PGS Publication: PGP000272

Publication Information (EuropePMC)
Title Impact of adiposity on risk of female gout among those genetically predisposed: sex-specific prospective cohort study findings over >32 years.
PubMed ID 34857519(Europe PMC)
doi 10.1136/annrheumdis-2021-221635
Publication Date Dec. 2, 2021
Journal Ann Rheum Dis
Author(s) McCormick N, Yokose C, Lu N, Joshi AD, Curhan GC, Choi HK.
Released in PGS Catalog: Jan. 24, 2022

Associated Polygenic Score(s)

Filter PGS by Participant Ancestry
Individuals included in:
G - Source of Variant Associations (GWAS)
D - Score Development/Training
E - PGS Evaluation
List of ancestries includes:
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Additional Asian Ancestries
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Greater Middle Eastern
Hispanic or Latin American
Additional Diverse Ancestries
Not Reported

External PGS Evaluated By This Publication

Polygenic Score ID & Name PGS Publication ID (PGP) Reported Trait Mapped Trait(s) (Ontology) Number of Variants Ancestry distribution
GWAS
Dev
Eval
 Scoring File (FTP Link)
PGS000126
(Urate_GRS)
 PGP000063 |
Tin A et al. Nat Genet (2019)
 Serum urate urate measurement 114
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000126/ScoringFiles/PGS000126.txt.gz

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		Evaluated Score PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM012772 PGS000126
(Urate_GRS)
 PSS009550|
European Ancestry|
8,246 individuals
 PGP000272 |
McCormick N et al. Ann Rheum Dis (2021)
|Ext.		 Reported Trait: Incident gout — — Relative Risk (RR): 2.01 [1.69, 2.39] BMI, age, total energy intake, consumption of meat, seafood and dairy foods, history of hypertension, diuretic use, menopausal status (women only), and use of oral contraceptive or postmenopausal hormone therapy (women only). —
PPM012773 PGS000126
(Urate_GRS)
 PSS009549|
European Ancestry|
10,888 individuals
 PGP000272 |
McCormick N et al. Ann Rheum Dis (2021)
|Ext.		 Reported Trait: Incident gout — — Relative Risk (RR): 1.41 [1.34, 1.48] age, total energy intake, consumption of meat, seafood and dairy foods, history of hypertension, diuretic use, menopausal status (women only), and use of oral contraceptive or postmenopausal hormone therapy (women only). —
PPM012774 PGS000126
(Urate_GRS)
 PSS009549|
European Ancestry|
10,888 individuals
 PGP000272 |
McCormick N et al. Ann Rheum Dis (2021)
|Ext.		 Reported Trait: Incident gout — — Relative Risk (RR): 1.97 BMI, age, total energy intake, consumption of meat, seafood and dairy foods, history of hypertension, diuretic use, menopausal status (women only), and use of oral contraceptive or postmenopausal hormone therapy (women only). —
PPM012771 PGS000126
(Urate_GRS)
 PSS009550|
European Ancestry|
8,246 individuals
 PGP000272 |
McCormick N et al. Ann Rheum Dis (2021)
|Ext.		 Reported Trait: Incident gout — — Relative Risk (RR): 1.41 [1.19, 1.68] age, total energy intake, consumption of meat, seafood and dairy foods, history of hypertension, diuretic use, menopausal status (women only), and use of oral contraceptive or postmenopausal hormone therapy (women only). —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS009549 — —
[
  • 1,703 cases
  • , 9,185 controls
]
,
100.0 % Male samples
 — European — HPFS —
PSS009550 — —
[
  • 188 cases
  • , 8,058 controls
]
,
0.0 % Male samples
 — European — NHS2 —