousaki D et al. J Bone Miner Res (2020)
|Ext.		 Reported Trait: Incident major osteoporotic fracture OR: 0.69 [0.65, 0.71] — — — —
PPM001853 PGS000657
(gSOS)
 PSS000937|
European Ancestry|
80,014 individuals
 PGP000153 |
Manousaki D et al. J Bone Miner Res (2020)
|Ext.		 Reported Trait: Incident major osteoporotic fracture OR: 0.68 [0.64, 0.73] — Odds ratio (OR, bottom 50% vs top 50%): 1.86 [1.62, 2.13] Baseline fracture risk (FRAX), fracture-related drug use, fracture-related drug use*gSOS —
PPM001854 PGS000657
(gSOS)
 PSS000936|
European Ancestry|
80,014 individuals
 PGP000153 |
Manousaki D et al. J Bone Miner Res (2020)
|Ext.		 Reported Trait: Incident hip fracture OR: 0.76 [0.67, 0.87] — Odds ratio (OR, bottom 50% vs top 50%): 1.42 [1.08, 1.88] Basline fracture risk (FRAX), fracture-related drug use —
PPM001855 PGS000657
(gSOS)
 PSS000936|
European Ancestry|
80,014 individuals
 PGP000153 |
Manousaki D et al. J Bone Miner Res (2020)
|Ext.		 Reported Trait: Incident hip fracture OR: 0.74 [0.64, 0.78] — — — —
PPM001856 PGS000657
(gSOS)
 PSS000936|
European Ancestry|
80,014 individuals
 PGP000153 |
Manousaki D et al. J Bone Miner Res (2020)
|Ext.		 Reported Trait: Incident hip fracture OR: 0.76 [0.64, 0.89] — — Baseline fracture risk (FRAX), fracture-related drug use, fracture-related drug use*gSOS —
PPM001857 PGS000657
(gSOS)
 PSS000933|
European Ancestry|
12,678 individuals
 PGP000153 |
Manousaki D et al. J Bone Miner Res (2020)
|Ext.		 Reported Trait: Incident major osteoporotic fracture in fracture-related drug users OR: 0.78 [0.68, 0.88] — Odds ratio (OR, bottom 50% vs top 50%): 1.54 [1.19, 1.99] Basline fracture risk (FRAX) —
PPM001858 PGS000657
(gSOS)
 PSS000932|
European Ancestry|
12,678 individuals
 PGP000153 |
Manousaki D et al. J Bone Miner Res (2020)
|Ext.		 Reported Trait: incident hip fracture in fracture-related drug users OR: 0.77 [0.61, 0.98] — Odds ratio (OR, bottom 50% vs top 50%): 1.99 [1.19, 3.31] Basline fracture risk (FRAX) —
PPM001859 PGS000657
(gSOS)
 PSS000935|
European Ancestry|
67,336 individuals
 PGP000153 |
Manousaki D et al. J Bone Miner Res (2020)
|Ext.		 Reported Trait: Incident major osteoporotic fracture in individuals who don’t use fracture-related drugs OR: 0.57 [0.54, 0.61] — Odds ratio (OR, bottom 50% vs top 50%): 1.75 [1.65, 1.86] Basline fracture risk (FRAX) —
PPM001860 PGS000657
(gSOS)
 PSS000934|
European Ancestry|
67,336 individuals
 PGP000153 |
Manousaki D et al. J Bone Miner Res (2020)
|Ext.		 Reported Trait: Incident hip fracture in individuals who don’t use fracture-related drugs OR: 0.36 [0.3, 0.43] — Odds ratio (OR, bottom 50% vs top 50%): 2.81 [2.35, 3.36] Basline fracture risk (FRAX) —
PPM001865 PGS000657
(gSOS)
 PSS000948|
European Ancestry|
80,014 individuals
 PGP000154 |
Lu T et al. Genome Med (2021)
|Ext.		 Reported Trait: Incident major osteoporotic fracture OR: 0.68 [0.65, 0.72] AUROC: 0.68 [0.673, 0.688] — Age, sex —
PPM001868 PGS000657
(gSOS)
 PSS000942|
European Ancestry|
4,663 individuals
 PGP000154 |
Lu T et al. Genome Med (2021)
|Ext.		 Reported Trait: Incident major osteoporotic fracture OR: 0.76 [0.69, 0.85] — — Age, sex, body mass index, prior fracture, smoking, corticosteroids use, rheumatoid arthritis, parental fracture, at-risk drinking, falls at baseline, secondary osteoperosis —
PPM001869 PGS000657
(gSOS)
 PSS000940|
European Ancestry|
1,880 individuals
 PGP000154 |
Lu T et al. Genome Med (2021)
|Ext.		 Reported Trait: Incident major osteoporotic fracture OR: 0.69 [0.61, 0.78] — — Age, sex —
PPM001870 PGS000657
(gSOS)
 PSS000940|
European Ancestry|
1,880 individuals
 PGP000154 |
Lu T et al. Genome Med (2021)
|Ext.		 Reported Trait: Incident major osteoporotic fracture OR: 0.72 [0.61, 0.85] — — Age, sex, body mass index, prior fracture, smoking, corticosteroids use, rheumatoid arthritis, parental fracture, at-risk drinking, falls at baseline, secondary osteoperosis —
PPM001871 PGS000657
(gSOS)
 PSS000946|
European Ancestry|
3,615 individuals
 PGP000154 |
Lu T et al. Genome Med (2021)
|Ext.		 Reported Trait: Incident major osteoporotic fracture OR: 0.74 [0.68, 0.81] — — Age, sex —
PPM001872 PGS000657
(gSOS)
 PSS000946|
European Ancestry|
3,615 individuals
 PGP000154 |
Lu T et al. Genome Med (2021)
|Ext.		 Reported Trait: Incident major osteoporotic fracture OR: 0.75 [0.68, 0.83] — — Age, sex, body mass index, prior fracture, smoking, corticosteroids use, rheumatoid arthritis, parental fracture, at-risk drinking, falls at baseline, secondary osteoperosis —
PPM001873 PGS000657
(gSOS)
 PSS000938|
East Asian Ancestry|
25,034 individuals
 PGP000154 |
Lu T et al. Genome Med (2021)
|Ext.		 Reported Trait: Incident major osteoporotic fracture OR: 0.79 [0.71, 0.88] — — Age, sex Only 13,848 of the original 21717 SNPs (63.8%) were used due to difference in reference panel.
PPM001874 PGS000657
(gSOS)
 PSS000938|
East Asian Ancestry|
25,034 individuals
 PGP000154 |
Lu T et al. Genome Med (2021)
|Ext.		 Reported Trait: Incident major osteoporotic fracture OR: 0.82 [0.74, 0.92] — — Age, sex, body mass index, prior fracture, smoking, corticosteroids use, rheumatoid arthritis, parental fracture, at-risk drinking, falls at baseline, secondary osteoperosis Only 13,848 of the original 21717 SNPs (63.8%) were used due to difference in reference panel.
PPM001875 PGS000657
(gSOS)
 PSS000947|
European Ancestry|
80,014 individuals
 PGP000154 |
Lu T et al. Genome Med (2021)
|Ext.		 Reported Trait: Incident hip fracture OR: 0.73 [0.63, 0.84] AUROC: 0.739 [0.724, 0.754] — Age, sex —
PPM001876 PGS000657
(gSOS)
 PSS000947|
European Ancestry|
80,014 individuals
 PGP000154 |
Lu T et al. Genome Med (2021)
|Ext.		 Reported Trait: Incident hip fracture OR: 0.75 [0.65, 0.86] — — Age, sex, body mass index, prior fracture, smoking, corticosteroids use, rheumatoid arthritis, parental fracture, at-risk drinking, falls at baseline, secondary osteoperosis —
PPM001877 PGS000657
(gSOS)
 PSS000941|
European Ancestry|
4,663 individuals
 PGP000154 |
Lu T et al. Genome Med (2021)
|Ext.		 Reported Trait: Incident hip fracture OR: 0.73 [0.64, 0.83] — — Age, sex —
PPM001878 PGS000657
(gSOS)
 PSS000941|
European Ancestry|
4,663 individuals
 PGP000154 |
Lu T et al. Genome Med (2021)
|Ext.		 Reported Trait: Incident hip fracture OR: 0.75 [0.65, 0.87] — — Age, sex, body mass index, prior fracture, smoking, corticosteroids use, rheumatoid arthritis, parental fracture, at-risk drinking, falls at baseline, secondary osteoperosis —
PPM001879 PGS000657
(gSOS)
 PSS000939|
European Ancestry|
1,880 individuals
 PGP000154 |
Lu T et al. Genome Med (2021)
|Ext.		 Reported Trait: Incident hip fracture OR: 0.76 [0.63, 0.93] — — Age, sex —
PPM001880 PGS000657
(gSOS)
 PSS000939|
European Ancestry|
1,880 individuals
 PGP000154 |
Lu T et al. Genome Med (2021)
|Ext.		 Reported Trait: Incident hip fracture OR: 0.74 [0.58, 0.95] — — Age, sex, body mass index, prior fracture, smoking, corticosteroids use, rheumatoid arthritis, parental fracture, at-risk drinking, falls at baseline, secondary osteoperosis —
PPM001881 PGS000657
(gSOS)
 PSS000945|
European Ancestry|
3,615 individuals
 PGP000154 |
Lu T et al. Genome Med (2021)
|Ext.		 Reported Trait: Incident hip fracture OR: 0.76 [0.7, 0.84] — — Age, sex —
PPM001882 PGS000657
(gSOS)
 PSS000945|
European Ancestry|
3,615 individuals
 PGP000154 |
Lu T et al. Genome Med (2021)
|Ext.		 Reported Trait: Incident hip fracture OR: 0.76 [0.68, 0.84] — — Age, sex, body mass index, prior fracture, smoking, corticosteroids use, rheumatoid arthritis, parental fracture, at-risk drinking, falls at baseline, secondary osteoperosis —
PPM001883 PGS000657
(gSOS)
 PSS000949|
European Ancestry|
4,717 individuals
 PGP000154 |
Lu T et al. Genome Med (2021)
|Ext.		 Reported Trait: Incident major osteoporotic fracture OR: 0.71 [0.59, 0.85] — — Clinical risk factor-based score (FRAX-CRF) —
PPM001884 PGS000657
(gSOS)
 PSS000942|
European Ancestry|
4,663 individuals
 PGP000154 |
Lu T et al. Genome Med (2021)
|Ext.		 Reported Trait: Incident major osteoporotic fracture OR: 0.74 [0.67, 0.81] — — Clinical risk factor-based score (FRAX-CRF) —
PPM001885 PGS000657
(gSOS)
 PSS000940|
European Ancestry|
1,880 individuals
 PGP000154 |
Lu T et al. Genome Med (2021)
|Ext.		 Reported Trait: Incident major osteoporotic fracture OR: 0.72 [0.63, 0.81] — — Clinical risk factor-based score (FRAX-CRF) —
PPM001886 PGS000657
(gSOS)
 PSS000946|
European Ancestry|
3,615 individuals
 PGP000154 |
Lu T et al. Genome Med (2021)
|Ext.		 Reported Trait: Incident major osteoporotic fracture OR: 0.77 [0.7, 0.84] — — Clinical risk factor-based score (FRAX-CRF) —
PPM001887 PGS000657
(gSOS)
 PSS000941|
European Ancestry|
4,663 individuals
 PGP000154 |
Lu T et al. Genome Med (2021)
|Ext.		 Reported Trait: Incident hip fracture OR: 0.74 [0.65, 0.83] — — Clinical risk factor-based score (FRAX-CRF) —
PPM001888 PGS000657
(gSOS)
 PSS000939|
European Ancestry|
1,880 individuals
 PGP000154 |
Lu T et al. Genome Med (2021)
|Ext.		 Reported Trait: Incident hip fracture OR: 0.8 [0.67, 0.96] — — Clinical risk factor-based score (FRAX-CRF) —
PPM001889 PGS000657
(gSOS)
 PSS000945|
European Ancestry|
3,615 individuals
 PGP000154 |
Lu T et al. Genome Med (2021)
|Ext.		 Reported Trait: Incident hip fracture OR: 0.76 [0.69, 0.84] — — Clinical risk factor-based score (FRAX-CRF) —
PPM001890 PGS000657
(gSOS)
 PSS000949|
European Ancestry|
4,717 individuals
 PGP000154 |
Lu T et al. Genome Med (2021)
|Ext.		 Reported Trait: Incident major osteoporotic fracture OR: 0.75 [0.63, 0.9] — — Age, sex, measured femoral neck bone mineral density —
PPM001891 PGS000657
(gSOS)
 PSS000942|
European Ancestry|
4,663 individuals
 PGP000154 |
Lu T et al. Genome Med (2021)
|Ext.		 Reported Trait: Incident major osteoporotic fracture OR: 0.82 [0.75, 0.9] — — Age, sex, measured femoral neck bone mineral density —
PPM001892 PGS000657
(gSOS)
 PSS000940|
European Ancestry|
1,880 individuals
 PGP000154 |
Lu T et al. Genome Med (2021)
|Ext.		 Reported Trait: Incident major osteoporotic fracture OR: 0.78 [0.68, 0.88] — — Age, sex, measured femoral neck bone mineral density —
PPM001893 PGS000657
(gSOS)
 PSS000946|
European Ancestry|
3,615 individuals
 PGP000154 |
Lu T et al. Genome Med (2021)
|Ext.		 Reported Trait: Incident major osteoporotic fracture OR: 0.82 [0.75, 0.9] — — Age, sex, measured femoral neck bone mineral density —
PPM001894 PGS000657
(gSOS)
 PSS000941|
European Ancestry|
4,663 individuals
 PGP000154 |
Lu T et al. Genome Med (2021)
|Ext.		 Reported Trait: Incident hip fracture OR: 0.85 [0.75, 0.97] — — Age, sex, measured femoral neck bone mineral density —
PPM001895 PGS000657
(gSOS)
 PSS000945|
European Ancestry|
3,615 individuals
 PGP000154 |
Lu T et al. Genome Med (2021)
|Ext.		 Reported Trait: Incident hip fracture OR: 0.83 [0.76, 0.93] — — Age, sex, measured femoral neck bone mineral density —
PPM001896 PGS000657
(gSOS)
 PSS000949|
European Ancestry|
4,717 individuals
 PGP000154 |
Lu T et al. Genome Med (2021)
|Ext.		 Reported Trait: Incident major osteoporotic fracture OR: 0.75 [0.63, 0.89] — — Clinical risk factor-based score including bone mineral density (FRAX-BMD) —
PPM001897 PGS000657
(gSOS)
 PSS000942|
European Ancestry|
4,663 individuals
 PGP000154 |
Lu T et al. Genome Med (2021)
|Ext.		 Reported Trait: Incident major osteoporotic fracture OR: 0.78 [0.71, 0.85] — — Clinical risk factor-based score including bone mineral density (FRAX-BMD) —
PPM001898 PGS000657
(gSOS)
 PSS000940|
European Ancestry|
1,880 individuals
 PGP000154 |
Lu T et al. Genome Med (2021)
|Ext.		 Reported Trait: Incident major osteoporotic fracture OR: 0.75 [0.66, 0.85] — — Clinical risk factor-based score including bone mineral density (FRAX-BMD) —
PPM001899 PGS000657
(gSOS)
 PSS000946|
European Ancestry|
3,615 individuals
 PGP000154 |
Lu T et al. Genome Med (2021)
|Ext.		 Reported Trait: Incident major osteoporotic fracture OR: 0.82 [0.75, 0.89] — — Clinical risk factor-based score including bone mineral density (FRAX-BMD) —
PPM001900 PGS000657
(gSOS)
 PSS000941|
European Ancestry|
4,663 individuals
 PGP000154 |
Lu T et al. Genome Med (2021)
|Ext.		 Reported Trait: Incident hip fracture OR: 0.76 [0.68, 0.87] — — Clinical risk factor-based score including bone mineral density (FRAX-BMD) —
PPM001901 PGS000657
(gSOS)
 PSS000945|
European Ancestry|
3,615 individuals
 PGP000154 |
Lu T et al. Genome Med (2021)
|Ext.		 Reported Trait: Incident hip fracture OR: 0.8 [0.73, 0.88] — — Clinical risk factor-based score including bone mineral density (FRAX-BMD) —
PPM001902 PGS000657
(gSOS)
 PSS000944|
European Ancestry|
8,278 individuals
 PGP000154 |
Lu T et al. Genome Med (2021)
|Ext.		 Reported Trait: Incident major osteoporotic fracture — C-index: 0.66 [0.641, 0.679] — Clinical risk factor-based score (FRAX-CRF) —
PPM001903 PGS000657
(gSOS)
 PSS000943|
European Ancestry|
8,278 individuals
 PGP000154 |
Lu T et al. Genome Med (2021)
|Ext.		 Reported Trait: Incident hip fracture — C-index: 0.682 [0.66, 0.704] — Clinical risk factor-based score (FRAX-CRF) —
PPM001851 PGS000657
(gSOS)
 PSS000937|
European Ancestry|
80,014 individuals
 PGP000153 |
Manousaki D et al. J Bone Miner Res (2020)
|Ext.		 Reported Trait: Incident major osteoporotic fracture OR: 0.7 [0.66, 0.75] — Odds Ratio (OR, bottom 50% vs top 50%): 1.79 [1.58, 2.01] Basline fracture risk (FRAX), fracture-related drug use —
PPM001866 PGS000657
(gSOS)
 PSS000948|
European Ancestry|
80,014 individuals
 PGP000154 |
Lu T et al. Genome Med (2021)
|Ext.		 Reported Trait: Incident major osteoporotic fracture OR: 0.7 [0.66, 0.75] — — Age, sex, body mass index, prior fracture, smoking, corticosteroids use, rheumatoid arthritis, parental fracture, at-risk drinking, falls at baseline, secondary osteoperosis —
PPM007945 PGS001037
(GBE_INI78)
 PSS007478|
European Ancestry|
12,376 individuals
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
 Reported Trait: Heel bone mineral density (BMD) T-score, automated — — R²: 0.1881 [0.17936, 0.19685]
Incremental R2 (full-covars): 0.13506
PGS R2 (no covariates): 0.13678 [0.12885, 0.14471]		 age, sex, UKB array type, Genotype PCs —
PPM007943 PGS001037
(GBE_INI78)
 PSS007476|
African Ancestry|
2,253 individuals
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
 Reported Trait: Heel bone mineral density (BMD) T-score, automated — — R²: 0.0346 [0.02587, 0.04333]
Incremental R2 (full-covars): 0.01755
PGS R2 (no covariates): 0.01827 [0.01182, 0.02472]		 age, sex, UKB array type, Genotype PCs —
PPM007944 PGS001037
(GBE_INI78)
 PSS007477|
East Asian Ancestry|
795 individuals
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
 Reported Trait: Heel bone mineral density (BMD) T-score, automated — — Incremental R2 (full-covars): 0.06623
R²: 0.09833 [0.07154, 0.12513]
PGS R2 (no covariates): 0.06929 [0.04608, 0.09251]		 age, sex, UKB array type, Genotype PCs —
PPM007946 PGS001037
(GBE_INI78)
 PSS007479|
South Asian Ancestry|
2,312 individuals
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
 Reported Trait: Heel bone mineral density (BMD) T-score, automated — — R²: 0.10193 [0.08923, 0.11462]
Incremental R2 (full-covars): 0.06757
PGS R2 (no covariates): 0.07119 [0.06021, 0.08216]		 age, sex, UKB array type, Genotype PCs —
PPM007947 PGS001037
(GBE_INI78)
 PSS007480|
European Ancestry|
38,834 individuals
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
 Reported Trait: Heel bone mineral density (BMD) T-score, automated — — R²: 0.19661 [0.19123, 0.20198]
Incremental R2 (full-covars): 0.1419
PGS R2 (no covariates): 0.14159 [0.13671, 0.14646]		 age, sex, UKB array type, Genotype PCs —
PPM007948 PGS001038
(GBE_INI4106)
 PSS007296|
African Ancestry|
3,560 individuals
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
 Reported Trait: Heel bone mineral density (BMD) T-score, automated (L) — — R²: 0.02571 [0.01812, 0.03331]
Incremental R2 (full-covars): 0.00529
PGS R2 (no covariates): 0.00688 [0.00288, 0.01089]		 age, sex, UKB array type, Genotype PCs —
PPM007949 PGS001038
(GBE_INI4106)
 PSS007297|
East Asian Ancestry|
781 individuals
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
 Reported Trait: Heel bone mineral density (BMD) T-score, automated (L) — — R²: 0.10298 [0.0757, 0.13026]
Incremental R2 (full-covars): 0.08297
PGS R2 (no covariates): 0.082 [0.05709, 0.10691]		 age, sex, UKB array type, Genotype PCs —
PPM007950 PGS001038
(GBE_INI4106)
 PSS007298|
European Ancestry|
10,636 individuals
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
 Reported Trait: Heel bone mineral density (BMD) T-score, automated (L) — — R²: 0.17491 [0.16634, 0.18348]
Incremental R2 (full-covars): 0.11202
PGS R2 (no covariates): 0.11274 [0.10534, 0.12014]		 age, sex, UKB array type, Genotype PCs —
PPM007951 PGS001038
(GBE_INI4106)
 PSS007299|
South Asian Ancestry|
5,043 individuals
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
 Reported Trait: Heel bone mineral density (BMD) T-score, automated (L) — — R²: 0.08123 [0.06963, 0.09282]
Incremental R2 (full-covars): 0.05296
PGS R2 (no covariates): 0.05415 [0.04441, 0.0639]		 age, sex, UKB array type, Genotype PCs —
PPM007952 PGS001038
(GBE_INI4106)
 PSS007300|
European Ancestry|
25,716 individuals
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
 Reported Trait: Heel bone mineral density (BMD) T-score, automated (L) — — R²: 0.17984 [0.17459, 0.18509]
Incremental R2 (full-covars): 0.11708
PGS R2 (no covariates): 0.11589 [0.11134, 0.12043]		 age, sex, UKB array type, Genotype PCs —
PPM007953 PGS001039
(GBE_INI4125)
 PSS007326|
African Ancestry|
3,592 individuals
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
 Reported Trait: Heel bone mineral density (BMD) T-score, automated (R) — — R²: 0.02463 [0.01719, 0.03207]
Incremental R2 (full-covars): 0.00616
PGS R2 (no covariates): 0.00698 [0.00294, 0.01101]		 age, sex, UKB array type, Genotype PCs —
PPM007954 PGS001039
(GBE_INI4125)
 PSS007327|
East Asian Ancestry|
782 individuals
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
 Reported Trait: Heel bone mineral density (BMD) T-score, automated (R) — — R²: 0.09885 [0.072, 0.1257]
Incremental R2 (full-covars): 0.07541
PGS R2 (no covariates): 0.07555 [0.05147, 0.09963]		 age, sex, UKB array type, Genotype PCs —
PPM007955 PGS001039
(GBE_INI4125)
 PSS007328|
European Ancestry|
10,633 individuals
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
 Reported Trait: Heel bone mineral density (BMD) T-score, automated (R) — — R²: 0.1752 [0.16663, 0.18378]
Incremental R2 (full-covars): 0.11145
PGS R2 (no covariates): 0.11271 [0.10531, 0.12011]		 age, sex, UKB array type, Genotype PCs —
PPM007956 PGS001039
(GBE_INI4125)
 PSS007329|
South Asian Ancestry|
5,041 individuals
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
 Reported Trait: Heel bone mineral density (BMD) T-score, automated (R) — — R²: 0.08262 [0.07095, 0.0943]
Incremental R2 (full-covars): 0.05817
PGS R2 (no covariates): 0.05815 [0.0481, 0.06821]		 age, sex, UKB array type, Genotype PCs —
PPM007957 PGS001039
(GBE_INI4125)
 PSS007330|
European Ancestry|
25,728 individuals
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
 Reported Trait: Heel bone mineral density (BMD) T-score, automated (R) — — R²: 0.19359 [0.18823, 0.19894]
Incremental R2 (full-covars): 0.1242
PGS R2 (no covariates): 0.12266 [0.11802, 0.1273]		 age, sex, UKB array type, Genotype PCs —
PPM007080 PGS001402
(GBE_INI3148)
 PSS007241|
African Ancestry|
2,248 individuals
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
 Reported Trait: Heel bone mineral density (BMD) — — R²: 0.03461 [0.02588, 0.04334]
Incremental R2 (full-covars): 0.01792
PGS R2 (no covariates): 0.01849 [0.012, 0.02498]		 age, sex, UKB array type, Genotype PCs —
PPM007081 PGS001402
(GBE_INI3148)
 PSS007242|
East Asian Ancestry|
794 individuals
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
 Reported Trait: Heel bone mineral density (BMD) — — R²: 0.0956 [0.0691, 0.1221]
Incremental R2 (full-covars): 0.06421
PGS R2 (no covariates): 0.06783 [0.04482, 0.09083]		 age, sex, UKB array type, Genotype PCs —
PPM007082 PGS001402
(GBE_INI3148)
 PSS007243|
European Ancestry|
12,374 individuals
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
 Reported Trait: Heel bone mineral density (BMD) — — R²: 0.18897 [0.18022, 0.19773]
Incremental R2 (full-covars): 0.13548
PGS R2 (no covariates): 0.13714 [0.1292, 0.14508]		 age, sex, UKB array type, Genotype PCs —
PPM007083 PGS001402
(GBE_INI3148)
 PSS007244|
South Asian Ancestry|
2,310 individuals
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
 Reported Trait: Heel bone mineral density (BMD) — — R²: 0.10415 [0.09135, 0.11695]
Incremental R2 (full-covars): 0.06926
PGS R2 (no covariates): 0.07321 [0.06211, 0.08432]		 age, sex, UKB array type, Genotype PCs —
PPM007084 PGS001402
(GBE_INI3148)
 PSS007245|
European Ancestry|
38,814 individuals
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
 Reported Trait: Heel bone mineral density (BMD) — — R²: 0.19926 [0.19386, 0.20465]
Incremental R2 (full-covars): 0.14341
PGS R2 (no covariates): 0.14309 [0.1382, 0.14798]		 age, sex, UKB array type, Genotype PCs —
PPM007100 PGS001403
(GBE_INI4105)
 PSS007291|
African Ancestry|
3,558 individuals
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
 Reported Trait: Heel bone mineral density (BMD) (L) — — R²: 0.02599 [0.01836, 0.03363]
Incremental R2 (full-covars): 0.00518
PGS R2 (no covariates): 0.00667 [0.00273, 0.01062]		 age, sex, UKB array type, Genotype PCs —
PPM007101 PGS001403
(GBE_INI4105)
 PSS007292|
East Asian Ancestry|
781 individuals
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
 Reported Trait: Heel bone mineral density (BMD) (L) — — R²: 0.10653 [0.07889, 0.13417]
Incremental R2 (full-covars): 0.08652
PGS R2 (no covariates): 0.08516 [0.05986, 0.11046]		 age, sex, UKB array type, Genotype PCs —
PPM007102 PGS001403
(GBE_INI4105)
 PSS007293|
European Ancestry|
10,626 individuals
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
 Reported Trait: Heel bone mineral density (BMD) (L) — — R²: 0.17743 [0.16883, 0.18604]
Incremental R2 (full-covars): 0.11194
PGS R2 (no covariates): 0.11269 [0.10529, 0.12009]		 age, sex, UKB array type, Genotype PCs —
PPM007103 PGS001403
(GBE_INI4105)
 PSS007294|
South Asian Ancestry|
5,037 individuals
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
 Reported Trait: Heel bone mineral density (BMD) (L) — — R²: 0.08239 [0.07073, 0.09405]
Incremental R2 (full-covars): 0.05357
PGS R2 (no covariates): 0.05487 [0.04506, 0.06467]		 age, sex, UKB array type, Genotype PCs —
PPM007104 PGS001403
(GBE_INI4105)
 PSS007295|
European Ancestry|
25,706 individuals
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
 Reported Trait: Heel bone mineral density (BMD) (L) — — R²: 0.18131 [0.17605, 0.18657]
Incremental R2 (full-covars): 0.11744
PGS R2 (no covariates): 0.11656 [0.11201, 0.12112]		 age, sex, UKB array type, Genotype PCs —
PPM007110 PGS001404
(GBE_INI4124)
 PSS007321|
African Ancestry|
3,586 individuals
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
 Reported Trait: Heel bone mineral density (BMD) (R) — — R²: 0.02449 [0.01707, 0.03191]
Incremental R2 (full-covars): 0.00554
PGS R2 (no covariates): 0.00662 [0.00269, 0.01055]		 age, sex, UKB array type, Genotype PCs —
PPM007111 PGS001404
(GBE_INI4124)
 PSS007322|
East Asian Ancestry|
782 individuals
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
 Reported Trait: Heel bone mineral density (BMD) (R) — — R²: 0.09993 [0.07297, 0.12689]
Incremental R2 (full-covars): 0.0765
PGS R2 (no covariates): 0.0766 [0.05238, 0.10082]		 age, sex, UKB array type, Genotype PCs —
PPM007112 PGS001404
(GBE_INI4124)
 PSS007323|
European Ancestry|
10,627 individuals
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
 Reported Trait: Heel bone mineral density (BMD) (R) — — R²: 0.17605 [0.16746, 0.18463]
Incremental R2 (full-covars): 0.11134
PGS R2 (no covariates): 0.11225 [0.10487, 0.11964]		 age, sex, UKB array type, Genotype PCs —
PPM007113 PGS001404
(GBE_INI4124)
 PSS007324|
South Asian Ancestry|
5,032 individuals
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
 Reported Trait: Heel bone mineral density (BMD) (R) — — R²: 0.08461 [0.07282, 0.0964]
Incremental R2 (full-covars): 0.05881
PGS R2 (no covariates): 0.05872 [0.04862, 0.06882]		 age, sex, UKB array type, Genotype PCs —
PPM007114 PGS001404
(GBE_INI4124)
 PSS007325|
European Ancestry|
25,715 individuals
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
 Reported Trait: Heel bone mineral density (BMD) (R) — — R²: 0.196 [0.19063, 0.20138]
Incremental R2 (full-covars): 0.12507
PGS R2 (no covariates): 0.12352 [0.11887, 0.12817]		 age, sex, UKB array type, Genotype PCs —
PPM007075 PGS001529
(GBE_INI3146)
 PSS007231|
African Ancestry|
1,434 individuals
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
 Reported Trait: Speed of sound through heel — — R²: 0.03275 [0.02202, 0.04347]
Incremental R2 (full-covars): 0.0181
PGS R2 (no covariates): 0.01912 [0.01081, 0.02743]		 age, sex, UKB array type, Genotype PCs —
PPM007076 PGS001529
(GBE_INI3146)
 PSS007232|
East Asian Ancestry|
500 individuals
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
 Reported Trait: Speed of sound through heel — — R²: 0.10987 [0.07399, 0.14575]
Incremental R2 (full-covars): 0.07069
PGS R2 (no covariates): 0.08324 [0.05108, 0.11541]		 age, sex, UKB array type, Genotype PCs —
PPM007077 PGS001529
(GBE_INI3146)
 PSS007233|
European Ancestry|
7,691 individuals
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
 Reported Trait: Speed of sound through heel — — R²: 0.17225 [0.16143, 0.18307]
Incremental R2 (full-covars): 0.13354
PGS R2 (no covariates): 0.13618 [0.12614, 0.14622]		 age, sex, UKB array type, Genotype PCs —
PPM007078 PGS001529
(GBE_INI3146)
 PSS007234|
South Asian Ancestry|
1,449 individuals
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
 Reported Trait: Speed of sound through heel — — R²: 0.11013 [0.09349, 0.12678]
Incremental R2 (full-covars): 0.08026
PGS R2 (no covariates): 0.08576 [0.07067, 0.10085]		 age, sex, UKB array type, Genotype PCs —
PPM007079 PGS001529
(GBE_INI3146)
 PSS007235|
European Ancestry|
24,146 individuals
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
 Reported Trait: Speed of sound through heel — — R²: 0.18117 [0.17451, 0.18783]
Incremental R2 (full-covars): 0.13986
PGS R2 (no covariates): 0.14001 [0.13386, 0.14616]		 age, sex, UKB array type, Genotype PCs —
PPM007095 PGS001530
(GBE_INI4103)
 PSS007281|
African Ancestry|
3,560 individuals
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
 Reported Trait: Speed of sound through heel (L) — — R²: 0.02043 [0.01363, 0.02724]
Incremental R2 (full-covars): 0.00372
PGS R2 (no covariates): 0.00552 [0.00193, 0.00911]		 age, sex, UKB array type, Genotype PCs —
PPM007096 PGS001530
(GBE_INI4103)
 PSS007282|
East Asian Ancestry|
781 individuals
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
 Reported Trait: Speed of sound through heel (L) — — R²: 0.1024 [0.07518, 0.12962]
Incremental R2 (full-covars): 0.0813
PGS R2 (no covariates): 0.08045 [0.05573, 0.10516]		 age, sex, UKB array type, Genotype PCs —
PPM007097 PGS001530
(GBE_INI4103)
 PSS007283|
European Ancestry|
10,636 individuals
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
 Reported Trait: Speed of sound through heel (L) — — R²: 0.16053 [0.15218, 0.16889]
Incremental R2 (full-covars): 0.10916
PGS R2 (no covariates): 0.11118 [0.10382, 0.11854]		 age, sex, UKB array type, Genotype PCs —
PPM007098 PGS001530
(GBE_INI4103)
 PSS007284|
South Asian Ancestry|
5,043 individuals
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
 Reported Trait: Speed of sound through heel (L) — — R²: 0.07631 [0.06501, 0.0876]
Incremental R2 (full-covars): 0.05214
PGS R2 (no covariates): 0.05376 [0.04404, 0.06347]		 age, sex, UKB array type, Genotype PCs —
PPM007099 PGS001530
(GBE_INI4103)
 PSS007285|
European Ancestry|
25,716 individuals
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
 Reported Trait: Speed of sound through heel (L) — — R²: 0.16377 [0.15866, 0.16887]
Incremental R2 (full-covars): 0.11885
PGS R2 (no covariates): 0.118 [0.11343, 0.12257]		 age, sex, UKB array type, Genotype PCs —
PPM007105 PGS001531
(GBE_INI4122)
 PSS007311|
African Ancestry|
3,592 individuals
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
 Reported Trait: Speed of sound through heel (R) — — R²: 0.02141 [0.01445, 0.02837]
Incremental R2 (full-covars): 0.0063
PGS R2 (no covariates): 0.00698 [0.00295, 0.01101]		 age, sex, UKB array type, Genotype PCs —
PPM007106 PGS001531
(GBE_INI4122)
 PSS007312|
East Asian Ancestry|
782 individuals
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
 Reported Trait: Speed of sound through heel (R) — — R²: 0.09852 [0.07171, 0.12534]
Incremental R2 (full-covars): 0.07672
PGS R2 (no covariates): 0.07776 [0.05339, 0.10214]		 age, sex, UKB array type, Genotype PCs —
PPM007107 PGS001531
(GBE_INI4122)
 PSS007313|
European Ancestry|
10,633 individuals
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
 Reported Trait: Speed of sound through heel (R) — — R²: 0.16134 [0.15298, 0.16971]
Incremental R2 (full-covars): 0.10988
PGS R2 (no covariates): 0.11176 [0.10439, 0.11914]		 age, sex, UKB array type, Genotype PCs —
PPM007108 PGS001531
(GBE_INI4122)
 PSS007314|
South Asian Ancestry|
5,041 individuals
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
 Reported Trait: Speed of sound through heel (R) — — R²: 0.07785 [0.06646, 0.08924]
Incremental R2 (full-covars): 0.05682
PGS R2 (no covariates): 0.05742 [0.04742, 0.06742]		 age, sex, UKB array type, Genotype PCs —
PPM007109 PGS001531
(GBE_INI4122)
 PSS007315|
European Ancestry|
25,728 individuals
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
 Reported Trait: Speed of sound through heel (R) — — R²: 0.17507 [0.16986, 0.18028]
Incremental R2 (full-covars): 0.12574
PGS R2 (no covariates): 0.12479 [0.12013, 0.12946]		 age, sex, UKB array type, Genotype PCs —
PPM010515 PGS001955
(portability-PLR_log_heel_BMD)
 PSS009446|
European Ancestry|
11,484 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Heel bone mineral density (BMD) — — Partial Correlation (partial-r): 0.4537 [0.4391, 0.4682] sex, age, birth date, deprivation index, 16 PCs —
PPM010516 PGS001955
(portability-PLR_log_heel_BMD)
 PSS009220|
European Ancestry|
2,146 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Heel bone mineral density (BMD) — — Partial Correlation (partial-r): 0.4397 [0.4048, 0.4734] sex, age, birth date, deprivation index, 16 PCs —
PPM010519 PGS001955
(portability-PLR_log_heel_BMD)
 PSS008326|
South Asian Ancestry|
1,972 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Heel bone mineral density (BMD) — — Partial Correlation (partial-r): 0.3477 [0.3081, 0.3861] sex, age, birth date, deprivation index, 16 PCs —
PPM010520 PGS001955
(portability-PLR_log_heel_BMD)
 PSS008103|
East Asian Ancestry|
820 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Heel bone mineral density (BMD) — — Partial Correlation (partial-r): 0.3057 [0.2415, 0.3672] sex, age, birth date, deprivation index, 16 PCs —
PPM010521 PGS001955
(portability-PLR_log_heel_BMD)
 PSS007890|
African Ancestry|
790 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Heel bone mineral density (BMD) — — Partial Correlation (partial-r): 0.1895 [0.1204, 0.2567] sex, age, birth date, deprivation index, 16 PCs —
PPM010522 PGS001955
(portability-PLR_log_heel_BMD)
 PSS008994|
African Ancestry|
1,406 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Heel bone mineral density (BMD) — — Partial Correlation (partial-r): 0.1746 [0.1231, 0.2252] sex, age, birth date, deprivation index, 16 PCs —
PPM010517 PGS001955
(portability-PLR_log_heel_BMD)
 PSS008774|
European Ancestry|
3,461 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Heel bone mineral density (BMD) — — Partial Correlation (partial-r): 0.3929 [0.3643, 0.4208] sex, age, birth date, deprivation index, 16 PCs —
PPM010518 PGS001955
(portability-PLR_log_heel_BMD)
 PSS008548|
Greater Middle Eastern Ancestry|
506 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Heel bone mineral density (BMD) — — Partial Correlation (partial-r): 0.2944 [0.211, 0.3736] sex, age, birth date, deprivation index, 16 PCs —
PPM022387 PGS001955
(portability-PLR_log_heel_BMD)
 PSS011935|
East Asian Ancestry|
3,744 individuals
 PGP000710 |
Chen JJ et al. Arch Osteoporos (2023)
|Ext.		 Reported Trait: Fracture of vertebral column without mention of spinal cord injury (Phecode 805) OR: 1.93 — — — —
PPM022388 PGS001955
(portability-PLR_log_heel_BMD)
 PSS011935|
East Asian Ancestry|
3,744 individuals
 PGP000710 |
Chen JJ et al. Arch Osteoporos (2023)
|Ext.		 Reported Trait: Osteoporosis (Phecode 743.1) OR: 1.68 — — — —
PPM022389 PGS001955
(portability-PLR_log_heel_BMD)
 PSS011935|
East Asian Ancestry|
3,744 individuals
 PGP000710 |
Chen JJ et al. Arch Osteoporos (2023)
|Ext.		 Reported Trait: Osteoporosis NOS (Phecode 743.11) OR: 1.68 — — — —
PPM022390 PGS001955
(portability-PLR_log_heel_BMD)
 PSS011935|
East Asian Ancestry|
3,744 individuals
 PGP000710 |
Chen JJ et al. Arch Osteoporos (2023)
|Ext.		 Reported Trait: Osteoporosis (Phecode 743) OR: 1.61 — — — —
PPM022391 PGS001955
(portability-PLR_log_heel_BMD)
 PSS011935|
East Asian Ancestry|
3,744 individuals
 PGP000710 |
Chen JJ et al. Arch Osteoporos (2023)
|Ext.		 Reported Trait: Fracture of upper limb (Phecode 803) OR: 2.93 — — — —
PPM022392 PGS001955
(portability-PLR_log_heel_BMD)
 PSS011935|
East Asian Ancestry|
3,744 individuals
 PGP000710 |
Chen JJ et al. Arch Osteoporos (2023)
|Ext.		 Reported Trait: Fracture of radius and ulna (Phecode 803.2) OR: 3.64 — — — —
PPM022393 PGS001955
(portability-PLR_log_heel_BMD)
 PSS011935|
East Asian Ancestry|
3,744 individuals
 PGP000710 |
Chen JJ et al. Arch Osteoporos (2023)
|Ext.		 Reported Trait: Fracture of lower limb (Phecode 800) OR: 2.51 — — — —
PPM022394 PGS001955
(portability-PLR_log_heel_BMD)
 PSS011935|
East Asian Ancestry|
3,744 individuals
 PGP000710 |
Chen JJ et al. Arch Osteoporos (2023)
|Ext.		 Reported Trait: Fracture of humerus (Phecode 803.1) OR: 3.54 — — — —
PPM022395 PGS001955
(portability-PLR_log_heel_BMD)
 PSS011935|
East Asian Ancestry|
3,744 individuals
 PGP000710 |
Chen JJ et al. Arch Osteoporos (2023)
|Ext.		 Reported Trait: Fracture of ankle and foot (Phecode 801) OR: 2.78 — — — —
PPM022396 PGS001955
(portability-PLR_log_heel_BMD)
 PSS011935|
East Asian Ancestry|
3,744 individuals
 PGP000710 |
Chen JJ et al. Arch Osteoporos (2023)
|Ext.		 Reported Trait: Fracture of tibia and fibula (Phecode 800.3) OR: 4.45 — — — —
PPM010523 PGS001956
(portability-PLR_log_heel_BUA)
 PSS009447|
European Ancestry|
11,485 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Heel Broadband ultrasound attenuation, direct entry — — Partial Correlation (partial-r): 0.4264 [0.4113, 0.4413] sex, age, birth date, deprivation index, 16 PCs —
PPM010524 PGS001956
(portability-PLR_log_heel_BUA)
 PSS009221|
European Ancestry|
2,147 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Heel Broadband ultrasound attenuation, direct entry — — Partial Correlation (partial-r): 0.4076 [0.3715, 0.4424] sex, age, birth date, deprivation index, 16 PCs —
PPM010525 PGS001956
(portability-PLR_log_heel_BUA)
 PSS008775|
European Ancestry|
3,463 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Heel Broadband ultrasound attenuation, direct entry — — Partial Correlation (partial-r): 0.3665 [0.3372, 0.395] sex, age, birth date, deprivation index, 16 PCs —
PPM010526 PGS001956
(portability-PLR_log_heel_BUA)
 PSS008549|
Greater Middle Eastern Ancestry|
505 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Heel Broadband ultrasound attenuation, direct entry — — Partial Correlation (partial-r): 0.306 [0.223, 0.3845] sex, age, birth date, deprivation index, 16 PCs —
PPM010527 PGS001956
(portability-PLR_log_heel_BUA)
 PSS008327|
South Asian Ancestry|
1,968 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Heel Broadband ultrasound attenuation, direct entry — — Partial Correlation (partial-r): 0.3216 [0.2812, 0.3609] sex, age, birth date, deprivation index, 16 PCs —
PPM010528 PGS001956
(portability-PLR_log_heel_BUA)
 PSS008104|
East Asian Ancestry|
819 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Heel Broadband ultrasound attenuation, direct entry — — Partial Correlation (partial-r): 0.2762 [0.2109, 0.3391] sex, age, birth date, deprivation index, 16 PCs —
PPM010529 PGS001956
(portability-PLR_log_heel_BUA)
 PSS007891|
African Ancestry|
795 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Heel Broadband ultrasound attenuation, direct entry — — Partial Correlation (partial-r): 0.1457 [0.076, 0.2139] sex, age, birth date, deprivation index, 16 PCs —
PPM010530 PGS001956
(portability-PLR_log_heel_BUA)
 PSS008995|
African Ancestry|
1,404 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Heel Broadband ultrasound attenuation, direct entry — — Partial Correlation (partial-r): 0.1465 [0.0946, 0.1977] sex, age, birth date, deprivation index, 16 PCs —
PPM012231 PGS002173
(portability-ldpred2_log_heel_BMD)
 PSS009446|
European Ancestry|
11,484 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Heel bone mineral density (BMD) — — Partial Correlation (partial-r): 0.4429 [0.428, 0.4575] sex, age, birth date, deprivation index, 16 PCs —
PPM012232 PGS002173
(portability-ldpred2_log_heel_BMD)
 PSS009220|
European Ancestry|
2,146 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Heel bone mineral density (BMD) — — Partial Correlation (partial-r): 0.4242 [0.3886, 0.4584] sex, age, birth date, deprivation index, 16 PCs —
PPM012233 PGS002173
(portability-ldpred2_log_heel_BMD)
 PSS008774|
European Ancestry|
3,461 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Heel bone mineral density (BMD) — — Partial Correlation (partial-r): 0.384 [0.3551, 0.4121] sex, age, birth date, deprivation index, 16 PCs —
PPM012234 PGS002173
(portability-ldpred2_log_heel_BMD)
 PSS008548|
Greater Middle Eastern Ancestry|
506 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Heel bone mineral density (BMD) — — Partial Correlation (partial-r): 0.3123 [0.2297, 0.3904] sex, age, birth date, deprivation index, 16 PCs —
PPM012235 PGS002173
(portability-ldpred2_log_heel_BMD)
 PSS008326|
South Asian Ancestry|
1,972 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Heel bone mineral density (BMD) — — Partial Correlation (partial-r): 0.338 [0.2981, 0.3767] sex, age, birth date, deprivation index, 16 PCs —
PPM012236 PGS002173
(portability-ldpred2_log_heel_BMD)
 PSS008103|
East Asian Ancestry|
820 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Heel bone mineral density (BMD) — — Partial Correlation (partial-r): 0.285 [0.22, 0.3474] sex, age, birth date, deprivation index, 16 PCs —
PPM012237 PGS002173
(portability-ldpred2_log_heel_BMD)
 PSS007890|
African Ancestry|
790 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Heel bone mineral density (BMD) — — Partial Correlation (partial-r): 0.1699 [0.1005, 0.2377] sex, age, birth date, deprivation index, 16 PCs —
PPM012238 PGS002173
(portability-ldpred2_log_heel_BMD)
 PSS008994|
African Ancestry|
1,406 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Heel bone mineral density (BMD) — — Partial Correlation (partial-r): 0.1647 [0.113, 0.2154] sex, age, birth date, deprivation index, 16 PCs —
PPM012240 PGS002174
(portability-ldpred2_log_heel_BUA)
 PSS009221|
European Ancestry|
2,147 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Heel Broadband ultrasound attenuation, direct entry — — Partial Correlation (partial-r): 0.3925 [0.3559, 0.4278] sex, age, birth date, deprivation index, 16 PCs —
PPM012241 PGS002174
(portability-ldpred2_log_heel_BUA)
 PSS008775|
European Ancestry|
3,463 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Heel Broadband ultrasound attenuation, direct entry — — Partial Correlation (partial-r): 0.3599 [0.3305, 0.3887] sex, age, birth date, deprivation index, 16 PCs —
PPM012242 PGS002174
(portability-ldpred2_log_heel_BUA)
 PSS008549|
Greater Middle Eastern Ancestry|
505 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Heel Broadband ultrasound attenuation, direct entry — — Partial Correlation (partial-r): 0.3282 [0.2463, 0.4054] sex, age, birth date, deprivation index, 16 PCs —
PPM012243 PGS002174
(portability-ldpred2_log_heel_BUA)
 PSS008327|
South Asian Ancestry|
1,968 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Heel Broadband ultrasound attenuation, direct entry — — Partial Correlation (partial-r): 0.3051 [0.2643, 0.3449] sex, age, birth date, deprivation index, 16 PCs —
PPM012244 PGS002174
(portability-ldpred2_log_heel_BUA)
 PSS008104|
East Asian Ancestry|
819 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Heel Broadband ultrasound attenuation, direct entry — — Partial Correlation (partial-r): 0.2633 [0.1976, 0.3267] sex, age, birth date, deprivation index, 16 PCs —
PPM012245 PGS002174
(portability-ldpred2_log_heel_BUA)
 PSS007891|
African Ancestry|
795 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Heel Broadband ultrasound attenuation, direct entry — — Partial Correlation (partial-r): 0.1219 [0.0519, 0.1907] sex, age, birth date, deprivation index, 16 PCs —
PPM012246 PGS002174
(portability-ldpred2_log_heel_BUA)
 PSS008995|
African Ancestry|
1,404 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Heel Broadband ultrasound attenuation, direct entry — — Partial Correlation (partial-r): 0.1515 [0.0996, 0.2026] sex, age, birth date, deprivation index, 16 PCs —
PPM012239 PGS002174
(portability-ldpred2_log_heel_BUA)
 PSS009447|
European Ancestry|
11,485 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Heel Broadband ultrasound attenuation, direct entry — — Partial Correlation (partial-r): 0.4168 [0.4015, 0.4318] sex, age, birth date, deprivation index, 16 PCs —
PPM014968 PGS002768
(BMD_prscs)
 PSS009939|
European Ancestry|
39,444 individuals
 PGP000364 |
Mars N et al. Am J Hum Genet (2022)
 Reported Trait: Osteoporosis OR: 1.31 [1.25, 1.38] — — age, sex, 10 PCs, technical covariates —
PPM017631 PGS003535
(cont-decay-log_heel_BMD)
 PSS010647|
European Ancestry|
3,384 individuals
 PGP000457 |
Ding Y et al. bioRxiv (2022)
|Pre		 Reported Trait: Heel bone mineral density (BMD) — — partial-R2: 0.15 sex, age, deprivation index, PC1-16 —
PPM017799 PGS003535
(cont-decay-log_heel_BMD)
 PSS010227|
European Ancestry|
1,383 individuals
 PGP000457 |
Ding Y et al. bioRxiv (2022)
|Pre		 Reported Trait: Heel bone mineral density (BMD) — — partial-R2: 0.17 sex, age, deprivation index, PC1-16 —
PPM017883 PGS003535
(cont-decay-log_heel_BMD)
 PSS010479|
South Asian Ancestry|
1,965 individuals
 PGP000457 |
Ding Y et al. bioRxiv (2022)
|Pre		 Reported Trait: Heel bone mineral density (BMD) — — partial-R2: 0.11 sex, age, deprivation index, PC1-16 —
PPM017967 PGS003535
(cont-decay-log_heel_BMD)
 PSS010395|
East Asian Ancestry|
811 individuals
 PGP000457 |
Ding Y et al. bioRxiv (2022)
|Pre		 Reported Trait: Heel bone mineral density (BMD) — — partial-R2: 0.07 sex, age, deprivation index, PC1-16 —
PPM018051 PGS003535
(cont-decay-log_heel_BMD)
 PSS010311|
African Ancestry|
786 individuals
 PGP000457 |
Ding Y et al. bioRxiv (2022)
|Pre		 Reported Trait: Heel bone mineral density (BMD) — — partial-R2: 0.02 sex, age, deprivation index, PC1-16 —
PPM018135 PGS003535
(cont-decay-log_heel_BMD)
 PSS010731|
African Ancestry|
1,397 individuals
 PGP000457 |
Ding Y et al. bioRxiv (2022)
|Pre		 Reported Trait: Heel bone mineral density (BMD) — — partial-R2: 0.03 sex, age, deprivation index, PC1-16 —
PPM017463 PGS003535
(cont-decay-log_heel_BMD)
 PSS010899|
European Ancestry|
11,350 individuals
 PGP000457 |
Ding Y et al. bioRxiv (2022)
|Pre		 Reported Trait: Heel bone mineral density (BMD) — — partial-R2: 0.2 sex, age, deprivation index, PC1-16 —
PPM017547 PGS003535
(cont-decay-log_heel_BMD)
 PSS010815|
European Ancestry|
2,145 individuals
 PGP000457 |
Ding Y et al. bioRxiv (2022)
|Pre		 Reported Trait: Heel bone mineral density (BMD) — — partial-R2: 0.19 sex, age, deprivation index, PC1-16 —
PPM017715 PGS003535
(cont-decay-log_heel_BMD)
 PSS010563|
Greater Middle Eastern Ancestry|
487 individuals
 PGP000457 |
Ding Y et al. bioRxiv (2022)
|Pre		 Reported Trait: Heel bone mineral density (BMD) — — partial-R2: 0.1 sex, age, deprivation index, PC1-16 —
PPM020526 PGS004411
(X78.score)
 PSS011364|
European Ancestry|
56,192 individuals
 PGP000561 |
Jung H et al. Commun Biol (2024)
 Reported Trait: Heel bone mineral density (BMD) T-score, automated — — PGS R2 (no covariates): 0.30125 — —
PPM020530 PGS004415
(X3148.score)
 PSS011364|
European Ancestry|
56,192 individuals
 PGP000561 |
Jung H et al. Commun Biol (2024)
 Reported Trait: Heel bone mineral density (BMD) — — PGS R2 (no covariates): 0.30248 — —
PPM020534 PGS004419
(X4105.score)
 PSS011364|
European Ancestry|
56,192 individuals
 PGP000561 |
Jung H et al. Commun Biol (2024)
 Reported Trait: Heel bone mineral density (BMD) (left) — — PGS R2 (no covariates): 0.2483 — —
PPM020535 PGS004420
(X4106.score)
 PSS011364|
European Ancestry|
56,192 individuals
 PGP000561 |
Jung H et al. Commun Biol (2024)
 Reported Trait: Heel bone mineral density (BMD) T-score, automated (left) — — PGS R2 (no covariates): 0.24744 — —
PPM020539 PGS004424
(X4124.score)
 PSS011364|
European Ancestry|
56,192 individuals
 PGP000561 |
Jung H et al. Commun Biol (2024)
 Reported Trait: Heel bone mineral density (BMD) (right) — — PGS R2 (no covariates): 0.24863 — —
PPM020540 PGS004425
(X4125.score)
 PSS011364|
European Ancestry|
56,192 individuals
 PGP000561 |
Jung H et al. Commun Biol (2024)
 Reported Trait: Heel bone mineral density (BMD) T-score, automated (right) — — PGS R2 (no covariates): 0.24814 — —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS007231 — — 1,434 individuals — African unspecified — UKB —
PSS007232 — — 500 individuals — East Asian — UKB —
PSS007233 — — 7,691 individuals — European non-white British ancestry UKB —
PSS007234 — — 1,449 individuals — South Asian — UKB —
PSS007235 — — 24,146 individuals — European white British ancestry UKB Testing cohort (heldout set)
PSS007241 — — 2,248 individuals — African unspecified — UKB —
PSS007242 — — 794 individuals — East Asian — UKB —
PSS007243 — — 12,374 individuals — European non-white British ancestry UKB —
PSS007244 — — 2,310 individuals — South Asian — UKB —
PSS007245 — — 38,814 individuals — European white British ancestry UKB Testing cohort (heldout set)
PSS007281 — — 3,560 individuals — African unspecified — UKB —
PSS007282 — — 781 individuals — East Asian — UKB —
PSS007283 — — 10,636 individuals — European non-white British ancestry UKB —
PSS007284 — — 5,043 individuals — South Asian — UKB —
PSS007285 — — 25,716 individuals — European white British ancestry UKB Testing cohort (heldout set)
PSS007291 — — 3,558 individuals — African unspecified — UKB —
PSS007292 — — 781 individuals — East Asian — UKB —
PSS007293 — — 10,626 individuals — European non-white British ancestry UKB —
PSS007294 — — 5,037 individuals — South Asian — UKB —
PSS007295 — — 25,706 individuals — European white British ancestry UKB Testing cohort (heldout set)
PSS007296 — — 3,560 individuals — African unspecified — UKB —
PSS007297 — — 781 individuals — East Asian — UKB —
PSS007298 — — 10,636 individuals — European non-white British ancestry UKB —
PSS007299 — — 5,043 individuals — South Asian — UKB —
PSS007300 — — 25,716 individuals — European white British ancestry UKB Testing cohort (heldout set)
PSS009220 — — 2,146 individuals — European Poland (NE Europe) UKB —
PSS009221 — — 2,147 individuals — European Poland (NE Europe) UKB —
PSS010731 — — 1,397 individuals,
49.0 % Male samples
 Mean = 51.9 years
Sd = 8.1 years		 African unspecified Nigerian UKB —
PSS007311 — — 3,592 individuals — African unspecified — UKB —
PSS007312 — — 782 individuals — East Asian — UKB —
PSS007313 — — 10,633 individuals — European non-white British ancestry UKB —
PSS007314 — — 5,041 individuals — South Asian — UKB —
PSS007315 — — 25,728 individuals — European white British ancestry UKB Testing cohort (heldout set)
PSS010227 — — 1,383 individuals,
46.0 % Male samples
 Mean = 57.7 years
Sd = 7.1 years		 European Ashkenazi UKB —
PSS007321 — — 3,586 individuals — African unspecified — UKB —
PSS007322 — — 782 individuals — East Asian — UKB —
PSS007323 — — 10,627 individuals — European non-white British ancestry UKB —
PSS007324 — — 5,032 individuals — South Asian — UKB —
PSS007325 — — 25,715 individuals — European white British ancestry UKB Testing cohort (heldout set)
PSS007326 — — 3,592 individuals — African unspecified — UKB —
PSS007327 — — 782 individuals — East Asian — UKB —
PSS007328 — — 10,633 individuals — European non-white British ancestry UKB —
PSS007329 — — 5,041 individuals — South Asian — UKB —
PSS007330 — — 25,728 individuals — European white British ancestry UKB Testing cohort (heldout set)
PSS008774 — — 3,461 individuals — European Italy (South Europe) UKB —
PSS008775 — — 3,463 individuals — European Italy (South Europe) UKB —
PSS011935 — — 3,744 individuals,
24.0 % Male samples
 Mean = 66.7 years East Asian — TPMI —
PSS010815 — — 2,145 individuals,
39.0 % Male samples
 Mean = 54.3 years
Sd = 7.2 years		 European Polish UKB —
PSS010311 — — 786 individuals,
35.0 % Male samples
 Mean = 52.2 years
Sd = 8.1 years		 African American or Afro-Caribbean Caribbean UKB —
PSS008326 — — 1,972 individuals — South Asian India (South Asia) UKB —
PSS008327 — — 1,968 individuals — South Asian India (South Asia) UKB —
PSS009939 — — 39,444 individuals — European
(Finnish)		 — FinnGen —
PSS010899 — — 11,350 individuals,
46.0 % Male samples
 Mean = 56.9 years
Sd = 7.8 years		 European white British UKB —
PSS007476 — — 2,253 individuals — African unspecified — UKB —
PSS007477 — — 795 individuals — East Asian — UKB —
PSS007478 — — 12,376 individuals — European non-white British ancestry UKB —
PSS007479 — — 2,312 individuals — South Asian — UKB —
PSS007480 — — 38,834 individuals — European white British ancestry UKB Testing cohort (heldout set)
PSS010395 — — 811 individuals,
35.0 % Male samples
 Mean = 51.9 years
Sd = 7.5 years		 East Asian Chinese UKB —
PSS007890 — — 790 individuals — African American or Afro-Caribbean Carribean UKB —
PSS007891 — — 795 individuals — African American or Afro-Caribbean Carribean UKB —
PSS009446 — — 11,484 individuals — European UK (+ Ireland) UKB —
PSS000585 — — 4,741 individuals,
47.5 % Male samples
 Mean = 55.8 years
Sd = 7.6 years		 European — UKB —
PSS000585 — — 6,704 individuals,
49.3 % Male samples
 Mean = 62.6 years
Sd = 9.9 years		 European, NR — CLSA —
PSS000585 — — 3,426 individuals,
0.0 % Male samples
 Mean = 71.5 years
Sd = 5.3 years		 European, NR — SOF —
PSS000585 — — 4,657 individuals,
100.0 % Male samples
 Mean = 74.0 years
Sd = 6.0 years		 European — MrOS-USA —
PSS000585 — — 1,880 individuals,
100.0 % Male samples
 Mean = 75.4 years
Sd = 3.2 years		 European
(Swedish)		 — MrOS-SWE —
PSS000586 — — 80,027 individuals,
47.5 % Male samples
 Mean = 55.8 years
Sd = 7.6 years		 European — UKB —
PSS009447 — — 11,485 individuals — European UK (+ Ireland) UKB —
PSS010479 — — 1,965 individuals,
55.0 % Male samples
 Mean = 52.7 years
Sd = 8.2 years		 South Asian Indian UKB —
PSS011364 — — 56,192 individuals — European — UKB —
PSS008994 — — 1,406 individuals — African unspecified Nigeria (West Africa) UKB —
PSS008995 — — 1,404 individuals — African unspecified Nigeria (West Africa) UKB —
PSS000932 Incident major osteoporotic fractures (MOF; composite of hip, clinical spine, forearm, humerus)(16) were identified from ques- tionnaire data from UK Biobank from the baseline assessment and ICD-10 codes from hospital admissions (primary diagnoses). ICD codes used to identify Fracture cases include: M8002, M8003, M8082, M8083, S422, S423, S424, S520, S521, S522, S523, S525, S526, S529, M8005, M8085, S720, S721,S722, M8008, M8088, S220, S320 —
[
  • 68 cases
  • , 12,610 controls
]
,
40.52 % Male samples
 Mean = 58.6 years
Sd = 7.7 years		 European — UKB —
PSS000933 Incident major osteoporotic fractures (MOF; composite of hip, clinical spine, forearm, humerus)(16) were identified from ques- tionnaire data from UK Biobank from the baseline assessment and ICD-10 codes from hospital admissions (primary diagnoses). ICD codes used to identify Fracture cases include: M8002, M8003, M8082, M8083, S422, S423, S424, S520, S521, S522, S523, S525, S526, S529, M8005, M8085, S720, S721,S722, M8008, M8088, S220, S320 —
[
  • 256 cases
  • , 12,422 controls
]
,
40.52 % Male samples
 Mean = 58.6 years
Sd = 7.6 years		 European — UKB —
PSS000934 Incident major osteoporotic fractures (MOF; composite of hip, clinical spine, forearm, humerus)(16) were identified from ques- tionnaire data from UK Biobank from the baseline assessment and ICD-10 codes from hospital admissions (primary diagnoses). ICD codes used to identify Fracture cases include: M8002, M8003, M8082, M8083, S422, S423, S424, S520, S521, S522, S523, S525, S526, S529, M8005, M8085, S720, S721,S722, M8008, M8088, S220, S322 —
[
  • 141 cases
  • , 67,195 controls
]
,
46.27 % Male samples
 Mean = 56.5 years
Sd = 8.2 years		 European — UKB —
PSS000935 Incident major osteoporotic fractures (MOF; composite of hip, clinical spine, forearm, humerus)(16) were identified from ques- tionnaire data from UK Biobank from the baseline assessment and ICD-10 codes from hospital admissions (primary diagnoses). ICD codes used to identify Fracture cases include: M8002, M8003, M8082, M8083, S422, S423, S424, S520, S521, S522, S523, S525, S526, S529, M8005, M8085, S720, S721,S722, M8008, M8088, S220, S321 —
[
  • 933 cases
  • , 66,403 controls
]
,
46.27 % Male samples
 Mean = 56.5 years
Sd = 8.1 years		 European — UKB —
PSS000936 Incident major osteoporotic fractures (MOF; composite of hip, clinical spine, forearm, humerus)(16) were identified from ques- tionnaire data from UK Biobank from the baseline assessment and ICD-10 codes from hospital admissions (primary diagnoses). ICD codes used to identify Fracture cases include: M8002, M8003, M8082, M8083, S422, S423, S424, S520, S521, S522, S523, S525, S526, S529, M8005, M8085, S720, S721,S722, M8008, M8088, S220, S320 —
[
  • 209 cases
  • , 79,805 controls
]
,
45.36 % Male samples
 Mean = 56.8 years
Sd = 8.1 years		 European — UKB —
PSS000937 Incident major osteoporotic fractures (MOF; composite of hip, clinical spine, forearm, humerus)(16) were identified from ques- tionnaire data from UK Biobank from the baseline assessment and ICD-10 codes from hospital admissions (primary diagnoses). ICD codes used to identify Fracture cases include: M8002, M8003, M8082, M8083, S422, S423, S424, S520, S521, S522, S523, S525, S526, S529, M8005, M8085, S720, S721,S722, M8008, M8088, S220, S320 —
[
  • 1,189 cases
  • , 78,825 controls
]
,
45.36 % Male samples
 Mean = 56.8 years
Sd = 8.0 years		 European — UKB —
PSS000938 Cases included individuals with a major osteoporotic fracture that occurred after the baseline visit. —
[
  • 323 cases
  • , 24,711 controls
]
,
42.7 % Male samples
 Mean = 53.7 years
Sd = 11.0 years		 East Asian — CKB —
PSS000939 Cases included individuals with a hip fracture that occurred after the baseline visit. —
[
  • 129 cases
  • , 1,751 controls
]
,
100.0 % Male samples
 Mean = 75.4 years
Sd = 3.2 years		 European — MrOS-SWE —
PSS000940 Cases included individuals with a major osteoporotic fracture that occurred after the baseline visit. —
[
  • 337 cases
  • , 1,543 controls
]
,
100.0 % Male samples
 Mean = 75.4 years
Sd = 3.2 years		 European — MrOS-SWE —
PSS000941 Cases included individuals with a hip fracture that occurred after the baseline visit. Mean = 4.5 years
[
  • 273 cases
  • , 4,390 controls
]
,
100.0 % Male samples
 Mean = 74.0 years
Sd = 6.0 years		 European — MrOS-USA —
PSS000942 Cases included individuals with a major osteoporotic fracture that occurred after the baseline visit. Mean = 4.5 years
[
  • 560 cases
  • , 4,103 controls
]
,
100.0 % Male samples
 Mean = 74.0 years
Sd = 6.0 years		 European — MrOS-USA —
PSS000943 Cases included individuals with a hip fracture that occurred after the baseline visit. Range = [4.5, 14.5] years
[
  • 829 cases
  • , 7,449 controls
]
,
56.33 % Male samples
 — European — MrOS-USA, SOF —
PSS000944 Cases included individuals with a major osteoporotic fracture that occurred after the baseline visit. Range = [4.5, 14.5] years
[
  • 1,267 cases
  • , 7,011 controls
]
,
56.33 % Male samples
 — European — MrOS-USA, SOF —
PSS000945 Cases included individuals with a hip fracture that occurred after the baseline visit. Mean = 14.5 years
[
  • 556 cases
  • , 3,059 controls
]
,
0.0 % Male samples
 Mean = 71.5 years
Sd = 5.3 years		 European — SOF —
PSS000946 Cases included individuals with a major osteoporotic fracture that occurred after the baseline visit. Mean = 14.5 years
[
  • 707 cases
  • , 2,908 controls
]
,
0.0 % Male samples
 Mean = 71.5 years
Sd = 5.3 years		 European — SOF —
PSS000947 Cases included individuals with a hip fracture that occurred after the baseline visit. —
[
  • 209 cases
  • , 79,805 controls
]
,
45.36 % Male samples
 Mean = 56.8 years
Sd = 8.0 years		 European — UKB —
PSS000948 Cases included individuals with a major osteoporotic fracture that occurred after the baseline visit. ICD 10 codes include: M8002, M8003, M8005, M8008, M8082, M8083, M8085, M8088, S220, S320, S422, S423, S424, S520, S521, S522, S523, S525, S526, S529, S720, S721, and S722. —
[
  • 1,189 cases
  • , 78,825 controls
]
,
45.36 % Male samples
 Mean = 56.8 years
Sd = 8.0 years		 European — UKB —
PSS000949 Cases included individuals with a major osteoporotic fracture that occurred after the baseline visit. ICD 10 codes include: M8002, M8003, M8005, M8008, M8082, M8083, M8085, M8088, S220, S320, S422, S423, S424, S520, S521, S522, S523, S525, S526, S529, S720, S721, and S722. —
[
  • 125 cases
  • , 4,592 controls
]
 — European — UKB —
PSS000950 Cases included individuals with a hip fracture that occurred after the baseline visit. Range = [4.5, 14.5] years
[
  • 1,167 cases
  • , 89,005 controls
]
,
31.61 % Male samples
 — European — MrOS-SWE, MrOS-USA, SOF, UKB —
PSS000951 Cases included individuals with a major osteoporotic fracture that occurred after the baseline visit. UKB cohort: Sitespecific major osteoporotic fractures were defined basedon ICD10 codes of primary diagnoses (M8002, M8003, M8005, M8008, M8082, M8083, M8085, M8088, S220, S320, S422, S423, S424, S520, S521, S522, S523, S525, S526, S529, S720, S721, and S722) and self-reported medical history. Range = [4.5, 14.5] years
[
  • 2,793 cases
  • , 87,379 controls
]
,
31.61 % Male samples
 — European — MrOS-SWE, MrOS-USA, SOF, UKB —
PSS008548 — — 506 individuals — Greater Middle Eastern (Middle Eastern, North African or Persian) Iran (Middle East) UKB —
PSS008549 — — 505 individuals — Greater Middle Eastern (Middle Eastern, North African or Persian) Iran (Middle East) UKB —
PSS010563 — — 487 individuals,
65.0 % Male samples
 Mean = 51.1 years
Sd = 7.6 years		 Greater Middle Eastern (Middle Eastern, North African or Persian) Iranian UKB —
PSS008103 — — 820 individuals — East Asian China (East Asia) UKB —
PSS008104 — — 819 individuals — East Asian China (East Asia) UKB —
PSS010647 — — 3,384 individuals,
46.0 % Male samples
 Mean = 54.5 years
Sd = 8.2 years		 European Italian UKB —