PGS Publication: PGP000280

Publication Information (EuropePMC)
Title Polygenic Risk Scores and Physical Activity.
PubMed ID 32049886(Europe PMC)
doi 10.1249/mss.0000000000002290
Publication Date July 1, 2020
Journal Med Sci Sports Exerc
Author(s) Kujala UM, Palviainen T, Pesonen P, Waller K, Sillanpää E, Niemelä M, Kangas M, Vähä-Ypyä H, Sievänen H, Korpelainen R, Jämsä T, Männikkö M, Kaprio J.
Released in PGS Catalog: Feb. 16, 2022

Associated Polygenic Score(s)

Filter PGS by Participant Ancestry
Individuals included in:
G - Source of Variant Associations (GWAS)
D - Score Development/Training
E - PGS Evaluation
List of ancestries includes:
Display options:
Ancestry legend
Multi-ancestry (including European)
Multi-ancestry (excluding European)
African
East Asian
South Asian
Additional Asian Ancestries
European
Greater Middle Eastern
Hispanic or Latin American
Additional Diverse Ancestries
Not Reported

PGS Developed By This Publication

Polygenic Score ID & Name PGS Publication ID (PGP) Reported Trait Mapped Trait(s) (Ontology) Number of Variants Ancestry distribution
GWAS
Dev
Eval
 Scoring File (FTP Link)
PGS002255
(PRS_measured)
 PGP000280 |
Kujala UM et al. Med Sci Sports Exerc (2020)
 Physical activity (measured) physical activity measurement 1,140,182
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS002255/ScoringFiles/PGS002255.txt.gz
PGS002254
(PRS_reported)
 PGP000280 |
Kujala UM et al. Med Sci Sports Exerc (2020)
 Physical activity (self-reported) physical activity measurement,
self-reported trait		 1,142,416
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS002254/ScoringFiles/PGS002254.txt.gz

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		Evaluated Score PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM012823 PGS002254
(PRS_reported)
 PSS009569|
European Ancestry|
11,528 individuals
 PGP000280 |
Kujala UM et al. Med Sci Sports Exerc (2020)
 Reported Trait: Daily leisure-time physical activity (MET score) β: 0.1717 (0.0323) — ΔR2 (%): 0.25 age, sex, and four genetic principal components —
PPM012824 PGS002254
(PRS_reported)
 PSS009571|
European Ancestry|
4,061 individuals
 PGP000280 |
Kujala UM et al. Med Sci Sports Exerc (2020)
 Reported Trait: Daily leisure-time physical activity (MET score) β: 0.0355 (0.0113) — ΔR2 (%): 0.24 age, sex, and four genetic principal components —
PPM012825 PGS002255
(PRS_measured)
 PSS009569|
European Ancestry|
11,528 individuals
 PGP000280 |
Kujala UM et al. Med Sci Sports Exerc (2020)
 Reported Trait: Daily leisure-time physical activity (MET score) β: 0.0908 (0.0321) — ΔR2 (%): 0.07 age, sex, and four genetic principal components —
PPM012826 PGS002255
(PRS_measured)
 PSS009571|
European Ancestry|
4,061 individuals
 PGP000280 |
Kujala UM et al. Med Sci Sports Exerc (2020)
 Reported Trait: Daily leisure-time physical activity (MET score) β: 0.0405 (0.0112) — ΔR2 (%): 0.32 age, sex, and four genetic principal components —
PPM012827 PGS002255
(PRS_measured)
 PSS009570|
European Ancestry|
765 individuals
 PGP000280 |
Kujala UM et al. Med Sci Sports Exerc (2020)
 Reported Trait: Daily moderate-to-vigorous physical activity β: 2.497 (1.093) — ΔR2 (%): 0.9 age, sex, and four genetic principal components —
PPM012828 PGS002255
(PRS_measured)
 PSS009571|
European Ancestry|
4,061 individuals
 PGP000280 |
Kujala UM et al. Med Sci Sports Exerc (2020)
 Reported Trait: Daily moderate-to-vigorous physical activity β: 0.162 (0.0335) — ΔR2 (%): 0.62 age, sex, and four genetic principal components —
PPM012829 PGS002255
(PRS_measured)
 PSS009570|
European Ancestry|
765 individuals
 PGP000280 |
Kujala UM et al. Med Sci Sports Exerc (2020)
 Reported Trait: Daily steps β: 369.8 (123.3) — ΔR2 (%): 1.44 age, sex, and four genetic principal components —
PPM012830 PGS002255
(PRS_measured)
 PSS009571|
European Ancestry|
4,061 individuals
 PGP000280 |
Kujala UM et al. Med Sci Sports Exerc (2020)
 Reported Trait: Daily steps β: 365.82 (64.04) — ΔR2 (%): 0.96 age, sex, and four genetic principal components —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS009569 — — 11,528 individuals,
46.0 % Male samples
 Mean = 44.0 years European
(Finnish)		 — FTC —
PSS009570 — — 765 individuals,
46.0 % Male samples
 Mean = 73.0 years European
(Finnish)		 — NR MOBILETWIN Study
PSS009571 — — 4,061 individuals,
48.0 % Male samples
 Mean = 46.0 years European
(Finnish)		 — NFBC —