| Publication Information (EuropePMC) | |
| Title | Genetic analysis of over 1 million people identifies 535 new loci associated with blood pressure traits. |
| PubMed ID | 30224653(Europe PMC) |
| doi | 10.1038/s41588-018-0205-x |
| Publication Date | Sept. 17, 2018 |
| Journal | Nat Genet |
| Author(s) | Evangelou E, Warren HR, Mosen-Ansorena D, Mifsud B, Pazoki R, Gao H, Ntritsos G, Dimou N, Cabrera CP, Karaman I, Ng FL, Evangelou M, Witkowska K, Tzanis E, Hellwege JN, Giri A, Velez Edwards DR, Sun YV, Cho K, Gaziano JM, Wilson PWF, Tsao PS, Kovesdy CP, Esko T, Mägi R, Milani L, Almgren P, Boutin T, Debette S, Ding J, Giulianini F, Holliday EG, Jackson AU, Li-Gao R, Lin WY, Luan J, Mangino M, Oldmeadow C, Prins BP, Qian Y, Sargurupremraj M, Shah N, Surendran P, Thériault S, Verweij N, Willems SM, Zhao JH, Amouyel P, Connell J, de Mutsert R, Doney ASF, Farrall M, Menni C, Morris AD, Noordam R, Paré G, Poulter NR, Shields DC, Stanton A, Thom S, Abecasis G, Amin N, Arking DE, Ayers KL, Barbieri CM, Batini C, Bis JC, Blake T, Bochud M, Boehnke M, Boerwinkle E, Boomsma DI, Bottinger EP, Braund PS, Brumat M, Campbell A, Campbell H, Chakravarti A, Chambers JC, Chauhan G, Ciullo M, Cocca M, Collins F, Cordell HJ, Davies G, de Borst MH, de Geus EJ, Deary IJ, Deelen J, Del Greco M F, Demirkale CY, Dörr M, Ehret GB, Elosua R, Enroth S, Erzurumluoglu AM, Ferreira T, Frånberg M, Franco OH, Gandin I, Gasparini P, Giedraitis V, Gieger C, Girotto G, Goel A, Gow AJ, Gudnason V, Guo X, Gyllensten U, Hamsten A, Harris TB, Harris SE, Hartman CA, Havulinna AS, Hicks AA, Hofer E, Hofman A, Hottenga JJ, Huffman JE, Hwang SJ, Ingelsson E, James A, Jansen R, Jarvelin MR, Joehanes R, Johansson Å, Johnson AD, Joshi PK, Jousilahti P, Jukema JW, Jula A, Kähönen M, Kathiresan S, Keavney BD, Khaw KT, Knekt P, Knight J, Kolcic I, Kooner JS, Koskinen S, Kristiansson K, Kutalik Z, Laan M, Larson M, Launer LJ, Lehne B, Lehtimäki T, Liewald DCM, Lin L, Lind L, Lindgren CM, Liu Y, Loos RJF, Lopez LM, Lu Y, Lyytikäinen LP, Mahajan A, Mamasoula C, Marrugat J, Marten J, Milaneschi Y, Morgan A, Morris AP, Morrison AC, Munson PJ, Nalls MA, Nandakumar P, Nelson CP, Niiranen T, Nolte IM, Nutile T, Oldehinkel AJ, Oostra BA, O'Reilly PF, Org E, Padmanabhan S, Palmas W, Palotie A, Pattie A, Penninx BWJH, Perola M, Peters A, Polasek O, Pramstaller PP, Nguyen QT, Raitakari OT, Ren M, Rettig R, Rice K, Ridker PM, Ried JS, Riese H, Ripatti S, Robino A, Rose LM, Rotter JI, Rudan I, Ruggiero D, Saba Y, Sala CF, Salomaa V, Samani NJ, Sarin AP, Schmidt R, Schmidt H, Shrine N, Siscovick D, Smith AV, Snieder H, Sõber S, Sorice R, Starr JM, Stott DJ, Strachan DP, Strawbridge RJ, Sundström J, Swertz MA, Taylor KD, Teumer A, Tobin MD, Tomaszewski M, Toniolo D, Traglia M, Trompet S, Tuomilehto J, Tzourio C, Uitterlinden AG, Vaez A, van der Most PJ, van Duijn CM, Vergnaud AC, Verwoert GC, Vitart V, Völker U, Vollenweider P, Vuckovic D, Watkins H, Wild SH, Willemsen G, Wilson JF, Wright AF, Yao J, Zemunik T, Zhang W, Attia JR, Butterworth AS, Chasman DI, Conen D, Cucca F, Danesh J, Hayward C, Howson JMM, Laakso M, Lakatta EG, Langenberg C, Melander O, Mook-Kanamori DO, Palmer CNA, Risch L, Scott RA, Scott RJ, Sever P, Spector TD, van der Harst P, Wareham NJ, Zeggini E, Levy D, Munroe PB, Newton-Cheh C, Brown MJ, Metspalu A, Hung AM, O'Donnell CJ, Edwards TL, Psaty BM, Tzoulaki I, Barnes MR, Wain LV, Elliott P, Caulfield MJ, Million Veteran Program. |
| Polygenic Score ID & Name | PGS Publication ID (PGP) | Reported Trait | Mapped Trait(s) (Ontology) | Number of Variants |
Ancestry distribution GWAS Dev Eval |
Scoring File (FTP Link) |
|---|---|---|---|---|---|---|
| PGS002258 (GRS901_DBP) |
PGP000283 | Evangelou E et al. Nat Genet (2018) |
Diastolic blood pressure | diastolic blood pressure | 885 | - |
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS002258/ScoringFiles/PGS002258.txt.gz |
| PGS002257 (GRS901_SBP) |
PGP000283 | Evangelou E et al. Nat Genet (2018) |
Systolic blood pressure | systolic blood pressure | 884 | - |
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS002257/ScoringFiles/PGS002257.txt.gz |
|
PGS Performance Metric ID (PPM) |
Evaluated Score |
PGS Sample Set ID (PSS) |
Performance Source | Trait |
PGS Effect Sizes (per SD change) |
Classification Metrics | Other Metrics | Covariates Included in the Model |
PGS Performance: Other Relevant Information |
|---|---|---|---|---|---|---|---|---|---|
| PPM012835 | PGS002257 (GRS901_SBP) |
PSS009574| European Ancestry| 14,004 individuals |
PGP000283 | Evangelou E et al. Nat Genet (2018) |
Reported Trait: Systolic blood pressure | β: 2.06 [1.79, 2.32] | — | — | — | *Note performance is based on the average between GRS901_SBP and GRS_901_DBP |
| PPM012836 | PGS002257 (GRS901_SBP) |
PSS009574| European Ancestry| 14,004 individuals |
PGP000283 | Evangelou E et al. Nat Genet (2018) |
Reported Trait: Diastolic blood pressure | β: 1.64 [1.46, 1.81] | — | — | — | *Note performance is based on the average between GRS901_SBP and GRS_901_DBP |
| PPM012837 | PGS002257 (GRS901_SBP) |
PSS009574| European Ancestry| 14,004 individuals |
PGP000283 | Evangelou E et al. Nat Genet (2018) |
Reported Trait: Pulse pressure | β: 0.42 [0.25, 0.58] | — | — | — | *Note performance is based on the average between GRS901_SBP and GRS_901_DBP |
| PPM012838 | PGS002257 (GRS901_SBP) |
PSS009574| European Ancestry| 14,004 individuals |
PGP000283 | Evangelou E et al. Nat Genet (2018) |
Reported Trait: Hypertension | OR: 1.27 [1.23, 1.32] | — | — | — | *Note performance is based on the average between GRS901_SBP and GRS_901_DBP |
| PPM012839 | PGS002257 (GRS901_SBP) |
PSS009575| African Ancestry| 6,970 individuals |
PGP000283 | Evangelou E et al. Nat Genet (2018) |
Reported Trait: Systolic blood pressure | β: 2.38 [1.85, 2.9] | — | — | — | *Note performance is based on the average between GRS901_SBP and GRS_901_DBP |
| PPM012840 | PGS002257 (GRS901_SBP) |
PSS009575| African Ancestry| 6,970 individuals |
PGP000283 | Evangelou E et al. Nat Genet (2018) |
Reported Trait: Diastolic blood pressure | β: 1.39 [1.09, 1.7] | — | — | — | *Note performance is based on the average between GRS901_SBP and GRS_901_DBP |
| PPM012841 | PGS002257 (GRS901_SBP) |
PSS009575| African Ancestry| 6,970 individuals |
PGP000283 | Evangelou E et al. Nat Genet (2018) |
Reported Trait: Pulse pressure | β: 0.99 [0.65, 1.32] | — | — | — | *Note performance is based on the average between GRS901_SBP and GRS_901_DBP |
| PPM012842 | PGS002257 (GRS901_SBP) |
PSS009575| African Ancestry| 6,970 individuals |
PGP000283 | Evangelou E et al. Nat Genet (2018) |
Reported Trait: Hypertension | OR: 1.26 [1.2, 1.33] | — | — | — | *Note performance is based on the average between GRS901_SBP and GRS_901_DBP |
| PPM012843 | PGS002257 (GRS901_SBP) |
PSS009576| South Asian Ancestry| 8,827 individuals |
PGP000283 | Evangelou E et al. Nat Genet (2018) |
Reported Trait: Systolic blood pressure | β: 2.58 [2.13, 3.03] | — | — | — | *Note performance is based on the average between GRS901_SBP and GRS_901_DBP |
| PPM012844 | PGS002257 (GRS901_SBP) |
PSS009576| South Asian Ancestry| 8,827 individuals |
PGP000283 | Evangelou E et al. Nat Genet (2018) |
Reported Trait: Diastolic blood pressure | β: 1.49 [1.25, 1.74] | — | — | — | *Note performance is based on the average between GRS901_SBP and GRS_901_DBP |
| PPM012845 | PGS002257 (GRS901_SBP) |
PSS009576| South Asian Ancestry| 8,827 individuals |
PGP000283 | Evangelou E et al. Nat Genet (2018) |
Reported Trait: Pulse pressure | β: 1.09 [0.8, 1.39] | — | — | — | *Note performance is based on the average between GRS901_SBP and GRS_901_DBP |
| PPM012846 | PGS002257 (GRS901_SBP) |
PSS009576| South Asian Ancestry| 8,827 individuals |
PGP000283 | Evangelou E et al. Nat Genet (2018) |
Reported Trait: Hypertension | OR: 1.3 [1.24, 1.36] | — | — | — | *Note performance is based on the average between GRS901_SBP and GRS_901_DBP |
| PPM012847 | PGS002258 (GRS901_DBP) |
PSS009574| European Ancestry| 14,004 individuals |
PGP000283 | Evangelou E et al. Nat Genet (2018) |
Reported Trait: Systolic blood pressure | β: 2.06 [1.79, 2.32] | — | — | — | *Note performance is based on the average between GRS901_SBP and GRS_901_DBP |
| PPM012848 | PGS002258 (GRS901_DBP) |
PSS009574| European Ancestry| 14,004 individuals |
PGP000283 | Evangelou E et al. Nat Genet (2018) |
Reported Trait: Diastolic blood pressure | β: 1.64 [1.46, 1.81] | — | — | — | *Note performance is based on the average between GRS901_SBP and GRS_901_DBP |
| PPM012849 | PGS002258 (GRS901_DBP) |
PSS009574| European Ancestry| 14,004 individuals |
PGP000283 | Evangelou E et al. Nat Genet (2018) |
Reported Trait: Pulse pressure | β: 0.42 [0.25, 0.58] | — | — | — | *Note performance is based on the average between GRS901_SBP and GRS_901_DBP |
| PPM012850 | PGS002258 (GRS901_DBP) |
PSS009574| European Ancestry| 14,004 individuals |
PGP000283 | Evangelou E et al. Nat Genet (2018) |
Reported Trait: Hypertension | OR: 1.27 [1.23, 1.32] | — | — | — | *Note performance is based on the average between GRS901_SBP and GRS_901_DBP |
| PPM012851 | PGS002258 (GRS901_DBP) |
PSS009575| African Ancestry| 6,970 individuals |
PGP000283 | Evangelou E et al. Nat Genet (2018) |
Reported Trait: Systolic blood pressure | β: 2.38 [1.85, 2.9] | — | — | — | *Note performance is based on the average between GRS901_SBP and GRS_901_DBP |
| PPM012852 | PGS002258 (GRS901_DBP) |
PSS009575| African Ancestry| 6,970 individuals |
PGP000283 | Evangelou E et al. Nat Genet (2018) |
Reported Trait: Diastolic blood pressure | β: 1.39 [1.09, 1.7] | — | — | — | *Note performance is based on the average between GRS901_SBP and GRS_901_DBP |
| PPM012853 | PGS002258 (GRS901_DBP) |
PSS009575| African Ancestry| 6,970 individuals |
PGP000283 | Evangelou E et al. Nat Genet (2018) |
Reported Trait: Pulse pressure | β: 0.99 [0.65, 1.32] | — | — | — | *Note performance is based on the average between GRS901_SBP and GRS_901_DBP |
| PPM012854 | PGS002258 (GRS901_DBP) |
PSS009575| African Ancestry| 6,970 individuals |
PGP000283 | Evangelou E et al. Nat Genet (2018) |
Reported Trait: Hypertension | OR: 1.26 [1.2, 1.33] | — | — | — | *Note performance is based on the average between GRS901_SBP and GRS_901_DBP |
| PPM012855 | PGS002258 (GRS901_DBP) |
PSS009576| South Asian Ancestry| 8,827 individuals |
PGP000283 | Evangelou E et al. Nat Genet (2018) |
Reported Trait: Systolic blood pressure | β: 2.58 [2.13, 3.03] | — | — | — | *Note performance is based on the average between GRS901_SBP and GRS_901_DBP |
| PPM012856 | PGS002258 (GRS901_DBP) |
PSS009576| South Asian Ancestry| 8,827 individuals |
PGP000283 | Evangelou E et al. Nat Genet (2018) |
Reported Trait: Diastolic blood pressure | β: 1.49 [1.25, 1.74] | — | — | — | *Note performance is based on the average between GRS901_SBP and GRS_901_DBP |
| PPM012857 | PGS002258 (GRS901_DBP) |
PSS009576| South Asian Ancestry| 8,827 individuals |
PGP000283 | Evangelou E et al. Nat Genet (2018) |
Reported Trait: Pulse pressure | β: 1.09 [0.8, 1.39] | — | — | — | *Note performance is based on the average between GRS901_SBP and GRS_901_DBP |
| PPM012858 | PGS002258 (GRS901_DBP) |
PSS009576| South Asian Ancestry| 8,827 individuals |
PGP000283 | Evangelou E et al. Nat Genet (2018) |
Reported Trait: Hypertension | OR: 1.3 [1.24, 1.36] | — | — | — | *Note performance is based on the average between GRS901_SBP and GRS_901_DBP |
|
PGS Sample Set ID (PSS) |
Phenotype Definitions and Methods | Participant Follow-up Time | Sample Numbers | Age of Study Participants | Sample Ancestry | Additional Ancestry Description | Cohort(s) | Additional Sample/Cohort Information |
|---|---|---|---|---|---|---|---|---|
| PSS009574 | — | — | 14,004 individuals | — | European | — | Airwave | — |
| PSS009575 | — | — | 6,970 individuals | — | African unspecified | — | UKB | — |
| PSS009576 | — | — | 8,827 individuals | — | South Asian | — | UKB | — |