PGS Publication: PGP000615

Publication Information (EuropePMC)
Title Serum Urate Polygenic Risk Score Can Improve Gout Risk Prediction: A Large-Scale Cohort Study.
PubMed ID 33613619(Europe PMC)
doi 10.3389/fgene.2020.604219
Publication Date Feb. 4, 2021
Journal Front Genet
Author(s) Zhang Y, Lee MTM.
Released in PGS Catalog: April 18, 2024

Associated Polygenic Score(s)

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Individuals included in:
G - Source of Variant Associations (GWAS)
D - Score Development/Training
E - PGS Evaluation
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External PGS Evaluated By This Publication

Polygenic Score ID & Name PGS Publication ID (PGP) Reported Trait Mapped Trait(s) (Ontology) Number of Variants Ancestry distribution
GWAS
Dev
Eval
 Scoring File (FTP Link)
PGS000126
(Urate_GRS)
 PGP000063 |
Tin A et al. Nat Genet (2019)
 Serum urate urate measurement 114
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000126/ScoringFiles/PGS000126.txt.gz

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		Evaluated Score PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM021126 PGS000126
(Urate_GRS)
 PSS011533|
European Ancestry|
43,991 individuals
 PGP000615 |
Zhang Y et al. Front Genet (2021)
|Ext.		 Reported Trait: Gout β: 1.495 [1.372, 1.619] — — Age, sex, body mass index, first 10 PCs Only 110 of 114 SNPs were used for score calculation due to poor imputation quality for 4 SNPs
PPM021127 PGS000126
(Urate_GRS)
 PSS011534|
European Ancestry|
12,164 individuals
 PGP000615 |
Zhang Y et al. Front Genet (2021)
|Ext.		 Reported Trait: Gout — AUROC: 0.804 — Age, sex, body mass index Only 110 of 114 SNPs were used for score calculation due to poor imputation quality for 4 SNPs

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS011533 Cases are individuals with gout (phecode: 274.10) —
[
  • 2,858 cases
  • , 41,133 controls
]
 — European — MyCode Possible partial sample overlap between this dataset and the MyCode cohort used to source the score
PSS011534 Cases are individuals with gout —
[
  • 561 cases
  • , 11,603 controls
]
 — European — MyCode —