Trait: longevity

Experimental Factor Ontology (EFO) Information
Identifier EFO_0004300
Description
  • The length of time of an organism's life.
  • Combine with age, or move?
Trait category
Other measurement
Synonym length of life
Mapped terms 2 mapped terms
  • MeSH:D008136
  • SNOMEDCT:111951006

Associated Polygenic Score(s)

Filter PGS by Participant Ancestry
Individuals included in:
G - Source of Variant Associations (GWAS)
D - Score Development/Training
E - PGS Evaluation
List of ancestries includes:
Display options:
Ancestry legend
Multi-ancestry (including European)
Multi-ancestry (excluding European)
African
East Asian
South Asian
Additional Asian Ancestries
European
Greater Middle Eastern
Hispanic or Latin American
Additional Diverse Ancestries
Not Reported
Polygenic Score ID & Name PGS Publication ID (PGP) Reported Trait Mapped Trait(s) (Ontology) Number of Variants Ancestry distribution
GWAS
Dev
Eval
 Scoring File (FTP Link)
PGS000906
(PRS-5)
 PGP000237 |
Tesi N et al. J Gerontol A Biol Sci Med Sci (2021)
 Longevity longevity 330
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000906/ScoringFiles/PGS000906.txt.gz
PGS002795
(PRS_longetivity)
 PGP000378 |
Schoepf IC et al. Clin Infect Dis (2021)
 Longevity (>90th survival percentile) longevity 4
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS002795/ScoringFiles/PGS002795.txt.gz

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		Evaluated Score PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM002679 PGS000906
(PRS-5)
 PSS001184|
European Ancestry|
1,620 individuals
 PGP000237 |
Tesi N et al. J Gerontol A Biol Sci Med Sci (2021)
 Reported Trait: Survival HR: 0.89 [0.8, 0.98] — — Age at inclusion, gender, PCs(1-5), and APOE-ε4 carriership (dichotomized) Survival analysis performed in the control samples used to develop the PRS
PPM015503 PGS002795
(PRS_longetivity)
 PSS009965|
European Ancestry|
836 individuals
 PGP000378 |
Schoepf IC et al. Clin Infect Dis (2021)
 Reported Trait: Coronary artery disease — — Odds Ratio (OR, fifth vs. first quintile): 1.61 [0.89, 2.91] Clinical risk factors —
PPM015505 PGS002795
(PRS_longetivity)
 PSS009965|
European Ancestry|
836 individuals
 PGP000378 |
Schoepf IC et al. Clin Infect Dis (2021)
 Reported Trait: Coronary artery disease — — Odds Ratio (OR, fifth vs. first quintile): 3.67 [2.0, 6.73] Clinical risk factors, PGS000018 Combined as metaPRS

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS009965 CAD events were defined according to the Data Collection on Adverse events of Anti-HIV Drugs (D:A:D) study and the MONICA Project of the World Health Organization, as reported elsewhere —
[
  • 269 cases
  • , 567 controls
]
 — European — SHCS —
PSS001184 — Mean = 10.4 years
Sd = 6.9 years		 1,620 individuals,
47.0 % Male samples
 Mean = 62.7 years
Sd = 6.4 years		 European
(Dutch, NR)		 — 100-plus, LASA, NBB, NTR This dataset overlaps fully with the controls used to develop the score