PGS Publication: PGP000237

Publication Information (EuropePMC)
Title Polygenic Risk Score of Longevity Predicts Longer Survival Across an Age Continuum.
PubMed ID 33216869(Europe PMC)
doi 10.1093/gerona/glaa289
Publication Date April 1, 2021
Journal J Gerontol A Biol Sci Med Sci
Author(s) Tesi N, van der Lee SJ, Hulsman M, Jansen IE, Stringa N, van Schoor NM, Scheltens P, van der Flier WM, Huisman M, Reinders MJT, Holstege H.
Released in PGS Catalog: Sept. 17, 2021

Associated Polygenic Score(s)

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Individuals included in:
G - Source of Variant Associations (GWAS)
D - Score Development/Training
E - PGS Evaluation
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PGS Developed By This Publication

Polygenic Score ID & Name PGS Publication ID (PGP) Reported Trait Mapped Trait(s) (Ontology) Number of Variants Ancestry distribution
GWAS
Dev
Eval
 Scoring File (FTP Link)
PGS000906
(PRS-5)
 PGP000237 |
Tesi N et al. J Gerontol A Biol Sci Med Sci (2021)
 Longevity longevity 330
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000906/ScoringFiles/PGS000906.txt.gz

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		Evaluated Score PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM002679 PGS000906
(PRS-5)
 PSS001184|
European Ancestry|
1,620 individuals
 PGP000237 |
Tesi N et al. J Gerontol A Biol Sci Med Sci (2021)
 Reported Trait: Survival HR: 0.89 [0.8, 0.98] — — Age at inclusion, gender, PCs(1-5), and APOE-ε4 carriership (dichotomized) Survival analysis performed in the control samples used to develop the PRS

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS001184 — Mean = 10.4 years
Sd = 6.9 years		 1,620 individuals,
47.0 % Male samples
 Mean = 62.7 years
Sd = 6.4 years		 European
(Dutch, NR)		 — 100-plus, LASA, NBB, NTR This dataset overlaps fully with the controls used to develop the score