PGS Publication: PGP000254

Publication Information (EuropePMC)
Title Prediction of Parkinson's Disease Risk Based on Genetic Profile and Established Risk Factors.
PubMed ID 34440451(Europe PMC)
doi 10.3390/genes12081278
Publication Date Aug. 20, 2021
Journal Genes (Basel)
Author(s) Chairta PP, Hadjisavvas A, Georgiou AN, Loizidou MA, Yiangou K, Demetriou CA, Christou YP, Pantziaris M, Michailidou K, Zamba-Papanicolaou E.
Released in PGS Catalog: Nov. 25, 2021

Associated Polygenic Score(s)

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Individuals included in:
G - Source of Variant Associations (GWAS)
D - Score Development/Training
E - PGS Evaluation
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Not Reported

PGS Developed By This Publication

Polygenic Score ID & Name PGS Publication ID (PGP) Reported Trait Mapped Trait(s) (Ontology) Number of Variants Ancestry distribution
GWAS
Dev
Eval
 Scoring File (FTP Link)
PGS001774
(PRS12_PD)
 PGP000254 |
Chairta PP et al. Genes (Basel) (2021)
 Parkinson's disease Parkinson disease 12
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS001774/ScoringFiles/PGS001774.txt.gz

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		Evaluated Score PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM009233 PGS001774
(PRS12_PD)
 PSS007662|
European Ancestry|
699 individuals
 PGP000254 |
Chairta PP et al. Genes (Basel) (2021)
 Reported Trait: Parkinson's disease OR: 1.39 [1.06, 1.84] AUROC: 0.55 — — Prior to imputation of missing data
PPM009234 PGS001774
(PRS12_PD)
 PSS007662|
European Ancestry|
699 individuals
 PGP000254 |
Chairta PP et al. Genes (Basel) (2021)
 Reported Trait: Parkinson's disease — AUROC: 0.79 [0.75, 0.83] — Age, gender, head injury, family history of Parkinson's disease, depression, smoking (current or ever), body mass index Prior to imputation of missing data
PPM009235 PGS001774
(PRS12_PD)
 PSS007662|
European Ancestry|
699 individuals
 PGP000254 |
Chairta PP et al. Genes (Basel) (2021)
 Reported Trait: Parkinson's disease OR: 1.39 [1.06, 1.83] AUROC: 0.55 — — Following imputation of missing data
PPM009236 PGS001774
(PRS12_PD)
 PSS007662|
European Ancestry|
699 individuals
 PGP000254 |
Chairta PP et al. Genes (Basel) (2021)
 Reported Trait: Parkinson's disease — AUROC: 0.8 [0.77, 0.84] — Age, gender, head injury, family history of Parkinson's disease, depression, smoking (current or ever), body mass index Following imputation of missing data

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS007662 Cases were individuals with Parkinson's disease (PD). All cases were recruited in the study after a clinical diagnosis of PD. —
[
  • 235 cases
  • , 464 controls
]
,
51.36 % Male samples
 — European — NR —