Polygenic Score (PGS) ID: PGS000126

Predicted Trait
Reported Trait Serum urate
Mapped Trait(s) urate measurement (EFO_0004531)
Released in PGS Catalog: March 27, 2020
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Score Details

Score Construction
PGS Name Urate_GRS
Development Method
Name Genome-wide significant variants
Parameters Conditionally independent GWAS loci in Europeans
Variants
Original Genome Build GRCh37
Number of Variants 114
Effect Weight Type NR
PGS Source
PGS Catalog Publication (PGP) ID PGP000063
Citation (link to publication) Tin A et al. Nat Genet (2019)
Ancestry Distribution
Source of Variant
Associations (GWAS)
European: 100%
288,649 individuals (100%)
PGS Evaluation
European: 100%
5 Sample Sets

Development Samples

Source of Variant Associations (GWAS)
Study Identifiers Sample Numbers Sample Ancestry Cohort(s)
GWAS Catalog: GCST008971
Europe PMC: 31578528
 288,649 individuals European NR

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM000406 PSS000233|
European Ancestry|
334,880 individuals
 PGP000063 |
Tin A et al. Nat Genet (2019)
 Reported Trait: Prevalent gout cases — AUROC: 0.84 — age, sex —
PPM000405 PSS000233|
European Ancestry|
334,880 individuals
 PGP000063 |
Tin A et al. Nat Genet (2019)
 Reported Trait: Prevalent gout cases — AUROC: 0.67 — — —
PPM012772 PSS009550|
European Ancestry|
8,246 individuals
 PGP000272 |
McCormick N et al. Ann Rheum Dis (2021)
|Ext.		 Reported Trait: Incident gout — — Relative Risk (RR): 2.01 [1.69, 2.39] BMI, age, total energy intake, consumption of meat, seafood and dairy foods, history of hypertension, diuretic use, menopausal status (women only), and use of oral contraceptive or postmenopausal hormone therapy (women only). —
PPM012773 PSS009549|
European Ancestry|
10,888 individuals
 PGP000272 |
McCormick N et al. Ann Rheum Dis (2021)
|Ext.		 Reported Trait: Incident gout — — Relative Risk (RR): 1.41 [1.34, 1.48] age, total energy intake, consumption of meat, seafood and dairy foods, history of hypertension, diuretic use, menopausal status (women only), and use of oral contraceptive or postmenopausal hormone therapy (women only). —
PPM012774 PSS009549|
European Ancestry|
10,888 individuals
 PGP000272 |
McCormick N et al. Ann Rheum Dis (2021)
|Ext.		 Reported Trait: Incident gout — — Relative Risk (RR): 1.97 BMI, age, total energy intake, consumption of meat, seafood and dairy foods, history of hypertension, diuretic use, menopausal status (women only), and use of oral contraceptive or postmenopausal hormone therapy (women only). —
PPM012771 PSS009550|
European Ancestry|
8,246 individuals
 PGP000272 |
McCormick N et al. Ann Rheum Dis (2021)
|Ext.		 Reported Trait: Incident gout — — Relative Risk (RR): 1.41 [1.19, 1.68] age, total energy intake, consumption of meat, seafood and dairy foods, history of hypertension, diuretic use, menopausal status (women only), and use of oral contraceptive or postmenopausal hormone therapy (women only). —
PPM021126 PSS011533|
European Ancestry|
43,991 individuals
 PGP000615 |
Zhang Y et al. Front Genet (2021)
|Ext.		 Reported Trait: Gout β: 1.495 [1.372, 1.619] — — Age, sex, body mass index, first 10 PCs Only 110 of 114 SNPs were used for score calculation due to poor imputation quality for 4 SNPs
PPM021127 PSS011534|
European Ancestry|
12,164 individuals
 PGP000615 |
Zhang Y et al. Front Genet (2021)
|Ext.		 Reported Trait: Gout — AUROC: 0.804 — Age, sex, body mass index Only 110 of 114 SNPs were used for score calculation due to poor imputation quality for 4 SNPs

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS000233 Gout identified by self-report at the inclusion visit, individuals with an ICD-10 for gout (M10) in hospital admissions who did not self-report gout were excluded from the analysis. —
[
  • 4,908 cases
  • , 329,972 controls
]
 — European White British subset, unrelated UKB —
PSS009549 — —
[
  • 1,703 cases
  • , 9,185 controls
]
,
100.0 % Male samples
 — European — HPFS —
PSS009550 — —
[
  • 188 cases
  • , 8,058 controls
]
,
0.0 % Male samples
 — European — NHS2 —
PSS011533 Cases are individuals with gout (phecode: 274.10) —
[
  • 2,858 cases
  • , 41,133 controls
]
 — European — MyCode Possible partial sample overlap between this dataset and the MyCode cohort used to source the score
PSS011534 Cases are individuals with gout —
[
  • 561 cases
  • , 11,603 controls
]
 — European — MyCode —