| Publication Information (EuropePMC) | |
| Title | Risk Stratification for Early-Onset Colorectal Cancer Using a Combination of Genetic and Environmental Risk Scores: An International Multi-Center Study. |
| PubMed ID | 35026030(Europe PMC) |
| doi | 10.1093/jnci/djac003 |
| Publication Date | Jan. 13, 2022 |
| Journal | J Natl Cancer Inst |
| Author(s) | Archambault AN, Jeon J, Lin Y, Thomas M, Harrison TA, Bishop DT, Brenner H, Casey G, Chan AT, Chang-Claude J, Figueiredo JC, Gallinger S, Gruber SB, Gunter MJ, Guo F, Hoffmeister M, Jenkins MA, Keku TO, Le Marchand L, Li L, Moreno V, Newcomb PA, Pai R, Parfrey PS, Rennert G, Sakoda LC, Lee JK, Slattery ML, Song M, Ko Win A, Woods MO, Murphy N, Campbell PT, Su YR, Lansdorp-Vogelaar I, Peterse EF, Cao Y, Zeleniuch-Jacquotte A, Liang PS, Du M, Corley DA, Hsu L, Peters U, Hayes RB. |
| Polygenic Score ID & Name | PGS Publication ID (PGP) | Reported Trait | Mapped Trait(s) (Ontology) | Number of Variants |
Ancestry distribution GWAS Dev Eval |
Scoring File (FTP Link) |
|---|---|---|---|---|---|---|
| PGS002252 (PRS_CRC) |
PGP000279 | Archambault AN et al. J Natl Cancer Inst (2022) |
Colorectal cancer | colorectal cancer | 141 | - |
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS002252/ScoringFiles/PGS002252.txt.gz |
|
PGS Performance Metric ID (PPM) |
Evaluated Score |
PGS Sample Set ID (PSS) |
Performance Source | Trait |
PGS Effect Sizes (per SD change) |
Classification Metrics | Other Metrics | Covariates Included in the Model |
PGS Performance: Other Relevant Information |
|---|---|---|---|---|---|---|---|---|---|
| PPM012805 | PGS002252 (PRS_CRC) |
PSS009566| European Ancestry| 7,376 individuals |
PGP000279 | Archambault AN et al. J Natl Cancer Inst (2022) |
Reported Trait: Early-onset colorectal cancer | OR: 1.59 [1.51, 1.68] | AUROC: 0.628 [0.613, 0.644] | — | Age, sex, genotype platform, family history, principal components | — |
| PPM012806 | PGS002252 (PRS_CRC) |
PSS009566| European Ancestry| 7,376 individuals |
PGP000279 | Archambault AN et al. J Natl Cancer Inst (2022) |
Reported Trait: Early-onset colorectal cancer (men) | — | AUROC: 0.61 [0.592, 0.651] | — | Age, family history, genotype platform, principal components | — |
| PPM012807 | PGS002252 (PRS_CRC) |
PSS009566| European Ancestry| 7,376 individuals |
PGP000279 | Archambault AN et al. J Natl Cancer Inst (2022) |
Reported Trait: Early-onset colorectal cancer (women) | — | AUROC: 0.633 [0.612, 0.655] | — | Age, family history, genotype platform, principal components | — |
| PPM012808 | PGS002252 (PRS_CRC) |
PSS009566| European Ancestry| 7,376 individuals |
PGP000279 | Archambault AN et al. J Natl Cancer Inst (2022) |
Reported Trait: Proximal colon cancer | OR: 1.38 [1.27, 1.5] | AUROC: 0.592 [0.554, 0.63] | — | Age, family history, genotype platform, principal components | — |
| PPM012809 | PGS002252 (PRS_CRC) |
PSS009566| European Ancestry| 7,376 individuals |
PGP000279 | Archambault AN et al. J Natl Cancer Inst (2022) |
Reported Trait: Distal colon cancer | OR: 1.73 [1.6, 1.87] | AUROC: 0.643 [0.614, 0.671] | — | Age, family history, genotype platform, principal components | — |
| PPM012810 | PGS002252 (PRS_CRC) |
PSS009566| European Ancestry| 7,376 individuals |
PGP000279 | Archambault AN et al. J Natl Cancer Inst (2022) |
Reported Trait: Rectal cancer | OR: 1.67 [1.55, 1.8] | AUROC: 0.654 [0.63, 0.68] | — | Age, family history, genotype platform, principal components | — |
|
PGS Sample Set ID (PSS) |
Phenotype Definitions and Methods | Participant Follow-up Time | Sample Numbers | Age of Study Participants | Sample Ancestry | Additional Ancestry Description | Cohort(s) | Additional Sample/Cohort Information |
|---|---|---|---|---|---|---|---|---|
| PSS009566 | — | — | [
|
Maximum = 50.0 years | European | — | 9 cohorts
|
CRCGEN, Kentucky, LCCS |